公开(公告)号：US3686171A

公开(公告)日：1972-08-22

申请号：US3686171D

申请日：1970-12-02

Applicant: ABBOTT LAB

Inventor： SWETT LEO RALPH ,  RATAJCZYK JAMES DANIEL ,  YOUNG PATRICK RICHARD

IPC: C07D231/38 ,  C07D49/20

CPC classification number: C07D231/38 ,  Y10S514/916

Abstract: A NOVEL SERIES OF N''-(4-FORMYL)-5-AMIDO-PYRAZOLES WHICH ARE USEFUL AS INTERMEDIATS IN PREPARING N''-(4(HYDROXYMETHYL)-5-PYRAZOLYL)AMIDINES, THE AMIDINES ARE EFFECTIVE ANTI-FLAMMATORY AGENTS.

公开(公告)号：US3867402A

公开(公告)日：1975-02-18

申请号：US34144473

申请日：1973-03-15

Applicant: ABBOTT LAB

Inventor： PARIS GERARD YVON ,  SWETT LEO RALPH

IPC: C07D231/38 ,  C07D57/02

CPC classification number: C07D231/38 ,  Y10S514/825

Abstract: 1-Methyl-4,5-di(p-methoxyphenyl)-6H-pyrrolo (2,3-c)pyrazole, which is useful as an anti-inflammatory agent, as well as methods for preparing the compound.

Abstract translation: 可用作抗炎剂的1-甲基-4,5-二（对甲氧基苯基）-6H-吡咯并[2,3-c]吡唑，以及制备该化合物的方法。

公开(公告)号：US3701785A

公开(公告)日：1972-10-31

申请号：US3701785D

申请日：1971-02-04

Applicant: ABBOTT LAB

Inventor： SWETT LEO RALPH ,  PARIS GERARD YVON

IPC: C07D231/38 ,  C07D57/02

CPC classification number: C07D231/38 ,  Y10S514/916

Abstract: 1,3-DIMETHYL-4,6-DI(P-SUBSTITUTED PHENYL)-6H-PYRROLO(2,3-C)PYRAZOLES AND NOVEL INTERMEDIATES USEFUL IN THEIR SYNTHESIS. THE COMPOUNDS ARE USEFUL AS ANTI-INFLAMMATORY AND ANTI-PYRETIC AGENTS.

公开(公告)号：US3665008A

公开(公告)日：1972-05-23

申请号：US3665008D

申请日：1970-06-17

Applicant: ABBOTT LAB

Inventor： SWETT LEO RALPH ,  RATAJCZYK JAMES DANIEL

IPC: C07D231/18 ,  C07D495/04 ,  C07D49/18

CPC classification number: C07D495/04 ,  C07D231/18

Abstract: 1,3-Disubstituted-5,6-dihydrothiopyrano(2,3-c) pyrazoles are synthesized from the new 3-((1,3-disubstituted-5pyrazolyl)thio)propionic acids described. The new fused-ring compounds have excellent anti-inflammatory activity; they relieve edemas and are also useful as antipyretics and analgesics.

公开(公告)号：US3590048A

公开(公告)日：1971-06-29

申请号：US3590048D

申请日：1968-04-01

Applicant: ABBOTT LAB

Inventor： SWETT LEO RALPH ,  RATAJCZYK JAMES DANIEL

IPC: C07D495/04 ,  C07D65/08

CPC classification number: C07D495/04 ,  Y10S514/87 ,  Y10S514/916

Abstract: 1,3-DISUBSTITUTED-5,6-DIHYDROTHIOPYRANO(2,3-C) PYRAZ OLES ARE SYNTHESIZED FROM THE NEW 3-((1,3-DISUBSTITUTED5-PYRAZOLYL)THIO)PROPIONIC ACIDS DESCRIBED. THE NEW FUSED-RING COMPOUNDS HAVE EXCELLENT ANTI-INFLAMMATORY ACTIVITY; THEY RELIEVE EDEMAS AND ARE ALSO USEFUL AS ANTIPYRETICS AND ANALGESICS.

公开(公告)号：US3476748A

公开(公告)日：1969-11-04

申请号：US3476748D

申请日：1967-01-04

Applicant: ABBOTT LAB

Inventor： SWETT LEO RALPH ,  RATAJCZYK JAMES DANIEL ,  KIMURA EUGENE TATSURU

IPC: C07D513/04 ,  C07D93/12 ,  A61K27/00 ,  C07D99/10

CPC classification number: C07D513/04

公开(公告)号：US3891630A

公开(公告)日：1975-06-24

申请号：US44808674

申请日：1974-03-04

Applicant: ABBOTT LAB

Inventor： SWETT LEO RALPH

IPC: A61K31/55 ,  A61P29/00 ,  C07D471/04 ,  C07D513/04 ,  C07D99/10 ,  C07D99/00

CPC classification number: C07D471/04 ,  C07D513/04

Abstract: 1-H Pyrazolo(3,4-e)(1,4)thiazepin-7(8H)-ones which may be substituted in the 1, 3, 4, 6 and 8-position, and the corresponding isoxazolo(5,4-e)(1,4)thiazepin-7(8H)-ones which may be substituted in the 3, 4, 6 and/or 8-position are prepared by converting 5-aminopyrazole which may be substituted in the 1and/or 3-positions or a 5-aminoisoxazole which may be substituted in the 3-position into 4-arylidene or alkylidine-5-imino derivatives and subsequent condensation with thioglycolic acid or a substituted thioglycolic acid. The new compounds are useful anti-inflammatories.

Abstract translation: 可以在1,3,4,6和8位取代的1-H吡唑并[3,4-e] [1,4]硫氮杂-7（8H） - 酮和相应的异恶唑并[5,4 可以在3,4,6和/或8位上被取代的-e] [1,4]硫氮杂-7（8H） - 酮，其可通过将5-氨基吡唑转化成1-和/ 或3-位或5-氨基异恶唑，其可以在3-位被取代成4-亚芳基或亚烷基-5-亚氨基衍生物，随后与巯基乙酸或取代的巯基乙酸缩合。 新化合物是有用的抗炎药。

公开(公告)号：US3669983A

公开(公告)日：1972-06-13

申请号：US3669983D

申请日：1970-08-20

Applicant: ABBOTT LAB

Inventor： SWETT LEO RALPH ,  RATAJCZYK JAMES DANIEL

IPC: C07D231/38 ,  C07D85/22

CPC classification number: C07D231/38

Abstract: 7,8-Dihydro-4-oxopyrazolo(3,4-d) (1,3)thiazepines which may be substituted in the 1-, 3-, 5-, 7- and/or 8- position and the corresponding isoxazolo(5,4-d) (1,3)thiazepines which may be substituted in the 3-, 5-, 7- and/or 8- position are prepared by converting a 5-aminopyrazole which may be substituted in the 1and/or 3-positions or a 5-aminoisoxazole which may be substituted in the 3-position into a Schiff base and subsequent condensation of the Schiff base with thioglycolic acid or a substituted thioglycolic acid. The new compounds are useful antiinflammatories.

Abstract translation: 可以在1-，3-，5-，7-和/或8-位置被取代的7,8-二氢-4-氧代吡唑并[3,4-d] [1,3]噻吩并与相应的异恶唑并[ 可以在3-，5-，7-和/或8-位置被取代的5,4-d] [1,3]硫杂吗啉是通过将可被取代的5-氨基吡唑转化成1-和/ 或3-位或5-氨基异恶唑，其可以在3-位被取代成席夫碱，随后将席夫碱与巯基乙酸或取代的巯基乙酸缩合。 新化合物是有用的抗炎药。

公开(公告)号：US3424758A

公开(公告)日：1969-01-28

申请号：US3424758D

申请日：1967-12-19

Applicant: ABBOTT LAB

Inventor： SWETT LEO RALPH ,  STEIN ROBERT GEORGE ,  KIMURA EUGENE TATSURU

IPC: C07D231/18 ,  C07D231/20 ,  C07D498/04 ,  C07D513/04 ,  C07D99/04 ,  A61K27/00 ,  C07D99/06

CPC classification number: C07D513/04 ,  C07D231/18 ,  C07D231/20 ,  C07D498/04 ,  Y10S514/916

公开(公告)号：US3657271A

公开(公告)日：1972-04-18

申请号：US3657271D

申请日：1970-06-22

Applicant: ABBOTT LAB

Inventor： SWETT LEO RALPH

IPC: C07D231/16 ,  C07D231/38 ,  C07D231/40 ,  C07D487/04 ,  C07D57/02

CPC classification number: C07D231/38 ,  C07D231/16 ,  C07D231/40 ,  C07D487/04 ,  Y10S514/825

Abstract: 1,3-DIMETHYL-5-METHYLAMINO-8-PHENYLPYRAZOLO (4,3-E) (1,4) DIAZEPINE AND ITS METHOD OF PREPARATION. THE COMPOUND EXHIBITS ANTI-INFLAMMATORY ACTIVITY.