公开(公告)号：US3894005A

公开(公告)日：1975-07-08

申请号：US47312274

申请日：1974-05-24

Applicant: SQUIBB & SONS INC

Inventor： HOEHN HANS ,  SCHULZE ERNST

IPC: C07D471/04 ,  C07D31/42 ,  C07D39/00

CPC classification number: C07D471/04

Abstract: New hydrazones of pyrazolo(3,4-b)pyridines have the general formula:

They are useful as anti-inflammatory agents. In addition, this type of compound increases the intra-cellular concentration of adenosine-3'',5-cyclic monophosphate.

Abstract translation: 吡唑并[3,4-b]吡啶的新腙具有以下通式：

公开(公告)号：US3894021A

公开(公告)日：1975-07-08

申请号：US43746174

申请日：1974-01-28

Applicant: SQUIBB & SONS INC

Inventor： DENZEL THEODOR ,  HOEHN HANS

IPC: C07D471/04 ,  C07D471/14 ,  C07D51/42

CPC classification number: C07D471/04 ,  C07D471/14

Abstract: The new derivatives of 1,7-Dihydro-2H-pyrazolo-(4'',3'': 5,6)pyrido(4,3-d)pyrimidine-2,4-(3H)-diones have the general formula

R1 is hydrogen, lower alkyl, phenyl or phenyl-lower alkyl. R2 is hydrogen, lower alkyl or phenyl. R3 is hydrogen, lower alkyl, phenyl, phenyl-lower alkyl, (lower alkyl)amino-lower alkyl or di(lower alkyl)amino-lower alkyl. R4 is lower alkyl, phenyl, lower alkyl-phenyl or cyclo lower alkyl. R5 is hydrogen or lower alkyl. They are useful as anti-inflammatory agents and central nervous system depressants. In addition, this type of compound increases the intracellular concentration of adenosine-3'',5-cyclic monophosphate.

Abstract translation: 1,7-二氢-2H-吡唑并[4'，3'：5,6]吡啶并[4,3-d]嘧啶-2,4-（3H） - 二基的新衍生物具有通式R 1 是氢，低级烷基，苯基或苯基 - 低级烷基。

公开(公告)号：US3414573A

公开(公告)日：1968-12-03

申请号：US41890964

申请日：1964-12-16

Applicant: SQUIBB & SONS INC

Inventor： BREUER HERMANN ,  HOEHN HANS ,  ROESCH EGON

IPC: A61K31/505 ,  C07D239/91

CPC classification number: C07D239/91 ,  A61K31/505

公开(公告)号：US3929812A

公开(公告)日：1975-12-30

申请号：US47153774

申请日：1974-05-20

Applicant: SQUIBB & SONS INC

Inventor： DENZEL THEODOR ,  HOEHN HANS

IPC: C07D213/80 ,  C07D471/04 ,  C07D213/55

CPC classification number: C07D213/80 ,  C07D471/04

Abstract: New derivatives of 1H-triazolo(4,5-c)pyridine-7-carboxylic acids and esters and their acid addition salts having the general formula

ARE DISCLOSED. They are useful as anti-inflammatory agents and central nervous system depressants. In addition, this type of compound increases the intracellular concentration of adenosine3'',5''-cyclic monophosphate.

Abstract translation: 具有通式ARE的1H-三唑并[4,5-c]吡啶-7-羧酸和酯及其酸加成盐的新衍生物。 它们可用作抗炎剂和中枢神经系统抑制剂。 此外，这种化合物增加腺苷-3'，5'-环状单磷酸的细胞内浓度。

公开(公告)号：US3880867A

公开(公告)日：1975-04-29

申请号：US43977774

申请日：1974-02-05

Applicant: SQUIBB & SONS INC

Inventor： DENZEL THEODOR ,  HOEHN HANS

IPC: C07D491/147 ,  A23K1/16 ,  C07D471/04 ,  C07D491/14 ,  C07D99/04

CPC classification number: C07D471/04 ,  C07D491/14

Abstract: New derivatives of furo(2,3-d)pyrazolo(3,4-b)pyridines have the general formula

They are useful as antiinflammatory agents and central nervous system depressants. In addition, this type of compound increases the intra-cellular concentration of adenosine-3'', 5''-cyclic monophosphate.

Abstract translation: 呋喃并[2,3-d]吡唑并[3,4-b]吡啶的新衍生物具有通式，它们可用作抗炎剂和中枢神经系统抑制剂。 此外，这种化合物增加了腺苷-3'，5'-环状单磷酸的细胞内浓度。

公开(公告)号：US3669950A

公开(公告)日：1972-06-13

申请号：US3669950D

申请日：1970-12-01

Applicant: SQUIBB & SONS INC

Inventor： HOEHN HANS ,  SCHULZE ERNEST

IPC: C07D471/04 ,  C07D471/14 ,  C07D31/44

CPC classification number: C07D471/04 ,  C07D471/14

Abstract: New dipyrazolo(3,4-b:3'',4''-d)pyridin-3-ones and their salts are useful as central nervous system depressants. This type of compound also increases the intracellular concentration of adenosine-3'' ,5''-cyclic monophosphate.

Abstract translation: 新的二吡唑并[3,4-b：3'，4'-d]吡啶-3-酮及其盐可用作中枢神经系统抑制剂。 这种化合物也增加了腺苷-3'，5'-环状单磷酸的细胞内浓度。

公开(公告)号：US3629271A

公开(公告)日：1971-12-21

申请号：US3629271D

申请日：1969-06-16

Applicant: SQUIBB & SONS INC

Inventor： HOEHN HANS

IPC: C07D231/38 ,  C07D471/04 ,  C07D31/36

CPC classification number: C07D231/38 ,  C07D471/04

Abstract: NEW PYRAZOLIPYRIDINE CARBOXYLIC ACID COMPOUNDS AND DERIVATIES OF THE GENERAL FORMULA

1-R2,3-R3,4-(R-O-),5-(R1-OOC-)-1H-PYRAZOLO(3,4-B)PYRIDINE

WHICH ARE ANTIMICROBIAL AGENTS AND CENTRAL DEPRESSANTS, AS WELL AS INTERMEDIATES THEREFOR, ARE THE SUBJECT OF THIS INVENTION.

公开(公告)号：US3591599A

公开(公告)日：1971-07-06

申请号：US3591599D

申请日：1969-12-31

Applicant: SQUIBB & SONS INC

Inventor： HOEHN HANS ,  SCHULZE ERNST

IPC: C07D513/04 ,  C07D99/06

CPC classification number: C07D513/04

Abstract: NEW ISOIDOLO(1,2-B)BENZOTHIAZOL-11(4BH)ONE 5-OXIDES WHICH ARE ANTI-INFLAMMATORY AND ANALGESTIC AGENTS HAVE THE FORMULA

4B-R1,5-(O=),R2-ISOINDOLO(1,2-B)BENZOTHIAZOL-11(4BH)-ONE

公开(公告)号：US3515787A

公开(公告)日：1970-06-02

申请号：US3515787D

申请日：1967-09-15

Applicant: SQUIBB & SONS INC

Inventor： BREUER HERMANN ,  HOEHN HANS ,  ROESCH EGON

IPC: A61K31/505 ,  C07D239/91 ,  A61K27/00

CPC classification number: C07D239/91 ,  A61K31/505

公开(公告)号：US4026893A

公开(公告)日：1977-05-31

申请号：US63012075

申请日：1975-11-07

Applicant: SQUIBB & SONS INC

Inventor： DENZEL THEODOR ,  HOEHN HANS

IPC: A61K31/505 ,  A61P25/00 ,  A61P29/00 ,  C07D471/14 ,  C07D487/04 ,  C07D487/14

CPC classification number: C07D471/14 ,  C07D487/04

Abstract: New derivatives of pyrazolo[1,5-a]pyrido[3,2-e]-pyrimidine-7-carboxylic acid have the general formula The new compounds are useful as central nervous system depressants and as anti-inflammatory agents.

Abstract translation: 吡唑并[1,5-a]吡啶并[3,2-e] - 嘧啶-7-羧酸的新衍生物具有通式：该化合物可用作中枢神经系统抑制剂和抗炎剂。