公开(公告)号：US3875161A

公开(公告)日：1975-04-01

申请号：US33156173

申请日：1973-02-12

Applicant: SANDOZ AG

Inventor： HARDTMANN GOETZ E

IPC: C07D487/04 ,  C07D51/42

CPC classification number: C07D487/04 ,  Y10S514/826

Abstract: The compounds are of the class of imidazo(2,1-b)quinazolin5(1OH)-ones, useful, for example, as bronchodilator agents. The compounds are prepared by dehydrogenation of the corresponding 2,3-dihydro-imidazo(2,1-b)quinazolin-5(1OH)-ones.

Abstract translation: 这些化合物是咪唑并[2,1-b]喹唑啉-5（10H）酮类，可用于例如支气管扩张剂。 通过相应的2,3-二氢 - 咪唑并[2,1-b]喹唑啉-5（1OH）酮的脱氢制备化合物。

公开(公告)号：US3868373A

公开(公告)日：1975-02-25

申请号：US31746772

申请日：1972-12-21

Applicant: HOFFMANN LA ROCHE

Inventor： HOFFER MAX

IPC: C07F7/18 ,  C07H13/08 ,  C07H19/06 ,  C07D51/42

CPC classification number: C07H13/08 ,  C07F7/1804 ,  C07H19/06

Abstract: 4-Amino-5-fluoro-2-triloweralkylsilyloxypyrimidines, useful as an intermediate in the production of antibacterial and antiviral, 1- Beta -D-arabinofuranosyl-5-fluorocytosine from fluorocytosine.

Abstract translation: 4-氨基-5-氟-2-三氟烷基甲硅烷氧基嘧啶，可用作生产抗细菌和抗病毒药物的中间体，来自氟胞嘧啶的1-β-D-阿拉伯呋喃糖基-5-氟胞嘧啶。

公开(公告)号：US3867386A

公开(公告)日：1975-02-18

申请号：US37663573

申请日：1973-07-05

Applicant: AMERICAN HOME PROD

Inventor： KIM DONG H ,  SANTILLI ARTHUR A

IPC: C07D487/04 ,  C07D51/42

CPC classification number: C07D487/04

Abstract: The disclosure is directed to 5-amino-2,6-substituted-7Hpyrrolo(2,3-d)pyrimidines and related compounds and to 4-halo-5pyrimidinecarbonitriles and their derivatives. The compounds have central nervous system activity as depressants. That is, they produce a calming effect in the host.

Abstract translation: 本公开涉及5-氨基-2,6-取代的-7H-吡咯并[2,3-d]嘧啶及其相关化合物和4-卤代-5-嘧啶碳腈及其衍生物。 该化合物具有作为抑制剂的中枢神经系统活性。 也就是说，它们在主机中产生平静的效果。

公开(公告)号：US3847920A

公开(公告)日：1974-11-12

申请号：US36136573

申请日：1973-05-17

Applicant: WARNER LAMBERT CO

Inventor： KLUTCHKO S ,  VON STRANDTMANN M

IPC: C07D209/40 ,  C07D487/04 ,  C07D51/42

CPC classification number: C07D487/04 ,  C07D209/40 ,  Y10S514/927

Abstract: 1. A MEMBER SELECTED FROM THE GROUP CONSISTING OF COMPOUNDS OF THE FORMULAS:

3-R-PYRIMIDO(4,5-B)INDOLIUM X(-) OR 3-R-3,4-DIHYDRO-

PYRIMIDO(4,5-B)INDOLE

WHEREIN R IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF ALKYL, DIALKYLAMINOALKYL, MONOHYDROXYALKYL IN WHICH ALKYL HAS 1 TO 7 CARBON ATOMS, PHENYL, ALKYLPHENYL HAVING A TOTAL OF 7 TO 10 CARBON ATOMS, N-OXIDE, CARBOXYMETHYL, CARBOXYMETHYL ANION, AND X IS CHLORO OR BROMO OR NONEXISTENT IN THE CASE OF ZWITTERIONS.

公开(公告)号：US3845055A

公开(公告)日：1974-10-29

申请号：US25141172

申请日：1972-05-08

Applicant: CIBA GEIGY CORP

Inventor： BOEHLER P ,  ACKERMANN H ,  HOEGERLE K ,  VOGEL C

IPC: C07D239/30 ,  C07D239/42 ,  C07D239/48 ,  C07D51/42

CPC classification number: C07D239/30 ,  C07D239/42 ,  C07D239/48

Abstract: 1. 2-ISOPROPYLAMINO - 4 - METHYLAMINOPYRIMIDIENE-5CARBOXYLIC ACID METHYLAMIDE AND ITS SALTS.

公开(公告)号：US3819629A

公开(公告)日：1974-06-25

申请号：US16982871

申请日：1971-08-06

Applicant: BURROUGHS WELLCOME CO

Inventor： ROTH B ,  STRELITZ J

IPC: C07D239/49 ,  C07D51/42

CPC classification number: C07D239/49

Abstract: THE METHOD OF PREPARING A COMPOUND I

2,4-DI(NH2-),5-((3,5-DI(CH3-O-),4-HO-PHENYL)-CH2-)-

PYRIMIDINE

WHREIN R IS AN ALKYL GROUP, OR AN UNSATURATED ALKYL GROUP, AND WHEREIN THE ALKYL GROUPS MAY ALSO BEAR HALOGEN SUBSTITUTION BY REACTING A COMPOUND II

2,4-DI(NH2-),5-((3,5-DI(CH3-O-),4-HO-PHENYL)-CH2-)-

PYRIMIDINE

WITH AN ALKYL HALIDE WHEREIN R IS DEFINED AS ABOVE. THE INVENTION ALSO COMPRISES COMPOUNDS OF FORMULA (I) WHEREIN R'' IS SELECTED FROM THE CLASS CONSISTING OF AN ALKYL GROUP HAVING A HALOGEN SUBSTITUTION AND AN UNSATURATED ALKYL GROUP. ADDITIONALLY, THE TERM R IN THE FORMULAS ABOVE MAY BE AN ARALKYL GROUP OR AN ALKYL OR ALKOXY SUBSTITUTED ARALKYL GROUP.

公开(公告)号：US3796713A

公开(公告)日：1974-03-12

申请号：US3796713D

申请日：1971-12-20

Applicant: HOFFMANN LA ROCHE

Inventor： DERIEG M ,  FRYER R ,  STERNBACH L

IPC: C07D487/04 ,  C07D51/42

CPC classification number: C07D487/04 ,  Y10S514/906

Abstract: NOVEL 1H - 1,4 - BENZODIAZEPINE BEARING BETWEEN THE 1,2-POSITIONS A 5- OR 6-MEMBERED HERETOCYCLIC RING POSSESSING TWO NITROGEN ATOMS ARE DISCLOSED. THESE 1,2-HETEROCYCLIC-1H-1,4-BENZODIAZEPINES ARE USEFUL AS MUSCLE RELAXANT, ANTI-CONVULSANT AND SEDATIVE AGENTS.

公开(公告)号：US3792051A

公开(公告)日：1974-02-12

申请号：US3792051D

申请日：1972-03-17

Applicant: BASF AG

Inventor： GRASER F

IPC: C08K5/3462 ,  C09B5/62 ,  C07D51/42

CPC classification number: C09B5/62 ,  C08K5/3462

Abstract: PERYLENE 3,9,10-TETRACARBOXYLIC ACID-BIS-(2-AMIDO-4METHYLPYRIMIDINE) WHICH IS USEFUL AS A PIGMENT HAVING VERY GOOD FASTNESS PROPERTIES.

公开(公告)号：US3715357A

公开(公告)日：1973-02-06

申请号：US3715357D

申请日：1970-06-04

Applicant: HOFFMANN LA ROCHE

Inventor： REY BELLET G ,  SCHWARTZ D ,  REINER R

IPC: C07D239/48 ,  C07D239/49 ,  C07D51/42

CPC classification number: C07D239/49

Abstract: Antibacterially active N-oxides of 2,4-diamino-benzylpyrimidines are described.

Abstract translation: 描述2,4-二氨基 - 苄基嘧啶的抗菌活性N-氧化物。

公开(公告)号：US3703517A

公开(公告)日：1972-11-21

申请号：US3703517D

申请日：1971-05-14

Applicant: AMERICAN HOME PROD

Inventor： KIM DONG H ,  SANTILLI ARTHUR A

IPC: C07D239/42 ,  C07D51/42

CPC classification number: C07D239/42

Abstract: THE DISCLOSURE IS DIRECTED TO 5 - HYDROXY - 7H-PYRROLO (2,3-D)PYRIMIDINE-6-CARBOXYLIC ACID ESTERS AND TO 4-((CARBOXYALKYL)AMINO)-5-PYRIMIDINECARBOXYLIC ACID ESTERS. ALL THESE COMPOUNDS HAVE CENTRAL NERVOUS SYSTEM ACITIVITY AS DEPRESSANTS WHILE THE LATTER COMPOUNDS MAY ALSO BE USED IN THE PREPARATION OF THE FORMER COMPOUNDS.