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    Anthelmintic compounds
    2.
    发明授权
    Anthelmintic compounds 失效
    ANTHELMINTIC化合物

    公开(公告)号：US3852336A

    公开(公告)日：1974-12-03

    申请号：US22956372

    申请日：1972-02-25

    申请人： BURROUGHS WELLCOME CO

    发明人： HARFENIST M

    IPC分类号： A61K31/165 ,  C07C233/16 ,  C07C69/40 ,  C07C69/48

    CPC分类号： A61K31/165 ,  C07C233/16

    摘要： The compound of formula (I)

    wherein R and R1 are the same or different and each is hydrogen, an optionally substituted aliphatic hydrocarbon group having 1 to 7 carbon atoms, or an unsaturated aliphatic hydrocarbon group having 2 to 4 carbon atoms; R2 and R3 are the same or different and each is hydrogen or an alkyl group having 1 to 4 carbon atoms; Z is the group v,4/4 WHERE M IS 0 OR 1, AND X, X1 and X2 are the same or different and each is hydrogen or an alkyl group having 1 to 3 carbon atoms; and A is 1) a carbonyldioxy group (-O-CO-O-) or is a divalent residue of a monocarboxylic acid or a dicarboxylic acid containing 2 to 14 carbon atoms and having two ester linkages, or one ester and one ether linkage, to the rest of the molecule. The compounds are useful in the treatment of liver fluke infections of mammals.

    摘要翻译： 式（I）的化合物，其中R和R 1相同或不同，各自为氢，任选取代的具有1至7个碳原子的脂族烃基或具有2至4个碳原子的不饱和脂族烃基; R2和R3相同或不同，各自为氢或具有1至4个碳原子的烷基; Z是基团v，4/4，其中M是0或1，X，X1和X2相同或不同，各自为氢或具有1至3个碳原子的烷基; 并且A为1）羰基二氧基（-O-CO-O-），或为含有2至14个碳原子且具有两个酯键的一元羧酸或二羧酸的二价残基或一个酯和一个醚键， 到分子的其余部分。 该化合物可用于治疗哺乳动物的肝吸虫感染。

    Culture apparatus
    3.
    发明授权
    Culture apparatus 失效
    文化装置

    公开(公告)号：US3827943A

    公开(公告)日：1974-08-06

    申请号：US17903271

    申请日：1971-09-09

    申请人： BURROUGHS WELLCOME CO

    发明人： MANN G

    IPC分类号： C12M3/04 ,  C12B1/04

    CPC分类号： C12M25/10 ,  C12M27/14

    摘要： A CULTURE VESSEL, COMPRISING A PLURALITY OF PARALLEL CULTURE OF SUBSTANTIALLY UNIFORM LENGHT MOUNTED AROUND A CENTRALLY POSITIONED SUPPORTING MEMBER BY MANIFOLD PLATES AT EACH OF ITS TWO ENDS EXERTING AXIAL PRESSURE ON THE TUBES TO SEAL THE ENDS THEREO, THE TWO PLATES (A) HAVING COMMUNICATING CHANNELS, WHICH ARE ADAPTED TO INTERCONNECT FALL THE TUBES AND ARE PROVIDED WITH A COMMON INLET OUTLET FIRST OPENING ON ONE OF THE END-PLATES WHICH CAN BE CONNECTED TO A SERVICE TUBE EQUIPPED WITH FLOW CONTROLLING MEANS, AND A COMMON SECOND OPENING ON THE OTHER ENDPLATE WHICH CAN BE USED WITH A FILTER TUBE, (B) BEING MOUNTED ONTHE SUPPORTING MEMBER AND (C) BEING ADAPTED TO LOCATE AND HOLD THE TUBES TO FORM A SEALED VESSEL CAPABLE OF BEING DETACHED FROM GENERAL SUPPORTING MEANS AND BEING ROLLED BY DRIVING MEANS, AND ITS USE IN THE CULTIVATION OF MICROBILOGICAL MATERIAL IN LIQUID SUSPENSION.

    Chemical compounds, processes for their preparation, and pharmaceutical compositions incorporating the same
    5.
    发明授权
    Chemical compounds, processes for their preparation, and pharmaceutical compositions incorporating the same 失效
    化学化合物，其制备方法和含有它们的药物组合物

    公开(公告)号：US3742050A

    公开(公告)日：1973-06-26

    申请号：US3742050D

    申请日：1970-02-16

    申请人： BURROUGHS WELLCOME CO

    发明人： HODSON H

    IPC分类号： A61K31/155 ,  A61K31/38 ,  C07C67/00 ,  C07C239/00 ,  C07C257/14 ,  C07D333/16 ,  C07D333/20 ,  C07D333/24 ,  C07D333/28 ,  C07D333/36 ,  C07C123/00

    CPC分类号： C07C255/00 ,  C07D333/16 ,  C07D333/28

    摘要： An amidine of general formula I, as shown in the accompanying drawings, or an acid addition salt thereof wherein: R1 and R2 are the same of different and each is a phenyl or thien-2-yl group, optionally substituted in one or more positions by a substituent selected from the class consisting of halogen, lower alkyl, lower alkoxy, hydroxy, lower alkylthio, trifluoromethyl, phenyl, phenoxy, phenyl-(lower alkyl) and phenyl-(lower alkoxy), each of said phenyl, phenoxy, phenyl-(lower alkyl) and phenyl-(lower alkoxy) substituent groups being optionally substituted in one or more positions by a member selected from the class consisting of halogen, lower alkyl, lower alkoxy, hydroxy and lower alkylthio; A1 is a divalent straight or branched alkylene group containing from two to six carbon atoms and one or two divalent atoms which are each an oxygen or sulphur atom, provided that there are at least two carbon atoms between the divalent atom and the -NHgroup and between the two divalent atoms; A2 is a straight or branched alkylene chain containing from one to four carbon atoms; and Z is a member selected from the class consisting of hydrogen and lower alkyl. The compounds are specific antagonists of serotonin, useful specifically as antipressor agents, anticontracting agents and anti-inflammatory agents. Their high activity is maintained for at least 24 hours.

    摘要翻译： 如附图所示的通式I的脒或其酸加成盐，其中：R 1和R 2相同，各自为苯基或噻吩-2-基，任选在一个或多个位置上被取代 选自卤素，低级烷基，低级烷氧基，羟基，低级烷硫基，三氟甲基，苯基，苯氧基，苯基 - （低级烷基）和苯基 - （低级烷氧基）的取代基，各自为苯基，苯氧基，苯基 - （低级烷基）和苯基 - （低级烷氧基）取代基任选在一个或多个位置被选自卤素，低级烷基，低级烷氧基，羟基和低级烷硫基的成员取代; A 1是含有2至6个碳原子和一个或两个二价原子的二价直链或支链亚烷基，它们各自为氧或硫原子，条件是在二价原子和-NH- 两个二价原子之间; A2是含有1-4个碳原子的直链或支链亚烷基链; Z为选自氢和低级烷基的成员。

    Method of treating or preventing coccidiosis with thiosemicarbazone derivatives
    7.
    发明授权
    Method of treating or preventing coccidiosis with thiosemicarbazone derivatives 失效
    用硫代青霉烯酮衍生物治疗或预防结肠癌的方法

    公开(公告)号：US3629416A

    公开(公告)日：1971-12-21

    申请号：US3629416D

    申请日：1969-03-12

    申请人： BURROUGHS WELLCOME CO

    发明人： BARRETT PAUL ANTHONY

    IPC分类号： A61K31/175 ,  A61K27/00

    CPC分类号： A61K31/175 ,  Y10S514/889

    摘要： A METHOD OF TREATING OR PREVENTING COCCIDIOSIS IN AN ANIMAL WHICH COMPRISES ADMINSTERING TO THE ANIMAL AN EFFECTIVE AMOUNT OF A COMPOUND

    OR A PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALT THEREOF WHERE R1 IS SLECTED FROM THE CLASS CONSISTING OF HYDROGEN, LOWER ALKYL, CYCLOHEXYL, BENZYL, LOWER ALKOXY LOWER ALKYL, ACETOXYMETHYL AND PHENYL, R2 IS SELECTED FROM THE CLASS CONSISTING OF HYDROGEN, LOWER ALKYL, BENZYL AND PHENYL, A IS ALKYLENE HAVING 1 TO 8 PREFERABLY 1 TO 5 CARBON ATOMS AND NR32 IS SELECTED FROM THE CLASS CONSISTING OF DIALKYLAMINO, PYRROLIDINO, PIPERIDINO AND MORPHOLINO.

    Process for phosphonic ethylation of amines
    8.
    发明授权
    Process for phosphonic ethylation of amines 失效
    氨基磷酸化方法

    公开(公告)号：US3560494A

    公开(公告)日：1971-02-02

    申请号：US3560494D

    申请日：1966-10-18

    申请人： BURROUGHS WELLCOME CO

    发明人： COPP FREDERICK CHARLES

    IPC分类号： C07F9/54 ,  C07D87/26

    CPC分类号： C07F9/5407

    摘要： A METHOD FOR PREPARING THE CATION OF FORMULA 1

    Z=N-CH(-R5)-CH(-R4)-P(+)(-R1)(-R2)-R3

    WHICH COMPRISES REACTING A CATION OF FORMULA II

    Q-CH(-R5)-CH(-R4)-P(+)(-R1)(-R2)-R3

    WITH A SECONDARY AMINE Z=NH; WHERE R1,R2 AND R3 ARE LOWER ALKYL OR PHENYL. R4 IS HYDROGEN, R5 IS HYDROGEN OR LOWER ALKYL, Q IS PHENOXY UNSUBSTITUTED OR SUBSTITUTED WITH LOWER ALKYL, LOWER ALKOXY OR HALOGENO, Z=N- IS UNSUBSTITUTED DI-LOWER ALKYLAMINO, PYRROLIDINO, MORPHOLINO OR PIPERIDINO, IN ALL DEFINITIONS ABOVE LOWER ALKYL AND LOWER ALKOXY HAVE 1 TO 5 CARBONS. THE PRODUCTS OF THIS METHOD ARE USEFUL AS INTERMEDIATES IN THE PREPARATION OF WELL KNOWN ANTIHISTIMINES AND ANALGESICS.