公开(公告)号：US3560494A

公开(公告)日：1971-02-02

申请号：US3560494D

申请日：1966-10-18

申请人： BURROUGHS WELLCOME CO

发明人： COPP FREDERICK CHARLES

IPC分类号： C07F9/54 ,  C07D87/26

CPC分类号： C07F9/5407

摘要： A METHOD FOR PREPARING THE CATION OF FORMULA 1

Z=N-CH(-R5)-CH(-R4)-P(+)(-R1)(-R2)-R3

WHICH COMPRISES REACTING A CATION OF FORMULA II

Q-CH(-R5)-CH(-R4)-P(+)(-R1)(-R2)-R3

WITH A SECONDARY AMINE Z=NH; WHERE R1,R2 AND R3 ARE LOWER ALKYL OR PHENYL. R4 IS HYDROGEN, R5 IS HYDROGEN OR LOWER ALKYL, Q IS PHENOXY UNSUBSTITUTED OR SUBSTITUTED WITH LOWER ALKYL, LOWER ALKOXY OR HALOGENO, Z=N- IS UNSUBSTITUTED DI-LOWER ALKYLAMINO, PYRROLIDINO, MORPHOLINO OR PIPERIDINO, IN ALL DEFINITIONS ABOVE LOWER ALKYL AND LOWER ALKOXY HAVE 1 TO 5 CARBONS. THE PRODUCTS OF THIS METHOD ARE USEFUL AS INTERMEDIATES IN THE PREPARATION OF WELL KNOWN ANTIHISTIMINES AND ANALGESICS.

公开(公告)号：US3474134A

公开(公告)日：1969-10-21

申请号：US3474134D

申请日：1965-09-23

申请人： BURROUGHS WELLCOME CO

发明人： COPP FREDERICK CHARLES ,  HODSON HAROLD FRANCIS

IPC分类号： A61K31/155 ,  C07C51/60 ,  C07C205/37 ,  C07C129/12 ,  A61K27/00

CPC分类号： A61K31/155 ,  C07C51/60 ,  C07C205/37 ,  C07C59/70