公开(公告)号：US12011497B2

公开(公告)日：2024-06-18

申请号：US17413358

申请日：2019-12-11

申请人： Molgenbio Co. Ltd.

发明人： Yeo Joon Yoon ,  Eunji Cheong ,  Seung-Woo Cho ,  Myoung-Chong Song ,  Ji Yoon Beom ,  Jin A Jung ,  Jong Seung Lee ,  Heon-Joo Lee

IPC分类号： A61K8/49 ,  A23L29/00 ,  A23L33/10 ,  A61K31/407 ,  A61K31/436 ,  A61P17/14 ,  A61Q7/00

CPC分类号： A61K8/4926 ,  A23L29/045 ,  A23L33/10 ,  A61K31/407 ,  A61K31/436 ,  A61P17/14 ,  A61Q7/00

摘要： Provided are preparation and use of novel compounds available as main ingredients of a composition for promoting hair growth, wherein the novel compounds are 9-deoxo-31-O-demethyl-prolyl-FK506, 9-deoxo-36,37-dihydro-FK506, 31-O-demethyl-36,37-dihydro-FK506, 9-deoxo-31-O-demethyl-36,37-dihydro-FK506, 9-deoxo-FK520, 31-O-demethyl-FK520, 9-deoxo-31-O-demethyl-FK520, 9-deoxo-FK523, and 9-deoxo-31-O-demethyl-FK523.

公开(公告)号：US20240180945A1

公开(公告)日：2024-06-06

申请号：US18493421

申请日：2023-10-24

申请人： SyneuRx International (Taiwan) Corp.

发明人： Guochuan Emil Tsai ,  Yi-Wen Mao ,  Lu-Ping Lu ,  Wei-Hua Chang ,  Han-Yi Hsieh ,  Jhe Wei Hu ,  Tsai-Miao Shih ,  ChanHui Huang

IPC分类号： A61K31/7048 ,  A23L33/00 ,  A23L33/10 ,  A61K31/235 ,  A61K31/36 ,  A61K31/40 ,  A61K31/415 ,  A61K31/7034 ,  A61P25/18 ,  C07C69/90 ,  C07D207/34 ,  C07D231/14 ,  C07D317/68 ,  C07H15/22 ,  C07H15/26

CPC分类号： A61K31/7048 ,  A23L33/10 ,  A23L33/40 ,  A61K31/235 ,  A61K31/36 ,  A61K31/40 ,  A61K31/415 ,  A61K31/7034 ,  A61P25/18 ,  C07C69/90 ,  C07D207/34 ,  C07D231/14 ,  C07D317/68 ,  C07H15/22 ,  C07H15/26 ,  A23V2002/00

摘要： A compound of Formula (I):




or a pharmaceutically acceptable salt thereof, in which Ring X is a 3 to 7 membered monocyclic ring, at least one of R1, R2, R3, and R4 is OR5 or CH2OR5 and the other R1, R2, R3, and R4 each independently are halogen, OH, OR5, CH2OR5, CO2H, OC═OR6, (C═O)R6, R6, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, H, or absent. Also provided herein are therapeutic uses of the compound of Formula (I).

公开(公告)号：US11998571B2

公开(公告)日：2024-06-04

申请号：US18046719

申请日：2022-10-14

申请人： DESIGNED CELLS CO., LTD.

发明人： Yun Bae Kim ,  Ehn Kyoung Choi ,  Tae Myoung Kim

IPC分类号： A61K35/50 ,  A23L33/10 ,  A61K9/127 ,  A61P27/02 ,  A61P27/06 ,  C12N5/073

CPC分类号： A61K35/50 ,  A23L33/10 ,  A61K9/127 ,  A61P27/02 ,  A61P27/06 ,  C12N5/0605 ,  A23V2002/00 ,  C12N2500/02

摘要： Disclosed herein is a pharmaceutical composition comprising at least one selected from the group consisting of a stem cell-conditioned medium and an exosome isolated therefrom as an active ingredient for prevention or treatment of an ocular disease. Containing exosomes, growth factors and neurotrophic factors at high levels and functioning to: promote retinal cell proliferation and wound recovery; protect retinal cells against oxidative stress or hypoxia; lower the increased intraocular pressure and restore the atrophy of the retinal layer and the retinal ganglion cell layer to normal levels in the glaucoma animal model; and have a protective effect on retinal ganglion cells and nerve cells, the stem cell-conditioned medium according to the present disclosure can find advantageous applications in the therapy of an ocular disease.

公开(公告)号：US20240115552A1

公开(公告)日：2024-04-11

申请号：US18525209

申请日：2023-11-30

申请人： The Johns Hopkins University

发明人： Gregory Riggins ,  Renyuan Bai ,  Verena Staedtke ,  Avadhut D. Joshi ,  Tara Williamson

IPC分类号： A61K31/4184 ,  A23L33/10 ,  A61K9/00 ,  A61K9/16 ,  A61K9/50 ,  A61K31/192 ,  A61K31/473 ,  A61K45/06

CPC分类号： A61K31/4184 ,  A23L33/10 ,  A61K9/0056 ,  A61K9/1605 ,  A61K9/50 ,  A61K31/192 ,  A61K31/473 ,  A61K45/06 ,  A61P35/00 ,  C07B2200/13

摘要： Mebendazole is an antiparasitic drug with over 40 years of safe use. Recently mebendazole was repurposed for glioblastoma therapy. Three polymorphs of mebendazole exist, but the relative polymorph content for existing drugs varies, and the therapeutic anti-cancer relevance of the different polymorphs was unknown. As an oral drug mebendazole polymorph C is a superior form, and it reaches the brain and brain tumors in effective concentrations. Efficacy is further improved by combining mebendazole with a P-glycoprotein inhibitor. Mebendazole may also be used for therapy of other cancers, as well as a chemo-preventative agent.

公开(公告)号：US11950615B2

公开(公告)日：2024-04-09

申请号：US17523683

申请日：2021-11-10

申请人： OTSUKA PHARMACEUTICAL CO., LTD.

发明人： Lawrence Arne ,  Mark Zdeblick ,  Aditya Dua ,  George Savage ,  Robert Leichner ,  Jafar Shenasa ,  Patricia Johnson ,  Raymond Schmidt ,  Zahedeh Hatamkhany ,  Veeraperumanallu Muralidharan

IPC分类号： A23L33/10 ,  A23L33/00 ,  A23L35/00 ,  A23P20/00 ,  A23P20/10 ,  G06K7/10 ,  G06K19/07 ,  H04B5/00

CPC分类号： A23L33/10 ,  A23L33/00 ,  A23L35/00 ,  A23P20/10 ,  A23P20/19 ,  G06K7/10366 ,  G06K19/0717 ,  G06K19/0723 ,  H04B5/0031 ,  H04B5/0062 ,  A23V2002/00

摘要： An apparatus includes a food product, at least one ingestible device associated with the food product to communicate information and at least one coating material surrounding the at least one ingestible device is disclosed. The ingestible device is associated with an ingestible medication to be ingested in conjunction with the food product. The coating is configured to release the at least one ingestible device upon the occurrence of an event.

公开(公告)号：US11945779B2

公开(公告)日：2024-04-02

申请号：US17052865

申请日：2019-05-02

申请人： VSpharmtech

发明人： Byoung-Mog Kwon ,  Dong Cho Han ,  Yae Jin Yoon ,  Yu Jin Lee ,  Jiyoun Choi ,  Sangku Lee

IPC分类号： A61K31/445 ,  A23L33/10 ,  A61K45/06 ,  C07D211/14

CPC分类号： C07D211/14 ,  A23L33/10 ,  A61K45/06

摘要： The present invention relates to a pharmaceutical composition for preventing or treating cancer metastasis, a health functional food, and a method for preventing or treating cancer metastasis using the same, containing a novel compound for inhibiting migration and invasion of cancer cells or a pharmaceutically acceptable salt thereof as an active ingredient.

公开(公告)号：US11938123B2

公开(公告)日：2024-03-26

申请号：US17059046

申请日：2019-05-29

申请人： Pharos iBio Co., Ltd.

发明人： Jeong Hyeok Yoon ,  Ky Youb Nam

IPC分类号： A61K31/4535 ,  A23L33/10 ,  A61K45/06 ,  A61P35/00

CPC分类号： A61K31/4535 ,  A23L33/10 ,  A61K45/06 ,  A61P35/00

摘要： A composition for preventing, ameliorating or treating breast cancer, the composition containing a 2,3,5-substituted thiophene compound according to one embodiment of the present disclosure has an excellent activity of inhibiting the proliferation of breast cancers, particularly triple-negative breast cancer and Herceptin-resistant breast cancer, which have high mortality because there has yet been no effective therapeutic method therefor. Thus, the composition may be advantageously used for the prevention, amelioration or treatment of breast cancer.

公开(公告)号：US11904037B2

公开(公告)日：2024-02-20

申请号：US17251052

申请日：2019-06-03

申请人： BIONUCLEI

发明人： Han Athalin ,  Jean-Noël Thorel

IPC分类号： A61K8/27 ,  A23L33/10 ,  A61K8/34 ,  A61Q17/04 ,  A61Q19/08

CPC分类号： A61K8/27 ,  A23L33/10 ,  A61K8/347 ,  A61Q17/04 ,  A61Q19/08 ,  A61K2800/10 ,  A61K2800/413 ,  A61K2800/522 ,  A61K2800/58 ,  A61K2800/622

摘要： Semiconductor colloids grafted covalently with an antioxidant, the colloids being semiconductor colloids constituted by at least one element chosen from the group comprising C, Si, Ge, Sn, S, Se, Te, B, N, P, As, Al, Sb, Ga, In, Cd, Zn, O, Cu, Cl, Pb, Tl, Bi, Ti, U, Ba, Sr, Li, Nb, La, I, Mo, Mn, Ca, Fe, Ni, Eu, Cr, Br, Ag, Pt, Hg, and combinations thereof.

公开(公告)号：US20240041776A1

公开(公告)日：2024-02-08

申请号：US18120054

申请日：2023-03-10

申请人： University of Central Lancashire

发明人： Mohamed Albed Alhnan

IPC分类号： A61K9/20 ,  A23L33/00 ,  A23P30/00 ,  A61K31/522 ,  A23L33/10 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y50/02 ,  B33Y80/00 ,  A61K31/549

CPC分类号： A61K9/2072 ,  A61K9/2027 ,  A61K9/2095 ,  A23L33/00 ,  A23P30/00 ,  A61K31/522 ,  A23L33/10 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y50/02 ,  B33Y80/00 ,  A61K31/549 ,  B29C64/106

摘要： The present invention relates to a solid form, particularly to a 3D-printed immediate release solid dosage form (e.g. based on a pharmaceutical, nutraceutical, or food supplement composition). To overcome some of the solubility and disintegration problems inherited by 3D-printed solid dosage forms, the solid form comprises one or more channels, generally in the form of tubular passages or grooves, through the body of the solid form or the surface thereof.

公开(公告)号：US11878971B2

公开(公告)日：2024-01-23

申请号：US17525116

申请日：2021-11-12

申请人： HUSCION CO., LTD.

发明人： Seong Soo Joo ,  Nareum Ha ,  Jungmin Yu ,  Youngsoo Gyoung ,  Jonggab Jun ,  Heonse Jeong ,  Sukil Jang

IPC分类号： C07D413/12 ,  A23L33/10 ,  A23L33/00 ,  A61P37/06 ,  A61K9/00 ,  C07C235/78 ,  C07C235/88 ,  C07D207/38 ,  C07D211/76 ,  C07D211/86 ,  C07D295/185 ,  C07D405/06

CPC分类号： C07D413/12 ,  A23L33/10 ,  A23L33/40 ,  A61K9/0056 ,  A61P37/06 ,  C07C235/78 ,  C07C235/88 ,  C07D207/38 ,  C07D211/76 ,  C07D211/86 ,  C07D295/185 ,  C07D405/06 ,  A23V2002/00

摘要： Disclosed are a novel piperlongumine-based compound, an immuno regulator containing as an active ingredient the compound, or a pharmaceutically acceptable salt or solvate thereof, and a health functional food for immune regulation.