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公开(公告)号：US11998571B2
公开(公告)日：2024-06-04
申请号：US18046719
申请日：2022-10-14
发明人： Yun Bae Kim , Ehn Kyoung Choi , Tae Myoung Kim
CPC分类号： A61K35/50 , A23L33/10 , A61K9/127 , A61P27/02 , A61P27/06 , C12N5/0605 , A23V2002/00 , C12N2500/02
摘要： Disclosed herein is a pharmaceutical composition comprising at least one selected from the group consisting of a stem cell-conditioned medium and an exosome isolated therefrom as an active ingredient for prevention or treatment of an ocular disease. Containing exosomes, growth factors and neurotrophic factors at high levels and functioning to: promote retinal cell proliferation and wound recovery; protect retinal cells against oxidative stress or hypoxia; lower the increased intraocular pressure and restore the atrophy of the retinal layer and the retinal ganglion cell layer to normal levels in the glaucoma animal model; and have a protective effect on retinal ganglion cells and nerve cells, the stem cell-conditioned medium according to the present disclosure can find advantageous applications in the therapy of an ocular disease.
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公开(公告)号：US20230096790A1
公开(公告)日：2023-03-30
申请号：US17937096
申请日：2022-09-30
发明人： Yun Bae Kim , Ehn Kyoung Choi , Tae Myoung Kim
摘要： Disclosed herein is a pharmaceutical composition containing a neprilysin-overexpressing stem cell, a conditioned medium thereof, and an exosome isolated therefrom as an active ingredient for prevention or treatment of cognitive impairment. Having the functions of protecting nerve cells, inhibiting the accumulation of amyloid beta, known as a cause of cognitive impairment-related disease in animal models, increasing an expression level of acetyl choline, and improving cognitive functions in animal models, the neprilysin-overexpressing stem cells, the conditioned medium thereof, or the exosomes isolated therefrom according to the present disclosure can find advantageous applications in treating cognitive impairment.
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