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公开(公告)号：US20160355897A1
公开(公告)日：2016-12-08
申请号：US15173450
申请日：2016-06-03
Applicant: The United States of America, as represented by the Secretary, Dept. of Health and Human Services
Inventor： William Allan Nix , M. Steven Oberste
IPC: C12Q1/70
CPC classification number: C12Q1/701 , A61K2300/00 , A61K39/12 , A61K2039/6075 , C12N7/00 , C12N2770/32311 , C12N2770/32351 , C07K14/005 , C12Q1/70 , C12Q1/6806 , G01N33/56983
Abstract: Disclosed herein are methods and compositions for detection of enterovirus D in a sample, particularly detection of enterovirus D68. The methods include contacting a sample with at least one primer (such as a forward primer and/or a reverse primer) capable of specifically amplifying an EV-D68 viral protein 1 (VP1) nucleic acid or a portion thereof and/or a detectably labeled probe capable of specifically hybridizing to an EV-D68 VP1 nucleic acid, under conditions sufficient for specific amplification of the EV-D68 VP1 nucleic acid by the at least one primer and/or under conditions sufficient for specific hybridization of the probe to the EV-D68 nucleic acid. The amplification of the EV-D68 VP1 nucleic acid and/or the hybridization of the probe to the EV-D68 VP1 nucleic acid is detected, thereby identifying presence of EV-D68 in the sample.
Abstract translation: 本文公开了用于检测样品中肠道病毒D的方法和组合物，特别是肠道病毒D68的检测。 所述方法包括将样品与能够特异性扩增EV-D68病毒蛋白1（VP1）核酸或其部分和/或可检测标记的至少一个引物（例如正向引物和/或反向引物）接触 能够在足以用于通过至少一个引物特异性扩增EV-D68 VP1核酸的条件下和/或在足以使探针与EV- D68 VP1核酸特异性杂交的条件下，与EV-D68 VP1核酸特异性杂交的探针， D68核酸。 检测EV-D68 VP1核酸的扩增和/或探针与EV-D68 VP1核酸的杂交，从而鉴定样品中EV-D68的存在。
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12.发明授权Broad-spectrum antivirals against 3C or 3C-like proteases of picornavirus-like supercluster: picornaviruses, caliciviruses and coronaviruses 有权针对微小核糖核酸病毒超级集群的3C或3C样蛋白酶的广谱抗病毒药物：小核糖核酸病毒，杯状病毒和冠状病毒公开(公告)号：US09474759B2
公开(公告)日：2016-10-25
申请号：US14347756
申请日：2012-09-27
Applicant: Kansas State University Research Foundation , The Ohio State University , Wichita State University
Inventor： Kyeong-Ok Chang , Yunjeong Kim , William C. Groutas , Duy Hua , Linda J. Saif
IPC: A61K38/06 , A61K31/5377 , A61K31/4015 , A61K31/422 , A61K31/427 , A61K45/06 , C07D207/27
CPC classification number: A61K31/5377 , A61K31/4015 , A61K31/422 , A61K31/427 , A61K38/06 , A61K45/06 , C07D207/27 , C12N2770/16011 , C12N2770/20011 , C12N2770/32111 , C12N2770/32311 , C12N2770/32411 , C12N2770/32611 , Y02A50/463
Abstract: Antiviral protease inhibitors, including peptidyl aldehydes, peptidyl α-ketoamides, peptidyl bisulfate salts, and peptidyl heterocycles, are disclosed, along with related antiviral compounds, and methods of using the same to treat or prevent viral infection and disease. The compounds possess broad-spectrum activity against viruses that belong to the picornavirus-like supercluster, which include important human and animal pathogens including noroviruses, enteroviruses, poliovirus, foot-and-mouth disease virus, hepatitis A virus, human rhinovirus (cause of common cold), human coronavirus (another cause of common cold), transmissible gastroenteritis virus, murine hepatitis virus, feline infectious peritonitis virus, and severe acute respiratory syndrome coronavirus.
Abstract translation: 公开了抗病毒蛋白酶抑制剂，包括肽基醛，肽基α-酮酰胺，硫酸氢酯盐和肽基杂环，以及相关的抗病毒化合物，以及使用它们来治疗或预防病毒感染和疾病的方法。 该化合物对属于小核糖核酸病毒超级群集的病毒具有广谱活性，其包括重要的人和动物病原体，包括诺维病毒，肠道病毒，脊髓灰质炎病毒，口蹄疫病毒，甲型肝炎病毒，人类鼻病毒（常见病因 感冒），人类冠状病毒（普通感冒的另一原因），传染性胃肠炎病毒，鼠肝炎病毒，猫感染性腹膜炎病毒和严重急性呼吸综合征冠状病毒。
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13.发明申请BROAD-SPECTRUM ANTIVIRALS AGAINST 3C OR 3C-LIKE PROTEASES OF PICORNAVIRUS-LIKE SUPERCLUSTER: PICORNAVIRUSES, CALICIVIRUSES AND CORONAVIRUSES 有权广谱抗真菌药对3C型或3C型血清型血清型病毒抗原：烟草病毒，血清病毒和镰刀菌病毒公开(公告)号：US20140243341A1
公开(公告)日：2014-08-28
申请号：US14347756
申请日：2012-09-27
Applicant: Kansas State University Research Foundation , Wichita State University , The Ohio State University
Inventor： Kyeong-Ok Chang , Yunjeong Kim , William C. Groutas , Duy Hua , Linda J. Saif
IPC: A61K31/5377 , A61K31/4015 , A61K45/06 , C07D207/27
CPC classification number: A61K31/5377 , A61K31/4015 , A61K31/422 , A61K31/427 , A61K38/06 , A61K45/06 , C07D207/27 , C12N2770/16011 , C12N2770/20011 , C12N2770/32111 , C12N2770/32311 , C12N2770/32411 , C12N2770/32611 , Y02A50/463
Abstract: Antiviral protease inhibitors, including peptidyl aldehydes, peptidyl α-ketoamides, peptidyl bisulfite salts, and peptidyl heterocycles, are disclosed, along with related antiviral compounds, and methods of using the same to treat or prevent viral infection and disease. The compounds possess broad-spectrum activity against viruses that belong to the picornavirus-like supercluster, which include important human and animal pathogens including noroviruses, enteroviruses, poliovirus, foot-and-mouth disease virus, hepatitis A virus, human rhinovirus (cause of common cold), human coronavirus (another cause of common cold), transmissible gastroenteritis virus, murine hepatitis virus, feline infectious peritonitis virus, and severe acute respiratory syndrome coronavirus.
Abstract translation: 公开了抗病毒蛋白酶抑制剂，包括肽基醛，肽基α-酮酰胺，亚硫酸氢盐和肽基杂环，以及相关的抗病毒化合物，以及使用它们来治疗或预防病毒感染和疾病的方法。 该化合物对属于小核糖核酸病毒超集群的病毒具有广谱活性，其包括重要的人和动物病原体，包括诺维病毒，肠道病毒，脊髓灰质炎病毒，口蹄疫病毒，甲型肝炎病毒，人类鼻病毒（常见病因 感冒），人类冠状病毒（普通感冒的另一原因），传染性胃肠炎病毒，鼠肝炎病毒，猫感染性腹膜炎病毒和严重急性呼吸综合征冠状病毒。
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公开(公告)号：US20130345414A1
公开(公告)日：2013-12-26
申请号：US13952343
申请日：2013-07-26
Inventor： Stephen James Russell , Elizabeth J. Kelly , Elizabeth M. Hadac
IPC: C07K14/005
CPC classification number: C07K14/005 , A61K35/768 , C12N7/00 , C12N2770/32311 , C12N2770/32332 , C12N2770/32611 , C12N2770/32632 , C12N2840/102 , Y02A50/465
Abstract: This document provides methods and materials related to the use of nucleic acid coding for viruses to reduce the number of viable cancer cells within a mammal. For example, methods for using infectious nucleic acid to treat cancer, engineered viral nucleic acid, methods for making engineered viral nucleic acid, methods for identifying infectious nucleic acid for treating cancer, methods and materials for controlling virus-mediated cell lysis, and methods and materials for assessing the control of virus-mediated cell lysis are provided.
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15.发明授权Antisense antiviral compound and method for treating picornavirus infection 失效反义抗病毒化合物及治疗小RNA病毒感染的方法公开(公告)号：US08329668B2
公开(公告)日：2012-12-11
申请号：US11518058
申请日：2006-09-08
Applicant: David A. Stein , Cornelis A. Rijnbrand , Patrick L. Iversen , Dwight D. Weller
Inventor： David A. Stein , Cornelis A. Rijnbrand , Patrick L. Iversen , Dwight D. Weller
CPC classification number: C12N15/1131 , C12N2310/11 , C12N2310/3145 , C12N2310/3233 , C12N2310/3513 , C12N2770/32311 , C12N2770/32711
Abstract: The invention provides antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Picornaviridae family and in the treatment of a viral infection. The compounds are particularly useful in the treatment of Enterovirus and/or Rhinovirus infection in a mammal. The antisense antiviral compounds are substantially uncharged, including partially positively charged, morpholino oligonucleotides have a sequence of 12-40 subunits, including at least 12 subunits having a targeting sequence that is complementary to a region associated with viral RNA sequences within a 32 nucleotide region of the viral 5′ untranslated region identified by SEQ ID NO:4.
Abstract translation: 本发明提供反义抗病毒化合物及其在抑制小核糖核酸病毒科家族病毒生长和用于病毒感染治疗中的用途和生产方法。 所述化合物特别可用于治疗哺乳动物中的肠病毒和/或鼻病毒感染。 反义抗病毒化合物是基本上不带电的，包括部分带正电荷的吗啉代寡核苷酸具有12-40个亚基的序列，包括至少12个亚基，其具有与与32个核苷酸区域内的病毒RNA序列相关的区域互补的靶向序列 由SEQ ID NO：4鉴定的病毒5'非翻译区。
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Patent Agency Ranking
16.发明授权Mixed cell diagnostic systems for detection of respiratory, herpes and enteric viruses 有权用于检测呼吸道，疱疹和肠道病毒的混合细胞诊断系统公开(公告)号：US08142997B2
公开(公告)日：2012-03-27
申请号：US12253127
申请日：2008-10-16
Applicant: David R. Scholl , Yung T. Huang , Patricia Gail Ray Goodrum
Inventor： David R. Scholl , Yung T. Huang , Patricia Gail Ray Goodrum
IPC: C12Q1/70
CPC classification number: C12Q1/02 , C12N7/00 , C12N2710/16611 , C12N2760/16051 , C12N2770/20011 , C12N2770/32311 , C12Q1/04 , C12Q1/18 , G01N2333/11 , G01N2333/29 , G01N2333/295
Abstract: The present invention generally relates to the field of diagnostic microbiology, and, more particularly, to compositions and methods for detecting and differentiating one or more viruses or other intracellular parasites present in a specimen. The present invention also provides compositions and methods to evaluate the susceptibility of organisms to antimicrobial agents.
Abstract translation: 本发明一般涉及诊断微生物领域，更具体地，涉及用于检测和分化存在于样品中的一种或多种病毒或其它细胞内寄生虫的组合物和方法。 本发明还提供了评估生物体对抗微生物剂的敏感性的组合物和方法。
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17.发明授权Method of allophycocyanin inhibition of enterovirus and influenza virus reproduction resulting in cytopathic effect 失效别藻蓝蛋白抑制肠道病毒和流感病毒繁殖的方法导致细胞病变效应公开(公告)号：US06346408B1
公开(公告)日：2002-02-12
申请号：US09698111
申请日：2000-10-30
Applicant: Chuang-Chun Chueh
Inventor： Chuang-Chun Chueh
IPC: C12N500
CPC classification number: C12N7/00 , C12N2760/16011 , C12N2770/32311
Abstract: A method of allophycocyanin inhibition of enterovirus and influenza virus reproduction resulting in cytopathic effect, with the ingredients utilized including allophycocyanin, wherein a virus and cell culture is first cultivated in an incubator containing a culture medium solution and following cell preparation, the virus suspension of the preparation is quantitatively determined and an antiviral pharmaceutical inhibition concentration determination procedure is utilized for pharmaceutical neutralization experiments, the results indicating that allophycocyanin possesses enterovirus neutralization capability; furthermore, utilizing ingredients including allophycocyanin as the primary ingredient, virus and cells are first cultivated in an incubator containing a culture medium solution and following a virus plaque inhibition assay, the results indicate that allophycocyanin possesses influenza virus reproduction inhibition capability.
Abstract translation: 使用含有别藻蓝蛋白的成分，其中病毒和细胞培养物首先在含有培养基溶液和细胞制备的培养箱中培养的同种异体蓝霉素抑制肠道病毒和流感病毒繁殖导致细胞病变效应的方法，其中所用的成分包括别藻蓝蛋白， 定量测定制剂，采用抗病毒药物抑制浓度测定方法进行药物中和实验，结果表明别藻蓝蛋白具有肠道病毒中和能力; 此外，利用含有别藻蓝蛋白作为主要成分的成分，病毒和细胞首先在含有培养基溶液的培养箱中培养，并进行病毒斑块抑制测定，结果表明别藻蓝蛋白具有流感病毒繁殖抑制能力。
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公开(公告)号：US09689018B2
公开(公告)日：2017-06-27
申请号：US14450673
申请日：2014-08-04
Inventor： David R. Scholl , Yung T. Huang , Patricia Gail Ray Goodrum
CPC classification number: C12Q1/02 , C12N7/00 , C12N2710/16611 , C12N2760/16051 , C12N2770/20011 , C12N2770/32311 , C12Q1/04 , C12Q1/18 , G01N2333/11 , G01N2333/29 , G01N2333/295
Abstract: The present invention generally relates to the field of diagnostic microbiology, and, more particularly, to compositions and methods for detecting and differentiating one or more viruses or other intracellular parasites present in a specimen. The present invention also provides compositions and methods to evaluate the susceptibility of organisms to antimicrobial agents.
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公开(公告)号：US20160030518A1
公开(公告)日：2016-02-04
申请号：US14777388
申请日：2014-03-31
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Jay A. Levy
CPC classification number: A61K38/1793 , A61K31/7088 , A61K38/17 , A61K38/1709 , A61K45/06 , A61K48/005 , C07K14/4702 , C07K14/70596 , C12N7/00 , C12N2710/16111 , C12N2710/16163 , C12N2710/16511 , C12N2710/16563 , C12N2720/12311 , C12N2720/12363 , C12N2740/16011 , C12N2740/16063 , C12N2760/10011 , C12N2760/14111 , C12N2760/18063 , C12N2760/18211 , C12N2770/24111 , C12N2770/24163 , C12N2770/32311 , C12N2770/32663 , C12N2770/32763 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/465 , A61K2300/00
Abstract: The present disclosure provides methods of inhibiting viral activity in a cell, the methods generally involving contacting the cell with a soluble CD137 polypeptide or a FAM3C polypeptide. The present disclosure provides methods for treating a virus infection in an individual, the methods generally involving administering to the individual an effective amount of a soluble CD137 polypeptide or a FAM3C polypeptide.
Abstract translation: 本公开提供了抑制细胞中病毒活性的方法，所述方法通常涉及使细胞与可溶性CD137多肽或FAM3C多肽接触。 本公开提供了治疗个体中的病毒感染的方法，所述方法通常涉及向个体施用有效量的可溶性CD137多肽或FAM3C多肽。
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公开(公告)号：US20150299271A1
公开(公告)日：2015-10-22
申请号：US14792178
申请日：2015-07-06
Inventor： Stephen James Russell , Elizabeth J. Kelly , Elizabeth M. Hadac
IPC: C07K14/005 , C12N7/00
CPC classification number: C07K14/005 , A61K35/768 , C12N7/00 , C12N2770/32311 , C12N2770/32332 , C12N2770/32611 , C12N2770/32632 , C12N2840/102 , Y02A50/465
Abstract: This document provides methods and materials related to the use of nucleic acid coding for viruses to reduce the number of viable cancer cells within a mammal. For example, methods for using infectious nucleic acid to treat cancer, engineered viral nucleic acid, methods for making engineered viral nucleic acid, methods for identifying infectious nucleic acid for treating cancer, methods and materials for controlling virus-mediated cell lysis, and methods and materials for assessing the control of virus-mediated cell lysis are provided.
Abstract translation: 本文件提供了与使用编码病毒的核酸相关的方法和材料，以减少哺乳动物内活细胞的数量。 例如，使用感染性核酸治疗癌症的方法，工程化病毒核酸，制备工程化病毒核酸的方法，用于鉴定用于治疗癌症的感染性核酸的方法，用于控制病毒介导的细胞裂解的方法和材料，以及方法和 提供了评估病毒介导的细胞裂解控制的材料。
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