公开(公告)号：US20130202587A1

公开(公告)日：2013-08-08

申请号：US13594721

申请日：2012-08-24

Applicant: John Lamont

Inventor： John Lamont

IPC: C12Q1/68

CPC classification number: C12Q1/6883 ,  A61K31/404 ,  A61K31/4439 ,  A61K31/517 ,  C12Q2600/106 ,  C12Q2600/156

Abstract: The present disclosure provides a method for identifying whether a subject is more or less likely to be responsive to VEGF-based therapy, comprising screening a nucleic acid sample obtained from the subject to provide output information which identifies the presence or absence of an allelic variant, wherein the presence or absence of an allelic variant indicates whether the subject is more or less likely to be responsive to VEGF-based therapy.

公开(公告)号：US07846713B2

公开(公告)日：2010-12-07

申请号：US10491811

申请日：2002-10-10

Applicant: John Victor Lamont ,  Robert Ivan McConnell ,  Stephen Peter Fitzgerald ,  Maria Luz Rodriguez

Inventor： John Victor Lamont ,  Robert Ivan McConnell ,  Stephen Peter Fitzgerald ,  Maria Luz Rodriguez

IPC: C12M1/00

CPC classification number: G01N33/54386 ,  G01N33/54306 ,  Y10S436/807 ,  Y10S436/809

Abstract: An assay for measuring the amount of a first analyte in a sample, comprises the steps of: (i) contacting the sample with a device that comprises one or more first reaction sites which comprise a first ligand having affinity for the first analyte, and a series of second reaction sites each comprising different known concentrations of an immobilized second analyte; (ii) removing any unbound first analyte; (iii) contacting the device with a second ligand that is detectably labelled and which has affinity for the first analyte, and a third ligand that is detectably labelled and which has affinity for the second analyte; (iv) removing any unbound second and third ligands; and (v) measuring the amount of second and third ligands, wherein measurement of the third ligand is used to establish a calibration curve, used to determine the amount of first analyte present in sample.

Abstract translation: 用于测量样品中第一分析物的量的测定包括以下步骤：（i）使样品与包含一个或多个包含对第一分析物具有亲和力的第一配体的第一反应位点的装置接触，以及 一系列第二反应位点各自包含不同已知浓度的固定化第二分析物; （ii）去除任何未结合的第一分析物; （iii）使该装置与可检测标记并对第一分析物具有亲和力的第二配体和可检测地标记并对第二分析物具有亲和力的第三配体; （iv）除去任何未结合的第二和第三配体; 和（v）测量第二和第三配体的量，其中第三配体的测量用于建立校准曲线，用于确定样品中存在的第一分析物的量。

公开(公告)号：US20090192107A1

公开(公告)日：2009-07-30

申请号：US12226012

申请日：2007-04-10

Applicant: Martin Andrew Crockard ,  John Victor Lamont ,  Stephen Peter Fitzgerald

Inventor： Martin Andrew Crockard ,  John Victor Lamont ,  Stephen Peter Fitzgerald

IPC: A61K31/7088 ,  C12Q1/68 ,  C07H21/00 ,  C07K7/06 ,  C07K16/00 ,  A61P35/00

CPC classification number: C12Q1/6886 ,  C07K14/4702 ,  C12Q2600/158

Abstract: A method for the detection of the presence of or the risk of cancer in a patient, comprising, with reference to a normal control, the step of: (i) detecting the expression level of a gene characterised by any of the nucleotide sequences identified herein as SEQ ID No. 1 to SEQ ID No. 10, in a sample isolated from a patient, wherein an increased expression level of the gene characterised by any of SEQ ID Nos. 1 to 6 and 10, or a decreased expression level of the gene characterised by any of SEQ ID Nos. 7 to 9, indicates the presence of or the risk of cancer in the patient from whom the sample was isolated.

Abstract translation: 一种检测患者癌症存在或癌症风险的方法，包括参照正常对照的步骤：（i）检测以本文所鉴定的任何核苷酸序列为特征的基因的表达水平 作为SEQ ID No.1〜SEQ ID No.10所示的样品，分离自患者的样品，其中以SEQ ID NO：1至6和10中任一个为特征的基因的表达水平提高，或者表达水平降低 以SEQ ID NO：7至9中任一项为特征的基因表示在分离样品的患者中存在癌症的风险或癌症的风险。

公开(公告)号：US20040191890A1

公开(公告)日：2004-09-30

申请号：US10643926

申请日：2003-08-20

Applicant: RANDOX LABORATORIES LTD

Inventor： James Rudolf Meyer ,  Ahti Kalevi Kansanaho ,  Stephen Peter Fitzgerald ,  Robert Ivan McConnell ,  John Victor Lamont ,  Bailin Cao

IPC: C12M001/34

CPC classification number: G01N35/028 ,  G01N35/00029 ,  G01N35/0099 ,  G01N2035/00158 ,  G01N2035/00326 ,  G01N2035/0425 ,  Y10T436/113332

Abstract: An assay device processing instrument comprises a plurality of processing modules. A transport system transports an assay device to each processing module, the transport system being adapted to transfer the assay device from the transport system to the module to enable the transport system to transport another assay device while the first is processed by the processing module. A control system controls operation of the transport system such that each assay device is transferred between the modules in a predetermined sequence, and such that a number of assay devices can be processed in different modules simultaneously.

Abstract translation: 测定装置处理装置包括多个处理模块。 运输系统将测定装置运送到每个处理模块，所述运输系统适于将测定装置从运输系统传送到模块，以使得运输系统能够在第一个由处理模块处理的同时运送另一个测定装置。 控制系统控制运输系统的操作，使得每个测定装置以预定顺序在模块之间转移，并且使得可以同时在不同模块中处理多个测定装置。

公开(公告)号：US20030044833A1

公开(公告)日：2003-03-06

申请号：US10233419

申请日：2002-09-04

Applicant: Randox Laboratories Ltd.

Inventor： Elouard Benchikh ,  Robert Ivan McConnell ,  John Victor Lamont ,  Stephen Peter Fitzgerald

IPC: C12Q001/68 ,  B05D003/00 ,  G01N033/53 ,  G01N033/542 ,  C12M001/34

CPC classification number: G01N33/54353 ,  G01N33/54393 ,  G01N33/551

Abstract: Multi-analyte microarrays are produced by first attaching to the surface of a solid support, a silane with an electrophilic terminal group, contacting the terminal group with a polyamine, and activating the polyamine with an electrophilic, bifunctional linker.

Abstract translation: 多分析物微阵列通过首先附着到固体支持物的表面，具有亲电子端基的硅烷，与末端基团与多胺接触，并用亲电子双功能连接体活化多胺来制备。

公开(公告)号：US20020086337A1

公开(公告)日：2002-07-04

申请号：US09949756

申请日：2001-09-12

Applicant: RANDOX LABORATORIES LTD.

Inventor： Stephen Peter Fitzgerald ,  John Victor Lamont ,  Robert Ivan McConnell

IPC: G01N033/53 ,  G01N033/542 ,  G01N033/536

CPC classification number: G01N33/94 ,  G01N33/54306

Abstract: An assay for an analyte in a sample, wherein the sample is contacted with an array of ligands including a ligand specific for the analyte, additionally comprises including a scavenger material that binds the analyte and thereby reduces its available concentration.

Abstract translation: 样品中分析物的分析物，其中样品与包括对分析物特异性的配体的配体阵列接触，另外包括包含结合分析物的清除剂材料，从而降低其可用浓度。

公开(公告)号：US20020058319A1

公开(公告)日：2002-05-16

申请号：US09949757

申请日：2001-09-12

Applicant: RANDOX LABORATORIES LTD.

Inventor： Stephen Peter Fitzgerald ,  John Campbell ,  John Victor Lamont ,  Marlene King

IPC: C12N009/96 ,  A61K038/54

CPC classification number: C12N9/0065 ,  C12N9/0006 ,  C12N9/96

Abstract: A method for stabilizing an enzyme during freezing, wherein the enzyme is in a zwitterionic buffer solution. The zwitterionic buffer is able to maintain the activity of the enzyme during freezing and thawing.

Abstract translation: 一种用于在冷冻期间稳定酶的方法，其中所述酶在两性离子缓冲溶液中。 两性离子缓冲液能够在冷冻和解冻期间保持酶的活性。

公开(公告)号：US20240310400A1

公开(公告)日：2024-09-19

申请号：US18576835

申请日：2022-07-08

Applicant: RANDOX LABORATORIES LTD.

Inventor： James DAVIDSON ,  Ivan MCCONNELL ,  Peter FITZGERALD

IPC: G01N35/10 ,  G01N1/14 ,  G01N35/00 ,  G01N35/04

CPC classification number: G01N35/1011 ,  G01N1/14 ,  G01N35/00732 ,  G01N2035/00277 ,  G01N2035/0405

Abstract: There is provided an apparatus and method for extracting a biological sample from a sample container. The apparatus comprising: a holder arranged in use to support a sample container; an extractor moveable in use between a first position disengaged from the container when the container is supported by the holder and a second position engaged with the container when the container is supported by the holder, the extractor being arranged in use to obtain matter from the container when in the second position; and an imager arranged in use to capture an image of the extractor at the first position when the extractor is moved from the second position to the first position and to identify, based on analysis of the captured image, when sample is present outside the container.

公开(公告)号：US20240296539A1

公开(公告)日：2024-09-05

申请号：US18572687

申请日：2022-07-01

Applicant: Randox Laboratories Ltd.

Inventor： Deepesh UPADHYAY ,  Peter FITZGERALD ,  Ivan MCCONNELL

IPC: G06T7/00 ,  H04N23/56 ,  H04N23/695

CPC classification number: G06T7/0004 ,  H04N23/56 ,  H04N23/695 ,  G06T2207/30072

Abstract: There is provided a vision system for assessing defects on biochips and a corresponding method. The vision system comprises an imaging region in which a biochip sheet including at least one biochip is locatable in use: an imager arranged in use to image at least a portion of the imaging region, wherein, when the biochip sheet is located in the imaging region. the portion includes at least a face of the biochip sheet: and an illumination source arranged in use to direct illumination on to the face the biochip sheet. thereby illuminating defects on the at least one biochip when a mask material layer is present on the at least one biochip and when a mask material is absent and allowing the defects to be included in the imaged at least a portion of the imaging region.

公开(公告)号：US11988607B2

公开(公告)日：2024-05-21

申请号：US16632270

申请日：2018-07-18

Applicant: Randox Laboratories Ltd

Inventor： Marc Wharry ,  P. Evans ,  Stuart Jackson

IPC: B01L3/00 ,  G01N21/76

CPC classification number: G01N21/76 ,  B01L3/50855 ,  B01L2200/02 ,  B01L2200/0689

Abstract: There is provided a chemiluminescence detector sample enclosure. The enclosure comprises a first interface member forming part of a chemiluminescence detector and having a first sealing element and a second interface member comprising a plurality of sample holders, each sample holder having a second sealing element. The first interface member is engagable with and moveable between sample holder subsets of the plurality of sample holders, engagement with a respective sample holder subset providing engagement of the first interface member with each sample holder of the respective sample holder subset and relative movement of the first and second interface members providing movement between sample holder subsets; and when the first interface member is engaged with each respective sample holder, the first sealing element and the respective second sealing element are adapted to interact so as to form a light restricting seal between the first interface member and said sample holder.