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    Morpholinos with Increased Delivery Efficiency
    11.
    发明公开
    Morpholinos with Increased Delivery Efficiency 审中-公开

    公开(公告)号：US20230357763A1

    公开(公告)日：2023-11-09

    申请号：US17803316

    申请日：2022-05-06

    Applicant: James E. Summerton ,  Yongfu Li ,  Shan Jiang ,  Daniel Bryce Summerton

    Inventor： James E. Summerton ,  Yongfu Li ,  Shan Jiang ,  Daniel Bryce Summerton

    IPC: C12N15/113

    CPC classification number: C12N15/113 ,  C12N2310/11 ,  C12N2310/3233 ,  C12N2310/3513 ,  C12N2310/51 ,  C12N2320/30

    Abstract: Morpholino antisense oligos (Morpholinos) are a class of synthetic non-ionic molecules, each designed to very specifically bind to a selected complementary RNA sequence (targeted RNA transcript). Custom-sequence Morpholinos are used in a broad range of biological research areas, as well as for therapeutic applications in vivo (in living animals such as humans).
    For most in vivo applications the “bare” Morpholino (FIG. 1a) is linked to a cationic delivery component to give a “delivery-enabled” Morpholino (FIG. 1b) with significantly improved delivery efficiency. However, cytosolic delivery was still markedly less than expected. Then recently we discovered that by adding a special disconnect component between the Morpholino component and the cationic delivery component (FIG. 1c), the cytosolic delivery efficiency for the Morpholino was dramatically increased (about a 1,000% increase in delivery efficiency).
    This patent application describes designing, making, and using such delivery-enabled Morpholinos containing a key disconnect component.

    System for forming janus particles
    13.
    发明授权
    System for forming janus particles 有权
    用于形成珍珠粒子的系统

    公开(公告)号：US07875654B2

    公开(公告)日：2011-01-25

    申请号：US11690671

    申请日：2007-03-23

    Applicant: Liang Hong ,  Shan Jiang ,  Steve Granick

    Inventor： Liang Hong ,  Shan Jiang ,  Steve Granick

    IPC: B01F3/22 ,  B32B5/00

    CPC classification number: B01J13/00 ,  Y10T428/2991

    Abstract: The invention is a method of forming Janus particles, that includes forming an emulsion that contains initial particles, a first liquid, and a second liquid; solidifying the first liquid to form a solid that contains at least a portion of the initial particles on a surface of the solid; and treating the exposed particle sides with a first surface modifying agent, to form the Janus particles. Each of the initial particles on the surface has an exposed particle side and a blocked particle side.

    Abstract translation: 本发明是形成Janus颗粒的方法，其包括形成含有初始颗粒，第一液体和第二液体的乳液; 固化第一液体以形成在固体表面上含有至少一部分初始颗粒的固体; 并用第一表面改性剂处理暴露的颗粒侧，以形成Janus颗粒。 表面上的每个初始颗粒具有暴露的颗粒侧和阻塞的颗粒侧。

    SOLID STATE DISK AND METHOD OF MANAGING POWER SUPPLY THEREOF AND TERMINAL INCLUDING THE SAME
    14.
    发明申请
    SOLID STATE DISK AND METHOD OF MANAGING POWER SUPPLY THEREOF AND TERMINAL INCLUDING THE SAME 有权
    固态盘及其电源管理方法及其终端

    公开(公告)号：US20100050007A1

    公开(公告)日：2010-02-25

    申请号：US12544018

    申请日：2009-08-19

    Applicant: Shan Jiang

    Inventor： Shan Jiang

    IPC: G06F1/32 ,  G06F12/00 ,  G06F12/02 ,  G06F1/26

    CPC classification number: G06F3/0634 ,  G06F1/3203 ,  G06F1/3268 ,  G06F3/0625 ,  G06F3/0679 ,  Y02D10/154 ,  Y02D50/20

    Abstract: A solid state disk and a method for managing power supply of the solid state disk and a terminal including the solid state disk. The solid state disk includes at least one data storage module for storing data, a management module for controlling data operation for said data storage module, controlling said data storage module as an operating power supply state when said data storage module is performing the data operation, and controlling said data storage module as a non-operating power supply state at other times. The data storage module may be enabled as the operating power supply state only when the data operation is performed for a certain data storage module, and the data storage module may be set as the non-operating power supply state when it is in the idle state or after the data operation is completed. Thus, the power consumption of the solid state disk is effectively saved, and the duration of the notebook computer which applies the solid state disk is prolonged.

    Abstract translation: 一种固态盘和一种用于管理固态盘的电源和包括该固态盘的终端的方法。 固态盘包括用于存储数据的至少一个数据存储模块，用于控制所述数据存储模块的数据操作的管理模块，当所述数据存储模块正在执行数据操作时，将所述数据存储模块控制为工作电源状态， 以及在其他时间将所述数据存储模块控制为非操作电源状态。 只有当数据存储模块执行数据操作时，数据存储模块可以被用作工作电源状态，并且当数据存储模块处于空闲状态时可以被设置为非工作电源状态 或数据操作完成后。 因此，有效地节省了固态盘的功耗，延长了应用固态盘的笔记本电脑的持续时间。

    SYSTEM FOR FORMING JANUS PARTICLES
    15.
    发明申请
    SYSTEM FOR FORMING JANUS PARTICLES 有权
    形成甘薯颗粒的系统

    公开(公告)号：US20080234394A1

    公开(公告)日：2008-09-25

    申请号：US11690671

    申请日：2007-03-23

    Applicant: Liang Hong ,  Shan Jiang ,  Steve Granick

    Inventor： Liang Hong ,  Shan Jiang ,  Steve Granick

    IPC: B01F3/08

    CPC classification number: B01J13/00 ,  Y10T428/2991

    Abstract: The invention is a method of forming Janus particles, that includes forming an emulsion that contains initial particles, a first liquid, and a second liquid; solidifying the first liquid to form a solid that contains at least a portion of the initial particles on a surface of the solid; and treating the exposed particle sides with a first surface modifying agent, to form the Janus particles. Each of the initial particles on the surface has an exposed particle side and a blocked particle side.

    Abstract translation: 本发明是形成Janus颗粒的方法，其包括形成含有初始颗粒，第一液体和第二液体的乳液; 固化第一液体以形成在固体表面上含有至少一部分初始颗粒的固体; 并用第一表面改性剂处理暴露的颗粒侧，以形成Janus颗粒。 表面上的每个初始颗粒具有暴露的颗粒侧和阻塞的颗粒侧。

    Variable gain received signal strength indicator
    16.
    发明授权
    Variable gain received signal strength indicator 有权
    可变增益接收信号强度指示器

    公开(公告)号：US07339363B2

    公开(公告)日：2008-03-04

    申请号：US10799557

    申请日：2004-03-11

    Applicant: Shahla Khorram ,  Shan Jiang

    Inventor： Shahla Khorram ,  Shan Jiang

    IPC: G01S3/02 ,  G01R31/00

    CPC classification number: H04B17/318

    Abstract: An RSSI circuit provides a relatively inexpensive technique for accurately measuring received signal strength over a wide dynamic range. A received signal is processed by a rectifier circuit that generates a series of DC offsets of increasing magnitude. The DC offsets are imposed on a first polarity of the received signal to create a series of outputs that are the first polarity of the received signal with increasing DC offsets. Each of the outputs is coupled to one input of a weighted comparator with the other input of the comparator coupled to a second and opposite polarity of the received signal with no offset. The comparators determine when overlap occurs to indicate particular signal levels.

    Abstract translation: RSSI电路提供了用于在宽动态范围内精确测量接收信号强度的相对便宜的技术。 接收信号由整流电路处理，该整流电路产生一系列增加幅度的直流偏移。 直流偏移被施加在接收信号的第一极性上，以产生一系列输出，它们是具有增加的直流偏移的接收信号的第一极性。 每个输出耦合到加权比较器的一个输入端，比较器的另一个输入端与接收信号的第二和相反极性相耦合，没有偏移。 比较器确定何时发生重叠以指示特定的信号电平。

    THROMBIN COMPOSITIONS
    17.
    发明申请
    THROMBIN COMPOSITIONS 有权
    硫酚组合物

    公开(公告)号：US20070104705A1

    公开(公告)日：2007-05-10

    申请号：US11539276

    申请日：2006-10-06

    Applicant: Shan Jiang ,  Richard Senderoff ,  Jeffrey Meyer

    Inventor： Shan Jiang ,  Richard Senderoff ,  Jeffrey Meyer

    IPC: C12N9/74 ,  A61K38/48

    CPC classification number: A61K9/19 ,  A61K31/7012 ,  A61K38/4833 ,  A61L24/106 ,  C12N9/6429 ,  C12N9/96 ,  C12Y304/21005

    Abstract: Compositions comprising thrombin and methods of preparing them are disclosed. The composition may be in the form of an aqueous solution at pH 5.7-7.4 consisiting essentially of 0.1 mg/mL to 5.0 mg/mL thrombin, 2% to 4% (w/v) sucrose, 3.5% to 5% (w/v) mannitol, 50 mM to 300 mM NaCl, 0-5 mM CaCl2, 0.03% to 1% (w/v) of a surfactant or high-molecular-weight polyethylene glycol, and a physiologically acceptable buffer, or may be in lyophilized form.

    Abstract translation: 公开了包含凝血酶的组合物及其制备方法。 组合物可以是pH 5.7-7.4的水溶液形式，其基本上由0.1mg / mL至5.0mg / mL凝血酶，2％至4％（w / v）蔗糖，3.5％至5％（w / v）甘露醇，50mM至300mM NaCl，0-5mM CaCl 2，0.03％至1％（w / v）的表面活性剂或高分子量聚乙二醇，以及生理学上 可接受的缓冲液，或可以是冻干形式。

    Method of searching for the devices automatically in network
    18.
    发明申请
    Method of searching for the devices automatically in network 审中-公开
    在网络中自动搜索设备的方法

    公开(公告)号：US20060143181A1

    公开(公告)日：2006-06-29

    申请号：US10525380

    申请日：2003-06-30

    Applicant: Xiangdong Liu ,  Yujin Luo ,  Yuanyi Zhang ,  Jingnan Huang ,  Weifeng Zhuang ,  Dekui Zhang ,  Yanpin Ren ,  Ming Li ,  Chuang Meng ,  Shan Jiang

    Inventor： Xiangdong Liu ,  Yujin Luo ,  Yuanyi Zhang ,  Jingnan Huang ,  Weifeng Zhuang ,  Dekui Zhang ,  Yanpin Ren ,  Ming Li ,  Chuang Meng ,  Shan Jiang

    IPC: G06F17/30

    CPC classification number: H04L67/16 ,  H04L12/2803 ,  H04L41/12

    Abstract: The invention discloses a method of searching for devices automatically in a network. The method including the steps of: when two devices are interconnected, firstly searching, by a device initiating party, whether a resource management device exists in the network, if so, then sending a device searching request from the device initiating party to the resource management device, upon receiving the request, making a search, by the resource management device, among device registration information stored therein, after a device satisfying conditions is found out, information related to that device being immediately sent to the device initiating party, otherwise, informing the device initiating party that the information is not found; if not, announcing its own device information, by the device initiating party, to all other devices in the network, at the same time, monitoring announcement information of all the other devices, when receiving information of other devices, sending a connection request from the device initiating party to a device requiring connection, and completing corresponding operations after receiving a response. The method makes automatic searching and connecting with respect to each other among devices possible so as to facilitate the user's operation and improve automatic and intelligent performance of the network.

    Abstract translation: 本发明公开了一种在网络中自动搜索设备的方法。 所述方法包括以下步骤：当两个设备互连时，首先由设备发起方搜索资源管理设备是否存在于网络中，如果是，则将设备发起方的设备搜索请求发送到资源管理 设备，在接收到请求之后，由资源管理设备进行搜索，在存储在其中的设备注册信息中，在发现满足条件的设备之后，与该设备相关的信息被立即发送到设备发起方，否则通知 未找到信息的设备发起方; 如果没有，则通过设备发起方将自己的设备信息通告给网络中的所有其他设备，同时监视所有其他设备的通告信息，当接收到其他设备的信息时，从 设备启动一方到需要连接的设备，并在接收到响应后完成相应的操作。 该方法可以在设备之间相互自动搜索和连接，以便于用户的操作，并提高网络的自动和智能性能。

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