公开(公告)号：US20130165475A1

公开(公告)日：2013-06-27

申请号：US13817505

申请日：2011-09-01

Applicant: Shan Jiang ,  Qishan Wang ,  Xiaoyong Gao

Inventor： Shan Jiang ,  Qishan Wang ,  Xiaoyong Gao

IPC: C07D401/06 ,  C07D471/04

CPC classification number: C07D401/06 ,  C07D403/06 ,  C07D471/04

Abstract: The present invention provides deuterium-enriched heteroaryl-containing urea compounds (I) and use of the same for treating conditions mediated by protein kinase such as

Abstract translation: 本发明提供了含氘富含杂芳基的脲化合物（I）及其用于治疗蛋白激酶介导的病症，例如

公开(公告)号：US08648086B2

公开(公告)日：2014-02-11

申请号：US12922527

申请日：2010-08-20

Applicant: Shan Jiang ,  Xinglong Xing ,  Qishan Wang ,  Ren Kong

Inventor： Shan Jiang ,  Xinglong Xing ,  Qishan Wang ,  Ren Kong

IPC: A61K31/52 ,  C07D513/02

CPC classification number: C07D471/04

Abstract: The present invention provides 5,6-bicyclic heteroaryl-containing urea compounds of Formula I or II and use of the same for treating conditions mediated by protein kinase such as VEGFR2, c-Met, PDGFRβ c-Kit, CSF1R, or EphA2.

Abstract translation: 本发明提供式I或II的5,6-双环杂芳基脲化合物及其用于治疗由蛋白激酶（例如VEGFR2，c-Met，PDGFRβC-Kit，CSF1R或EphA2）介导的病症的用途。

公开(公告)号：US20120122895A1

公开(公告)日：2012-05-17

申请号：US12922527

申请日：2010-08-20

Applicant: Shan Jiang ,  Xinglong Xing ,  Qishan Wang ,  Ren Kong

Inventor： Shan Jiang ,  Xinglong Xing ,  Qishan Wang ,  Ren Kong

IPC: A61K31/437 ,  A61P35/00 ,  A61P29/00 ,  A61P37/06 ,  A61P13/12 ,  A61K31/52 ,  A61P17/06 ,  A61P27/02 ,  C07D487/04 ,  A61K31/519 ,  C07D473/00 ,  C07D471/04 ,  A61P3/10

CPC classification number: C07D471/04

Abstract: The present invention provides 5,6-bicyclic heteroaryl-containing urea compounds of Formula I or II and use of the same for treating conditions mediated by protein kinase such as VEGFR2, c-Met, PDGFRβ c-Kit, CSF1R, or EphA2.

Abstract translation: 本发明提供了式I或II的5,6-双环杂芳基脲化合物及其用于治疗由蛋白激酶介导的病症如VEGFR2，c-Met，PDGFR＆bgr; c-Kit，CSF1R或EphA2。