公开(公告)号：US08012432B2

公开(公告)日：2011-09-06

申请号：US11493697

申请日：2006-07-27

申请人： Ingemar Berndtsson

发明人： Ingemar Berndtsson

IPC分类号： B01L3/00

CPC分类号： B01L3/502 ,  A61M39/223 ,  B01L2300/0645 ,  B01L2400/0478 ,  B01L2400/0644 ,  B01L2400/065 ,  G01N1/38 ,  Y10T436/25 ,  Y10T436/25625 ,  Y10T436/2575

摘要： A disposable apparatus for use in blood testing and being adapted for simultaneous dilution of a blood sample into two different dilution ratios, said apparatus including a block-shaped housing having integrated therein a first and a second receptacle, one of which as a first blood sample receiver being adapted to receive a blood sample; a first and a second container, each containing a defined volume of a diluting agent; a valve including a valve body having three valve body channels extending therethrough and being positionable in three distinct positions, one of which putting the receptacles in simultaneous communication with a respective one of the containers through pairs of the channels; and displacers for displacing the diluting agent and the diluted sample through said channels between said containers and said receptacles.

摘要翻译： 一种用于血液测试并用于将血液样品同时稀释成两种不同稀释比率的一次性装置，所述装置包括块形壳体，其中集成有第一和第二容器，其中之一作为第一血液样品 接收器适于接收血液样本; 第一和第二容器，每个容器含有限定体积的稀释剂; 阀门包括具有延伸穿过其中的三个阀体通道并且可定位在三个不同位置的阀体，其中一个通过成对的通道将容器与相应的一个容器同时连通; 以及用于使稀释剂和稀释样品通过所述容器和所述容器之间的所述通道移置的置换器。

公开(公告)号：US07521256B2

公开(公告)日：2009-04-21

申请号：US10553866

申请日：2004-11-24

申请人： Ingemar Berndtsson

发明人： Ingemar Berndtsson

IPC分类号： G01N1/18

CPC分类号： B01L3/0293 ,  B01F5/0683 ,  B01F5/0689 ,  B01F11/0071 ,  B01F13/0059 ,  B01L3/5027 ,  B01L2200/0605 ,  B01L2400/0644 ,  B01L2400/065 ,  G01N2035/1034 ,  Y10T436/118339 ,  Y10T436/25375 ,  Y10T436/2575

摘要： A method and a device for separating a small defined volume of a liquid sample from a relatively large undefined volume of the sample. In a surface of a first body (10) at least one cavity (12) having said small defined volume is provided. The relatively large volume of sample is applied onto the surface and into the cavity. A scraping edge (15) is moved relative to the surface and the cavity, thereby scraping a volume of the relatively large volume from the surface and leaving said small defined volume in the cavity.

摘要翻译： 一种用于将较小限定体积的液体样品与相对大的未定义体积的样品分离的方法和装置。 在第一主体（10）的表面中，提供具有所述小的限定体积的至少一个空腔（12）。 将相对较大体积的样品施加到表面上并进入腔中。 刮削边缘（15）相对于表面和空腔移动，从而刮擦相对较大体积的体积并从该表面留出所述小的限定体积。

公开(公告)号：US20060194335A1

公开(公告)日：2006-08-31

申请号：US10553866

申请日：2004-11-24

申请人： Ingemar Berndtsson

发明人： Ingemar Berndtsson

IPC分类号： G01N1/18

CPC分类号： B01L3/0293 ,  B01F5/0683 ,  B01F5/0689 ,  B01F11/0071 ,  B01F13/0059 ,  B01L3/5027 ,  B01L2200/0605 ,  B01L2400/0644 ,  B01L2400/065 ,  G01N2035/1034 ,  Y10T436/118339 ,  Y10T436/25375 ,  Y10T436/2575

摘要： A method and a device for separating a small defined volume of a liquid sample from a relatively large undefined volume of the sample. In a surface of a first body (10) at least one cavity (12) having said small defined volume is provided. The relatively large volume of sample is applied onto the surface and into the cavity. A scraping edge (15) is moved relative to the surface and the cavity, thereby scraping a volume of the relatively large volume from the surface and leaving said small defined volume in the cavity.

摘要翻译： 一种用于将较小限定体积的液体样品与相对大的未定义体积的样品分离的方法和装置。 在第一主体（10）的表面中，提供具有所述小的限定体积的至少一个空腔（12）。 将相对较大体积的样品施加到表面上并进入腔中。 刮削边缘（15）相对于表面和空腔移动，从而刮擦相对较大体积的体积并从该表面留出所述小的限定体积。

公开(公告)号：US20100120083A1

公开(公告)日：2010-05-13

申请号：US12270083

申请日：2008-11-13

申请人： Kalle RITZEN ,  Ingemar Berndtsson ,  Bjorn Roos ,  Gunnar Magnusson

发明人： Kalle RITZEN ,  Ingemar Berndtsson ,  Bjorn Roos ,  Gunnar Magnusson

IPC分类号： C12Q1/24 ,  C12M1/34 ,  B01J19/08

CPC分类号： G01N35/00029 ,  B01L3/502715 ,  B01L3/502723 ,  B01L2200/143 ,  B01L2200/16 ,  B01L2300/044 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0874 ,  B01L2400/0481 ,  G01N2035/00148

摘要： A disposable cassette for blood analysis includes a housing having an upper panel and a sampling section having a filling inlet; at least one pair of chambers in a form of depression of the upper panel of the housing and sealed by a diaphragm; portions of the diaphragm over the chambers being flexible; and one or more channels adapted to interconnect the pair of chambers; one of the chambers containing a predetermined amount of a reagent for blood analysis; and a sample outlet disposed next to and connected to the chamber containing the reagent, the sample outlet including an outlet cavity recessed from the upper panel, a divider disposed therein, and a cover covering the outlet cavity; the sample outlet sealing the reagent to the chamber containing the reagent. Further disclosed is the method of using the disposable cassette for measurements of hematology parameters on a blood analyzer.

摘要翻译： 用于血液分析的一次性盒包括具有上面板的壳体和具有填充入口的取样部分; 至少一对腔室，其形式为凹陷的壳体的上面板并由隔膜密封; 腔室上的隔膜的部分是柔性的; 以及适于互连所述一对腔室的一个或多个通道; 其中一个腔室含有预定量的用于血液分析的试剂; 以及旁边设置并连接到容纳所述试剂的室的样品出口，所述样品出口包括从所述上面板凹入的出口空腔，设置在其中的分隔件和覆盖所述出口腔的盖; 样品出口将试剂密封到含有试剂的室中。 还公开了使用一次性盒用于血液分析仪上血液学参数测量的方法。

公开(公告)号：US20060263246A1

公开(公告)日：2006-11-23

申请号：US11493697

申请日：2006-07-27

申请人： Ingemar Berndtsson

发明人： Ingemar Berndtsson

IPC分类号： G01N31/22

CPC分类号： B01L3/502 ,  A61M39/223 ,  B01L2300/0645 ,  B01L2400/0478 ,  B01L2400/0644 ,  B01L2400/065 ,  G01N1/38 ,  Y10T436/25 ,  Y10T436/25625 ,  Y10T436/2575

摘要： A disposable apparatus for use in blood testing and being adapted for simultaneous dilution of a blood sample into two different dilution ratios, said apparatus including a block-shaped housing having integrated therein a first and a second receptacle, one of which as a first blood sample receiver being adapted to receive a blood sample; a first and a second container, each containing a defined volume of a diluting agent; a valve including a valve body having three valve body channels extending therethrough and being positionable in three distinct positions, one of which putting the receptacles in simultaneous communication with a respective one of the containers through pairs of the channels; and displacers for displacing the diluting agent and the diluted sample through said channels between said containers and said receptacles.

摘要翻译： 一种用于血液测试并用于将血液样品同时稀释成两种不同稀释比率的一次性装置，所述装置包括块形壳体，其中集成有第一和第二容器，其中之一作为第一血液样品 接收器适于接收血液样本; 第一和第二容器，每个容器含有限定体积的稀释剂; 阀门包括具有延伸穿过其中的三个阀体通道并且可定位在三个不同位置的阀体，其中一个通过成对的通道将容器与相应的一个容器同时连通; 以及用于使稀释剂和稀释样品通过所述容器和所述容器之间的所述通道移置的置换器。

公开(公告)号：US6098471A

公开(公告)日：2000-08-08

申请号：US91345

申请日：1998-06-17

申请人： Ingemar Berndtsson ,  Tommy Andersson ,  Abraham Bottema

发明人： Ingemar Berndtsson ,  Tommy Andersson ,  Abraham Bottema

IPC分类号： G01N1/38 ,  G01N15/12 ,  G01N15/10

CPC分类号： G01N15/1209 ,  G01N1/38

摘要： A device for particle counting includes a metering device for metering a volume of a liquid sample containing particles and a cylinder for dosing a volume of a diluting liquid to a dilution chamber. The cylinder has first and second ends and a piston. A conduit connects a first end of the cylinder and the dilution chamber. The metering device introduces the liquid sample in the conduit and movement of the piston towards the first end displaces diluting liquid and sample to the dilution chamber which communicates with the second end of the cylinder and is preferably located therein, whereby movement of the piston towards the second end causes pressurizing of the dilution chamber to displace diluted sample from the dilution chamber through a particle counter. The piston has a piston rod extending through the first cylinder end, whereby movement of the piston towards the first end causes an increase in volume (V.sub.2) in the cylinder on the second piston side that is greater than the decrease in volume (V.sub.1) in the cylinder on the first piston side. The increase causes a lowered pressure on the second piston side that draws air into the dilution chamber.

摘要翻译： PCT No.PCT / SE97 / 01923 Sec。 371日期1998年6月17日第 102（e）日期1998年6月17日PCT 1997年11月17日PCT公布。 第WO98 / 22797号公报 日期1998年5月28日一种用于颗粒计数的装置包括用于计量一定体积的含有颗粒的液体样品的计量装置和用于将稀释液体积计量到稀释室的圆筒。 气缸具有第一和第二端以及活塞。 导管连接圆筒的第一端和稀释室。 计量装置将液体样品引入管道中，活塞朝向第一端的移动将稀释液体和样品移动到与气缸的第二端连通并且优选位于其中的稀释室，由此活塞向着 第二端引起稀释室的加压，以通过颗粒计数器从稀释室置换稀释的样品。 活塞具有延伸穿过第一气缸端部的活塞杆，由此活塞朝向第一端的运动导致在第二活塞侧的气缸中的体积（V2）的增加大于体积（V1）的减小 第一活塞侧的气缸。 该增加导致第二活塞侧的压力降低，其将空气吸入稀释室。

公开(公告)号：US08459130B2

公开(公告)日：2013-06-11

申请号：US13223843

申请日：2011-09-01

申请人： Ingemar Berndtsson ,  Tommy Andersson

发明人： Ingemar Berndtsson ,  Tommy Andersson

IPC分类号： G01N1/00

CPC分类号： G01N1/38 ,  B01L3/5027 ,  B01L2200/0605 ,  B01L2200/148 ,  B01L2300/021 ,  B01L2300/0867 ,  B01L2400/0622 ,  B01L2400/0644 ,  G01N35/1016 ,  G01N2035/00851

摘要： The invention provides a device for extraction of a defined sample volume from a larger sample volume. The device includes a body having a reference surface and a measuring cavity extending from a part of the reference surface into the body, thereby forming at least one opening plane substantially uniform with the reference surface. An information carrier is applied to or distributed with the device, having direct or indirect volume information about defined volume established for the cavity. The invention also relates to a method for determining the volume of such a cavity, to a set of at least two such devices, to a method for dilution of at least two liquid samples by using at least two such devices, to an analytic instrument, to a method for operating such an instrument, to a system including the device and the instrument, and to a method for operating the system.

摘要翻译： 本发明提供了一种用于从较大样品体积中提取定义的样品体积的装置。 该装置包括具有参考表面的主体和从参考表面的一部分延伸到主体中的测量腔，从而形成与参考表面基本一致的至少一个开口平面。 信息载体应用于或分布在该设备上，具有关于为空腔建立的限定体积的直接或间接体积信息。 本发明还涉及一种用于将至少两个这样的装置的这种空腔的体积确定为通过使用至少两个这样的装置将至少两个液体样品稀释到分析仪器的方法， 涉及一种用于操作这种仪器的方法，包括该装置和该仪器的系统，以及一种用于操作该系统的方法。

公开(公告)号：US08247191B2

公开(公告)日：2012-08-21

申请号：US12270083

申请日：2008-11-13

申请人： Kalle Ritzen ,  Ingemar Berndtsson ,  Björn Roos ,  Gunnar Magnusson

发明人： Kalle Ritzen ,  Ingemar Berndtsson ,  Björn Roos ,  Gunnar Magnusson

IPC分类号： C12Q1/24 ,  C12M1/34 ,  C12M3/00 ,  C12M1/00 ,  C12N11/00 ,  C25B9/00 ,  C25B11/00 ,  C25B13/00 ,  G01N1/00 ,  G01N27/26 ,  G01N31/00 ,  G01N33/50 ,  G01N33/487

CPC分类号： G01N35/00029 ,  B01L3/502715 ,  B01L3/502723 ,  B01L2200/143 ,  B01L2200/16 ,  B01L2300/044 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0874 ,  B01L2400/0481 ,  G01N2035/00148

摘要： A disposable cassette for blood analysis includes a housing having an upper panel and a sampling section having a filling inlet; at least one pair of chambers in a form of depression of the upper panel of the housing and sealed by a diaphragm; portions of the diaphragm over the chambers being flexible; and one or more channels adapted to interconnect the pair of chambers; one of the chambers containing a predetermined amount of a reagent for blood analysis; and a sample outlet disposed next to and connected to the chamber containing the reagent, the sample outlet including an outlet cavity recessed from the upper panel, a divider disposed therein, and a cover covering the outlet cavity; the sample outlet sealing the reagent to the chamber containing the reagent. Further disclosed is the method of using the disposable cassette for measurements of hematology parameters on a blood analyzer.

摘要翻译： 用于血液分析的一次性盒包括具有上面板的壳体和具有填充入口的取样部分; 至少一对腔室，其形式为凹陷的壳体的上面板并由隔膜密封; 腔室上的隔膜的部分是柔性的; 以及适于互连所述一对腔室的一个或多个通道; 其中一个腔室含有预定量的用于血液分析的试剂; 以及旁边设置并连接到容纳所述试剂的室的样品出口，所述样品出口包括从所述上面板凹入的出口空腔，设置在其中的分隔件和覆盖所述出口腔的盖; 样品出口将试剂密封到含有试剂的室中。 还公开了使用一次性盒用于血液分析仪上血液学参数测量的方法。

公开(公告)号：US08033186B2

公开(公告)日：2011-10-11

申请号：US12444394

申请日：2007-09-24

申请人： Ingemar Berndtsson ,  Tommy Andersson

发明人： Ingemar Berndtsson ,  Tommy Andersson

IPC分类号： G01N1/00

CPC分类号： G01N1/38 ,  B01L3/5027 ,  B01L2200/0605 ,  B01L2200/148 ,  B01L2300/021 ,  B01L2300/0867 ,  B01L2400/0622 ,  B01L2400/0644 ,  G01N35/1016 ,  G01N2035/00851

摘要： The invention provides a device for extraction of a defined sample volume from a larger sample volume. The device includes a body having a reference surface and a measuring cavity extending from a part of the reference surface into the body, thereby forming at least one opening plane substantially uniform with the reference surface, the body being adapted for reception of an excess sample volume at the cavity and elimination of sample above the reference surface to leave in the cavity a measured sample volume having the defined volume. An information carrier is applied to or arranged for distribution with the device, having direct or indirect volume information about the defined volume established for the cavity. The invention also relates to a method for determining the volume of such a cavity, to a set of at least two such devices, to a method for dilution of at least two liquid samples by the use of at least two such devices, to an analytic instrument, to a method for operating such an instrument, to a system including the device and the instrument, and to a method for operating the system.

摘要翻译： 本发明提供了一种用于从较大样品体积中提取定义的样品体积的装置。 该装置包括具有参考表面的主体和从参考表面的一部分延伸到主体中的测量腔，从而形成与参考表面基本一致的至少一个开口平面，该主体适于接收多余的样本体积 在空腔中并且在参考表面上方去除样品以在腔中留下具有确定体积的测量样品体积。 将信息载体应用于或布置成与装置一起分发，具有关于为空腔建立的限定体积的直接或间接体积信息。 本发明还涉及一种用于将至少两种这样的装置的这种空腔的体积确定为通过使用至少两种这样的装置将至少两种液体样品稀释到分析物的方法的方法 仪器，用于操作这种仪器的方法，涉及包括该装置和仪器的系统，以及一种用于操作该系统的方法。

公开(公告)号：US20100101318A1

公开(公告)日：2010-04-29

申请号：US12444394

申请日：2007-09-24

申请人： Ingemar Berndtsson ,  Tommy Andersson

发明人： Ingemar Berndtsson ,  Tommy Andersson

IPC分类号： G01F17/00 ,  B01L3/02

CPC分类号： G01N1/38 ,  B01L3/5027 ,  B01L2200/0605 ,  B01L2200/148 ,  B01L2300/021 ,  B01L2300/0867 ,  B01L2400/0622 ,  B01L2400/0644 ,  G01N35/1016 ,  G01N2035/00851

摘要： The invention provides a device for extraction of a defined sample volume from a larger sample volume. The device includes a body having a reference surface and a measuring cavity extending from a part of the reference surface into the body, thereby forming at least one opening plane substantially uniform with the reference surface, the body being adapted for reception of an excess sample volume at the cavity and elimination of sample above the reference surface to leave in the cavity a measured sample volume having the defined volume. An information carrier is applied to or arranged for distribution with the device, having direct or indirect volume information about the defined volume established for the cavity. The invention also relates to a method for determining the volume of such a cavity, to a set of at least two such devices, to a method for dilution of at least two liquid samples by the use of at least two such devices, to an analytic instrument, to a method for operating such an instrument, to a system including the device and the instrument, and to a method for operating the system.

摘要翻译： 本发明提供了一种用于从较大样品体积中提取定义的样品体积的装置。 该装置包括具有参考表面的主体和从参考表面的一部分延伸到主体中的测量腔，从而形成与参考表面基本一致的至少一个开口平面，该主体适于接收多余的样本体积 在空腔中并且在参考表面上方去除样品以在腔中留下具有确定体积的测量样品体积。 将信息载体应用于或布置成与装置一起分发，具有关于为空腔建立的限定体积的直接或间接体积信息。 本发明还涉及一种用于将至少两种这样的装置的这种空腔的体积确定为通过使用至少两种这样的装置将至少两种液体样品稀释到分析物的方法的方法 仪器，用于操作这种仪器的方法，涉及包括该装置和仪器的系统，以及一种用于操作该系统的方法。