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    Methods and apparatus for particle aggregation using acoustic standing waves
    12.
    发明授权
    Methods and apparatus for particle aggregation using acoustic standing waves 有权
    使用声驻波的粒子聚集方法和装置

    公开(公告)号：US09533241B2

    公开(公告)日：2017-01-03

    申请号：US15080354

    申请日：2016-03-24

    申请人： FloDesign Sonics, Inc.

    发明人： Walter M. Presz, Jr. ,  Kedar Chitale ,  Bart Lipkens

    IPC分类号： B01D41/00 ,  B01D21/28 ,  C02F1/36 ,  C12M1/00

    CPC分类号： B01D21/283 ,  C02F1/36 ,  C12M47/02

    摘要： Devices for separating materials from a host fluid are disclosed. The devices include an acoustic chamber having an inlet and an outlet. An ultrasonic transducer and reflector create a multi-dimensional acoustic standing wave in the acoustic chamber that traps the materials and permits a continuous separation of the materials from the host fluid. The materials and the host fluid can thus be separately collected. Multiple sets of trapping lines are generated by the acoustic standing wave, and the transducer is oriented to minimize cross-sectional area for straight vertical channels between the trapping lines.

    摘要翻译： 公开了用于从主体流体分离材料的装置。 这些装置包括具有入口和出口的声学室。 超声波换能器和反射器在声学室中产生多维声驻波，捕获材料并允许材料与主体流体的连续分离。 因此，可以分别收集材料和主体流体。 通过声驻波产生多组捕获线，并且换能器被定向成使捕获线之间的直立垂直通道的横截面面积最小化。

    ACOUSTOPHORETIC DEVICE WITH UNIFORM FLUID FLOW
    14.
    发明申请
    ACOUSTOPHORETIC DEVICE WITH UNIFORM FLUID FLOW 有权
    具有均匀流体流动的冲击装置

    公开(公告)号：US20160002070A1

    公开(公告)日：2016-01-07

    申请号：US14791115

    申请日：2015-07-02

    申请人： FloDesign Sonics, Inc.

    发明人： Bart Lipkens ,  Brian McCarthy ,  Jason Barnes ,  Dane Mealey ,  Ben Ross-Johnsrud ,  Walter M. Presz, JR. ,  Kedar Chitale

    IPC分类号： C02F1/36

    CPC分类号： B01D21/283 ,  B01D21/0045

    摘要： An acoustophoresis device which includes a substantially vertical flow path of the fluid mixture in order to improve separation of particles/secondary fluid from a primary fluid is disclosed. The vertical flow path reduces velocity non-uniformities in the acoustic chamber resulting from gravity forces. The device includes an acoustic chamber in which multidimensional acoustic standing waves are generated. The fluid can be introduced into the acoustic chamber using a dump diffuser in which a plurality of inlets enter near the bottom of the acoustic chamber such that flow symmetry reduces both, gravity driven flow non-uniformities, and any flow interference effects between inlet mixture flow into the acoustic chamber and the continuous gravity driven particle cluster drop out.

    摘要翻译： 公开了一种消声装置，其包括流体混合物的基本垂直的流动路径，以便改善颗粒/次级流体与初级流体的分离。 垂直流动路径降低了由重力引起的声室中的速度非均匀性。 该装置包括其中产生多维声驻波的声学室。 流体可以使用排放扩散器引入到声学室中，其中多个入口进入声室底部附近，使得流动对称性减小重力驱动的流动不均匀性，以及入口混合物流之间的任何流动干扰效应 进入声室，连续重力驱动的颗粒群落出。

    Methods and apparatus for particle aggregation using acoustic standing waves
    16.
    发明授权
    Methods and apparatus for particle aggregation using acoustic standing waves 有权

    公开(公告)号：US10106770B2

    公开(公告)日：2018-10-23

    申请号：US15397326

    申请日：2017-01-03

    申请人： FloDesign Sonics, Inc.

    发明人： Walter M. Presz, Jr. ,  Kedar Chitale ,  Bart Lipkens

    IPC分类号： C02F1/36 ,  C12M1/00 ,  C02F1/00 ,  B01D21/28 ,  B01D21/34 ,  B01D15/08 ,  C12N13/00 ,  B06B1/06 ,  C12M1/42 ,  C02F101/32

    摘要： Methods for generating particulate clusters and nodal trapping lines having desired widths are disclosed. The devices include an acoustic chamber having an inlet and an outlet. An ultrasonic transducer and reflector create a multi-dimensional acoustic standing wave that generates particulate clusters separated by a channel of fluid running therebetween and creates nodal trapping lines. The frequency of the multi-dimensional acoustic standing wave can be selectively tuned so as to selectively control at least one of (a) a width of each particulate cluster, or (b) a width of each channel of fluid. The frequency of the multi-dimensional acoustic standing wave can also be selectively tuned so as to selectively control the width of each nodal trapping line. Also disclosed are particulate clusters separated by a channel of fluid, wherein a ratio of the widths of the particulate clusters and the channel of fluid can be varied as desired.

    Acoustophoretic device with uniform fluid flow
    17.
    发明授权
    Acoustophoretic device with uniform fluid flow 有权

    公开(公告)号：US09827511B2

    公开(公告)日：2017-11-28

    申请号：US14791115

    申请日：2015-07-02

    申请人： FloDesign Sonics, Inc.

    发明人： Bart Lipkens ,  Brian McCarthy ,  Jason Barnes ,  Dane Mealey ,  Ben Ross-Johnsrud ,  Walter M. Presz, Jr. ,  Kedar Chitale

    IPC分类号： B01D21/28 ,  B01D21/00

    CPC分类号： B01D21/283 ,  B01D21/0045

    摘要： An acoustophoresis device which includes a substantially vertical flow path of the fluid mixture in order to improve separation of particles/secondary fluid from a primary fluid is disclosed. The vertical flow path reduces velocity non-uniformities in the acoustic chamber resulting from gravity forces. The device includes an acoustic chamber in which multidimensional acoustic standing waves are generated. The fluid can be introduced into the acoustic chamber using a dump diffuser in which a plurality of inlets enter near the bottom of the acoustic chamber such that flow symmetry reduces both, gravity driven flow non-uniformities, and any flow interference effects between inlet mixture flow into the acoustic chamber and the continuous gravity driven particle cluster drop out.

    ACOUSTIC SEPARATION OF CELLULAR SUPPORTING MATERIALS FROM CULTURED CELLS
    20.
    发明申请
    ACOUSTIC SEPARATION OF CELLULAR SUPPORTING MATERIALS FROM CULTURED CELLS 审中-公开

    公开(公告)号：US20170260493A1

    公开(公告)日：2017-09-14

    申请号：US15606962

    申请日：2017-05-26

    申请人： FloDesign Sonics, Inc.

    发明人： Bart Lipkens ,  Rudolf Gilmanshin ,  Ben Ross-Johnsrud ,  Kedar Chitale

    IPC分类号： C12M1/00 ,  C12N13/00 ,  C12M1/26

    CPC分类号： C12M47/04 ,  C12M33/00 ,  C12M33/08 ,  C12M47/02 ,  C12N5/0062 ,  C12N13/00 ,  C12N2527/00

    摘要： Methods, systems, and apparatus for acoustic separation of cellular supporting materials such as microcarriers or microbubbles from cell culture are provided. In one aspect, a method includes flowing a fluid containing the cellular supporting material and the cells through a flow chamber; driving at least one acoustic transducer to launch an acoustic wave from the acoustic transducer positioned on a first wall of the flow chamber to a reflector positioned on a second wall of the flow chamber to create, in the flow chamber, a multi-dimensional field that includes first spatial locales where acoustic pressure amplitude is elevated from a baseline level when the acoustic transducer is turned off, and second spatial locales where acoustic pressure amplitude is substantially identical to the baseline level when the acoustic transducer is turned off, wherein the first wall is opposite to the second wall; preferentially trapping, and gravity separating, the cellular supporting material or the cells at the first or second spatial locales inside the flow chamber; and collecting cells separated from the cellular supporting material using a first collection duct coupled to the flow chamber.