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公开(公告)号：US11179747B2
公开(公告)日：2021-11-23
申请号：US15206244
申请日：2016-07-09
发明人： Bart Lipkens , Walter M Presz, Jr. , Kedar Chitale , Thomas J Kennedy, III , Rudolf Gilmanshin , Dane Mealey , Brian Dutra , David Sokolowski
摘要： An acoustophoretic device is disclosed. The acoustophoretic device includes an acoustic chamber, an ultrasonic transducer, and a reflector. The ultrasonic transducer includes a piezoelectric material driven by a voltage signal to create a multi-dimensional acoustic standing wave in the acoustic chamber emanating from a non-planar face of the piezoelectric material. A method for separating a second fluid or a particulate from a host fluid is also disclosed. The method includes flowing the mixture through an acoustophoretic device. A voltage signal is sent to drive the ultrasonic transducer to create the multi-dimensional acoustic standing wave in the acoustic chamber such that the second fluid or particulate is continuously trapped in the standing wave, and then agglomerates, aggregates, clumps, or coalesces together, and subsequently rises or settles out of the host fluid due to buoyancy or gravity forces, and exits the acoustic chamber.
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公开(公告)号：US10967298B2
公开(公告)日：2021-04-06
申请号：US15872984
申请日：2018-01-16
发明人： Bart Lipkens , Ronald Musiak , Dane Mealey , John Artis , Ali Shajii
摘要： An acoustic standing wave is utilized to separate components from a multi-component fluid, such as oil from an oil-water mixture, or cells entrained in a fluid, in a fluid flow scheme with an acoustophoresis device. For example, the flow scheme and device allows for trapping of the oil as the oil coalesces, agglomerates, and becomes more buoyant than the water. A driver and controller for the acoustophoretic device accommodate variable loading as the components are separated, thereby improving separation efficiency.
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公开(公告)号：US20190360930A1
公开(公告)日：2019-11-28
申请号：US16443817
申请日：2019-06-17
发明人： Jason Barnes , Dane Mealey , Jeffrey King
摘要： Systems and methods for increasing the accuracy of a turbidity sensor are disclosed. The systems include a turbidity sensor and a flow module with a specialized flow path, with the turbidity sensor engaging with the flow module such that a measurement zone of the turbidity sensor is disposed within a flow path of the flow module and a bypass path of the flow module does not pass through the measurement zone. The methods include flowing a fluid containing bubbles into a system that separates the fluid in the flow module into a first stream of fluid containing relatively more bubbles and a second stream of fluid containing relatively fewer bubbles, the first stream flowing through a bypass path that does not pass through the measurement zone, and the second stream flowing through the measurement zone of the turbidity sensor.
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公开(公告)号：USD797887S1
公开(公告)日：2017-09-19
申请号：US29562478
申请日：2016-04-26
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公开(公告)号：US20170217794A1
公开(公告)日：2017-08-03
申请号：US15490878
申请日：2017-04-18
发明人： Bart Lipkens , Walter M. Presz, JR. , Kedar Chitale , Brian McCarthy , Benjamin Ross-Johnsrud , Thomas J. Kennedy, III , Dane Mealey , Brian Dutra , David Sokolowski
CPC分类号： C02F1/36 , B01D17/04 , B01D17/041 , B01D17/044 , B01D19/0078 , B01D21/28 , B06B1/0622 , B06B1/0644 , C02F1/40 , C12M35/04 , C12M47/02 , C12N1/02 , C12N13/00 , G10K11/28 , H01L41/0913
摘要： Separation of particles or droplets from a host fluid may be achieved using a transducer and/or reflector that is a thin, non-planar structure. The thin non-planar structure improves operation of an acoustic standing wave generated by an acoustic transducer. The structure may operate as a pressure release boundary and may be constructed as plastic film.
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公开(公告)号：US09512395B2
公开(公告)日：2016-12-06
申请号：US14533753
申请日：2014-11-05
发明人： Bart Lipkens , Jason Barnes , Dane Mealey , Walter M. Presz, Jr. , Stanley Kowalski, III , Louis Masi , Thomas J. Kennedy, III , Brian McCarthy , Ben Ross-Johnsrud
CPC分类号： C12M47/02 , A61M1/3678 , B01D21/0045 , B01D21/283 , B06B1/06 , C12M33/08 , C12M47/10
摘要： An acoustophoresis device made up of modular components is disclosed. Several modules are disclosed herein, including ultrasonic transducer modules, input/output modules, collection well modules, and various connector modules. These permit different systems to be constructed that have appropriate fluid dynamics for separation of particles, such as biological cells, from a fluid.
摘要翻译： 公开了一种由模块化部件组成的消声器。 本文公开了多个模块，包括超声换能器模块，输入/输出模块，收集井模块和各种连接器模块。 这些允许构建具有用于从流体分离颗粒（例如生物细胞）的适当流体动力学的不同系统。
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公开(公告)号：US20200292451A1
公开(公告)日：2020-09-17
申请号：US16889170
申请日：2020-06-01
发明人： Jason Barnes , Dane Mealey , Jeffrey King
摘要： Systems and methods for increasing the accuracy of a turbidity sensor are disclosed. The systems include a turbidity sensor and a flow module with a specialized flow path, with the turbidity sensor engaging with the flow module such that a measurement zone of the turbidity sensor is disposed within a flow path of the flow module and a bypass path of the flow module does not pass through the measurement zone. The methods include flowing a fluid containing bubbles into a system that separates the fluid in the flow module into a first stream of fluid containing relatively more bubbles and a second stream of fluid containing relatively fewer bubbles, the first stream flowing through a bypass path that does not pass through the measurement zone, and the second stream flowing through the measurement zone of the turbidity sensor.
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公开(公告)号：US09950282B2
公开(公告)日：2018-04-24
申请号：US15495471
申请日：2017-04-24
发明人： Bart Lipkens , Ronald Musiak , Dane Mealey , Ali Shajii
IPC分类号： C02F1/36 , B01D17/12 , B01D17/06 , B01D21/28 , B01D29/72 , H04R1/06 , H01L41/09 , H03H3/02 , H03H9/00 , B01D21/00 , B06B1/06 , C12M1/26 , C12M1/00 , A61M1/36
CPC分类号： B01D17/12 , A61M1/3678 , B01D17/06 , B01D21/0045 , B01D21/28 , B01D21/283 , B01D29/72 , B06B1/06 , B06B1/0622 , C02F1/36 , C12M33/08 , C12M47/02 , H01L41/09 , H03H3/02 , H03H9/009 , H04R1/06
摘要： Aspects of the disclosure are directed to an apparatus for separating a second fluid or a particulate from a host fluid. That apparatus comprises a flow chamber with at least one inlet and at least one outlet. A drive circuit configured to provide a drive signal to a filter circuit configured to receive the drive signal and provide a translated drive signal. An ultrasonic transducer is cooperatively arranged with the flow chamber, and transducer includes at least one piezoelectric element configured to be driven by the current drive signal to create an acoustic standing wave in the flow chamber. At least one reflector opposing the ultrasonic transducer to reflect acoustic energy.
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公开(公告)号：US09796956B2
公开(公告)日：2017-10-24
申请号：US15284529
申请日：2016-10-03
发明人： Bart Lipkens , Thomas J. Kennedy, III , Jeffrey King , Jason Barnes , Brian McCarthy , Dane Mealey , Erik Miller , Walter M. Presz, Jr. , Benjamin Ross-Johnsrud , John Rozembersky
CPC分类号： C12M33/08 , A61M1/3678 , B01D21/0045 , B01D21/283 , B06B1/0223 , B06B1/0276 , B06B1/06 , C12M47/02 , C12N13/00
摘要： An acoustophoresis device made up of modular components is disclosed. Several modules are disclosed herein, including ultrasonic transducer modules, input/output modules, collection well modules, and various connector modules. These permit different systems to be constructed that have appropriate fluid dynamics for separation of particles, such as biological cells, from a fluid.
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公开(公告)号：US20170291122A1
公开(公告)日：2017-10-12
申请号：US15495471
申请日：2017-04-24
发明人： Bart Lipkens , Ronald Musiak , Dane Mealey , Ali Shajii
IPC分类号： B01D17/12 , B01D21/28 , B01D29/72 , H03H9/00 , H04R1/06 , H01L41/09 , H03H3/02 , B01D17/06 , C02F1/36
CPC分类号： B01D17/12 , A61M1/3678 , B01D17/06 , B01D21/0045 , B01D21/28 , B01D21/283 , B01D29/72 , B06B1/06 , B06B1/0622 , C02F1/36 , C12M33/08 , C12M47/02 , H01L41/09 , H03H3/02 , H03H9/009 , H04R1/06
摘要： Aspects of the disclosure are directed to an apparatus for separating a second fluid or a particulate from a host fluid. That apparatus comprises a flow chamber with at least one inlet and at least one outlet. A drive circuit configured to provide a drive signal to a filter circuit configured to receive the drive signal and provide a translated drive signal. An ultrasonic transducer is cooperatively arranged with the flow chamber, and transducer includes at least one piezoelectric element configured to be driven by the current drive signal to create an acoustic standing wave in the flow chamber. At least one reflector opposing the ultrasonic transducer to reflect acoustic energy.
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