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公开(公告)号：US20170204093A1
公开(公告)日：2017-07-20
申请号：US15326740
申请日：2015-07-17
申请人： BIOGEN MA INC.
发明人： Timothy Chan , Kevin Guckian , Tracy Jenkins , Jermaine Thomas , Jeffery Vessels , Gnanasambandam Kumaravel , Robert Meissner , Joseph Lyssikatos , Brian Lucas , Irina Leaf , Jeremy Duffield
IPC分类号： C07D471/04 , C07D401/12 , C07D405/14 , C07D413/14 , C07B59/00 , C07D401/14 , C07D417/14
CPC分类号： C07D471/04 , A61K31/416 , A61P13/12 , C07B59/002 , C07B2200/05 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14
摘要： Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.
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公开(公告)号：US09708353B2
公开(公告)日：2017-07-18
申请号：US14620700
申请日：2015-02-12
申请人： BIOGEN MA INC.
发明人： Richard D. Caldwell , Kevin Guckian , Gnanasambandam Kumaravel , Wen-Cherng Lee , Edward Yin-Shiang Lin , Xiaogao Liu , Bin Ma , Daniel M. Scott , Zhan Shi , Jermaine Thomas , Arthur G. Taveras , Guo Zhu Zheng
IPC分类号： C07D263/24 , C07F9/6512 , C07C233/47 , C07C229/36 , C07C217/58 , C07D215/20 , C07F9/60 , C07D239/80
CPC分类号： C07F9/6512 , C07C217/58 , C07C217/74 , C07C229/36 , C07C233/47 , C07C2602/10 , C07D215/06 , C07D215/20 , C07D215/227 , C07D233/32 , C07D239/74 , C07D239/80 , C07D263/24 , C07D277/64 , C07D401/04 , C07F9/091 , C07F9/60 , C07F9/65744
摘要： Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
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公开(公告)号：US09572824B2
公开(公告)日：2017-02-21
申请号：US14874600
申请日：2015-10-05
申请人： Biogen MA Inc.
发明人： Jermaine Thomas , Xiaogao Liu , Edward Yin-Shiang Lin , Guo Zhu Zheng , Bin Ma , Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Arthur G. Taveras
IPC分类号： A61K31/695 , A61K31/11 , A61K31/18 , A61K31/216 , A61K31/197 , A61K31/397 , A61K31/40 , A61K31/445 , A61K31/683 , A61K31/662 , A61K31/47 , A61K31/277 , A61K31/41 , A61K31/4709 , A61K31/472 , A61K31/337 , A61K31/517 , A61K31/428 , A61K31/404 , A61K45/06 , A61K31/085 , C07C229/14 , C07C229/22 , C07C229/46 , C07C229/48 , C07C237/08 , C07C237/52 , C07C309/14 , C07C311/51 , C07D205/04 , C07D207/16 , C07D209/08 , C07D211/60 , C07D211/62 , C07D215/20 , C07D217/24 , C07D257/04 , C07D305/08 , C07D403/06 , C07D417/06 , C07F9/38 , C07F9/40 , C07C43/247 , C07C47/575 , C07C255/54 , C07D215/227 , C07D217/04 , C07D239/74 , C07D277/64 , C07D401/06 , C07F7/08
CPC分类号： A61K31/695 , A61K31/085 , A61K31/11 , A61K31/137 , A61K31/165 , A61K31/18 , A61K31/185 , A61K31/197 , A61K31/198 , A61K31/216 , A61K31/222 , A61K31/223 , A61K31/235 , A61K31/277 , A61K31/337 , A61K31/397 , A61K31/40 , A61K31/401 , A61K31/404 , A61K31/41 , A61K31/428 , A61K31/445 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/517 , A61K31/662 , A61K31/683 , A61K45/06 , C07C43/247 , C07C47/575 , C07C229/14 , C07C229/22 , C07C229/46 , C07C229/48 , C07C237/08 , C07C237/52 , C07C255/54 , C07C309/14 , C07C311/51 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07D205/04 , C07D207/16 , C07D209/08 , C07D211/60 , C07D211/62 , C07D215/20 , C07D215/227 , C07D217/04 , C07D217/24 , C07D239/74 , C07D257/04 , C07D277/64 , C07D305/08 , C07D401/06 , C07D403/06 , C07D417/06 , C07F7/081 , C07F9/3808 , C07F9/3834 , C07F9/4006
摘要： Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphin-gosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
摘要翻译： 提供了在一种或多种S1P受体上具有激动剂活性的化合物。 化合物是肌氨酸 - 甙类似物，磷酸化后，可以作为S1P受体的激动剂。
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公开(公告)号：US10894040B2
公开(公告)日：2021-01-19
申请号：US16542746
申请日：2019-08-16
申请人： BIOGEN MA INC.
发明人： Jermaine Thomas , Sha Mi , Edward Yin-Shiang Lin , Guo Zhu Zheng , Bin Ma , Richard D. Caldwell , Kevin Guckian , Gnanasambandam Kumaravel
IPC分类号： A61K31/445 , C07D211/34 , C07D211/60 , C07D211/62 , C07D405/12 , C07D401/06 , C07D215/20 , A61K31/225 , A61K31/4545 , A61K31/4709 , A61K31/498 , A61K31/517 , A61K31/55 , A61K31/695 , A61K38/21 , A61K39/395 , C07K16/28
摘要： The present invention provides compounds of formula (I) or (II) or a pharmaceutically acceptable salt thereof and their use in modulating the activity of S1P) receptors. Also provided is a pharmaceutical composition comprising the compounds of formula (I) or (II) or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipient or carrier.
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公开(公告)号：US20190248787A1
公开(公告)日：2019-08-15
申请号：US16271497
申请日：2019-02-08
申请人： BIOGEN MA INC.
发明人： Timothy Chan , Kevin Guckian , Tracy Jenkins , Jermaine Thomas , Jeffery Vessels , Gnanasambandam Kumaravel , Robert Meissner , Joseph Lyssikatos , Brian Lucas , Irina Leaf , Jeremy Duffield
IPC分类号： C07D471/04 , C07D417/14 , C07D413/14 , A61K31/416 , C07D401/12 , C07B59/00 , C07D405/14 , C07D401/14
摘要： Provided are compounds of Formula I, or pharmaceutically acceptable salts thereof, and methods for their use and production.
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公开(公告)号：US20190209592A1
公开(公告)日：2019-07-11
申请号：US16182845
申请日：2018-11-07
申请人： BIOGEN MA INC.
发明人： Jermaine Thomas , Xiaogao Liu , Edward Yin-Shiang Lin , Guo Zhu Zheng , Bin Ma , Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Arthur G. Taveras
IPC分类号： A61K31/695 , A61K31/11 , C07F7/08 , A61K31/165 , A61K31/137 , A61K31/235 , A61K31/223 , C07D401/06 , C07D277/64 , C07D239/74 , C07D217/04 , C07D215/227 , C07C255/54 , C07C47/575 , C07C43/247 , A61K45/06 , A61K31/683 , A61K31/662 , A61K31/517 , A61K31/472 , A61K31/4709 , A61K31/47 , A61K31/445 , A61K31/428 , A61K31/41 , A61K31/404 , A61K31/40 , A61K31/397 , A61K31/337 , A61K31/277 , A61K31/216 , A61K31/197 , A61K31/18 , C07F9/38 , A61K31/085 , C07F9/40 , C07D417/06 , C07D403/06 , C07D305/08 , C07D257/04 , C07D217/24 , C07D215/20 , C07D211/62 , C07D211/60 , C07D209/08 , C07D207/16 , C07D205/04 , C07C311/51 , C07C309/14 , C07C237/52 , C07C237/08 , C07C229/48 , C07C229/46 , C07C229/22 , C07C229/14 , A61K31/401 , A61K31/185 , A61K31/198 , A61K31/222
CPC分类号： A61K31/695 , A61K31/085 , A61K31/11 , A61K31/137 , A61K31/165 , A61K31/18 , A61K31/185 , A61K31/197 , A61K31/198 , A61K31/216 , A61K31/222 , A61K31/223 , A61K31/235 , A61K31/277 , A61K31/337 , A61K31/397 , A61K31/40 , A61K31/401 , A61K31/404 , A61K31/41 , A61K31/428 , A61K31/445 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/517 , A61K31/662 , A61K31/683 , A61K45/06 , C07C43/247 , C07C47/575 , C07C229/14 , C07C229/22 , C07C229/46 , C07C229/48 , C07C237/08 , C07C237/52 , C07C255/54 , C07C309/14 , C07C311/51 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07D205/04 , C07D207/16 , C07D209/08 , C07D211/60 , C07D211/62 , C07D215/20 , C07D215/227 , C07D217/04 , C07D217/24 , C07D239/74 , C07D257/04 , C07D277/64 , C07D305/08 , C07D401/06 , C07D403/06 , C07D417/06 , C07F7/081 , C07F9/3808 , C07F9/3834 , C07F9/4006
摘要： Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
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公开(公告)号：US10246456B2
公开(公告)日：2019-04-02
申请号：US15326740
申请日：2015-07-17
申请人： BIOGEN MA INC.
发明人： Timothy Chan , Kevin Guckian , Tracy Jenkins , Jermaine Thomas , Jeffery Vessels , Gnanasambandam Kumaravel , Robert Meissner , Joseph Lyssikatos , Brian Lucas , Irina Leaf , Jeremy Duffield
IPC分类号： C07D471/04 , C07D413/14 , C07D405/14 , C07D401/14 , A61K31/416 , A61P13/12 , C07B59/00 , C07D401/12 , C07D417/14
摘要： Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.
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公开(公告)号：US20180133233A1
公开(公告)日：2018-05-17
申请号：US15783809
申请日：2017-10-13
申请人： BIOGEN MA INC.
发明人： Jermaine Thomas , Xiaogao Liu , Edward Yin-Shiang Lin , Guo Zhu Zheng , Bin Ma , Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Arthur G. Taveras
IPC分类号： A61K31/695 , A61K31/11 , C07F7/08 , C07D401/06 , C07D277/64 , C07D239/74 , C07D217/04 , C07D215/227 , C07C255/54 , C07C47/575 , C07C43/247 , A61K45/06 , A61K31/683 , A61K31/662 , A61K31/517 , A61K31/472 , A61K31/4709 , A61K31/47 , A61K31/445 , A61K31/428 , A61K31/41 , A61K31/404 , A61K31/40 , A61K31/397 , A61K31/337 , A61K31/277 , A61K31/216 , A61K31/197 , A61K31/18 , C07F9/38 , A61K31/085 , C07F9/40 , C07D417/06 , C07D403/06 , C07D305/08 , C07D257/04 , C07D217/24 , C07D215/20 , C07D211/62 , C07D211/60 , C07D209/08 , C07D207/16 , C07D205/04 , C07C311/51 , C07C309/14 , C07C237/52 , C07C237/08 , C07C229/48 , C07C229/46 , C07C229/22 , C07C229/14 , A61K31/401 , A61K31/185 , A61K31/198 , A61K31/222 , A61K31/223 , A61K31/235 , A61K31/137 , A61K31/165
CPC分类号： A61K31/695 , A61K31/085 , A61K31/11 , A61K31/137 , A61K31/165 , A61K31/18 , A61K31/185 , A61K31/197 , A61K31/198 , A61K31/216 , A61K31/222 , A61K31/223 , A61K31/235 , A61K31/277 , A61K31/337 , A61K31/397 , A61K31/40 , A61K31/401 , A61K31/404 , A61K31/41 , A61K31/428 , A61K31/445 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/517 , A61K31/662 , A61K31/683 , A61K45/06 , C07C43/247 , C07C47/575 , C07C229/14 , C07C229/22 , C07C229/46 , C07C229/48 , C07C237/08 , C07C237/52 , C07C255/54 , C07C309/14 , C07C311/51 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07D205/04 , C07D207/16 , C07D209/08 , C07D211/60 , C07D211/62 , C07D215/20 , C07D215/227 , C07D217/04 , C07D217/24 , C07D239/74 , C07D257/04 , C07D277/64 , C07D305/08 , C07D401/06 , C07D403/06 , C07D417/06 , C07F7/081 , C07F9/3808 , C07F9/3834 , C07F9/4006
摘要： Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphin-gosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
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公开(公告)号：US11427561B2
公开(公告)日：2022-08-30
申请号：US16071200
申请日：2017-01-18
申请人： BIOGEN MA INC.
发明人： Timothy Chan , Kevin M. Guckian , Tracy Jenkins , Jermaine Thomas , Jeffrey Vessels , Gnanasambandam Kumaravel , Robert Meissner , Joseph P. Lyssikatos , Brian Lucas , Irina Leaf , Jeremy Duffield , Nathan Genung
IPC分类号： C07D401/14 , A61K45/06
摘要： Provided are compounds of Formula I, or pharmaceutically acceptable salts thereof, and methods for their use and production. Formula (I) The compounds are IRAK-4 inhibitors useful for treating an inflammatory disease, an autoimmune disease, cancer, a cardiovascular disease, a disease of the central nervous system, a disease of the skin, an ophthalmic disease and condition, and a bone disease.
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公开(公告)号：US10406144B2
公开(公告)日：2019-09-10
申请号：US16020696
申请日：2018-06-27
申请人： BIOGEN MA INC.
发明人： Jermaine Thomas , Sha Mi , Edward Yin-Shiang Lin , Guo Zhu Zheng , Bin Ma , Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel
IPC分类号： A61K31/445 , A61K31/225 , A61K31/4545 , A61K31/4709 , A61K31/498 , A61K31/517 , A61K31/55 , A61K31/695 , A61K39/395 , A61K38/21 , C07D211/34 , C07D211/60 , C07D211/62 , C07D401/06 , C07D405/12 , C07D215/20 , C07K16/28
摘要： Compounds of formula (I) or (II) can modulate the activity of S1P receptors.
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