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公开(公告)号：US20140249168A1
公开(公告)日：2014-09-04
申请号：US14194224
申请日：2014-02-28
发明人： Markus FOLLMANN , Johannes-Peter STASCH , Gorden REDLICH , Dieter LANG , Alexandros VAKALOPOULOS , Frank WUNDER , Adrian TERSTEEGEN
IPC分类号： C07D471/04 , A61K45/06 , A61K31/519
CPC分类号： C07D417/04 , A61K31/519 , A61K45/06 , C07D471/04 , C07D519/00
摘要： The present application relates to novel trifluoromethyl-substituted fused pyrimidines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新颖的三氟甲基取代的稠合嘧啶，其制备方法，单独使用或组合用于治疗和/或预防疾病的用途，以及其用于生产药物用于治疗和/或预防 疾病，特别是用于治疗和/或预防心血管疾病。
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公开(公告)号：US20170240566A1
公开(公告)日：2017-08-24
申请号：US15503578
申请日：2015-08-25
发明人： Alexandros VAKALOPOULOS , Gaelle VALOT , Markus FOLLMANN , Damian BROCKSCHNIEDER , Johannes-Peter STASCH , Tobias MARQUARDT , Adrian TERSTEEGEN , Frank WUNDER , Lisa DIETZ , Dieter LANG , Ursula KRENZ
IPC分类号： C07D519/00 , A61K31/519 , C07D487/04 , A61K45/06
CPC分类号： C07D519/00 , A61K31/519 , A61K45/06 , C07D487/04
摘要： The present application relates to novel amino-substituted fused pyrimidines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
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13.发明申请2,5-DISUBSTITUTED CYCLOPENTANECARBOXYLIC ACIDS AND THEIR USE 审中-公开2,5-DISUBSTITUTED CYPOPENTANECARBOXYLIC ACIDS AND THEE USE公开(公告)号：US20170022171A1
公开(公告)日：2017-01-26
申请号：US15301392
申请日：2015-03-31
发明人： Hartmut BECK , Volkhart Min-Jian LI , Yolanda CANCHO GRANDE , Andreas TIMMERMANN , Dirk BROHM , Hannah JÖRISSEN , Pamela BOGNER , Michael GERISCH , Dieter LANG
IPC分类号： C07D253/08 , A61K31/53 , C07D413/12 , A61K45/06
CPC分类号： C07D253/08 , A61K31/53 , A61K45/06 , C07D413/12
摘要： The present application relates to novel 2,5-disubstituted cyclopentanecarboxylic acid derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of respiratory, pulmonary and cardiovascular disorders.
摘要翻译： 本申请涉及新的2,5-二取代的环戊烷羧酸衍生物，其制备方法，单独使用或组合用于治疗和/或预防疾病及其用于生产用于治疗和/ 或预防疾病，特别是用于治疗和/或预防呼吸，肺和心血管疾病。
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公开(公告)号：US20160318901A1
公开(公告)日：2016-11-03
申请号：US15106284
申请日：2014-12-16
发明人： Eva Maria BECKER-PELSTER , Philipp BUCHGRABER , Anja BUCHMÜLLER , Karen ENGEL , Volker GEISS , Andreas GÖLLER , Herbert HIMMEL , Raimund KAST , Andreas KNORR , Dieter LANG , Gorden REDLICH , Carsten SCHMECK , Hanna TINEL , Frank WUNDER
IPC分类号： C07D401/14 , A61K45/06 , A61K31/5377 , A61K31/541 , C07D413/14 , A61K31/506 , C07D491/107
CPC分类号： C07D401/14 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D413/14 , C07D417/14 , C07D491/107
摘要： The present application relates to novel substituted piperidinyltetrahydroquinolines, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardial vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.
摘要翻译： 本申请涉及新的取代的哌啶基四氢喹啉，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途，特别是用于治疗和/ /或预防糖尿病性微血管病，四肢糖尿病性溃疡，特别是促进糖尿病足溃疡的伤口愈合，糖尿病性心力衰竭，糖尿病性冠状动脉微血管性心脏病，外周和心脏血管疾病，血栓栓塞性疾病和局部缺血，周围循环障碍，雷诺 现象，CREST综合征，微循环障碍，间歇性跛行，外周和自主神经病变。
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公开(公告)号：US20160318866A1
公开(公告)日：2016-11-03
申请号：US15106285
申请日：2014-12-16
发明人： Eva Maria BECKER-PELSTER , Philipp BUCHGRABER , Anja BUCHMÜLLER , Karen ENGEL , Mark Jean GNOTH , Herbert HIMMEL , Raimund KAST , Joerg KELDENICH , Jürgen KLAR , Andreas KNORR , Dieter LANG , Niels LINDNER , Carsten SCHMECK , Rudolf SCHOHE-LOOP , Hanna TINEL , Hubert TRÜBEL , Frank WUNDER
IPC分类号： C07D211/10 , C07D211/42 , C07D211/22 , A61K45/06 , C07D401/14 , C07D413/14 , C07D405/14 , C07D211/60 , A61K31/4545
CPC分类号： C07D211/10 , A61K31/4545 , A61K45/06 , C07D211/16 , C07D211/22 , C07D211/42 , C07D211/60 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/04 , C07D413/10 , C07D413/12 , C07D413/14
摘要： The invention relates to novel substituted bipiperidinyl derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardiac vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.
摘要翻译： 本发明涉及新的取代的二哌啶基衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途，特别是用于治疗和/ /或预防糖尿病性微血管病，四肢糖尿病溃疡，特别是用于促进糖尿病足溃疡的伤口愈合，糖尿病性心力衰竭，糖尿病性冠状动脉微血管性心脏病，外周和心脏血管疾病，血栓栓塞性疾病和局部缺血，外周循环障碍，雷诺 现象，CREST综合征，微循环障碍，间歇性跛行，外周和自主神经病变。
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公开(公告)号：US20160122325A1
公开(公告)日：2016-05-05
申请号：US14930157
申请日：2015-11-02
发明人： Carsten SCHMECK , Michael GERISCH , Nils GRIEBENOW , Peter KOLKHOF , Florian KOLLING , Anna ENGELEN , Axel KRETSCHMER , Dieter LANG , Klemens LUSTIG , Thomas MONDRITZKI , Elisabeth POOK , Hartmut BECK , Frank SÜßMEIER , Sonja VOLLMER , Pierre WASNAIRE
IPC分类号： C07D403/06 , A61K45/06 , A61K31/4196
CPC分类号： C07D249/12 , A61K31/4196 , A61K45/06 , C07D403/06
摘要： The present invention relates to novel 5-(hydroxyalkyl)-1-phenyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular and renal diseases.
摘要翻译： 本发明涉及新的5-（羟基烷基）-1-苯基-1,2,4-三唑衍生物，制备这些化合物的方法，含有这些化合物的药物组合物，以及这些化合物或组合物的用途 用于治疗和/或预防疾病，特别是用于治疗和/或预防心血管和肾脏疾病。
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公开(公告)号：US20160002267A1
公开(公告)日：2016-01-07
申请号：US14771542
申请日：2014-02-25
发明人： Markus FOLLMANN , Johannes-Peter STASCH , Gorden REDLICH , Dieter LANG , Alexandros VAKALOPOULOS , Frank WUNDER , Adrian TERSTEEGEN
IPC分类号： C07D519/00 , A61K45/06 , A61K31/519
CPC分类号： C07D519/00 , A61K31/519 , A61K45/06
摘要： The present application relates to novel benzyl-substituted pyrazolopyridines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新的苄基取代的吡唑并吡啶，其制备方法，单独使用或组合用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途 ，特别是用于治疗和/或预防心血管疾病。
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公开(公告)号：US20180194745A1
公开(公告)日：2018-07-12
申请号：US15742063
申请日：2016-07-05
发明人： Eloisa JIMENEZ NUNEZ , Jens ACKERSTAFF , Susanne RÖHRIG , Alexander HILLISCH , Katharina MEIER , Stefan HEITMEIER , Adrian TERSTEEGEN , Jan STAMPFUß , Pascal ELLERBROCK , Daniel MEIBOM , Dieter LANG
IPC分类号： C07D401/10 , C07D401/14 , C07D413/10 , C07D413/14 , A61P7/02
摘要： The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
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公开(公告)号：US20170121315A1
公开(公告)日：2017-05-04
申请号：US15317519
申请日：2015-06-08
发明人： Hartmut BECK , Volkhart Min-Jian LI , Yolanda CANCHO GRANDE , Andreas TIMMERMAN , Dirk BROHM , Hannah JÖRIßEN , Pamela BOGNER , Michael GERISCH , Dieter LANG
IPC分类号： C07D405/06 , A61K31/53 , C07D409/06 , C07D413/14 , C07D409/14 , C07D413/06 , A61K45/06 , C07D405/14
CPC分类号： C07D405/06 , A61K31/53 , A61K45/06 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/06 , C07D413/14
摘要： The present application relates to novel heterobicyclically substituted 4-oxobutanoic acid derivatives, to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of respiratory, pulmonary and cardiovascular disorders.
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公开(公告)号：US20170119776A1
公开(公告)日：2017-05-04
申请号：US15300436
申请日：2015-03-31
发明人： Hartmut BECK , Volkhart Min-Jian LI , Andreas TIMMERMANN , Pamela BOGNER , Yolanda CANCHO GRANDE , Dirk BROHM , Michael GERISCH , Hannah JÖRISSEN , Dieter LANG
IPC分类号： A61K31/53 , A61K45/06 , C07D253/08
CPC分类号： A61K31/53 , A61K45/06 , C07D253/08
摘要： The present application relates to novel, chiral 2,5-disubstituted cyclopentanecarboxylic acid derivatives, to a method for their preparation, to their use on their own or in combinations for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diseases of the respiratory tracts, the lung and the cardiovascular system.
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