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    Impedance based devices and methods for use in assays
    13.
    发明授权
    Impedance based devices and methods for use in assays 有权

    公开(公告)号：US10018581B2

    公开(公告)日：2018-07-10

    申请号：US13802174

    申请日：2013-03-13

    Applicant: ACEA BIOSCIENCES, INC

    Inventor： Xiaobo Wang ,  Xiao Xu

    IPC: B01L3/00 ,  G01N27/02 ,  C12M1/32 ,  C12M1/34 ,  G01N27/327

    CPC classification number: G01N27/02 ,  C12M23/12 ,  C12M41/36 ,  G01N27/3276 ,  Y10T29/49117

    Abstract: A method for assaying target molecules in a sample liquid, the method comprising: providing an impedance monitoring device operably connected to an impedance analyzer; adding a sample liquid suspected of having target molecules to the well thereby permitting binding of target molecules to the capture molecules; monitoring impedance of the well; and determining the presence, amount or concentration of target molecules in the liquid sample from the monitored impedance. The device includes a nonconducting substrate having a well, at least two electrodes fabricated on a bottom of the well and on a same plane, wherein the surfaces of the at least two electrodes are modified with capture molecules configured to bind target molecules in a liquid sample, and at least two connection pads electrically connected to the at least two electrodes.

    System and method for detecting multiple-excitation-induced light in a flow channel
    17.
    发明授权
    System and method for detecting multiple-excitation-induced light in a flow channel 有权
    用于检测流道中多激发光的系统和方法

    公开(公告)号：US09568423B2

    公开(公告)日：2017-02-14

    申请号：US13657845

    申请日：2012-10-22

    Applicant: ACEA BIOSCIENCES, INC

    Inventor： Nan Li ,  Jian Wu ,  Ye Chen ,  Tianxing Wang ,  Xiaobo Wang

    IPC: G01N21/64 ,  G01F1/00 ,  G01N15/14 ,  G01N15/10

    CPC classification number: G01N21/645 ,  G01N15/1429 ,  G01N15/1434 ,  G01N15/1459 ,  G01N21/64 ,  G01N21/6428 ,  G01N2015/1006 ,  G01N2015/1438 ,  G01N2015/149 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2021/6482 ,  G01N2201/06113 ,  G01N2201/0621

    Abstract: A system for detecting signal components of light induced by multiple excitation sources including: a flow channel including at least two spatially separated optical interrogation zones; a non-modulating excitation source that directs a light beam of a first wavelength at a near constant intensity onto a first of the optical interrogation zones; a modulating excitation source that directs a light beam of a second wavelength with an intensity modulated over time at a modulating frequency onto a second of the optical interrogation zones; a detector subsystem comprising a set of detectors configured to detect light emitted from particles flowing through the at least two optical interrogation zones and to convert the detected light into a total electrical signal; and a processor that determines signal components from the light detected from each of the optical interrogation zones.

    Abstract translation: 一种用于检测由多个激发源引起的光的信号分量的系统，包括：流路，包括至少两个空间分离的光询问区; 非调制激励源，其将第一波长的光束以接近恒定的强度引导到第一光学询问区上; 调制激励源，其将以调制频率随时间调制的第二波长的光束引导到第二光学询问区上; 检测器子系统，包括一组检测器，其被配置为检测从流过所述至少两个光询问区的颗粒发射的光并将检测到的光转换成总电信号; 以及处理器，其根据从每个光询问区检测的光来确定信号分量。

    IMPEDANCE BASED DEVICES AND METHODS FOR USE IN ASSAYS
    18.
    发明申请
    IMPEDANCE BASED DEVICES AND METHODS FOR USE IN ASSAYS 有权
    基于阻抗的设备和用于测量的方法

    公开(公告)号：US20140057283A1

    公开(公告)日：2014-02-27

    申请号：US13802174

    申请日：2013-03-13

    Applicant: ACEA BIOSCIENCES, INC

    Inventor： Xiaobo Wang ,  Xiao Xu

    IPC: G01N27/02

    CPC classification number: G01N27/02 ,  C12M23/12 ,  C12M41/36 ,  G01N27/3276 ,  Y10T29/49117

    Abstract: A method for assaying target molecules in a sample liquid, the method comprising: providing an impedance monitoring device operably connected to an impedance analyzer; adding a sample liquid suspected of having target molecules to the well thereby permitting binding of target molecules to the capture molecules; monitoring impedance of the well; and determining the presence, amount or concentration of target molecules in the liquid sample from the monitored impedance. The device includes a nonconducting substrate having a well, at least two electrodes fabricated on a bottom of the well and on a same plane, wherein the surfaces of the at least two electrodes are modified with capture molecules configured to bind target molecules in a liquid sample, and at least two connection pads electrically connected to the at least two electrodes.

    Abstract translation: 一种用于测定样品液体中的靶分子的方法，所述方法包括：提供可操作地连接到阻抗分析仪的阻抗监测装置; 将怀疑具有靶分子的样品液体加入到孔中，从而允许靶分子与捕获分子的结合; 监测井的阻抗; 以及从所监测的阻抗确定液体样品中靶分子的存在，量或浓度。 该器件包括具有阱的非导电衬底，至少两个电极，其制造在阱的底部并且在同一平面上，其中至少两个电极的表面被配置成结合在液体样品中的靶分子结合的俘获分子 以及至少两个电连接到所述至少两个电极的连接焊盘。

    NOVEL EGFR MODULATORS AND USES THEREOF
    19.
    发明申请
    NOVEL EGFR MODULATORS AND USES THEREOF 有权
    新型EGFR调节剂及其用途

    公开(公告)号：US20140038940A1

    公开(公告)日：2014-02-06

    申请号：US13843554

    申请日：2013-03-15

    Applicant: ACEA BIOSCIENCES INC.

    Inventor： Xiao XU ,  Xiaobo Wang ,  Long Mao ,  Li Zhao ,  Biao Xi

    IPC: A61K31/519 ,  C07D487/04

    CPC classification number: A61K31/519 ,  A61K45/06 ,  C07D487/04 ,  A61K2300/00

    Abstract: The present invention relates to certain pyrrolopyrimidine derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for the treatment of tumors and related diseases related to the dysregulation of kinase (such as EGFR (including HER), Alk, PDGFR, but not limited to) pathways.

    Abstract translation: 本发明涉及某些吡咯并嘧啶衍生物，含有它们的药物组合物及其使用方法，包括治疗肿瘤的方法和与激酶失调相关的相关疾病（如EGFR（包括HER），Alk，PDGFR），但是 途径。

    REAL TIME ELECTRONIC CELL SENSING SYSTEMS AND APPLICATIONS FOR CELL-BASED ASSAYS
    20.
    发明申请
    REAL TIME ELECTRONIC CELL SENSING SYSTEMS AND APPLICATIONS FOR CELL-BASED ASSAYS 审中-公开

    公开(公告)号：US20200348312A1

    公开(公告)日：2020-11-05

    申请号：US16833180

    申请日：2020-03-27

    Applicant: ACEA Biosciences, Inc.

    Inventor： Xiao Xu ,  Yama A. Abassi ,  Xiaobo Wang ,  Jiangbo Gan

    IPC: G01N33/68 ,  C12M1/12 ,  C12M1/34 ,  G01N33/50 ,  G01N33/483

    Abstract: Methods for identifying compounds that modulate cellular responses stimulated by IgE, which include providing an impedance-based system that monitors cell-substrate impedance of cells on a substrate; introducing cells to the substrate of the system; adding at least one test compound and IgE to the cells, wherein the at least one test compound is suspected of modulating cell responses stimulated by the IgE; adding an antigen to the cells; monitoring the cell-substrate impedance of cells on the substrate; and analyzing the cell-substrate impedance to evaluate whether the at least one test compound alters a cellular response to stimulation with the IgE.

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