公开(公告)号：US20240339643A1

公开(公告)日：2024-10-10

申请号：US18394890

申请日：2023-12-22

申请人： Washington University

发明人： Shrihari Sankarasubramanian ,  Vijay Ramani

IPC分类号： H01M8/18 ,  H01M4/94

CPC分类号： H01M8/188 ,  H01M4/94 ,  H01M2300/0011

摘要： Described herein is a novel electrode-decoupled redox flow battery, a novel reinforced electrode-decoupled redox flow battery, and methods of using same to store energy. Advantages of these novel electrode-decoupled redox flow batteries include long life, excellent rate capability, and stability.

公开(公告)号：US20240335657A1

公开(公告)日：2024-10-10

申请号：US18731925

申请日：2024-06-03

申请人： Washington University ,  Northwestern University

发明人： Wilson Z. Ray ,  Matthew R. MacEwan ,  Zohny S. Zohny ,  John A. Rogers

IPC分类号： A61N1/20 ,  A61N1/04 ,  A61N1/05 ,  A61N1/372 ,  A61N1/375

CPC分类号： A61N1/205 ,  A61N1/0456 ,  A61N1/0504 ,  A61N1/37217 ,  A61N1/375 ,  A61N1/20

摘要： A system for stimulating tissue generally comprises a resorbable implant. The resorbable implant includes a substrate, at least one contact, and a transceiver, wherein the substrate, the at least one contact, and the transceiver are resorbable. The system also includes a controller configured to communicate with the transceiver of the resorbable implant and a power supply connected to the controller. The controller delivers power to the resorbable implant from the power supply. The resorbable implant delivers electrical stimulation to tissue when the resorbable implant receives power.

公开(公告)号：US20240309077A1

公开(公告)日：2024-09-19

申请号：US18436678

申请日：2024-02-08

申请人： Washington University

发明人： David Holtzman ,  Hong Jiang ,  Thu Nga Bien-Ly ,  Mark S. Dennis ,  Jing Guo ,  Adam P. Silverman ,  Ryan J. Watts ,  Yin Zhang

IPC分类号： C07K16/18 ,  A61K9/00 ,  A61K9/127 ,  A61K31/192 ,  A61K39/00 ,  A61P25/28

CPC分类号： C07K16/18 ,  A61K9/0019 ,  A61K9/0085 ,  A61K9/127 ,  A61K31/192 ,  A61P25/28 ,  A61K2039/505 ,  C07K2317/33 ,  C07K2317/90 ,  C07K2317/92

摘要： The present disclosure encompasses compositions and methods for effectively treating at least one symptom or sign of Aβ plaque or cerebral amyloid angiopathy (CAA) associated symptoms, or for decreasing amyloid plaque load or CAA load. The method comprises administering an effective amount of an anti-ApoE antibody to a mammalian subject, such as to a human.

公开(公告)号：US20240307008A1

公开(公告)日：2024-09-19

申请号：US18578227

申请日：2022-07-13

申请人： Washington University

发明人： Abhinav Kumar JHA ,  Zekun LI ,  Daniel THOREK ,  Md Ashequr RAHMAN

IPC分类号： A61B6/03 ,  A61B6/00 ,  A61B6/46 ,  G06F30/25

CPC分类号： A61B6/032 ,  A61B6/469 ,  A61B6/5258 ,  G06F30/25

摘要： A system for low-count quantitative single-photon emission computed tomography (LC-QSPECT) is provided. The system is programmed to a) store a computer tomography (CT) scan of a subject being examining including a plurality of defined volumes of interest (VOIs) of the subject being examined; b) model a system matrix based on the stored CT, wherein the model describes the probability that photons emitted from each of the defined VOIs are detected in different projection bins, wherein a plurality of projection bins are defined around the subject and the defined VOIs; c) adjust the model with analysis of stray-radiation noise around the subject; d) detect, by the one or more sensors, one or more photons being emitted by an alpha-particle-emitting isotope; and e) execute the adjusted model with the one or more detected photons as inputs to determine a source VOI of the detected photons.

公开(公告)号：US20240293039A1

公开(公告)日：2024-09-05

申请号：US18176876

申请日：2023-03-01

申请人： Washington University

发明人： Hongyu An ,  Ulugbek Kamilov ,  Sihao Chen ,  Cihat Eldeniz ,  Weijie Gan ,  Jiaming Liu ,  Tyler Fraum

IPC分类号： A61B5/055

CPC分类号： A61B5/055 ,  G06T2207/20081 ,  G06T2207/20084

摘要： A method for reconstructing dynamic contrast-enhanced (DCE) MR images includes receiving a plurality of continuous free-breathing DCE images, the plurality of images obtained with a contrast, sorting the images by identifying a respiratory phase associated with each of the continuous free-breathing DCE images, reconstructing the plurality continuous free-breathing DCE images into a 4D respiratory motion-resolved image, obtaining 3D deformable motion vector fields (MVFs), and utilizing a deep learning based motion transformation integrated forward-Fourier (DL-MOTIF) model and the 3D deformable MVFs to reconstruct the DCE MR images.

公开(公告)号：US20240269473A1

公开(公告)日：2024-08-15

申请号：US18569649

申请日：2022-06-27

申请人： NORTHWESTERN UNIVERSITY ,  THE GEORGE WASHINGTON UNIVERSITY

发明人： John A. Rogers ,  Yeonsik Choi ,  Igor Efimov ,  Rose T. Yin

IPC分类号： A61N1/372 ,  A61L31/02 ,  A61L31/10 ,  A61L31/14 ,  A61N1/02 ,  A61N1/05 ,  A61N1/362 ,  A61N1/375 ,  A61N1/378 ,  A61N1/39

CPC分类号： A61N1/37229 ,  A61L31/10 ,  A61L31/148 ,  A61N1/025 ,  A61N1/059 ,  A61N1/0595 ,  A61N1/362 ,  A61N1/37512 ,  A61N1/3756 ,  A61N1/3758 ,  A61N1/3787 ,  A61N1/39622 ,  A61L31/022

摘要： A device implantable on a target of interest of a subject for pacemaker, neuromodulator, and/or defibrillator therapy comprises a wireless power harvesting unit configured to deliver power via resonant inductive coupling to the target tissue for stimulation in a manner that eliminates need for batteries and allows for externalized control without transcutaneous leads. The device relies exclusively on materials that resorb when exposed to biofluids in a time-controlled manner via metabolic action and hydrolysis. The materials and design choices create a thin, flexible, and lightweight form that maintain excellent biocompatibility and stable function throughout a desired period of use. Over a subsequent timeframe following the completion of therapy, the devices disappear completely through natural biological processes. These characteristics and a miniaturized geometry facilitate full implantation into the body to eliminate the need for percutaneous hardware, which thereby minimizes the risk of device-associated infections and dislodgement.

公开(公告)号：US12054788B2

公开(公告)日：2024-08-06

申请号：US18156014

申请日：2023-01-18

申请人： Washington University

发明人： Eric Claude Leuthardt ,  Gavin P. Dunn ,  Hong Chen ,  Allegra Petti

IPC分类号： A61B5/00 ,  A61B5/055 ,  A61B10/00 ,  A61B90/11 ,  A61N7/00 ,  C12Q1/6851 ,  C12Q1/6886

CPC分类号： C12Q1/6886 ,  A61B5/0042 ,  A61B5/055 ,  A61B5/6803 ,  A61B10/0045 ,  A61B90/11 ,  A61N7/00 ,  C12Q1/6851 ,  A61B2010/0077 ,  A61B2010/008 ,  A61N2007/0039 ,  A61N2007/006 ,  A61N2007/0078 ,  C12Q2600/156

摘要： Among the various aspects of the present disclosure is the provision of a noninvasive and localized brain liquid biopsy using focused ultrasound. Briefly, therefore, the present disclosure is directed to methods and systems to identify brain lesion or tumor characteristics without the need for a solid brain biopsy.

公开(公告)号：US20240254510A1

公开(公告)日：2024-08-01

申请号：US18282761

申请日：2022-03-21

申请人： Washington University ,  Shriners Hospitals for Children

发明人： Farshid Guilak ,  Robert Nims ,  Lara Pferdehirt

IPC分类号： C12N15/86 ,  C07K14/52 ,  C12N5/077

CPC分类号： C12N15/86 ,  C07K14/52 ,  C12N5/0655 ,  C12N2510/00 ,  C12N2740/15043 ,  C12N2830/002

摘要： Among the various aspects of the present disclosure is the provision of compositions and methods of making genetically modified cells comprising a synthetic circuit that is responsive to a mechanical input to the cell and methods of use thereof. This disclosure uses mechanotransduction to provide gene-based delivery of biologic drugs at prescribed times, phases and frequencies. Once reprogrammed, the cells can be reimplanted in the body for this purpose.

公开(公告)号：US12050257B2

公开(公告)日：2024-07-30

申请号：US18061254

申请日：2022-12-02

申请人： Washington University ,  Oregon Health and Science University

发明人： Nico Dosenbach ,  Jonathan Koller ,  Andrew Van ,  Abraham Snyder ,  Amy Mirro ,  Damien Fair ,  Eric Earl ,  Rachel Klein ,  Oscar Miranda Dominguez ,  Anders Perrone

IPC分类号： G01R33/56 ,  A61B5/055 ,  G01R33/00 ,  G01R33/483 ,  G01R33/565

CPC分类号： G01R33/56509 ,  A61B5/055 ,  G01R33/0041 ,  G01R33/4831 ,  G01R33/5608

摘要： Methods, computer-readable storage devices, and systems are described for reducing movement of a patient undergoing a magnetic resonance imaging (MRI) scan by aligning MRI data, the method implemented on a Framewise Integrated Real-time MRI Monitoring (“FIRMM”) computing device including at least one processor in communication with at least one memory device. Aspects of the method comprise receiving a data frame from the MRI system, aligning the received data frame to a preceding data frame, calculating motion of a body part between the received data frame and the preceding data frame, calculating total frame displacement, and excluding data frames with a cutoff above a pre-identified threshold of the total frame displacement.

公开(公告)号：US20240249453A1

公开(公告)日：2024-07-25

申请号：US18416578

申请日：2024-01-18

申请人： Washington University

发明人： Abhinav Kumar Jha ,  Zitong Yu ,  Md Ashequr Rahman

IPC分类号： G06T11/00 ,  A61B6/00 ,  A61B6/03

CPC分类号： G06T11/006 ,  A61B6/037 ,  A61B6/5282 ,  G06T2210/41 ,  G06T2211/441

摘要： A system for single-photon emission computed tomography (SPECT) is provided. The system includes a computer device comprises at least one processor in communication with at least one memory device. The at least one processor is programmed to: a) store a model trained to generate an attenuation map of a subject being examined; b) receive a scatter-energy window projection of a first subject to be examined; c) execute the model with the scatter-energy window projection of the first subject as an input, wherein the model generates an attenuation map; d) receive a photopeak-energy window projection of the first subject to be examined; and e) perform attenuation compensation on the photopeak-energy window projection using the generated attenuation map.