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公开(公告)号：US20240309077A1
公开(公告)日：2024-09-19
申请号：US18436678
申请日：2024-02-08
Applicant: Washington University
Inventor： David Holtzman , Hong Jiang , Thu Nga Bien-Ly , Mark S. Dennis , Jing Guo , Adam P. Silverman , Ryan J. Watts , Yin Zhang
CPC classification number: C07K16/18 , A61K9/0019 , A61K9/0085 , A61K9/127 , A61K31/192 , A61P25/28 , A61K2039/505 , C07K2317/33 , C07K2317/90 , C07K2317/92
Abstract: The present disclosure encompasses compositions and methods for effectively treating at least one symptom or sign of Aβ plaque or cerebral amyloid angiopathy (CAA) associated symptoms, or for decreasing amyloid plaque load or CAA load. The method comprises administering an effective amount of an anti-ApoE antibody to a mammalian subject, such as to a human.
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公开(公告)号：US09834596B2
公开(公告)日：2017-12-05
申请号：US14412309
申请日：2013-07-03
Applicant: Washington University
Inventor： David Holtzman , Hong Jiang , Marc Diamond , Najla Kfoury , Brandon Holmes
CPC classification number: C07K16/18 , A61K2039/505 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N2800/2821
Abstract: This invention relates to antibodies to tau and methods of use thereof.
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公开(公告)号：US20210284727A1
公开(公告)日：2021-09-16
申请号：US17275092
申请日：2019-09-11
Applicant: Washington University
Inventor： David Holtzman , Jason Ulrich , Hong Jiang
IPC: C07K16/28
Abstract: The present disclosure encompasses anti-TREM-2 antibodies that promote TREM-2 activation and methods of using the anti-TREM-2 agonist antibodies therapeutically.
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公开(公告)号：US20220064271A1
公开(公告)日：2022-03-03
申请号：US17464190
申请日：2021-09-01
Applicant: Washington University
Inventor： Randall Bateman , David Holtzman , Kanta Horie , Nicolas Barthelemy , Chihiro Sato , Hong Jiang
Abstract: This invention relates to epitope binding agents that specifically bind to tau and methods of use thereof. The disclosure provides immunoassays, kits, and pharmaceutical compositions which include an epitope binding agent that specifically bind to tau. The disclosure provides methods of reducing the spread of tau aggregates and methods of reducing a tauopathy-related pathology.
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公开(公告)号：US20180016328A1
公开(公告)日：2018-01-18
申请号：US15548353
申请日：2016-02-04
Applicant: Washington University
Inventor： David Holtzman , Hong Jiang , Gilbert Gallardo , Christina Ising , Cheryl Leyns
CPC classification number: C07K16/18 , A61K39/0007 , A61K48/005 , A61K2039/505 , C07K14/705 , C07K14/775 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/77 , C07K2319/00 , C07K2319/01 , C07K2319/02 , C07K2319/03 , C07K2319/06 , C07K2319/74 , C07K2319/95 , C12N7/00 , C12N15/86 , C12N2750/14121 , C12N2750/14143 , C12N2810/40
Abstract: The present invention provides anti-tau constructs. Anti-tau constructs of the invention are polynucleotide sequences encoding a polypeptide comprising at least one tau binding moiety and optionally comprising a signal peptide and/or a purification moiety. The present invention also provides isolated polypeptides encoded by anti-tau constructs, vectors comprising anti-tau constructs, and isolated cells comprising said vectors.
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公开(公告)号：US20150140672A1
公开(公告)日：2015-05-21
申请号：US14523148
申请日：2014-10-24
Applicant: WASHINGTON UNIVERSITY
Inventor： Randall Bateman , Kwasi Mawuenyega , Vitaliy Ovod , Anna Bareiss , Tom Kasten , David Holtzman
IPC: G01N33/68
CPC classification number: G01N33/6896 , G01N33/58 , G01N33/6893 , G01N2333/4709 , G01N2458/15 , G01N2560/00 , G01N2800/2821 , G01N2800/7047
Abstract: The present invention relates to methods of detecting, diagnosing, monitoring, and assessing treatment effects for Aβ amyloidosis, early in the course of clinical disease or prior to the onset of brain damage and clinical symptoms.
Abstract translation: 本发明涉及检测，诊断，监测和评估治疗效果的方法。 淀粉样变性，早期在临床疾病过程中或之前发生脑损伤和临床症状。
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公开(公告)号：US20250020669A1
公开(公告)日：2025-01-16
申请号：US18276710
申请日：2022-02-10
Applicant: Washington University
Inventor： Randall Bateman , Melissa Budelier , David Holtzman , Hong Jiang
Abstract: The present disclosure provides methods to detect and optionally quantify Nfl present in cerebrospinal fluid and blood and use of the methods to detect and optionally measure levels of Nfl biomarkers indicative of neuronal damage. Also disclosed are anti-Nfl antibodies.
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公开(公告)号：US11124562B2
公开(公告)日：2021-09-21
申请号：US16345637
申请日：2017-10-27
Applicant: Washington University , Denali Therapeutics Inc.
Inventor： David Holtzman , Hong Jiang , Fan Liao , Thu Nga Bien-Ly , Mark S. Dennis , Jing Guo , Adam P. Silverman , Ryan J. Watts , Yin Zhang
Abstract: The present disclosure encompasses compositions and methods for effectively treating at least one symptom or sign of A plaque or cerebral amyloid angiopathy (CAA) associated symptoms, or for decreasing amyloid plaque load or CAA load. The method comprises administering an effective amount of an anti-ApoE antibody to a mammalian subject, such as to a human.
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公开(公告)号：US10830775B2
公开(公告)日：2020-11-10
申请号：US15515909
申请日：2015-09-30
Applicant: Washington University
Inventor： Randall Bateman , Chihiro Sato , Kwasi Mawuenyega , Tim Miller , David Holtzman
Abstract: The invention relates to in vitro methods for measuring the in vivo metabolism of tau in a subject.
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公开(公告)号：US20170307639A1
公开(公告)日：2017-10-26
申请号：US15515909
申请日：2015-09-30
Applicant: Washington University
Inventor： Randall Bateman , Chihiro Sato , Kwasi Mawuenyega , Tim Miller , David Holtzman
Abstract: The invention relates to in vitro methods for measuring the in vivo metabolism of tau in a subject.
