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    Frequency-domain optical interferometry imaging apparatus and method for astigmatistic bi-focal illumination imaging of an eye
    11.
    发明授权
    Frequency-domain optical interferometry imaging apparatus and method for astigmatistic bi-focal illumination imaging of an eye 有权

    公开(公告)号：US10788309B2

    公开(公告)日：2020-09-29

    申请号：US16090409

    申请日：2017-04-03

    Applicant: THE UNIVERSITY OF LIVERPOOL

    Inventor： Yaochun Shen ,  Yalin Zheng ,  Yue Dong ,  Samuel Lawman

    IPC: G01B9/02 ,  A61B3/12 ,  A61B3/10 ,  A61B3/14

    Abstract: Embodiments of the present invention provide a method and apparatus for frequency-domain optical interferometry imaging. Embodiments of the invention include an apparatus comprising a line-shaping optical element for directing optical radiation into a line illumination, an imaging optical element for receiving optical radiation comprising radiation reflected from a target sample and a reference point associated with the target sample, and a detection unit for measuring common path interferences between a plurality of reflections from the target sample and the reference point. Embodiments of the invention include a method comprising directing radiation into a line illumination, directing the line illumination towards a target sample, receiving radiation reflected from the target sample at a detection unit, and measuring common path interferences between a plurality of reflections at the target sample and a reference point.

    Membrane-anchoring and apoptosis-inducing fusion protein comprising a fragment of TRAIL and CD40L and encoding polynucleotides
    14.
    发明授权
    Membrane-anchoring and apoptosis-inducing fusion protein comprising a fragment of TRAIL and CD40L and encoding polynucleotides 有权

    公开(公告)号：US10370422B2

    公开(公告)日：2019-08-06

    申请号：US15304282

    申请日：2015-04-15

    Applicant: The University of Liverpool

    Inventor： Daniel Palmer ,  Taha Elmitwalli

    IPC: C07K14/52 ,  C07K19/00 ,  C12N15/11 ,  C07K14/47 ,  C07K14/705

    Abstract: Provided are compositions comprising fusion proteins, polynucleotides and/or expression vectors with therapeutic utility for suppressing and/or treating cancer, as well as medical uses of these agents, and methods of treatment in which they are used. A fusion protein of the invention comprises an amino acid sequence that provides the apoptosis-inducing activity of TRAIL, and a membrane-anchoring amino acid sequence. The amino acid sequence that provides the apoptosis-inducing activity of TRAIL comprises the extracellular domain of TRAIL, or a fragment or variant thereof. A fusion protein comprising an amino acid sequence from TRAIL that is able to induce apoptosis, and a second sequence that anchors the first sequence to the cell membrane, is markedly more effective at reducing viability of TRAIL receptor positive cells than the naturally occurring (“wild type”) TRAIL protein itself.

    OPTICAL INTERFEROMETRY APPARATUS AND METHOD
    15.
    发明申请
    OPTICAL INTERFEROMETRY APPARATUS AND METHOD 审中-公开

    公开(公告)号：US20190113328A1

    公开(公告)日：2019-04-18

    申请号：US16090409

    申请日：2017-04-03

    Applicant: THE UNIVERSITY OF LIVERPOOL

    Inventor： Yaochun Shen ,  Yalin Zheng ,  Yue Dong ,  Samuel Lawman

    IPC: G01B9/02 ,  A61B3/10 ,  A61B3/14 ,  A61B3/12

    Abstract: Embodiments of the present invention provide a method and apparatus for frequency-domain optical interferometry imaging. Embodiments of the invention include an apparatus comprising a line-shaping optical element for directing optical radiation into a line illumination, an imaging optical element for receiving optical radiation comprising radiation reflected from a target sample and a reference point associated with the target sample, and a detection unit for measuring common path interferences between a plurality of reflections from the target sample and the reference point. Embodiments of the invention include a method comprising directing radiation into a line illumination, directing the line illumination towards a target sample, receiving radiation reflected from the target sample at a detection unit, and measuring common path interferences between a plurality of reflections at the target sample and a reference point.

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