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    Apparatus for treating prostate cancer and method for same
    13.
    发明授权
    Apparatus for treating prostate cancer and method for same 有权
    用于治疗前列腺癌的装置及其方法

    公开(公告)号：US07041121B1

    公开(公告)日：2006-05-09

    申请号：US10356226

    申请日：2003-01-31

    申请人： Stephen J. Williams ,  James G. Lovewell ,  Thomas H. McGaffigan

    发明人： Stephen J. Williams ,  James G. Lovewell ,  Thomas H. McGaffigan

    IPC分类号： A61N5/067 ,  A61N5/01

    CPC分类号： A61N5/062 ,  A61N5/0601 ,  A61N2005/061 ,  A61N2005/0652 ,  A61N2005/067

    摘要： A medical device for photodynamically treating cancerous tissue, such as prostate cancer, comprising a body, a needle extendable from the body and at least one light-emitting (e.g., laser) diode mounted on the needle. The body is sized and configured for introduction into the urethra of a patient. The needle is movable between a retracted position housed substantially within the cylindrical body, and a deployed position in which the needle extends from the cylindrical body to enable it to penetrate into prostate tissue. The light-emitting diode is adapted to emit light to activate a photosensitizing agent (e.g., porfimer sodium) in or adjacent cancerous tissue in the prostate. Methods of treating cancer and other embodiments of medical devices for cancer treatment are also disclosed.

    摘要翻译： 用于光动力治疗癌组织（例如前列腺癌）的医疗装置，包括主体，可从身体延伸的针和安装在针上的至少一个发光（例如，激光）二极管。 身体的大小和配置用于引入患者的尿道。 针可以在基本上容纳在圆柱体内的缩回位置和展开位置之间移动，在该展开位置，针从圆柱体延伸以使其能够穿透到前列腺组织中。 发光二极管适于发光以激活前列腺癌组织中或其附近的光敏剂（例如，卟吩醇钠）。 还公开了治疗癌症的方法和用于癌症治疗的医疗装置的其它实施方案。

    Tandem isotachophoresis/zone electrophoresis method and system
    14.
    发明授权
    Tandem isotachophoresis/zone electrophoresis method and system 有权
    串联等电泳/区域电泳方法和系统

    公开(公告)号：US06685813B2

    公开(公告)日：2004-02-03

    申请号：US09933993

    申请日：2001-08-20

    申请人： Stephen J. Williams ,  Hong Dong Tan ,  Hung Pin Kao ,  Wyatt N. Vreeland

    发明人： Stephen J. Williams ,  Hong Dong Tan ,  Hung Pin Kao ,  Wyatt N. Vreeland

    IPC分类号： B01D5902

    CPC分类号： B01L3/5027 ,  B01L3/502753 ,  B01L2200/0605 ,  B01L2300/0816 ,  B01L2400/0415 ,  B01L2400/0421 ,  B01L2400/049 ,  C07K1/26 ,  C07K1/28 ,  G01N27/44773

    摘要： A method of separating components having a given negative or positive charge and contained in a sample is disclosed. The method involves, in one embodiment, loading a microchannel with a sample, placed between a trailing-edge electrolyte having a selected concentration of a titratable species, and a leading-edge electrolyte. With the application of a voltage potential across the microchannel, charged components in the sample stack by isotachophoresis, and electrolytic hydroxyl or hydrogen ions formed by electrolysis at the upstream-end electrode migrate into the trailing-edge ion buffer, titrating the titratable species therein, where the concentration of the titratable species in the trailing-edge electrolyte is selected, in relation to the lengths of the upstream channel region and sample-loading volume, to permit the sample to stack into a relatively small sample volume before electrolytic-ion migration from the upstream electrode into and through the sample-volume region is effective to overtake the charged sample components. With continued application of an electric potential across the channel ends, charged sample components in the stacked sample volume separate by zone electrophoresis.

    摘要翻译： 公开了一种分离具有给定负电荷并包含在样品中的组分的方法。 在一个实施方案中，该方法包括将具有样品的微通道加载到放置在具有选定浓度的可滴定物质的后缘电解质和前沿电解质之间。 通过在微通道上施加电压电位，通过等速电泳施加样品叠层中的带电组分，并且通过在上游端电极处电解形成的电解羟基或氢离子迁移到后缘离子缓冲液中，滴定其中的可滴定物质， 其中选择后缘电解质中的可滴定物质的浓度，相对于上游通道区域的长度和样品加载体积，以允许样品在电离离子迁移之前堆积成相对小的样品体积 进入和通过样品体积区域的上游电极有效地超过带电的样品组分。 通过在通道末端继续施加电位，通过区域电泳分离堆叠样品体积中的带电样品组分。

    Prioritized PVC management queues for improved frame processing capabilities
    15.
    发明授权
    Prioritized PVC management queues for improved frame processing capabilities 失效
    优先的PVC管理队列，以提高帧处理能力

    公开(公告)号：US6144669A

    公开(公告)日：2000-11-07

    申请号：US989689

    申请日：1997-12-12

    申请人： Stephen J. Williams ,  Troy W. Manary ,  William R. McEachern

    发明人： Stephen J. Williams ,  Troy W. Manary ,  William R. McEachern

    IPC分类号： H04L12/46 ,  H04L12/56 ,  H04L12/66 ,  H04Q11/04

    CPC分类号： H04L47/521 ,  H04L12/46 ,  H04L12/5693 ,  H04L12/66 ,  H04L47/10 ,  H04L47/16 ,  H04L47/2433 ,  H04L47/522 ,  H04L47/6225 ,  H04L47/6255 ,  H04L49/90 ,  H04Q11/0478 ,  H04L2012/5651 ,  H04L2012/567

    摘要： There is provided a method and apparatus for the prioritization, multiple queuing and selective processing of PVC management frames by a Frame Relay message processing device. The device had an input port for receiving the messages. It also provides a number of message queues for storing and retrieving the received messages, each of the queues respectively corresponding to one of a number of response priority levels which vary from highest priority to lowest priority. Each of the response priority levels is assigned to a number of message classes associated with predetermined link management processes for communicating the status of message relay links among networking devices. The message processing device has a first processor for determining the message class associated with each of the received messages and for allocating each of the messages to a corresponding one of the queues based upon the response priority level assigned to the determined message class. A second processor is provided for retrieving each of the messages from the queues, and an output port is provided for dispatching the retrieved messages.

    摘要翻译： 提供了一种通过帧中继消息处理设备对PVC管理帧进行优先排序，多排队和选择性处理的方法和装置。 该设备具有用于接收消息的输入端口。 它还提供用于存储和检索接收到的消息的多个消息队列，每个队列分别对应于从最高优先权到最低优先级的多个响应优先级中的一个。 将每个响应优先级分配给与预定的链路管理过程相关联的消息类型的数目，用于​​在网络设备之间传送消息中继链路的状态。 消息处理设备具有第一处理器，用于确定与每个接收到的消息相关联的消息类别，并且基于分配给所确定的消息类别的响应优先级，将每个消息分配给对应的一个队列。 提供第二处理器用于从队列中检索每个消息，并且提供输出端口用于调度所检索的消息。

    Adaptive digital network interface
    16.
    发明授权
    Adaptive digital network interface 失效
    自适应数字网络接口

    公开(公告)号：US4935925A

    公开(公告)日：1990-06-19

    申请号：US234262

    申请日：1988-08-19

    申请人： Stephen J. Williams ,  Elden D. Traster

    发明人： Stephen J. Williams ,  Elden D. Traster

    IPC分类号： H04L12/52

    CPC分类号： H04L12/525

    摘要： A multiplexing data communication system (10) provides for communication between a plurality of microcomputer terminals (12) with a host computer (30). Communications from the microcomputer (12) are multiplexed over a T1 line (26) between two DMI interfaces (22 and 24). The DMI interface (24) includes an adaptive digital network interface (62) which processes the multiplex data in a serial manner allowing for flexibility in framing the data and processing protocol information. Program control in the adaptive digital network interface (62) is performed in part by the status of three counters (266, 268 and 272) and the bit present at the output of a fifo memory (112) allowing for increased processing speeds. Furthermore, processing speed is enhanced through use of an instruction set allowing simultaneous strobing and enabling of the elements of the adaptive digital network interface (62).

    摘要翻译： 复用数据通信系统（10）提供多个微型计算机终端（12）与主计算机（30）之间的通信。 来自微型计算机（12）的通信在两个DMI接口（22和24）之间的T1线路（26）上被复用。 DMI接口（24）包括自适应数字网络接口（62），其以串行方式处理复用数据，从而允许对数据进行成帧和处理协议信息的灵活性。 自适应数字网络接口（62）中的程序控制部分地由三个计数器（266,268和272）的状态和存在于fifo存储器（112）的输出端的位执行，从而允许增加的处理速度。 此外，通过使用允许自适应数字网络接口（62）的元件的同时选通和使能的指令集来提高处理速度。

    Methods and apparatus for adjusting blood circulation
    17.
    发明授权
    Methods and apparatus for adjusting blood circulation 有权
    调节血液循环的方法和装置

    公开(公告)号：US09308148B2

    公开(公告)日：2016-04-12

    申请号：US11945999

    申请日：2007-11-27

    申请人： John Roy Kane ,  Scott A. Christensen ,  Nathan Hamilton ,  Stephen J. Williams

    发明人： John Roy Kane ,  Scott A. Christensen ,  Nathan Hamilton ,  Stephen J. Williams

    IPC分类号： A61H7/00

    CPC分类号： A61H7/001 ,  A61H2201/0103 ,  A61H2201/0207 ,  A61H2201/0214 ,  A61H2201/0228 ,  A61H2201/0242 ,  A61H2201/025 ,  A61H2201/165 ,  A61H2201/5071 ,  A61H2205/065 ,  A61H2205/12 ,  A61H2230/50

    摘要： A method and device for increasing blood flow by applying positive pressure to extremities of a mammal and/or controlling the temperature of the mammal. The device includes one or more collapsible and pliant body elements capable of expanding and flexibly applying pressurized compression forces to the extremity of the mammal by attaching one or more pressure-applying gas plenums as close to the extremity as possibly. The flexible extremity device can be used independently or can be used in conjunction with thermal pads disposed to the one or more collapsible and pliant body elements. Alternatively, the one or more collapsible and pliant body elements can be manufactured into thermal pads.

    摘要翻译： 一种通过向哺乳动物的四肢施加正压和/或控制哺乳动物的温度来增加血流量的方法和装置。 该装置包括一个或多个可折叠和柔韧的身体元件，其能够通过将一个或多个压力施加气体增压室尽可能靠近地附接到末端而扩展并且将加压的压缩力施加到哺乳动物的末端。 柔性末端装置可以独立使用，也可以与设置在一个或多个可折叠和柔韧的身体元件上的热垫结合使用。 或者，可以将一个或多个可折叠和柔韧的主体元件制造成热垫。

    Methods and apparatus for adjusting blood circulation
    19.
    发明授权
    Methods and apparatus for adjusting blood circulation 有权
    调节血液循环的方法和装置

    公开(公告)号：US08603150B2

    公开(公告)日：2013-12-10

    申请号：US11870780

    申请日：2007-10-11

    申请人： John Roy Kane ,  Scott A. Christensen ,  Nathan Hamilton ,  Stephen J. Williams

    发明人： John Roy Kane ,  Scott A. Christensen ,  Nathan Hamilton ,  Stephen J. Williams

    IPC分类号： A61F7/00

    CPC分类号： A61H9/0007 ,  A61F7/007 ,  A61F7/02 ,  A61F2007/0029 ,  A61F2007/0036 ,  A61F2007/0039 ,  A61F2007/0045 ,  A61F2007/0054 ,  A61F2007/0071 ,  A61F2007/0086 ,  A61H2201/0207 ,  A61H2201/0228 ,  A61H2201/10 ,  A61H2201/1635 ,  A61H2201/164 ,  A61H2205/065 ,  A61H2209/00 ,  B29C65/04 ,  B29K2995/0082 ,  B29L2031/753

    摘要： Embodiments of the invention include a method and a device for increasing blood flow and controlling the temperature of a mammal by applying a desired pressure to extremities of a mammal. The device generally includes one or more collapsible and pliant body elements, capable of expanding from a first volume into an expanded second volume so the device can receive a portion of an extremity of the mammal therein and then be reduced from the expanded second volume into a pressurized third volume to conformably enclose the portion of the extremity. One or more thermal exchange units can be positioned in the one or more collapsible and pliant body elements. Accordingly, the temperature of the extremity of a mammal can be regulated by providing a heated or cooled fluid medium or electric thermal energy to the one or more thermal exchange units. Next, by evacuating the region in which the extremity is enclosed the contact surface area between the extremity of a mammal and the one or more thermal exchange units is increased, due to the external atmospheric pressure acting on the pliant body elements against the skin of the extremity of the mammal. The application of pressure assures that sufficient contact and thermal heat transfer (heating or cooling) is provided to the extremity of the mammal.

    摘要翻译： 本发明的实施方案包括通过向哺乳动物的四肢施加期望的压力来增加血流量并控制哺乳动物的温度的方法和装置。 该装置通常包括一个或多个可折叠和柔韧的主体元件，其能够从第一容积膨胀成扩展的第二容积，使得装置可以接收哺乳动物的一部分末端，然后从膨胀的第二容积减小到 加压第三体积以适形地包围末端的部分。 一个或多个热交换单元可以定位在一个或多个可折叠和柔韧的身体元件中。 因此，可以通过向一个或多个热交换单元提供加热或冷却的流体介质或电热能来调节哺乳动物末端的温度。 接下来，通过抽出其中包围末端的区域，由于外部大气压力作用于柔韧的身体元件抵抗皮肤上的哺乳动物的末端与一个或多个热交换单元之间的接触表面积增加 哺乳动物的极端。 施加压力确保了向哺乳动物的末端提供足够的接触和热传递（加热或冷却）。