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    Process for resolving amino acids using substituted lactones
    11.
    发明授权
    Process for resolving amino acids using substituted lactones 失效
    使用取代的内酯拆分氨基酸的方法

    公开(公告)号：US5136050A

    公开(公告)日：1992-08-04

    申请号：US154799

    申请日：1988-02-11

    申请人： Jacques Martel ,  Jean Tessier ,  Andre Teche

    发明人： Jacques Martel ,  Jean Tessier ,  Andre Teche

    IPC分类号： C07D207/16

    CPC分类号： C07D207/16

    摘要： Novel substituted lactones of amino acids in all their possible stereoisomeric forms or mixtures thereof of the formula ##STR1## wherein A is a hydrocarbon chain of 1 to 10 chain members containing one or more heteroatoms and one or more unsaturations and the chain members being a mono- or polycyclic system or comprises a system of spiro or endo type and may contain one or more chiral atoms or the lactone copula can present a supplementary chirality due to the asymetric spatial configuration of the molecule make up and R is selected from the group consisting of ##STR2## wherein Z is the organic remainder of an amino acid of the formula ##STR3## Y is derived from a primary, secondary or tertiary alcohol of the formula Y-OH and B is the remainder of a heterocycle amino acid of 3 to 6 carbon atoms of the formula ##STR4## and their preparation and their use for the resolution of amino acids.

    摘要翻译： 新颖的氨基酸的取代的内酯以其所有可能的立体异构体形式或其混合物，其中A为具有1至10个含有一个或多个杂原子和一个或多个不饱和基团的链成员的烃链，链成员为 单环或多环系统或包含螺或内型的系统，并且可以含有一个或多个手性原子，或由于分子组成的不对称空间构型，内酯共聚物可呈现辅助手性，并且R选自 其中Z是下式的氨基酸的有机剩余部分III1衍生自式Y-OH的伯，仲或叔醇，B是 其余的具有式（III）III2的3至6个碳原子的杂环氨基酸及其制备及其在分解氨基酸中的用途。

    Certain cyclopropanedicarboxylates with an unsaturated side chain having insecticidal activity
    12.
    发明授权
    Certain cyclopropanedicarboxylates with an unsaturated side chain having insecticidal activity 失效

    公开(公告)号：US4883806A

    公开(公告)日：1989-11-28

    申请号：US100284

    申请日：1987-09-23

    申请人： Jacques Martel ,  Jean Tessier ,  Andre Teche

    发明人： Jacques Martel ,  Jean Tessier ,  Andre Teche

    IPC分类号： A01N53/00 ,  A23K1/16 ,  A61K31/22 ,  C07D209/48 ,  C07D213/64 ,  C07D213/647 ,  C07D233/72 ,  C07D307/20 ,  C07D307/45 ,  C07D309/12

    CPC分类号： C07D213/647 ,  A01N53/00 ,  A23K20/105 ,  A23K20/111 ,  A23K20/132 ,  A61K31/22 ,  C07D209/48 ,  C07D233/72 ,  C07D307/20 ,  C07D307/42 ,  C07D309/12

    摘要： Novel isomers and mixtures thereof of cyclopropane carboxylic acid derivatives with a 3-unsaturated side chain of the formula ##STR1## wherein A' is selected from the group consisting of (1) alkyl of 1 to 18 carbon atoms, (2) benzyl optionally substituted with at least one member of the group consisting of alkyl of 1 to 4 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkenyloxy of 2 to 6 carbon atoms, alkadienyl of 4 to 8 carbon atoms, methylenedioxy or halogen, ##STR2## wherein R.sub.1 is selected from the group consisting of hydrogen and methyl and R.sub.2 is selected from the group consisting of --CH.sub.2 --C.tbd.CH and monocyclic aryl, ##STR3## wherein a is selected from the group consisting of hydrogen and methyl and R.sub.3 is an aliphatic group of 2 to 6 carbon atoms containing at least one carbon-carbon unsaturation ##STR4## wherein a and and R.sub.3 have the above definition and R.sub.1 ' and R.sub.2 ' are individually selected from the group consisting of hydrogen, halogen, alkyl of 1 to 6 carbon atoms, aryl of 6 to 10 carbon atoms, cyano and alkoxy carbonyl of 2 to 5 carbon atoms, (6) ##STR5## wherein B is selected from the group consisting of ##STR6## --O-- and --S--, R.sub.4 is selected from the group consisting of hydrogen, --CH.sub.3, --C.tbd.N--CONH.sub.2, --CSNH.sub.2 and --C.tbd.CH, n is an integer form 0, 1 or 2 and R.sub.5 is selected from the group consisting of halogen and --CH.sub.3 ##STR7## wherein R.sub.6, R.sub.7 , R.sub.8 and R.sub.9 are selected from the group consisting of hydrogen, chlorine and methyl and S/I symbolizes an aromatic ring or dihydro or tetrahydro ring, ##STR8## wherein R.sub.10 is selected from the group consisting of hydrogen and --CN, R.sub.12 is selected from the group consisting of --CH.sub.2 -- and --O-- and R.sub.11 is selected from the group consisting of thiazolyl and thiadiazolyl with the bond the bond to ##STR9## being in anyone of the positions, R.sub.12 being bonded to R.sub.11 by the carbon atom included between a sulfur atom and a nitrogen atom, ##STR10## wherein R.sub.13 is selected from the group consisting of hydrogen and --CN ##STR11## wherein R.sub.13 has the above definition and the benzoyl is in the 3- or 4-position; ##STR12## wherein R.sub.14 is; selected from the group consisting of hydrogen, methyl, ethynyl and --CN and R.sub.15 and R.sub.16 are individually selected from the group consisting of hydrogen, bromine and fluorine and ##STR13## wherein R.sub.14 has the above definition, p is 0, 1 or 2, each R.sub.17 is selected from the group consisting of alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, alkylthio of 1 to 4 carbon atoms, alkylsulfonyl of 1 to 4 carbon atoms, --CF.sub.3 3,4-methylenedioxy, chlorine, bromine and fluorine, B is selected from the group consisting of --O-- and --S-- and R is selected from the group consisting of alkyl of 1 to 18 carbon atoms substituted with one or more, optionally different functional groups, aryl of 6 to 14 carbon atoms optionally substituted with one or more optionally different functional groups, the double bond having Z or E geometry having insecticidal and nematocidal activity as well as plant and animal acaricidal activity and their preparation.

    Process for resolution of chiral alcohols or phenols or chiral lactonic compounds
    13.
    发明授权
    Process for resolution of chiral alcohols or phenols or chiral lactonic compounds 失效
    手性醇或酚或手性内酯化合物的拆分方法

    公开(公告)号：US4540797A

    公开(公告)日：1985-09-10

    申请号：US447442

    申请日：1982-12-06

    申请人： Jacques Martel ,  Jean Tessier ,  Andre Teche

    发明人： Jacques Martel ,  Jean Tessier ,  Andre Teche

    IPC分类号： B01J31/02 ,  C07B31/00 ,  C07B57/00 ,  C07B61/00 ,  C07C27/00 ,  C07C29/10 ,  C07C29/88 ,  C07C37/86 ,  C07C41/18 ,  C07C43/295 ,  C07C45/57 ,  C07C51/487 ,  C07C62/02 ,  C07C62/04 ,  C07C67/00 ,  C07D307/33 ,  C07D307/88 ,  C07D307/93 ,  C07D315/00 ,  C07D307/77

    CPC分类号： C07D307/33 ,  C07C29/10 ,  C07C41/26 ,  C07C43/295 ,  C07C45/57 ,  C07D307/93 ,  C07D315/00 ,  C07B2200/07 ,  C07C2101/14

    摘要： Novel ethers of organic compounds containing chiral atoms of the formula ##STR1## wherein A is a hydrocarbonated chain of 1 to 10 groups, the said chain containing one or more heteroatoms, one or more unsaturations, the assembly of the groups constituting the chain may represent a mono- or polycyclic system, including a system of the spiro or endo type, the chain A can contain one or more chiral atoms or the lactone moiety can present a chirality due to the dissymmetric spatial configuration of the whole of the molecule and Z is selected from the group consisting of primary, secondary or tertiary alcohol moiety containing at least an asymmetric carbon atom, a phenol moiety substituted comprising at least one asymmetric carbon atom and a substituted alcohol or phenol moiety with a chirality due to the dissymmetric spatial configuration of the whole of the molecule, with the proviso Z is not (R) or (S) .alpha.-cyano-3-phenoxy-benzyl when A is ##STR2## which are useful for the resolution of compounds of the formulae ##STR3## wherein A and Z have the above definitions and X is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms.

    摘要翻译： 含有式（I）的手性原子的有机化合物的新型醚，其中A是1至10个基团的烃化链，所述链含有一个或多个杂原子，一个或多个不饱和基团，构成链的基团的组合 代表单环或多环系统，包括螺或内型的系统，链A可以含有一个或多个手性原子，或者内酯部分可以由于整个分子和Z的不对称空间构型而呈现手性 选自含有至少不对称碳原子的伯，仲或叔醇部分，被至少一个不对称碳原子取代的苯酚部分和具有由于不对称空间构型引起的手性的取代的醇或苯酚部分 整个分子，条件是Z不是（R）或（S）α-氰基-3-苯氧基 - 苄基，当A是，它们对分辨率o有用 f化合物，其中A和Z具有上述定义，X选自氢和1至4个碳原子的烷基。

    Novel chiral ethers and their use in resolution of alcohols and phenols
    15.
    发明授权
    Novel chiral ethers and their use in resolution of alcohols and phenols 失效
    新型手性醚及其在醇和酚的拆分中的应用

    公开(公告)号：US4265817A

    公开(公告)日：1981-05-05

    申请号：US21833

    申请日：1979-03-19

    申请人： Jacques Martel ,  Jean Tessier ,  Andre Teche

    发明人： Jacques Martel ,  Jean Tessier ,  Andre Teche

    IPC分类号： B01J31/02 ,  C07B31/00 ,  C07B57/00 ,  C07B61/00 ,  C07C27/00 ,  C07C29/10 ,  C07C29/88 ,  C07C37/86 ,  C07C41/18 ,  C07C43/295 ,  C07C45/57 ,  C07C51/487 ,  C07C62/02 ,  C07C62/04 ,  C07C67/00 ,  C07D307/33 ,  C07D307/88 ,  C07D307/93 ,  C07D315/00 ,  C07D307/77

    CPC分类号： C07D307/33 ,  C07C29/10 ,  C07C41/26 ,  C07C43/295 ,  C07C45/57 ,  C07D307/93 ,  C07D315/00 ,  C07B2200/07 ,  C07C2101/14

    摘要： Novel ethers of organic compounds containing chiral atoms of the formula ##STR1## wherein A is a hydrocarbonated chain of 1 to 10 groups, the said chain containing one or more heteroatoms, one or more unsaturations, the assembly of the groups constituting the chain may represent a mono- or polycyclic system, including a system of the spiro or endo type, the chain A can contain one or more chiral atoms or the lactone moiety can present a chirality due to the dissymetric spatial configuration of the whole of the molecule and Z is selected from the group consisting of primary, secondary or tertiary alcohol moiety containing at least an asymetric carbon atom, a phenol moiety substituted comprising at least one asymetric carbon atom and an substituted alcohol or phenol moiety with a chirality due to the dissymetric spatial configuration of the whole of the molecule, with the proviso Z is not (R) or (S) .alpha.-cyano-3-phenoxy-benzyl when A is ##STR2## which are useful for the resolution of compounds of the formulae ##STR3## wherein A and Z have the above definitions and X is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms.

    摘要翻译： 含有式（I）的手性原子的有机化合物的新型醚，其中A是1至10个基团的烃化链，所述链含有一个或多个杂原子，一个或多个不饱和基团，构成链的基团的组合 代表单环或多环系统，包括螺或内型的系统，链A可以含有一个或多个手性原子，或者内酯部分可以呈现手性，这是由于整个分子的不对称空间结构和Z 选自包含至少一个不对称碳原子的伯，仲或叔醇部分，被至少一个不对称碳原子取代的苯酚部分和具有手性的取代的醇或苯酚部分，这些部分具有由于不对称空间构型的手性 整个分子，条件是Z不是（R）或（S）α-氰基-3-苯氧基 - 苄基，当A是，其可用于分辨c 其中A和Z具有上述定义并且X选自氢和1至4个碳原子的烷基的式的化合物。

    Epimerization process
    16.
    发明授权
    Epimerization process 失效
    差向异构化过程

    公开(公告)号：US4206124A

    公开(公告)日：1980-06-03

    申请号：US18308

    申请日：1979-03-07

    申请人： Jacques Martel ,  Jean Tessier ,  Andre Teche

    发明人： Jacques Martel ,  Jean Tessier ,  Andre Teche

    IPC分类号： C07C253/00 ,  A01N53/08 ,  C07C67/00 ,  C07C255/37 ,  C07D307/93

    CPC分类号： C07D307/93

    摘要： A novel process for the preparation of (1R,5S) 6,6-dimethyl-4(R)-[(S)-cyano-(3'-phenoxy-phenyl)-methoxy]-3-oxabicyclo-(3-1-0)-hexan-2-one which is an intermediate for the preparation of (S).alpha.-cyano-3-phenoxy-benzyl alcohol.

    摘要翻译： 制备（1R，5S）6,6-二甲基-4（R） - [（S） - 氰基 - （3'-苯氧基 - 苯基） - 甲氧基] -3-氧杂双环 - （3-1 -O） - 己烷-2-酮，其是制备（S）α-氰基-3-苯氧基 - 苄醇的中间体。

    Insecticidal esters
    20.
    发明授权
    Insecticidal esters 失效
    杀虫剂

    公开(公告)号：US4489093A

    公开(公告)日：1984-12-18

    申请号：US495481

    申请日：1983-05-17

    申请人： Jacques Martel ,  Jean Tessier ,  Andre Teche

    发明人： Jacques Martel ,  Jean Tessier ,  Andre Teche

    IPC分类号： A01N53/00 ,  A01N53/02 ,  A23K1/16 ,  A61K31/22 ,  A61K31/225 ,  C07D213/64 ,  C07D213/647 ,  C07D233/74 ,  C07F9/40 ,  C07C69/743 ,  C07C121/75

    CPC分类号： C07D213/647 ,  A01N53/00 ,  A23K20/105 ,  A23K20/111 ,  A61K31/22 ,  A61K31/225 ,  C07D233/74 ,  C07F9/4006

    摘要： Novel esters in all possible isomeric forms of the formula ##STR1## wherein R is selected from the group consisting of (a) optionally unsaturated alkyl of 1 to 8 carbon atoms and optionally unsaturated cycloalkyl or cycloalkyl-alkyl of 3 to 8 carbon atoms optionally substituted with at least one member of the group consisting of halogen, ##STR2## aryl optionally substituted with at least one member of the group consisting of --OH, alkoxy of 1 to 8 carbon atoms, alkyl of 1 to 8 carbon atoms, halogen, ##STR3## R' is alkyl of 1 to 8 carbon atoms, R" and R"' are individually selected from the group consisting of hydrogen and alkyl of 1 to 8 carbon atoms, AlK.sub.1, AlK.sub.2 and AlK.sub.3 are individually alkyl of 1 to 18 carbon atoms (b) aryl of 6 to 14 carbon atoms optionally substituted with at least one substituent selected from the group consisting of --OH, alkoxy of 1 to 8 carbon atoms, alkyl of 1 to 8 carbon atoms, halogen, --OCF.sub.3, --CF.sub.3 and --SCF.sub.3 and (c) heterocycle optionally substituted with at least one member of the group consisting of --OH, alkoxy of 1 to 8 carbon atoms, alkyl of 1 to 8 carbon atoms, halogen, --CF.sub.3, --OCF.sub.3 and --SCF.sub.3, B is selected from the group consisting of optionally unsaturated alkyl of 1 to 18 carbon atoms, optionally unsaturated cycloalkyl of 3 to 18 carbon atoms and the remainder of an alcohol used in synthesis of pyrethrinoid esters, X is halogen and the ethylenic double bond may have Z or E geometry having parasitic activity, especially insecticidal acaricidal and nematocidal activity.

    摘要翻译： 式（Ⅰ）的所有可能异构体形式的新型酯，其中R选自（a）1-8个碳原子的任选不饱和烷基和任选不饱和的环烷基或3-8个碳原子的环烷基 - 烷基， 被至少一个由以下组成的组中的至少一个取代：卤素，任选被至少一个由以下组成的组中的一个基团取代：-OH，含有1-8个碳原子的烷氧基， 1至8个碳原子，卤素，R'是1至8个碳原子的烷基，R“和R”'分别选自氢和1至8个碳原子的烷基，AlK1， AlK 2和AlK 3分别是1至18个碳原子的烷基（b）任选被至少一个选自-OH，1至8个碳原子的烷氧基，1至8个碳原子的烷基取代的6至14个碳原子的芳基， 8个碳原子，卤素，-OCF 3，-CF 3和-SCF 3和（c）任选的杂环 由至少一个由-OH组成的基团，1至8个碳原子的烷氧基，1至8个碳原子的烷基，卤素，-CF 3，-OCF 3和-SCF 3，B选自任选的 具有1至18个碳原子的不饱和烷基，3至18个碳原子的任选不饱和环烷基和用于合成除虫菊酯的醇的其余部分，X是卤素，烯键双键可具有具有寄生活性的Z或E几何形状，特别是 杀虫杀螨和杀线虫活性。