MODIFIED EXTRACELLULAR MATRIX-BASED HYDROGEL, MANUFACTURING METHOD OF THE SAME AND USE OF THE SAME

    公开(公告)号:US20220218465A1

    公开(公告)日:2022-07-14

    申请号:US17502152

    申请日:2021-10-15

    Abstract: A modified extracellular matrix-based hydrogel according to an example of the present disclosure includes an extracellular matrix-denatured collagen conjugate formed by a Michael addition reaction between an extracellular matrix having an amine group and a denatured collagen into which an ethylenically unsaturated bond functional group is introduced. The modified extracellular matrix-based hydrogel according to the present disclosure exhibits enhanced mechanical properties (e.g., viscoelasticity) compared to the extracellular matrix hydrogel before modification. In addition, it shows a high cell viability when the bioink is prepared by encapsulating cells in a modified extracellular matrix-based hydrogel according to the present disclosure. In addition, when an artificial living tissue for transplantation (for example, artificial corneal tissue) manufactured by 3-D printing bioink according to the present disclosure is transplanted into a damaged cornea, it can be sutured and has a transparency similar to that of the real cornea, and corneal tissue can be reconstructed without other side effects due to its enhanced mechanical properties. Accordingly, the modified extracellular matrix-based hydrogel according to the present disclosure can be applied in tissue engineering fields and related fields requiring improvement in physical properties and is particularly useful as a material for corneal transplants.

    DEVICE AND METHOD OF GENERATING NONLINIEAR WAVEFORM SIGNAL

    公开(公告)号:US20220209755A1

    公开(公告)日:2022-06-30

    申请号:US17560090

    申请日:2021-12-22

    Abstract: The present disclosure provides a device and method of generating a nonlinear waveform signal dissipating low power and operating at a high speed. The device includes: a digital preprocessing unit configured to quantize an effective input signal to generate a linear data signal and a residual signal that is a difference between the effective input signal and the linear data signal; a nonlinear digital-to-analog conversion circuit (DAC) having a nonlinear relationship between an input and an output and configured to convert the linear data signal into a first analog signal; a linear interpolation DAC configured to convert the residual signal into a second analog signal to enable a generation of a converted analog signal by an addition of the second analog signal to the first analog signal; and an output circuit configured to output the converted analog signal as a nonlinear waveform signal.

    PSEUDO-COMPLEMENTARY LOGIC NETWORK
    190.
    发明申请

    公开(公告)号:US20220069821A1

    公开(公告)日:2022-03-03

    申请号:US17298917

    申请日:2019-12-09

    Abstract: A pseudo-complementary logic network according to this embodiment includes a first logic stage including a first pull-up circuit of an N-type transistor and a first pull-down circuit and a second logic stage including a second pull-up circuit and a second pull-down circuit of an N-type transistor, wherein an output signal of the second logic stage is provided as an input of the first pull-down circuit, and the first pull-up circuit includes the second pull-down circuit.

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