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    MODIFIED EXTRACELLULAR MATRIX-BASED HYDROGEL, MANUFACTURING METHOD OF THE SAME AND USE OF THE SAME
    2.
    发明申请
    MODIFIED EXTRACELLULAR MATRIX-BASED HYDROGEL, MANUFACTURING METHOD OF THE SAME AND USE OF THE SAME 有权

    公开(公告)号：US20220218465A1

    公开(公告)日：2022-07-14

    申请号：US17502152

    申请日：2021-10-15

    Applicant: POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION

    Inventor： Hyeon Ji KIM ,  Dong Woo CHO ,  Jin Ah JANG

    IPC: A61F2/14 ,  A61L27/36 ,  A61L27/38 ,  B29C64/106

    Abstract: A modified extracellular matrix-based hydrogel according to an example of the present disclosure includes an extracellular matrix-denatured collagen conjugate formed by a Michael addition reaction between an extracellular matrix having an amine group and a denatured collagen into which an ethylenically unsaturated bond functional group is introduced. The modified extracellular matrix-based hydrogel according to the present disclosure exhibits enhanced mechanical properties (e.g., viscoelasticity) compared to the extracellular matrix hydrogel before modification. In addition, it shows a high cell viability when the bioink is prepared by encapsulating cells in a modified extracellular matrix-based hydrogel according to the present disclosure. In addition, when an artificial living tissue for transplantation (for example, artificial corneal tissue) manufactured by 3-D printing bioink according to the present disclosure is transplanted into a damaged cornea, it can be sutured and has a transparency similar to that of the real cornea, and corneal tissue can be reconstructed without other side effects due to its enhanced mechanical properties. Accordingly, the modified extracellular matrix-based hydrogel according to the present disclosure can be applied in tissue engineering fields and related fields requiring improvement in physical properties and is particularly useful as a material for corneal transplants.

    MULTIAXIAL ARTIFICIAL MUSCLE TISSUE, AND METHOD AND STRUCTURE FOR FORMING SAME
    4.
    发明公开
    MULTIAXIAL ARTIFICIAL MUSCLE TISSUE, AND METHOD AND STRUCTURE FOR FORMING SAME 审中-公开

    公开(公告)号：US20240350710A1

    公开(公告)日：2024-10-24

    申请号：US18034443

    申请日：2021-11-01

    Applicant: POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION

    Inventor： Jin Ah JANG ,  Dong Gyu HWANG

    IPC: A61L27/38 ,  A61F2/08 ,  A61L27/52

    CPC classification number: A61L27/3826 ,  A61F2/08 ,  A61L27/52 ,  A61L2430/20 ,  A61L2430/30

    Abstract: A multiaxial artificial muscle tissue is provided. The multiaxial artificial muscle tissue according to an embodiment of the present invention is a multiaxial artificial muscle tissue contractible or stretchable about a plurality of axes and comprises: a first module formed by gelling a hydrogel including muscle cells and extending in a first axial direction so as to be contractible or stretchable in the first axial direction; and a second module formed by gelling the hydrogel and extending in a second axial direction to be contractible or stretchable in the second axial direction, wherein a portion of the hydrogel and a portion of the hydrogel which constitute the first module and the second module, respectively, are integrated with each other such that a portion of the first module and a portion of the second module are connected to each other.

    EXTRACELLULAR MATRIX-BASED HYBRID INK FOR 3D PRINTING AND METHOD FOR MANUFACTURING THE SAME
    6.
    发明申请
    EXTRACELLULAR MATRIX-BASED HYBRID INK FOR 3D PRINTING AND METHOD FOR MANUFACTURING THE SAME 有权

    公开(公告)号：US20250058017A1

    公开(公告)日：2025-02-20

    申请号：US18721363

    申请日：2022-03-14

    Applicant: POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION

    Inventor： Jin Ah JANG ,  Hyeon Ji KIM ,  Seung Hyeon HWANG

    IPC: A61L27/20 ,  A61L27/22 ,  A61L27/36 ,  A61L27/56

    Abstract: One embodiment of the present disclosure provides an extracellular matrix-based hybrid ink for 3D printing, the hybrid ink including an extracellular matrix having an amine group and a modified hyaluronic acid introduced with an ethylenically unsaturated bond functional group, in which the extracellular matrix and the modified hyaluronic acid are in a crosslinked state by a chemical bond formed between at least some of amine groups present in the extracellular matrix and the ethylenically unsaturated bond functional group present in the modified hyaluronic acid. According to an embodiment of the present disclosure, the hybrid ink has mechanical properties suitable for 3D printing through chemical crosslinking between the extracellular matrix and modified hyaluronic acid as constituents, and can control the drug release rate by adjusting the chemical crosslinking density.

    EXTRACELLULAR MATRIX-BASED BIOADHESIVE
    7.
    发明申请
    EXTRACELLULAR MATRIX-BASED BIOADHESIVE 有权

    公开(公告)号：US20230111780A1

    公开(公告)日：2023-04-13

    申请号：US17936385

    申请日：2022-09-29

    Applicant: POSTECH Research and Business Development Foundation ,  Konkuk University Industrial Cooperation Corp

    Inventor： Hyeon Ji KIM ,  Je Hwan JANG ,  Won Il HAN ,  Joon Young KIM ,  Jin Ah JANG ,  Dong Woo CHO

    IPC: A61L24/00 ,  A61L24/10

    Abstract: An embodiment of the present disclosure provides an extracellular matrix-based bioadhesive as an adhesive in the form of a composition including an extracellular matrix-containing hydrogel and a gelatin curing agent, wherein the extracellular matrix-containing hydrogel is gelatinized. Since the extracellular matrix-based bioadhesive according to an embodiment of the present disclosure has the same or similar rheological properties as gelatin, the bioadhesive has flowability at a temperature of 30° C. or higher and may be evenly and easily applied to a lesion site in the body. In addition, the extracellular matrix-based bioadhesive according to an embodiment of the present disclosure may adhere well to the lesion site because of a level of adhesive strength that is about 2 to 6 times higher than that of fibrin glue used as a commercial tissue adhesive. In addition, the extracellular matrix-based bioadhesive according to an embodiment of the present disclosure is based on a tissue-derived extracellular matrix, and thus includes a tissue-derived wound healing component or a tissue regeneration component, and may be used for wound healing or tissue regeneration in addition to bioadhesive applications.

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