公开(公告)号：US20170003168A1

公开(公告)日：2017-01-05

申请号：US15188071

申请日：2016-06-21

Applicant: Panasonic Intellectual Property Management Co., Ltd.

Inventor： TOSHIYA FUJII ,  TAKAMASA ANDO

IPC: G01J3/28 ,  G01N21/359 ,  G01N21/65 ,  G01N21/33

CPC classification number: G01J3/2823 ,  A61B5/0042 ,  A61B5/0075 ,  A61B5/4064 ,  G01B11/24 ,  G01J3/0229 ,  G01J3/2803 ,  G01J3/2846 ,  G01J3/2889 ,  G01J2003/1213 ,  G01M3/38 ,  G01N21/64 ,  G01N21/65 ,  G01N2021/4797 ,  G01N2201/06113 ,  G01N2201/0697 ,  G01S7/4802 ,  G01S7/4816 ,  G01S7/4863 ,  G01S17/88 ,  G01S17/89

Abstract: An imaging device according to an aspect of the present disclosure is provided with: a light source that, in operation, emits pulsed light including components of different wavelengths; an encoding element that has regions each having different light transmittance, through which incident light from a target onto which the pulsed light has been irradiated is transmitted; a spectroscopic element that, in operation, causes the incident light transmitted through the regions to be dispersed into light rays in accordance with the wavelengths; and an image sensor that, in operation, receives the light rays dispersed by the spectroscopic element.

Abstract translation: 根据本公开的一个方面的成像装置设置有：在操作中发射包括不同波长的分量的脉冲光的光源; 具有各自具有不同透光率的区域的编码元件，通过该区域发射来自已经照射脉冲光的目标物的入射光; 一种分光元件，其在工作中使根据该波长将透过该区域的入射光分散成光线; 以及在操作中接收由分光元件分散的光线的图像传感器。

公开(公告)号：US20160356644A1

公开(公告)日：2016-12-08

申请号：US15117598

申请日：2015-02-05

Applicant: VICTORIA LINK LTD

Inventor： Justin M. Hodgkiss ,  Kai Chen

IPC: G01J1/42

CPC classification number: G01J1/4228 ,  G01J3/0232 ,  G01J3/2889 ,  G01J3/4406 ,  G01J2003/4424 ,  G01N21/636 ,  G01N21/6408 ,  G01N21/65 ,  G01N2201/061 ,  G01N2201/0696

Abstract: A transient grating (TG) is used as an optical gating element with sub-picosecond time resolution for luminescence measurements from a photo-detector array. The transient grating is formed in a gate medium by one or more pulsed gate beams. For photoluminescence measurements such as photoluminescence spectroscopy or imaging, a source is excited by a pulsed excitation beam, and the pulsed gate beams are synchronized to the pulsed excitation beam with an adjustable delay between the excitation of the source and the formation of the TG. Moreover, a source or its spectra can be imaged at two different regions of the photo-detector array at two different times spaced in time by a selected duration of time with sub-picosecond resolution over a range of a nanosecond or more. A beam from the source is deflected to the different regions by changing the frequency or geometry of the pulsed gate beams.

Abstract translation: 瞬态光栅（TG）被用作具有亚皮秒时间分辨率的来自光电检测器阵列的发光测量的光学门控元件。 瞬态光栅通过一个或多个脉冲栅极波束在栅极介质中形成。 对于诸如光致发光光谱或成像的光致发光测量，源通过脉冲激发光束激发，并且脉冲栅极光束与脉冲激发光束同步，在源的激发和TG的形成之间具有可调节的延迟。 此外，源或其光谱可以在光检测器阵列的两个不同的区域以两分之一的时间在一个纳秒或更多的范围内以一定的时间间隔以亚皮秒分辨率成像。 来自源极的光束通过改变脉冲栅极的频率或几何形状而偏转到不同的区域。

公开(公告)号：US20160213252A1

公开(公告)日：2016-07-28

申请号：US15087979

申请日：2016-03-31

Applicant: The Trustees of Columbia University in the City of New York

Inventor： Elizabeth Marjorie Clare Hillman ,  Sean A. Burgess

IPC: A61B5/00

CPC classification number: A61B5/0064 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/0073 ,  A61B5/0075 ,  A61B5/0088 ,  A61B5/444 ,  A61B5/445 ,  A61B2562/0238 ,  A61B2562/0242 ,  G01J3/2889 ,  G01J3/42 ,  G01J3/457 ,  G02B23/2476 ,  G02B26/101

Abstract: Optical imaging or spectroscopy described can use laminar optical tomography (LOT), diffuse correlation spectroscopy (DCS), or the like. An incident beam is scanned across a target. An orthogonal or oblique optical response can be obtained, such as concurrently at different distances from the incident beam. The optical response from multiple incident wavelengths can be concurrently obtained by dispersing the response wavelengths in a direction orthogonal to the response distances from the incident beam. Temporal correlation can be measured, from which flow and other parameters can be computed. An optical conduit can enable endoscopic or laparoscopic imaging or spectroscopy of internal target locations. An articulating arm can communicate the light for performing the LOT, DCS, or the like. The imaging can find use for skin cancer diagnosis, such as distinguishing lentigo maligna (LM) from lentigo maligna melanoma (LMM).

Abstract translation: 所描述的光学成像或光谱可以使用层状光学断层摄影（LOT），漫射相关光谱（DCS）等。 一个入射光束在目标上扫描。 可以获得正交或倾斜的光学响应，例如在与入射光束不同的距离处同时进行。 可以通过将响应波长分散在与入射光束的响应距离正交的方向上来同时获得来自多个入射波长的光学响应。 可以测量时间相关性，从中可以计算流量和其他参数。 光学导管可以实现内窥镜或腹腔镜成像或内部目标位置的光谱。 铰接臂可以通信用于执行LOT，DCS等的光。 成像可以用于皮肤癌诊断，例如区分恶性黑色素瘤（LMM）的恶性疟原虫（LM）。

公开(公告)号：US20150204722A1

公开(公告)日：2015-07-23

申请号：US14423765

申请日：2013-08-26

Applicant: Osaka University

Inventor： Takeshi Yasui ,  Mamoru Hashimoto ,  Tsutomu Araki ,  Yuki Iyonaga

IPC: G01J3/453 ,  G01J3/28

CPC classification number: G01J3/453 ,  G01J3/2889 ,  G01J3/42 ,  G01J2003/0281 ,  G01J2003/283 ,  G01N21/3581 ,  G01N21/3586 ,  G01N2021/3595

Abstract: Provided is a Fourier transform spectroscopy method that removes restrictions on spectral resolution and spectral accuracy in Fourier transform spectroscopy for observing a cyclic repeating phenomenon, that realizes, theoretically, infinitesimal spectral resolution accuracy. After accurately and sufficiently stabilizing the repetition period of a phenomenon, a temporal waveform is acquired by making a repetition period and a time width for observing the temporal waveform of a phenomenon strictly conform, and by performing a Fourier transform, acquired is a discrete separation spectrum in which the inverse number of the observation time window size T is made a frequency data gap. Measurement is repeated while causing the repetition period to change, and the gap of the discrete separation spectrum is supplemented. Thereby, in a case of an observation target in which the existence time of a phenomenon is longer than the repetition period, the spectral resolution of the obtained discrete separation spectrum becomes infinitesimal.

Abstract translation: 提供了傅里叶变换光谱法，其消除了用于观察循环重复现象的傅里叶变换光谱中的光谱分辨率和光谱精度的限制，从理论上实现了无穷小的光谱分辨率精度。 在精确而充分地稳定现象的重复周期之后，通过使重复周期和用于观察现象的时间波形严格符合的时间宽度获得时间波形，并且通过执行傅里叶变换获得离散分离频谱 其中观测时间窗口大小T的倒数成为频率数据间隙。 在重复周期变化的同时重复测量，并补充离散分离光谱的间隙。 因此，在现象的存在时间长于重复周期的观察目标的情况下，所得离散分离光谱的光谱分辨率变得无穷小。

公开(公告)号：US08935127B2

公开(公告)日：2015-01-13

申请号：US12970019

申请日：2010-12-16

Applicant: Mirko Liedtke ,  Frank Klemm ,  Manfred Loth

Inventor： Mirko Liedtke ,  Frank Klemm ,  Manfred Loth

IPC: G06F15/00 ,  G02B21/00 ,  G01J3/28 ,  G01J3/44

CPC classification number: G02B21/0076 ,  G01J3/2889 ,  G01J3/4406

Abstract: A method for recording pulse signals which allows the reconstruction of a time reference. The time of every pulse signal event can be determined by counting sampling result bits preceding the respective sampling result bit using the known sampling frequency. For this purpose, every period of the sampling frequency is associated with a bit representing the respective sampling result and the sampling result bits are stored one by one and per channel in data blocks. The sampling frequency is preferably higher than a pixel clock, a sampling result bit associated with a flank of the pixel clock being marked. The pixel clock can thus be synchronized with the individual events exactly per sampling period. The invention further relates to the field of fluorescence correlation spectroscopy using confocal microscopes or laser scanning microscopes.

Abstract translation: 一种用于记录允许重建时间基准的脉冲信号的方法。 可以通过使用已知的采样频率对相应采样结果位之前的采样结果位进行计数来确定每个脉冲信号事件的时间。 为此，采样频率的每个周期都与表示相应采样结果的位相关联，采样结果位逐个存储，每个通道存储在数据块中。 采样频率优选地高于像素时钟，与被标记的像素时钟的侧面相关联的采样结果位。 因此，像素时钟可以在每个采样周期精确地与各个事件同步。 本发明还涉及使用共焦显微镜或激光扫描显微镜的荧光相关光谱领域。

公开(公告)号：US08618486B2

公开(公告)日：2013-12-31

申请号：US13406491

申请日：2012-02-27

Applicant: Takeaki Itsuji

Inventor： Takeaki Itsuji

IPC: G01N21/00

CPC classification number: G01J3/0205 ,  G01J3/0229 ,  G01J3/2823 ,  G01J3/2889 ,  G01N21/3586

Abstract: An apparatus visualizing internal information of an object includes a detection unit of terahertz wave, a generating unit of a time waveform of the terahertz wave, a modulation unit, an adjustment unit, and an addition unit. The modulation unit sequentially performs spatial modulation on a propagation distance for each pixel of a terahertz wave corresponding to a pixel in a horizontal direction by using a plurality of modulation patterns, and emits a plurality of terahertz waves. Based on a time amount converted from the change of the propagation distances corresponding to the modulation patterns, the adjustment unit adjusts a position on a time axis of the time waveforms of a plurality of terahertz waves and calculates a new plurality of time waveforms. The addition unit adds a new time waveform for each pixel. The apparatus can suppress reduction in signal intensity of a terahertz wave while maintaining detection sensitivity.

Abstract translation: 可视化对象的内部信息的装置包括太赫兹波的检测单元，太赫兹波的时间波形的生成单元，调制单元，调整单元和加法单元。 调制单元通过使用多个调制图案，顺序对与水平方向的像素对应的太赫兹波的每个像素的传播距离进行空间调制，并发射多个太赫兹波。 基于从与调制图案对应的传播距离的变化而转换的时间量，调整单元调整多个太赫兹波的时间波形的时间轴上的位置，并计算新的多个时间波形。 加法单元为每个像素添加新的时间波形。 该装置可以在保持检测灵敏度的同时抑制太赫兹波的信号强度的降低。

公开(公告)号：US08400640B2

公开(公告)日：2013-03-19

申请号：US12566403

申请日：2009-09-24

Applicant: Chang-Seok Kim ,  Myung-Yung Jeong ,  Jae-Seok Park ,  Eun-Joo Jung ,  Hyung-Seok Lee

Inventor： Chang-Seok Kim ,  Myung-Yung Jeong ,  Jae-Seok Park ,  Eun-Joo Jung ,  Hyung-Seok Lee

IPC: G01B9/02

CPC classification number: G01J3/2889 ,  G01D5/35316 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0245 ,  G01J3/10 ,  G01J3/26 ,  G01J3/42 ,  G01J3/4338

Abstract: Provided is an optical sensor interrogation system. The optical sensor interrogation system includes: a light source unit which matches round-trip time of light and wavelength tunable cycle time of light in a resonator and emits light; a sensing unit which receives an optical signal in which a center wavelength periodically tunes, from the light source unit and tunes the center wavelength of the optical signal according to physical changes applied from the outside; and a signal processing unit which receives the optical signal reflected from the sensing unit, detects data, and images the data. In particular, the light source unit includes a delaying unit which delays the round-trip time of light and a tunable filter which tunes the wavelength of light so as to match the round-trip time of light with the wavelength tunable cycle time of light. Accordingly, a Fourier domain mode locking (FDML) wavelength swept laser, which operates at speed of several tens kHz or above, is used as a light source so that strain of a fluid, which changes in a short time interval of 0.1 msec or below, is precisely measured and thus a real-time analysis may be performed at high speed.

Abstract translation: 提供了一种光学传感器询问系统。 光传感器询问系统包括：光源单元，其匹配谐振器中的光的往返时间和波长可调周期时间，并发光; 感测单元，其从光源单元接收中心波长周期性调谐的光信号，并根据从外部施加的物理变化调谐光信号的中心波长; 以及信号处理单元，其接收从感测单元反射的光信号，检测数据并对数据进行成像。 特别地，光源单元包括延迟光的往返时间的延迟单元和调节光的波长的可调谐滤波器，以便匹配光的往返时间与光的波长可调周期时间。 因此，以几十kHz或更高速度运行的傅立叶域模式锁定（FDML）波长扫描激光器被用作光源，使得在0.1msec或更短的时间间隔内变化的流体应变 ，被精确测量，因此可以高速执行实时分析。

公开(公告)号：US08237835B1

公开(公告)日：2012-08-07

申请号：US13302814

申请日：2011-11-22

Applicant: Matthew Stefan Muller

Inventor： Matthew Stefan Muller

IPC: H04N3/14 ,  H04N5/335 ,  H04N7/18 ,  G06K9/00 ,  G01J1/20 ,  A61B3/10

CPC classification number: G02B21/0032 ,  A61B3/1025 ,  G01J3/0208 ,  G01J3/0224 ,  G01J3/0229 ,  G01J3/0232 ,  G01J3/2803 ,  G01J3/2889 ,  G01J3/513 ,  G02B21/004 ,  G02B21/0064 ,  G02B21/008 ,  G02B21/14 ,  H04N5/3532

Abstract: A digital imaging device comprising a light source, a pixel array detector having a rolling shutter functionality, a spatial light modulator configured to produce one or more modulation patterns during a frame exposure of the pixel array detector, and at least one timing signal configured to control a spatial-temporal relationship between a rolling shutter of the pixel array detector and the one or more modulation patterns provided by the spatial light modulator.

Abstract translation: 一种数字成像装置，包括光源，具有滚动快门功能的像素阵列检测器，被配置为在像素阵列检测器的帧曝光期间产生一个或多个调制图案的空间光调制器以及被配置为控制的至少一个定时信号 像素阵列检测器的滚动快门与由空间光调制器提供的一个或多个调制图案之间的空间 - 时间关系。

公开(公告)号：US08089625B2

公开(公告)日：2012-01-03

申请号：US12516341

申请日：2007-11-26

Applicant: Laura Marcu ,  Javier A. Jo ,  Daniel Elson

Inventor： Laura Marcu ,  Javier A. Jo ,  Daniel Elson

IPC: G01J3/30

CPC classification number: G01N21/6408 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0294 ,  G01J3/2889 ,  G01J3/4406 ,  G01N21/6402 ,  G01N21/6486 ,  G01N2021/6421 ,  G01N2021/6484

Abstract: One embodiment of the present invention provides a system that characterizes a biological sample by analyzing light emissions from the biological sample in response to an excitation. The system first radiates the biological sample with a laser impulse to cause the biological sample to produce a responsive light emission. Next, the system uses a wavelength splitting device to split the responsive light emission into a set of spectral bands of different central wavelengths. The system applies temporal delays to the set of spectral bands so that each spectral band arrives at an optical detector at a different time, thereby allowing the optical detector to temporally resolve the responsive light emission for each spectral band separately. Next, the system captures the delayed spectral bands within a single detection window of the optical detector. The system then processes the captured spectral bands.

Abstract translation: 本发明的一个实施方案提供了一种通过响应于激发分析来自生物样品的光发射来表征生物样品的系统。 系统首先用激光脉冲辐射生物样品，使生物样品产生响应性发光。 接下来，系统使用波长分离装置将响应光发射分成不同中心波长的一组光谱带。 该系统将时间延迟应用于频谱带集合，使得每个频谱带在不同时间到达光学检测器，从而允许光学检测器分别时间地分辨每个频谱带的响应光发射。 接下来，系统捕获在光学检测器的单个检测窗口内的延迟的光谱带。 然后系统处理捕获的光谱带。

公开(公告)号：US08072595B1

公开(公告)日：2011-12-06

申请号：US11873337

申请日：2007-10-16

Applicant: Glenn Bastiaans ,  Steve Hankins ,  Jerald Alan Cole

Inventor： Glenn Bastiaans ,  Steve Hankins ,  Jerald Alan Cole

IPC: G01J3/44

CPC classification number: G01N21/7703 ,  G01J1/46 ,  G01J3/027 ,  G01J3/2889 ,  G01J3/44 ,  G01J3/4412 ,  G01J2003/1213 ,  G01N21/65 ,  G01N2021/1793

Abstract: A time correlated single photon counting system having a programmable delay generator triggered by a laser fire event detector. The system may be used for chemical agent detection based on Rayleigh scattering using optical time domain reflectometry techniques. The system may also be used for Raman detection using frequency to time transformations.

Abstract translation: 具有由激光火灾事件检测器触发的可编程延迟发生器的时间相关单光子计数系统。 该系统可用于使用光时域反射测量技术的基于瑞利散射的化学试剂检测。 该系统也可以用于使用频率到时间变换的拉曼检测。