公开(公告)号：US20070038204A1

公开(公告)日：2007-02-15

申请号：US11357358

申请日：2006-02-17

Applicant: James Chen ,  Nicholas Yeo ,  Phillip Burwell ,  Thomas Wenger

Inventor： James Chen ,  Nicholas Yeo ,  Phillip Burwell ,  Thomas Wenger

IPC: A61B18/18 ,  A61N5/06

CPC classification number: A61K41/0071 ,  A61N5/0601 ,  A61N5/062 ,  A61N2005/0602 ,  A61N2005/0651 ,  A61N2005/0661

Abstract: A method of manufacture and medical apparatus that provides an apparatus useful in illuminating at least a portion of a lumen of a body. The apparatus includes an elongated flexible member and a polymer encasement portion encasing a plurality of light emitters. The light emitters may be electrically coupled to one another without the use of wire bonds, and in some embodiments may be coupled without intervening electrical paths or traces. A maximum cross-sectional dimension of the polymer encasement portion may be less than twice a dimension of one of the light emitters. In some embodiments the maximum cross-sectional dimension is less than or equal to the sum of the dimension of one of the light emitters and a marginal dimension by which an outer portion of the polymer encasement portion extends beyond the light emitter. Light emitters may be arranged linearly, helically or in partially overlapping back-to-back relation.

Abstract translation: 一种制造方法和医疗装置，其提供用于照亮身体的内腔的至少一部分的装置。 该装置包括细长的柔性构件和封装多个发光体的聚合物封装部分。 光发射器可以在不使用引线键的情况下彼此电耦合，并且在一些实施例中可以耦合而没有中间的电路径或迹线。 聚合物封装部分的最大横截面尺寸可以小于一个发光体的尺寸的两倍。 在一些实施例中，最大横截面尺寸小于或等于光发射器之一的尺寸之和和聚合物封装部分的外部部分延伸超过光发射器的边缘尺寸之和。 光发射器可以线性地，螺旋状地或以部分重叠的背靠背关系布置。

公开(公告)号：US5709653A

公开(公告)日：1998-01-20

申请号：US690330

申请日：1996-07-25

Applicant: James E. Leone

Inventor： James E. Leone

IPC: A61B18/22 ,  A61N5/06 ,  A61N1/30

CPC classification number: A61M25/1027 ,  A61N5/0601 ,  A61N5/062 ,  A61B2018/2261 ,  A61M2025/105 ,  A61M2025/1086 ,  A61M2025/1088 ,  A61N2005/0602

Abstract: A photodynamic therapy balloon catheter with microporous membrane is provided which has an elongated optical fiber, an inner tubular member, a porous balloon member surrounding the inner tubular member, and fluid material provided between the inner tubular member and the porous balloon member. The porous balloon member having a plurality of holes of a size to permit medication delivered through a lumen to pass outwardly through the holes. The balloon carries on an outer surface a substantially hydrophilic, tubular microporous membrane covering the holes, to break up streams of flowing medication. Light-reflective material is included in any one of a plurality of the inner member, fluid material, porous balloon member, and microporous membrane in any combination to provide a uniform light illumination for activating treatment fluids located on an elongated treatment site within a living body.

Abstract translation: 提供具有微孔膜的光动力治疗球囊导管，其具有细长的光纤，内部管状构件，围绕内部管状构件的多孔气囊构件，以及设置在内部管状构件和多孔气囊构件之间的流体材料。 多孔气囊构件具有多个孔，其尺寸允许通过内腔输送的药物向外通过孔。 气囊承载覆盖孔的基本上亲水的管状微孔膜的外表面，以分解流动的药物流。 光反射材料以任意组合包含在多个内部构件，流体材料，多孔气球构件和微孔膜中的任何一个中，以提供均匀的光照射，用于激活位于活体内的细长处理部位上的处理流体 。

公开(公告)号：US12127957B2

公开(公告)日：2024-10-29

申请号：US17298674

申请日：2019-11-28

Applicant: Universiteit Gent ,  IMEC VZW

Inventor： Rik Verplancke ,  Jan Vanfleteren

IPC: A61F2/86 ,  A61N5/06

CPC classification number: A61F2/86 ,  A61N5/0601 ,  A61N5/0622 ,  A61F2210/0014 ,  A61F2210/0057 ,  A61F2220/005 ,  A61F2250/006 ,  A61N2005/0602 ,  A61N2005/0632 ,  A61N2005/0652

Abstract: The present invention relates to a method for integrating an electronic circuit in or on a medical stent. The method comprises obtaining (101) a deformable medical stent (21) in a substantially planar shape, in which the deformable medical stent is adapted for being deployed in a substantially cylindrical shape in the body. The method also comprises attaching (104) a deformable electronic circuit (22) onto the deformable medical stent in the planar shape thereby forming a deformable hybrid structure. The method also comprises shaping (107) said hybrid structure into the cylindrical shape.

公开(公告)号：US20240299766A1

公开(公告)日：2024-09-12

申请号：US18665513

申请日：2024-05-15

Applicant: The Medical College of Wisconsin, Inc.

Inventor： Nicole Lohr ,  Michael Salinger

IPC: A61N5/06 ,  A61B17/00 ,  A61B18/00 ,  A61B18/24 ,  A61B90/00

CPC classification number: A61N5/0601 ,  A61B18/24 ,  A61N5/0613 ,  A61B2017/0019 ,  A61B2018/00351 ,  A61B2018/00577 ,  A61B2090/049 ,  A61N2005/0602 ,  A61N2005/063 ,  A61N2005/0651 ,  A61N2005/0663

Abstract: Reperfusion injury is limited during endovascular therapies (e.g., revascularization and/or reperfusion of end organ tissues) by conditioning the tissues against reperfusion injury using an optical fiber catheter to deliver far red and near infrared (R/NIR) light to the tissues. The light may be multiple wavelength or single wavelength light, and may have one or more wavelengths selected from the range of 510 to 830 nm. The R/NIR light may be delivered concurrently with the endovascular therapy, or in other instances may be delivered before or after a particular therapy.

公开(公告)号：US12076577B2

公开(公告)日：2024-09-03

申请号：US17543304

申请日：2021-12-06

Applicant: Prometheus Therapeutics Inc.

Inventor： Baruch B. Lieber ,  John A. Rose

IPC: A61N5/06 ,  A61B1/00 ,  A61B1/05 ,  A61B1/313 ,  A61B17/02 ,  A61B17/12 ,  A61B18/24 ,  A61F2/90 ,  A61M25/00 ,  A61B17/00 ,  A61B17/22 ,  A61B18/00 ,  A61B18/22 ,  A61B90/00 ,  A61F2/82

CPC classification number: A61N5/0601 ,  A61B1/00045 ,  A61B1/00087 ,  A61B1/05 ,  A61B1/3137 ,  A61B17/0218 ,  A61B17/12113 ,  A61B17/12168 ,  A61B17/12172 ,  A61B17/12181 ,  A61B18/24 ,  A61F2/90 ,  A61M25/00 ,  A61N5/062 ,  A61B2017/00292 ,  A61B2017/00557 ,  A61B2017/00778 ,  A61B2017/00907 ,  A61B2017/0225 ,  A61B17/12118 ,  A61B17/12136 ,  A61B17/12186 ,  A61B2017/22067 ,  A61B2018/00029 ,  A61B2018/00404 ,  A61B2018/00416 ,  A61B2018/00589 ,  A61B2018/00982 ,  A61B2018/2238 ,  A61B2018/2261 ,  A61B90/361 ,  A61B2217/007 ,  A61F2002/823 ,  A61F2002/826 ,  A61N2005/0602 ,  A61N2005/0659 ,  A61N2005/0662

Abstract: In some embodiments, an apparatus includes a catheter having a catheter body, a light emitter disposed at a distal end of the catheter body, and a fluid conduit coupleable to a source of fluid. The fluid conduit configured to discharge fluid from the source via the conduit and out a distal end of the catheter body. A spacing member is disposed at the distal end of the catheter body and can be moved between a collapsed configuration and an expanded configuration. In the expanded configuration, the spacing member is disposed about the light emitter. The spacing member is at least partially transmissive and/or transflective of light emitted from the light emitter. The apparatus configured to be inserted at least partially into a body lumen, to discharge fluid into the body lumen, and to emit light from the light emitter to illuminate an interior wall of the body lumen.

公开(公告)号：US20240176057A1

公开(公告)日：2024-05-30

申请号：US18384669

申请日：2023-10-27

Applicant: Proterial, Ltd.

Inventor： Kota TACHIBANA ,  Ryuta TAKAHASHI ,  Seiji KOJIMA

IPC: F21V8/00 ,  A61N5/06

CPC classification number: G02B6/001 ,  A61N5/0601 ,  A61N2005/0602 ,  A61N2005/063

Abstract: A peripheral surface-emitting linear light guide is provided with an optical fiber including a core, an outer peripheral surface of which is exposed from a cladding at one end in a longitudinal direction, and a light-scattering member that covers an entire periphery of the outer peripheral surface of the core in an exposed portion over a predetermined axial length range. The light emitted from the outer peripheral surface of the core is scattered and radiated by the light-scattering member. The light-scattering member includes a light transmissive base material having a higher refractive index than the core and light-scattering particles that scatter the light incident on the base material, and the light-scattering particles are dispersed and mixed in a certain proportion throughout the base material. At least a portion of the light-scattering member in the longitudinal direction is an increasing portion whose thickness increases gradually toward a tip side of the core.

公开(公告)号：US20240115875A1

公开(公告)日：2024-04-11

申请号：US18486376

申请日：2023-10-13

Applicant: Dream Big Biotechnologies B.V.

Inventor： Arjen BOGAARDS

IPC: A61N5/06

CPC classification number: A61N5/062 ,  A61N2005/0602 ,  A61N2005/0627

Abstract: Systems and methods for isolating a biological vessel from a surrounding target tissue include administering an energy-activatable substance to at least a portion of the target tissue and activating the energy-activatable substance via intraluminal irradiation of the portion of the target tissue with the energy-activatable substance, preferably while keeping the vessel wall substantially intact.

公开(公告)号：US20240024697A1

公开(公告)日：2024-01-25

申请号：US18229466

申请日：2023-08-02

Applicant: CEDARS-SINAI MEDICAL CENTER

Inventor： Ali Rezaie ,  Mark Pimentel ,  Gil Y. Melmed

IPC: A61N5/06 ,  A61B1/06

CPC classification number: A61N5/0624 ,  A61N5/0603 ,  A61B1/06 ,  A61N5/06 ,  A61B1/0684 ,  A61B1/0638 ,  A61N2005/0608 ,  A61N2005/0661 ,  A61N2005/0667 ,  A61N2005/0602 ,  A61N2005/0609 ,  A61N2005/061 ,  A61N2005/0611 ,  A61N2005/0652

Abstract: The disclosed technology relates to a system for delivering UV-A/B light with a catheter to treat infectious or inflammatory disorders in a patient. While UV light in the UV-C range has traditionally been used to treat skin disorders and for focused ablation of plaques in the arteries and other targeted internal uses, it has not been developed for broader infection, inflammation or neoplasia treatment inside the human body. Here, the inventor(s) developed a system for emission of therapeutic doses of UV light via a catheter, capsule, endoscope, tube or port that can be used to manage internal infections and inflammatory conditions inside a patient.

公开(公告)号：US11806549B2

公开(公告)日：2023-11-07

申请号：US15832242

申请日：2017-12-05

Applicant: Lumen Catheters, LLC

Inventor： Adam E. M. Eltorai

IPC: A61N5/06 ,  A61M25/00 ,  A61M25/10 ,  A61N5/067

CPC classification number: A61N5/0624 ,  A61N5/0601 ,  A61M25/0043 ,  A61M25/0097 ,  A61M25/10 ,  A61N5/067 ,  A61N2005/061 ,  A61N2005/0602 ,  A61N2005/063 ,  A61N2005/0604 ,  A61N2005/0661 ,  A61N2005/0663

Abstract: A light-emitting, antimicrobial tuber, instrument or catheter includes a thin, flexible tube having an optically transparent wall; and a light transmitter configured and arranged to emit light through the tube, which may be ultraviolet C (UVC) irradiation, photodynamic therapy (PDT), violet-blue light therapy, and other light-based therapies. In one embodiment, violet-blue light from 400-500 nm in wavelength, such as 405 nm, for instance, is used. The device is used on a patient and a therapeutic amount of light is administered to the patient, thereby reducing the risk of infections being transmitted from the instrument, tube or catheter to the patient, generally. The device may be configured for use in the urinary tract or as intravascular, and may be indwelling or temporary. Light may be administered for the duration of use or another time period effective to halt, inhibit, or reduce microbial or fungal growth.

公开(公告)号：US20180271539A1

公开(公告)日：2018-09-27

申请号：US15926291

申请日：2018-03-20

Applicant: Ghassan S. Kassab

Inventor： Ghassan S. Kassab

IPC: A61B17/12 ,  A61M31/00 ,  A61N5/06 ,  A61L31/14 ,  A61L31/00

CPC classification number: A61B17/12136 ,  A61B17/00491 ,  A61B17/1204 ,  A61B17/12109 ,  A61B17/12113 ,  A61B17/12131 ,  A61B2017/005 ,  A61B2017/00557 ,  A61B2017/00907 ,  A61B2017/00951 ,  A61B2017/1205 ,  A61B2017/12054 ,  A61F2/06 ,  A61F2/958 ,  A61L31/005 ,  A61L31/14 ,  A61L31/148 ,  A61M31/002 ,  A61N5/062 ,  A61N2005/0602 ,  A61N2005/0661

Abstract: Devices, systems, and methods for treating aneurysms and other medical conditions. A method of the present disclosure includes the steps of introducing a device into a lumen of a mammalian luminal organ at or near an aneurysm, the device comprising an expandable member, and a material layer coupled to the expandable member, wherein the expandable member is configured to attach to an elongated body configured to deliver an inflation material therethrough and into the expandable member, and inflating the expandable member so that the material layer contacts the mammalian luminal organ and adheres to the mammalian luminal organ at or near the aneurysm.