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1821 条记录 (耗时 0.049 秒)

    Direct Compression Polymer Tablet Core
    112.
    发明申请
    Direct Compression Polymer Tablet Core 有权
    直接压缩聚合物片芯

    公开(公告)号：US20150056278A1

    公开(公告)日：2015-02-26

    申请号：US14481071

    申请日：2014-09-09

    申请人： Genzyme Corporation

    发明人： Joseph Tyler ,  John S. Petersen

    IPC分类号： A61K31/785 ,  A61K9/28

    CPC分类号： A61K31/785 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/2027 ,  A61K9/28 ,  A61K9/282 ,  A61K9/2866

    摘要： The present invention provides a tablet core which comprises at least about 95% by weight of an aliphatic amine polymer. The invention also provides a method of producing a tablet core comprising at least about 95% by weight of an aliphatic amine polymer resin The method comprises the step of compressing the aliphatic amine polymer to form the tablet core. The tablet core can further include one or more excipients. In this embodiment, the method of producing the tablet core comprises the steps of: (1) hydrating the aliphatic amine polymer to the desired moisture level; (2) blending the aliphatic amine polymer with the excipients in amounts such that the polymer comprises at least about 95% by weight of the resulting blend; and (3) compressing the blend to form the tablet core. The present invention further relates to a coated tablet comprising an aliphatic amine polymer core wherein the coating is a water based coating.

    摘要翻译： 本发明提供一种片芯，其包含至少约95重量％的脂族胺聚合物。 本发明还提供一种生产包含至少约95重量％的脂族胺聚合物树脂的片芯的方法。该方法包括压缩脂族胺聚合物以形成片芯的步骤。 片芯可进一步包括一种或多种赋形剂。 在该实施方案中，制备片芯的方法包括以下步骤：（1）将脂族胺聚合物水合至期望的水分含量; （2）将脂族胺聚合物与赋形剂混合，使得聚合物包含至少约95重量％的所得共混物; 和（3）压缩混合物以形成片芯。 本发明还涉及一种包含脂族胺聚合物核心的包衣片剂，其中该涂料是水基涂料。

    pH-RESPONSIVE CELL SCAFFOLD AND METHOD OF USING SAME
    117.
    发明申请
    pH-RESPONSIVE CELL SCAFFOLD AND METHOD OF USING SAME 审中-公开
    pH响应细胞SCAFFOLD及其使用方法

    公开(公告)号：US20140328789A1

    公开(公告)日：2014-11-06

    申请号：US14269467

    申请日：2014-05-05

    申请人： Research Foundation of the City University of New York

    发明人： Debra T. Auguste ,  Jin-Oh You

    IPC分类号： A61K31/785 ,  C12N5/071

    CPC分类号： A61K31/785 ,  C12M23/20 ,  C12M25/14 ,  C12N5/0068 ,  C12N2533/30

    摘要： A pH-responsive cell scaffold for growing a cell culture is disclosed. The cell scaffold has pores in which biological cells may be disposed. As the pH of the local environment drops, the cell scaffold swells to draw in additional oxygen and/or other nutrients. The increased supply of oxygen and/or nutrients increases the longevity of the cells. In some embodiments, the cell scaffold induces a change in gene expression that promotes wound healing.

    摘要翻译： 公开了用于培养细胞培养物的pH响应细胞支架。 细胞支架具有可以设置生物细胞的孔。 随着局部环境的pH下降，细胞支架膨胀以吸收额外的氧气和/或其他营养物质。 氧气和/或营养物质的增加增加了细胞的寿命。 在一些实施方案中，细胞支架诱导促进伤口愈合的基因表达的改变。

    Controlled Release of Active Using pH
    118.
    发明申请
    Controlled Release of Active Using pH 审中-公开
    使用pH控制活性释放

    公开(公告)号：US20140322299A1

    公开(公告)日：2014-10-30

    申请号：US14358503

    申请日：2012-11-14

    申请人： Avery Dennison Corporation

    发明人： Anne Marie Wibaux

    IPC分类号： A61K47/32 ,  A61K9/70 ,  A61K31/155

    CPC分类号： A61K47/32 ,  A01N25/10 ,  A61K9/70 ,  A61K9/7061 ,  A61K31/155 ,  A61K31/785 ,  A61K33/38 ,  A61L15/22 ,  A61L15/46 ,  A61L15/62 ,  A01N47/44 ,  A01N59/16

    摘要： Dissolvable polymeric compositions are described which when exposed to certain pH conditions, controllably release one or more actives. The active agents can be nearly any active agent such as chlorhexidine gluconate (CHG). Also described are products using such compositions such as dressings. In addition, methods of controllably releasing one or more actives are described.

    摘要翻译： 描述了可溶性聚合物组合物，其当暴露于某些pH条件时，可控地释放一种或多种活性物质。 活性剂可以是几乎任何活性剂，例如葡萄糖酸氯己定（CHG）。 还描述了使用这种组合物如敷料的产品。 此外，描述了可控地释放一种或多种活性物质的方法。

    Anti-viral agents and compositions thereof
    119.
    发明授权
    Anti-viral agents and compositions thereof 有权
    抗病毒剂及其组合物

    公开(公告)号：US08840875B2

    公开(公告)日：2014-09-23

    申请号：US13886364

    申请日：2013-05-03

    申请人： Paolo Ferruti ,  Elisabetta Ranucci

    发明人： Paolo Ferruti ,  Roberta Cavalli ,  Elisabetta Ranucci ,  David Lembo

    IPC分类号： A61K31/785 ,  C08G69/02 ,  C08G73/02

    CPC分类号： C08G69/02 ,  A61K9/0014 ,  A61K31/785 ,  C08G73/028

    摘要： Guanidine-based poly (amidoamine) polymers of formula (I): wherein n is an integer between 3 and 400; R1 is H, C1-6 alkyl; or taken together with the N atoms to which is bound and R2 is a piperazinic ring; R2 is C2-6 alkylen; C5-6 cycloalkylen; CH—COOH, CH—COOR, wherein R is C1-4 alkyl, phenyl or benzyl; R3 is —(CH2)p-HN—C(NH2)═NH, wherein p is an integer 1 to 6; for use as antiviral agents in the prevention and/or treatment of viral infections in a mammal, preferably a human subject.

    摘要翻译： 基于胍的聚（酰氨基胺）聚合物，式（I）：其中n是3和400之间的整数; R1是H，C1-6烷基; 或与其结合的N原子一起取代，R 2是哌嗪环; R2是C2-6亚烷基; C5-6环烷基; CH-COOH，CH-COOR，其中R是C 1-4烷基，苯基或苄基; R3是 - （CH2）p-HN-C（NH2）= NH，其中p是1至6的整数; 用作预防和/或治疗哺乳动物，优选人受试者中的病毒感染的抗病毒剂。

    In-Situ Forming Foam for Endoscopic Lung Volume Reduction
    120.
    发明申请
    In-Situ Forming Foam for Endoscopic Lung Volume Reduction 审中-公开
    用于内窥镜肺容积减少的原位成型泡沫

    公开(公告)号：US20140271531A1

    公开(公告)日：2014-09-18

    申请号：US14205739

    申请日：2014-03-12

    申请人： TOBY FREYMAN ,  MEGHAN MCGILL ,  GREGORY T. ZUGATES

    发明人： TOBY FREYMAN ,  MEGHAN MCGILL ,  GREGORY T. ZUGATES

    IPC分类号： A61K31/785

    CPC分类号： A61K31/785

    摘要： Systems and methods related to polymer foams are generally described. Some embodiments relate to compositions and methods for the preparation of polymer foams, and methods for using the polymer foams. The polymer foams can be applied to a lung at or near an alveolar duct targeted for reduction, occluding the airway and leading to tissue necrosis because the foam prevents oxygenation of the tissue surrounding the duct. In some embodiments, the polymer foams can be formed within a body cavity (i.e., in-situ foam formation). In addition, the foam may form a seal, eliminating the source of air leaks.

    摘要翻译： 通常描述与聚合物泡沫有关的系统和方法。 一些实施方案涉及用于制备聚合物泡沫的组合物和方法，以及使用聚合物泡沫体的方法。 聚合物泡沫可以施用于肺减压的肺泡管或其附近，阻塞气道并导致组织坏死，因为泡沫阻止了管道周围组织的氧合。 在一些实施方案中，聚合物泡沫可以在体腔内形成（即原位泡沫形成）。 此外，泡沫可以形成密封，从而消除漏气源。