公开(公告)号：US20170202872A1

公开(公告)日：2017-07-20

申请号：US15420896

申请日：2017-01-31

申请人： Genzyme Corporation

发明人： Joseph Tyler ,  John S. Petersen

IPC分类号： A61K31/785 ,  A61K9/20 ,  A61K9/28

CPC分类号： A61K31/785 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/2027 ,  A61K9/28 ,  A61K9/282 ,  A61K9/2866

摘要： The present invention provides a tablet core which comprises at least about 95% by weight of an aliphatic amine polymer. The invention also provides a method of producing a tablet core comprising at least about 95% by weight of an aliphatic amine polymer resin The method comprises the step of compressing the aliphatic amine polymer to form the tablet core. The tablet core can further include one or more excipients. In this embodiment, the method of producing the tablet core comprises the steps of: (1) hydrating the aliphatic amine polymer to the desired moisture level; (2) blending the aliphatic amine polymer with the excipients in amounts such that the polymer comprises at least about 95% by weight of the resulting blend; and (3) compressing the blend to form the tablet core. The present invention further relates to a coated tablet comprising an aliphatic amine polymer core wherein the coating is a water based coating.

公开(公告)号：US09579343B2

公开(公告)日：2017-02-28

申请号：US14481071

申请日：2014-09-09

申请人： Genzyme Corporation

发明人： Joseph Tyler ,  John S. Petersen

IPC分类号： A61K9/28 ,  A61K31/785 ,  A61K9/20

CPC分类号： A61K31/785 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/2027 ,  A61K9/28 ,  A61K9/282 ,  A61K9/2866

摘要： The present invention provides a tablet core which comprises at least about 95% by weight of an aliphatic amine polymer. The invention also provides a method of producing a tablet core comprising at least about 95% by weight of an aliphatic amine polymer resin The method comprises the step of compressing the aliphatic amine polymer to form the tablet core. The tablet core can further include one or more excipients. In this embodiment, the method of producing the tablet core comprises the steps of: (1) hydrating the aliphatic amine polymer to the desired moisture level; (2) blending the aliphatic amine polymer with the excipients in amounts such that the polymer comprises at least about 95% by weight of the resulting blend; and (3) compressing the blend to form the tablet core. The present invention further relates to a coated tablet comprising an aliphatic amine polymer core wherein the coating is a water based coating.

摘要翻译： 本发明提供一种片芯，其包含至少约95重量％的脂族胺聚合物。 本发明还提供一种生产包含至少约95重量％的脂族胺聚合物树脂的片芯的方法。该方法包括压缩脂族胺聚合物以形成片芯的步骤。 片芯可进一步包括一种或多种赋形剂。 在该实施方案中，制备片芯的方法包括以下步骤：（1）将脂族胺聚合物水合至期望的水分含量; （2）将脂族胺聚合物与赋形剂混合，使得聚合物包含至少约95重量％的所得共混物; 和（3）压缩混合物以形成片芯。 本发明还涉及一种包含脂族胺聚合物核心的包衣片剂，其中该涂料是水基涂料。

公开(公告)号：US09931358B2

公开(公告)日：2018-04-03

申请号：US15420896

申请日：2017-01-31

申请人： Genzyme Corporation

发明人： Joseph Tyler ,  John S. Petersen

IPC分类号： A61K9/26 ,  A61K31/785 ,  A61K9/28 ,  A61K9/20

CPC分类号： A61K31/785 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/2027 ,  A61K9/28 ,  A61K9/282 ,  A61K9/2866

摘要： The present invention provides a tablet core which comprises at least about 95% by weight of an aliphatic amine polymer. The invention also provides a method of producing a tablet core comprising at least about 95% by weight of an aliphatic amine polymer resin The method comprises the step of compressing the aliphatic amine polymer to form the tablet core. The tablet core can further include one or more excipients. In this embodiment, the method of producing the tablet core comprises the steps of: (1) hydrating the aliphatic amine polymer to the desired moisture level; (2) blending the aliphatic amine polymer with the excipients in amounts such that the polymer comprises at least about 95% by weight of the resulting blend; and (3) compressing the blend to form the tablet core. The present invention further relates to a coated tablet comprising an aliphatic amine polymer core wherein the coating is a water based coating.

公开(公告)号：US20150056278A1

公开(公告)日：2015-02-26

申请号：US14481071

申请日：2014-09-09

申请人： Genzyme Corporation

发明人： Joseph Tyler ,  John S. Petersen

IPC分类号： A61K31/785 ,  A61K9/28

CPC分类号： A61K31/785 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/2027 ,  A61K9/28 ,  A61K9/282 ,  A61K9/2866

摘要： The present invention provides a tablet core which comprises at least about 95% by weight of an aliphatic amine polymer. The invention also provides a method of producing a tablet core comprising at least about 95% by weight of an aliphatic amine polymer resin The method comprises the step of compressing the aliphatic amine polymer to form the tablet core. The tablet core can further include one or more excipients. In this embodiment, the method of producing the tablet core comprises the steps of: (1) hydrating the aliphatic amine polymer to the desired moisture level; (2) blending the aliphatic amine polymer with the excipients in amounts such that the polymer comprises at least about 95% by weight of the resulting blend; and (3) compressing the blend to form the tablet core. The present invention further relates to a coated tablet comprising an aliphatic amine polymer core wherein the coating is a water based coating.

摘要翻译： 本发明提供一种片芯，其包含至少约95重量％的脂族胺聚合物。 本发明还提供一种生产包含至少约95重量％的脂族胺聚合物树脂的片芯的方法。该方法包括压缩脂族胺聚合物以形成片芯的步骤。 片芯可进一步包括一种或多种赋形剂。 在该实施方案中，制备片芯的方法包括以下步骤：（1）将脂族胺聚合物水合至期望的水分含量; （2）将脂族胺聚合物与赋形剂混合，使得聚合物包含至少约95重量％的所得共混物; 和（3）压缩混合物以形成片芯。 本发明还涉及一种包含脂族胺聚合物核心的包衣片剂，其中该涂料是水基涂料。