-
公开(公告)号：US10992302B2
公开(公告)日：2021-04-27
申请号：US16072833
申请日：2017-01-30
摘要： A waveform synthesizer comprises a controllable oscillator for generating an oscillator waveform having an oscillator cycle; a reference input for accepting a reference signal having a reference cycle; and a waveform detector coupled to said oscillator and said reference input. The waveform detector is arranged to sample said waveform in response to said reference input and to determine waveform information about said oscillator. The waveform information is operative to adjust said controllable oscillator.
-
公开(公告)号：US20200376969A1
公开(公告)日：2020-12-03
申请号：US16767811
申请日：2018-11-29
发明人： Robert SHORTEN , Julia O'CONNELL , Barry CARDIFF , Giovanni RUSSO , Pietro FERRARO , Paul Dermot CUFFE
摘要： Provided are an apparatus and system for directing power flow between multiple devices, the apparatus comprising: one or more inlet ports for connection to one or more devices; a plurality of outlet ports configured for supplying electrical power; and a computing device configured to route power from the one or more inlet ports to the outlet ports. The system comprises a plurality of the apparatus connected to each other.
-
公开(公告)号：US20200370030A1
公开(公告)日：2020-11-26
申请号：US16065617
申请日：2016-12-23
发明人： Hilary McMahon , Regina O'Sullivan , Ana Herrero
摘要： The present invention relates to a composition for degrading prion material comprising a Thermitase. Such compositions may be formed in solution and are particularly suited to degrading prion material on medical equipment or in the environment due to the Thermitases mild pH range and activity at relatively low temperatures. The present invention also relates to novel proteases, methods for prion degradation, decontamination or disinfection and a kit of parts.
-
104.发明授权公开(公告)号：US10822594B2
公开(公告)日：2020-11-03
申请号：US15536534
申请日：2015-12-09
发明人： Kevin O'Connor , Susan Molloy , Reeta Davis , Wesley Shaw
摘要： A method for the enzymatic conversion of a phenol substrate into a corresponding catechol product comprises the step of incubating the phenol substrate with a Ralstonia solanacearum tyrosinase enzyme, or a functional derivative thereof, in a reaction mixture, for a period of time sufficient to allow the enzyme convert at least some of the phenol substrate into the catechol product.
-
105.发明申请公开(公告)号：US20200247053A1
公开(公告)日：2020-08-06
申请号：US15774376
申请日：2016-11-09
发明人： Brian Rodriguez , Emmanuel Reynaud
IPC分类号： B29C64/314 , B33Y10/00 , B33Y30/00 , B33Y70/00 , B29C64/106 , B33Y40/10 , C12M1/12
摘要： A method for fabricating a structure by means of 3D printing, the method comprising the steps of extruding a polymer to form the structure on a platform (8), characterised in that the polymer is extruded, and the structure formed, in a liquid phase (12), and wherein the liquid phase is formulated to modify the structure being fabricated.
-
公开(公告)号：US20200179121A1
公开(公告)日：2020-06-11
申请号：US16617707
申请日：2018-05-04
发明人： Eoin O'Cearbhaill , Fergal Coulter
摘要： The invention broadly provides an implantable medical device comprising a liquid rope coil scaffold. The implant may consist essentially of the scaffold, where the scaffold is the implant and pores in the scaffold may incorporates one or more agents (i.e. drugs, growth factors), or the scaffold may comprise only part of the medical device, for example an implant that is partly or fully covered with a layer of the scaffold. The porosity of the scaffold may be tailored to suit the application, for example a porosity that is tailored to hold and release drug or biological molecules in vivo, a porosity to provide a surface roughness that is conducive to promotion of in-vivo bio-integration (for example vascularisation) or prevention of fibrosis, or a porosity that provides structural strength. The scaffold may be essentially tubular, or may be provided as a planar structure, or may be any shape and can be used to coat, fully or partially any shape or size of medical implant.
-
公开(公告)号：US10557175B2
公开(公告)日：2020-02-11
申请号：US15511890
申请日：2015-09-18
申请人： THE PROVOST, FELLOWS, SCHOLARS AND OTHER MEMBERS OF BOARD OF TRINITY COLLEGE DUBLIN , UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
发明人： Adrian Bracken , Fiona Lanigan , William Gallagher
IPC分类号： C12Q1/68 , C07H21/04 , C12Q1/6886 , G01N33/574 , A61K31/519
摘要： A method for predicting risk of recurrence of cancer in an individual with cancer, the method comprising a step of assaying a cancer sample from the individual for positive expression of at least two genes or proteins encoded by those genes selected from the group consisting of FOXM1, UHRF1, PTTG1, E2F1, MYBL2, HMGB2, ATAD2, E2F8, ZNF367 and TCF19, wherein positive expression of the at least two genes correlates with increased risk of recurrence of cancer compared with an individual who does not exhibit positive expression of the at least two genes or proteins encoded by those genes.
-
公开(公告)号：US20190209020A1
公开(公告)日：2019-07-11
申请号：US16184393
申请日：2018-11-08
发明人： Conor Heneghan , Chern-Pin Chua , Gareth McDarby
摘要： A method of monitoring sleep comprises simultaneously recording a person's electrocardiogram (ECG) and photoplethysmogram (PPG), deriving a plurality of parameters from the recorded data, and providing an output indicative of a sleep characteristic based upon an analysis of the parameters. The ECG and PPG may be recorded using an apparatus which is a combination of a Holter monitor and a pulse oximeter, which is wearable in ambulatory manner.
-
公开(公告)号：US10005677B2
公开(公告)日：2018-06-26
申请号：US14404575
申请日：2013-05-31
发明人： Gil Lee , Mark Platt , James O'Mahony
IPC分类号： A61K9/51 , C01G49/02 , A61K9/50 , B01J13/04 , B01J13/12 , H01F1/00 , B01F3/08 , B01F3/22 , B01F7/00 , B01F15/02 , A61B5/055 , B01F15/06
CPC分类号： C01G49/02 , A61B5/055 , A61K9/5094 , B01F3/0811 , B01F3/0853 , B01F3/223 , B01F7/00 , B01F15/0203 , B01F2015/062 , B01J13/043 , B01J13/125 , C01P2004/61 , C01P2006/42 , H01F1/0054
摘要： There is provided a method of producing microparticles using an emulsion based synthesis route including: Providing a first fluid phase and a second fluid phase, wherein the first fluid phase is a continuous phase and the second fluid phase is a dispersed phase comprising a dispersed material, wherein the continuous phase is immiscible with the dispersed phase; Mixing the first continuous phase and the second dispersed phase in the presence of a surfactant in a shear device to form an emulsion of droplets of controllable size and having a narrow drop size distribution; Drying the emulsion to form microparticles of controllable size and having narrow size distribution, and wherein the microparticles may comprise spherical, crumpled, dimpled, porous or hollow microparticles morphology. Also provided is a system including shear device and drying arrangement. Also provided are micro particles of controllable size and morphology formed by the method.
-
公开(公告)号：US20180148788A1
公开(公告)日：2018-05-31
申请号：US15511890
申请日：2015-09-18
申请人： THE PROVOST, FELLOWS, SCHOLARS AND OTHER MEMBERS OF BOARD OF TRINITY COLLEGE DUBLIN , UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
发明人： Adrian BRACKEN , Fiona LANIGAN , William GALLAGHER
IPC分类号： C12Q1/68 , G01N33/574 , A61K31/519
摘要： A method for predicting risk of recurrence of cancer in an individual with cancer, the method comprising a step of assaying a cancer sample from the individual for positive expression of at least two genes or proteins encoded by those genes selected from the group consisting of FOXM1, UHRF1, PTTG1, E2F1, MYBL2, HMGB2, ATAD2, E2F8, ZNF367 and TCF19, wherein positive expression of the at least two genes correlates with increased risk of recurrence of cancer compared with an individual who does not exhibit positive expression of the at least two genes or proteins encoded by those genes.
-
-
-
-
-
-
-
-
-
搜索结果
118 条记录 (耗时 0.034 秒)
