公开(公告)号：US20120019818A1

公开(公告)日：2012-01-26

申请号：US12840381

申请日：2010-07-21

Applicant: Sean Xiaolu Wang ,  Qun Li

Inventor： Sean Xiaolu Wang ,  Qun Li

IPC: G01J3/44

CPC classification number: G01J3/44 ,  G01J3/10 ,  G01J3/4406 ,  G01N21/64 ,  G01N21/65

Abstract: An improved apparatus and method for fluorescence subtraction in Raman spectroscopy, where a narrow band light source and a broad band light source are utilized to stimulate Raman scattering and fluorescence emission from the same subject to produce two Raman/fluorescence spectra. The two light sources, with matched output power, produce similar level of fluorescence emission, yet the Raman scattering signal produced by the broad band light source has much lower spectral intensity than that produced by the narrow band light source. By subtracting the two Raman/fluorescence spectra, the weak Raman signal can be extracted from a strong fluorescence background.

Abstract translation: 用于拉曼光谱中改进的荧光相减装置和方法，其中使用窄带光源和宽带光源来刺激来自相同受试者的拉曼散射和荧光发射以产生两个拉曼/荧光光谱。 具有匹配的输出功率的两个光源产生类似的荧光发射水平，而由宽带光源产生的拉曼散射信号的光强比由窄带光源产生的强度低得多。 通过减去两个拉曼/荧光光谱，可以从强荧光背景中提取弱拉曼信号。

公开(公告)号：US20120002201A1

公开(公告)日：2012-01-05

申请号：US13256917

申请日：2010-03-17

Applicant: Kazuaki Sawada ,  Hiroyasu Ishii ,  Hirokazu Nakazawa

Inventor： Kazuaki Sawada ,  Hiroyasu Ishii ,  Hirokazu Nakazawa

IPC: G01J3/02

CPC classification number: H01L31/101 ,  G01J3/4406 ,  H01L27/14643 ,  H01L31/113

Abstract: A spectroscopic device with high sensitivity is provided.A spectroscopic device has a charge generating section 3 for generating a charge by using an incident light, a charge generation controlling section for controlling the charge generating section 3 between a first state for capturing a charge generated in a range from a surface to a first depth of the charge generating section 3 and a second state for capturing a charge generated in a range from the surface to a second depth of the charge generating section 3, and a floating diffusion section 2 for outputting a signal corresponding to a charge quantity captured by the charge generating section 3. In the spectroscopic device, the charge capturing depth W in the charge generating section 3 is controlled by controlling the lowest potential Vc of the charge C filled in a charge well 105 of the charge generating section 3.

Abstract translation: 提供了一种灵敏度高的分光装置。 分光装置具有用于通过使用入射光产生电荷的电荷产生部分3，用于控制电荷产生部分3的电荷产生控制部分在用于捕获从表面到第一深度的范围内产生的电荷的第一状态 和用于捕获从电荷产生部3的表面到第二深度的范围内产生的电荷的第二状态，以及用于输出与由电荷产生部3捕获的电荷量相对应的信号的浮动扩散部2 在分光装置中，通过控制填充在电荷产生部3的电荷阱105中的电荷C的最低电位Vc来控制电荷产生部3中的电荷捕获深度W.

公开(公告)号：US20110285995A1

公开(公告)日：2011-11-24

申请号：US13127401

申请日：2009-11-04

Applicant: Tomasz S. Tkaczyk ,  Robert T. Kester ,  Liang Gao

Inventor： Tomasz S. Tkaczyk ,  Robert T. Kester ,  Liang Gao

IPC: G01J3/28

CPC classification number: G01J3/2823 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0229 ,  G01J3/36 ,  G01J3/4406 ,  G02B3/0087 ,  G02B13/22 ,  G02B27/0025 ,  G02B27/1066 ,  G02B27/143

Abstract: Devices and methods for hyperspectral and multispectral imaging are discussed. In particular, Image Mapping Spectrometer systems, methods of use, and methods of manufacture are presented. Generally, an image mapping spectrometer comprises an image mapping field unit, a spectral separation unit, and a selective imager. Image mapping spectrometers may be used in spectral imaging of optical samples. In some embodiments, the image mapping field unit of an image mapping spectrometer may be manufactured with surface shaped diamond tools.

Abstract translation: 讨论了高光谱和多光谱成像的设备和方法。 特别地，提出了图像映射光谱仪系统，使用方法和制造方法。 通常，图像映射光谱仪包括图像映射场单元，光谱分离单元和选择性成像器。 图像映射光谱仪可用于光学样品的光谱成像。 在一些实施例中，图像映射光谱仪的图像映射场单元可以用表面形状的金刚石工具制造。

公开(公告)号：US20110270092A1

公开(公告)日：2011-11-03

申请号：US13016642

申请日：2011-01-28

Applicant: Uk KANG ,  Soo Jin Bae ,  Guang Hoon Kim ,  Seung Yup Lee ,  Garry V. Papayan

Inventor： Uk KANG ,  Soo Jin Bae ,  Guang Hoon Kim ,  Seung Yup Lee ,  Garry V. Papayan

IPC: A61B6/00 ,  A61N5/06

CPC classification number: A61B5/0071 ,  A61N5/062 ,  A61N2005/0628 ,  G01J3/2823 ,  G01J3/4406 ,  G01J2003/1213

Abstract: The present invention provides a fluorescence detection and photodynamic therapy apparatus including: a combined light source unit 10 including a plurality of coherent and non-coherent light sources 11, 12 and 13 configured to irradiate light onto a to-be-observed object while performing continuous illumination; an optical imaging unit 20 configured to form an image of the to-be-observed object 70 and project the image to an image processing/controlling system 34; a multispectral imaging unit 30 including a one-chip multispectral sensor and the image processing/controlling system 34; a blocking filter 40 installed between the to-be-observed object 70 and the one-chip multispectral sensor 32, the blocking filter being configured to block some light reflected off from the to-be-observed object 70 while allowing some light and fluorescent light to pass therethrough; a computer system 50 configured to process, analyze, reproduce and store the image acquired from the multispectral imaging unit 30, and transfer the image to a display device 60 and control the overall operation of all the related elements; and the display device 60 configured to display a processing result of the image by the computer system 50.

Abstract translation: 本发明提供了一种荧光检测和光动力治疗装置，其包括：组合光源单元10，包括多个相干和非相干光源11,12和13，其被配置为将光照射到被观察物体上，同时执行连续 照明; 光学成像单元20，被配置为形成待观察对象70的图像，并将图像投影到图像处理/控制系统34; 包括单芯片多光谱传感器和图像处理/控制系统34的多光谱成像单元30; 安装在被观察物体70和单芯片多光谱传感器32之间的阻挡滤光器40，阻挡滤光器被配置为阻挡从被观察物体70反射的一些光，同时允许一些光和荧光灯 通过; 被配置为处理，分析，再现和存储从多光谱成像单元30获取的图像的计算机系统50，并将图像传送到显示设备60并控制所有相关元件的整体操作; 并且显示装置60被配置为通过计算机系统50显示图像的处理结果。

公开(公告)号：US08013984B2

公开(公告)日：2011-09-06

申请号：US12583530

申请日：2009-08-24

Applicant: Jorge E. Gonzalez Cruz ,  Alfredo Ortiz Vega ,  Victor M. Salazar Izquierdo

Inventor： Jorge E. Gonzalez Cruz ,  Alfredo Ortiz Vega ,  Victor M. Salazar Izquierdo

IPC: G01N21/00

CPC classification number: G01J3/4406 ,  G01N21/6402 ,  G01N21/6486

Abstract: A novel apparatus comprising three main systems: air sampling, detection and computerized electric system; and method of using the same in the sampling, detection and identification of bioaerosols, wherein the identification of the said bioaerosol is base on a multiphoton laser diagnostic technique along with the velocity and aerodynamic size of the particular bioaerosol. After exposing the said bioaerosols with near infrared wavelength laser, the obtained fluorescence spectra has been shown to be unique and particular for each bioaerosol, thus allowing the characterization of the said particles.

Abstract translation: 一种新型设备，包括三个主要系统：空气取样，检测和计算机化电气系统; 以及将其用于生物气溶胶的取样，检测和鉴定中的方法，其中所述生物气溶胶的鉴定与特定生物气溶胶的速度和空气动力学尺寸一起以多光子激光诊断技术为基础。 在用近红外波长激光曝光所述生物气溶胶之后，所获得的荧光光谱已被证明是独特的，对于每种生物气溶胶是特别的，从而允许表征所述颗粒。

公开(公告)号：US20110192992A1

公开(公告)日：2011-08-11

申请号：US13123100

申请日：2009-10-09

Applicant: Adnanul Haq ,  Richard J. Schoeneck

Inventor： Adnanul Haq ,  Richard J. Schoeneck

IPC: G01N21/64 ,  G01J1/58

CPC classification number: G01J3/36 ,  G01J3/10 ,  G01J3/4406 ,  G01N21/645 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6439

Abstract: A scanning photometer and attendant methods are provided. The scanning photometer is generally characterized by first and second fluorophore excitation sources, an objective lens, and a common emission detector for the detection of first and second fluorophore emission originating from the excitation of the fluorophores via passage of excitation energy, via an optical path of the objective lens, from the excitation sources. Excitation energy and emission energy conditioning elements are like-wise provided, operatively interposed before or after the objective lens as the case may be.

Abstract translation: 提供扫描光度计和附带的方法。 扫描光度计通常的特征在于第一和第二荧光团激发源，物镜和共同的发射检测器，用于通过激发能量经由经由激发能量的激发来检测源自荧光团的激发的第一和第二荧光团发射， 物镜，来自激发源。 激励能量和排放能量调节元件是类似方式设置的，根据情况可操作地插入在物镜之前或之后。

公开(公告)号：US20110104685A1

公开(公告)日：2011-05-05

申请号：US12914055

申请日：2010-10-28

Applicant: Kei Takenaka ,  Hideki Nakamoto ,  Kazuo Takei ,  Masahiro Kurihara ,  Yuusuke Watanabe ,  Hisao Saito ,  Yasuhiko Sasaki

Inventor： Kei Takenaka ,  Hideki Nakamoto ,  Kazuo Takei ,  Masahiro Kurihara ,  Yuusuke Watanabe ,  Hisao Saito ,  Yasuhiko Sasaki

IPC: C12Q1/68 ,  C12M1/34

CPC classification number: G01N21/6428 ,  G01J3/36 ,  G01J3/4406 ,  G01N21/645 ,  G01N2021/6421 ,  G01N2021/6441

Abstract: A means for accurately counting desired cells or microorganisms (viable bacteria) in a sample fluid in which contaminants are included is provided. One or plural types of membrane-permeable fluorochromes whose fluorescence amount is amplified by binding to a nucleic acid and glycerin are added to a sample fluid containing cells or microorganisms to be counted and allowed to stand for a certain time. Glycerin is added before or after or simultaneously with the mixing of the sample fluid and the fluorochrome(s). The cells or microorganisms to be counted are counted by staining the cells or microorganisms to be counted, followed by irradiating with light having a specific wavelength to detect the fluorescence emitted from the cells or microorganisms.

Abstract translation: 提供了在包含污染物的样品流体中精确计数期望的细胞或微生物（活细菌）的方法。 将其荧光量通过与核酸和甘油结合而扩增的一种或多种透膜型荧光染料加入含有要计数并允许静置一定时间的细胞或微生物的样品液中。 在样品流体和荧光染料的混合之前或之后或同时加入甘油。 通过染色要计数的细胞或微生物计数细胞或微生物，然后用特定波长的光照射以检测从细胞或微生物发出的荧光。

公开(公告)号：US20110079640A1

公开(公告)日：2011-04-07

申请号：US12855299

申请日：2010-08-12

Applicant: Young Min KIM ,  Yanning ZHU ,  Yash AGARWAL ,  Xiuzhong WANG ,  Aaron ARMSTRONG ,  Robert BORGERDING ,  Andrew MACGINITIE ,  Antti SEPPO ,  llia ICHETOVKIN ,  Michael KILPATRICK ,  Petros TSIPOURAS ,  Triantafyllos TAFAS

Inventor： Young Min KIM ,  Yanning ZHU ,  Yash AGARWAL ,  Xiuzhong WANG ,  Aaron ARMSTRONG ,  Robert BORGERDING ,  Andrew MACGINITIE ,  Antti SEPPO ,  llia ICHETOVKIN ,  Michael KILPATRICK ,  Petros TSIPOURAS ,  Triantafyllos TAFAS

IPC: G06F17/00 ,  G02B21/34

CPC classification number: G01N35/00732 ,  G01J3/2803 ,  G01J3/4406 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2021/6482 ,  G01N2035/00851 ,  G01N2201/06113 ,  G01N2201/12

Abstract: A method for automated microscopic analysis wherein the test protocol is obtained from interrogatable data affixed to each microscope slide. The method further comprises the algorithms that implement the test protocol.

Abstract translation: 一种用于自动显微镜分析的方法，其中从每个显微镜载片上的可询问数据获得测试方案。 该方法还包括实现测试协议的算法。

公开(公告)号：US20110066014A1

公开(公告)日：2011-03-17

申请号：US12875925

申请日：2010-09-03

Applicant: Kate Leeann Bechtel ,  Tobias Funk ,  Brian Patrick Wilfley ,  Joseph Anthony Heanue

Inventor： Kate Leeann Bechtel ,  Tobias Funk ,  Brian Patrick Wilfley ,  Joseph Anthony Heanue

IPC: A61B5/1455

CPC classification number: A61B5/0059 ,  A61B5/0091 ,  A61B5/14552 ,  A61B5/14553 ,  A61B5/415 ,  A61B5/418 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0218 ,  G01J3/10 ,  G01J3/2823 ,  G01J3/4406 ,  G01N21/6408 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: The present invention pertains to a method and apparatus for cerebral oximetry. A modulated optical signal based on a digital code sequence is transmitted to the human brain. A temporal transfer characteristic is derived from the modulated optical signal. Oxygen level in the brain is determined based on the temporal transfer characteristic.

Abstract translation: 本发明涉及脑血氧测定法的方法和装置。 基于数字码序列的调制光信号被传送到人脑。 从调制光信号导出时间传递特性。 基于时间转移特征确定脑中的氧水平。

公开(公告)号：US20110058984A1

公开(公告)日：2011-03-10

申请号：US12990789

申请日：2009-05-01

Applicant: Takahiro Sasaki ,  Yoichi Aruga ,  Hidetsugu Tanoue

Inventor： Takahiro Sasaki ,  Yoichi Aruga ,  Hidetsugu Tanoue

IPC: G01N21/00

CPC classification number: G01N21/6428 ,  G01J1/32 ,  G01J3/02 ,  G01J3/027 ,  G01J3/4406 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2035/0491 ,  G01N2201/062

Abstract: The automatic analyzer uses a marker that is to be attached to a measurement object. The marker is made of a substance that becomes excited when irradiated. The automatic analyzer has a function of varying irradiation intensity, and controls the intensity of light emitted from an item marker by adjusting the irradiation intensity for each analysis item or for each analysis vessel. Further, the automatic analyzer has a function of controlling the at least one of the position and angle of an analysis vessel during irradiation, and controls the amount of radiation to the measurement object by adjusting at least one of the distance and angle between an irradiation light source and analysis vessel for each analysis item. Furthermore, the automatic analyzer has a function of varying the integration time of photometric means and controls the integration time for each analysis item or for each analysis vessel.

Abstract translation: 自动分析仪使用要附着在测量对象上的标记。 标记由照射时变得激发的物质制成。 自动分析仪具有改变照射强度的功能，并且通过调整每个分析项目或每个分析容器的照射强度来控制从物品标记物发射的光的强度。 此外，自动分析仪具有控制分析容器在照射期间的位置和角度中的至少一个的功能，并且通过调节照射光线之间的距离和角度中的至少一个来控​​制对测量对象的辐射量 来源和分析船。 此外，自动分析仪具有改变测光装置的积分时间并且控制每个分析项目或每个分析容器的积分时间的功能。