公开(公告)号：US20150201839A1

公开(公告)日：2015-07-23

申请号：US14675753

申请日：2015-04-01

申请人： Uk Kang ,  Garry V. Papayan

发明人： Uk Kang ,  Garry V. Papayan

IPC分类号： A61B5/00

CPC分类号： A61B5/0071 ,  A61B5/441

摘要： Provided is a reflection detection type measurement method for skin fluorescence. The method includes: irradiating excitation light on a measurement target; detecting a reflected light and a skin fluorescence generated from the measurement target due to the excitation light; irradiating light with a wavelength range of the skin fluorescence on the measurement target; detecting a reflected light generated from the measurement target due to the light with a wavelength range of the skin fluorescence; and calculating a skin fluorescence value of the measurement target by correcting a calculation based on the detected reflected light and skin fluorescence.

摘要翻译： 提供了一种皮肤荧光的反射检测型测定方法。 该方法包括：在测量对象上照射激发光; 检测由于激发光而由测量对象产生的反射光和皮肤荧光; 将具有皮肤荧光的波长范围的光照射在测量对象上; 检测由于具有皮肤荧光的波长范围的光而由测量对象产生的反射光; 以及通过基于检测到的反射光和皮肤荧光校正计算来计算测量对象的皮肤荧光值。

公开(公告)号：US20130281865A1

公开(公告)日：2013-10-24

申请号：US13845974

申请日：2013-03-18

申请人： Uk KANG ,  Garry V. PAPAYAN ,  Il Hyung SHIN ,  Dae Sic LEE ,  Soo Jin BAE ,  Guang Hoon KIM

发明人： Uk KANG ,  Garry V. PAPAYAN ,  Il Hyung SHIN ,  Dae Sic LEE ,  Soo Jin BAE ,  Guang Hoon KIM

IPC分类号： A61B5/00

CPC分类号： A61B5/0071 ,  A61B5/7225 ,  A61B5/742

摘要： The present invention provides a transmitted light detection type measurement apparatus for skin fluorescence, which is configured to perform light irradiation and light detection on a reference sample and a measurement target. The apparatus includes a first light source, a second light source, a first optical detector and a second optical detector, a light source switching controller, and an operator.

摘要翻译： 本发明提供了一种用于皮肤荧光的透射光检测型测量装置，其被配置为对参考样品和测量目标进行光照射和光检测。 该装置包括第一光源，第二光源，第一光检测器和第二光检测器，光源切换控制器和操作器。

公开(公告)号：US07635330B2

公开(公告)日：2009-12-22

申请号：US11072995

申请日：2005-03-04

申请人： Uk Kang ,  Garry V. Papayan

发明人： Uk Kang ,  Garry V. Papayan

IPC分类号： A61B1/06

CPC分类号： A61B5/0071 ,  A61B1/00009 ,  A61B1/043 ,  A61B1/05 ,  A61B1/07 ,  A61B5/0084 ,  A61B2560/0233

摘要： Disclosed is an improved fluorescent endoscope system having reduced factors that cause errors during diagnosis based on quantitative evaluation of fluorescent intensity for improved accuracy of fluorescent endoscopic diagnosis. The fluorescent endoscope system includes an optical source module for providing white light or excitation light; an endoscope assembly having an optical transmission path for transmitting light provided from the optical source module to a diagnostic object and an optical detection module for transmitting reflection light and fluorescent light from the diagnostic object; an optical path split means for splitting the path of the reflection light and fluorescent light transmitted from the endoscope assembly; and a two-chip integration image detection module having a first optical detection chip for detecting the reflection light and outputting a first optical detection signal, a second optical detection chip for detecting the excitation light and outputting a second optical detection signal, a gain control unit for controlling a signal amplification gain value to adjust the brightness of an image detected by the first optical detection chip, a first amplification unit for amplifying the first optical detection signal according to the signal amplification gain value, and a second amplification unit for amplifying the second optical detection signal according to a changing ratio of the signal amplification gain value.

摘要翻译： 公开了一种改进的荧光内窥镜系统，其具有减少的因素，其基于荧光强度的定量评估在诊断期间引起误差，以提高荧光内窥镜诊断的准确度。 荧光内窥镜系统包括用于提供白光或激发光的光源模块; 具有用于将从所述光源模块提供的光传输到诊断对象的光传输路径的内窥镜组件和用于从所述诊断对象传送反射光和荧光的光学检测模块; 光路分离装置，用于分离从内窥镜组件发射的反射光和荧光的路径; 以及双芯片集成图像检测模块，具有用于检测反射光并输出第一光学检测信号的第一光学检测芯片，用于检测激发光并输出第二光学检测信号的第二光学检测芯片，增益控制单元 用于控制信号放大增益值以调节由第一光学检测芯片检测的图像的亮度;第一放大单元，用于根据信号放大增益值放大第一光检测信号;以及第二放大单元，用于放大第二光检测芯片 光检测信号根据信号放大增益值的变化率。

公开(公告)号：US20110270092A1

公开(公告)日：2011-11-03

申请号：US13016642

申请日：2011-01-28

申请人： Uk KANG ,  Soo Jin Bae ,  Guang Hoon Kim ,  Seung Yup Lee ,  Garry V. Papayan

发明人： Uk KANG ,  Soo Jin Bae ,  Guang Hoon Kim ,  Seung Yup Lee ,  Garry V. Papayan

IPC分类号： A61B6/00 ,  A61N5/06

CPC分类号： A61B5/0071 ,  A61N5/062 ,  A61N2005/0628 ,  G01J3/2823 ,  G01J3/4406 ,  G01J2003/1213

摘要： The present invention provides a fluorescence detection and photodynamic therapy apparatus including: a combined light source unit 10 including a plurality of coherent and non-coherent light sources 11, 12 and 13 configured to irradiate light onto a to-be-observed object while performing continuous illumination; an optical imaging unit 20 configured to form an image of the to-be-observed object 70 and project the image to an image processing/controlling system 34; a multispectral imaging unit 30 including a one-chip multispectral sensor and the image processing/controlling system 34; a blocking filter 40 installed between the to-be-observed object 70 and the one-chip multispectral sensor 32, the blocking filter being configured to block some light reflected off from the to-be-observed object 70 while allowing some light and fluorescent light to pass therethrough; a computer system 50 configured to process, analyze, reproduce and store the image acquired from the multispectral imaging unit 30, and transfer the image to a display device 60 and control the overall operation of all the related elements; and the display device 60 configured to display a processing result of the image by the computer system 50.

摘要翻译： 本发明提供了一种荧光检测和光动力治疗装置，其包括：组合光源单元10，包括多个相干和非相干光源11,12和13，其被配置为将光照射到被观察物体上，同时执行连续 照明; 光学成像单元20，被配置为形成待观察对象70的图像，并将图像投影到图像处理/控制系统34; 包括单芯片多光谱传感器和图像处理/控制系统34的多光谱成像单元30; 安装在被观察物体70和单芯片多光谱传感器32之间的阻挡滤光器40，阻挡滤光器被配置为阻挡从被观察物体70反射的一些光，同时允许一些光和荧光灯 通过; 被配置为处理，分析，再现和存储从多光谱成像单元30获取的图像的计算机系统50，并将图像传送到显示设备60并控制所有相关元件的整体操作; 并且显示装置60被配置为通过计算机系统50显示图像的处理结果。

公开(公告)号：US07297961B2

公开(公告)日：2007-11-20

申请号：US10975707

申请日：2004-10-28

申请人： Uk Kang ,  Garry V. Papayan

发明人： Uk Kang ,  Garry V. Papayan

IPC分类号： F21V9/16 ,  F21K2/00 ,  G01C19/66 ,  G01J1/00 ,  G01N21/41

CPC分类号： G02B21/16

摘要： The present invention relates, in general, to a fluorescence microscope and method of observing samples using the microscope and, more particularly, to a fluorescence microscope and method of observing samples using the microscope, which can reduce optical noise and obtain images with higher sensitivity, thus obtaining precise information about the density, quantity, location, etc. of a fluorophore, and which can simultaneously process separate images even when a plurality of fluorophores having different excitation and fluorescent wavelength ranges is distributed, thus easily obtaining information about the fluorophores. The fluorescence microscope of the present invention includes an objective lens, and first and third medium units. The first medium unit has a refractive index of n1 to accommodate one or more micro-objects including fluorophores and provide a path of excitation light to excite the fluorophores. The third medium unit has a refractive index of n3, and is placed between the first medium unit and the objective lens to totally reflect the excitation light incident through the first medium unit at an interface of the third medium unit coming into contact with the first medium unit. The refractive indices of the third and first medium units satisfy a relationship of n1>n3.

摘要翻译： 本发明一般涉及使用显微镜观察样品的荧光显微镜和方法，更具体地，涉及使用显微镜观察样品的荧光显微镜和方法，其可以降低光学噪声并获得具有更高灵敏度的图像， 从而获得关于荧光团的密度，数量，位置等的精确信息，即使分散具有不同激发和荧光波长范围的多个荧光团，也可以同时处理分离的图像，因此容易获得关于荧光团的信息。 本发明的荧光显微镜包括物镜以及第一和第三介质单元。 第一介质单元具有n 1的折射率，以容纳包括荧光团在内的一个或多个微物体，并提供激发光的路径以激发荧光团。 第三介质单元具有n 3的折射率，并且被放置在第一介质单元和物镜之间，以在第三介质的界面处全反射通过第一介质单元入射的激发光 单元与第一中间单元接触。 第三和第一介质单元的折射率满足n <1 n 3 3的关系。

公开(公告)号：US20150201840A1

公开(公告)日：2015-07-23

申请号：US14676802

申请日：2015-04-01

申请人： Uk Kang ,  Garry V. Papayan

发明人： Uk Kang ,  Garry V. Papayan

IPC分类号： A61B5/00

CPC分类号： A61B5/0071 ,  A61B5/441

摘要： Provided is a reflection detection type measurement apparatus for skin fluorescence. The apparatus includes: a first light source irradiating excitation light on a measurement target; a second light source irradiating light of a wavelength different from that of light from the first light source on the measurement target; a first optical detector detecting a reflected light generated from the measurement target due to the excitation light of the first light source; and a second optical detector detecting a skin fluorescence generated from the measurement target due to the excitation light of the first light source, and detecting a reflected light generated from the measurement target due to the excitation light of the second light source. The first optical detector is disposed in an area other than a total reflection area to which the excitation light of the first light source is reflected after irradiating to the measurement target.

摘要翻译： 提供了一种用于皮肤荧光的反射检测型测量装置。 该装置包括：在测量对象物上照射激发光的第一光源; 第二光源，将与来自第一光源的光不同的波长的光照射在测量对象上; 第一光学检测器，由于所述第一光源的激发光检测从所述测量对象产生的反射光; 以及第二光学检测器，其检测由于所述第一光源的激发光而从所述测量对象产生的皮肤荧光，并且检测由于所述第二光源的激发光而由所述测量对象产生的反射光。 第一光检测器设置在除了在照射到测量对象之后第一光源的激发光被反射的全反射区域以外的区域中。