公开(公告)号：US20240358273A1

公开(公告)日：2024-10-31

申请号：US18766498

申请日：2024-07-08

申请人： BIORA THERAPEUTICS, INC.

发明人： Mitchell Lawrence Jones ,  Alain Labbé ,  Mark Sasha Drlik ,  Christian Terry Proch McMechan

IPC分类号： A61B5/06 ,  A61B1/04 ,  A61B5/00 ,  A61B5/07 ,  H04B10/114 ,  H04B13/00

CPC分类号： A61B5/065 ,  A61B1/041 ,  A61B5/002 ,  A61B5/0086 ,  A61B5/073 ,  A61B5/6861 ,  A61B5/7264 ,  H04B10/1143 ,  H04B13/00 ,  A61B5/0017 ,  A61B2560/0443 ,  A61B2560/0462 ,  A61B2562/162

摘要： Various embodiments are described herein for a device, system, and method for identifying a location of an ingestible device within a gastrointestinal tract of a body. In some embodiments, the ingestible device includes a sensing unit with an axial optical sensing sub-unit located proximal to at least one end of the device, and a radial optical sensing sub-unit located proximal to a radial wall of the device, and may autonomously identify a location within the gastrointestinal tract. In some embodiments, the ingestible device includes optical illumination sources and detectors that operate at a plurality of different wavelengths, and may discern regions of a gastrointestinal tract by using the reflection properties of organ tissue and occasional particulates. In some embodiments, the ingestible device may sample fluid or release medicament based on a detected device location.

公开(公告)号：US20240341690A1

公开(公告)日：2024-10-17

申请号：US18424404

申请日：2024-01-26

申请人： GI Bionics, LLC

发明人： Hans Gregersen ,  Ghassan S. Kassab

IPC分类号： A61B5/00 ,  A61B1/04 ,  A61B5/03 ,  A61B5/0538 ,  A61B5/06 ,  A61B5/07 ,  A61B5/145 ,  A61B5/1473 ,  A61B90/00 ,  A61F5/00 ,  A61L31/00 ,  A61L31/14 ,  A61N1/36 ,  A61N2/02

CPC分类号： A61B5/6861 ,  A61B1/041 ,  A61B5/002 ,  A61B5/036 ,  A61B5/0538 ,  A61B5/064 ,  A61B5/073 ,  A61B5/14503 ,  A61B5/14507 ,  A61B5/14539 ,  A61B5/1473 ,  A61F5/003 ,  A61F5/0036 ,  A61L31/005 ,  A61L31/14 ,  A61N1/36007 ,  A61N2/02 ,  A61B5/0077 ,  A61B2090/3954 ,  A61B2090/3966 ,  A61B2562/0219 ,  A61B2562/0247 ,  A61B2562/0261 ,  A61B2562/06 ,  A61B2562/162 ,  A61B2562/166 ,  A61F2005/002 ,  A61F2005/0023

摘要： Autoexpandable devices for obtaining impedance, pressure, and other measurements in the gastrointestinal tract and other organs. In an exemplary embodiment of a capsule of the present disclosure, the capsule comprises an outer shell configured to dissolve or otherwise be digested within a stomach after ingestion, an expandable material positioned within the outer shell, the expandable material configured for expansion within the stomach after the outer shell has dissolved, and at least one element or sensor selected from the group consisting of an impedance element and a pressure sensor.

公开(公告)号：US12115330B2

公开(公告)日：2024-10-15

申请号：US17419187

申请日：2020-01-02

申请人： VIBRANT LTD.

发明人： Lior Ben-Tsur ,  Shai Molnar ,  Ronny Shabbat

IPC分类号： A61M31/00 ,  A61B5/00 ,  A61B5/07 ,  A61K9/00 ,  A61M37/00

CPC分类号： A61M31/002 ,  A61B5/0051 ,  A61B5/073 ,  A61B5/42 ,  A61B5/4839 ,  A61B5/6861 ,  A61K9/0053 ,  A61M31/00 ,  A61M37/00 ,  A61B2562/162 ,  A61M2205/3306 ,  A61M2205/3327 ,  A61M2205/3341 ,  A61M2205/3344 ,  A61M2205/3368 ,  A61M2205/8206 ,  A61M2210/1053 ,  A61M2210/106 ,  A61M2210/1064

摘要： Devices and methods for delivering an ingestible medicament of a medicament tablet into the gastrointestinal tract of a user. A device according to the invention includes a vibrating ingestible capsule and a hollow medicament compartment housing. The vibrating capsule includes a housing, a vibrating agitation mechanism disposed within the housing, a power supply, and a control element. The hollow medicament compartment housing is associated with the housing of the capsule and includes at least one aperture. The hollow of the medicament compartment housing is configured to have the medicament tablet disposed therein. The aperture(s) are dimensioned to enable fluid communication the surrounding environment and the hollow.

公开(公告)号：US20240252059A1

公开(公告)日：2024-08-01

申请号：US18560945

申请日：2022-05-18

申请人： ENTERASENSE LIMITED

发明人： Donal DEVERY ,  Maria Chiara DI CARLO

IPC分类号： A61B5/07 ,  A61B5/00 ,  A61B5/01 ,  A61B5/02 ,  A61B5/06 ,  A61B5/145

CPC分类号： A61B5/073 ,  A61B5/0013 ,  A61B5/0028 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/01 ,  A61B5/02042 ,  A61B5/065 ,  A61B5/14503 ,  A61B5/14507 ,  A61B5/14539 ,  A61B5/6852 ,  A61B5/7221 ,  A61B5/7271 ,  A61B5/743 ,  A61B5/4238 ,  A61B5/4255 ,  A61B2560/0462 ,  A61B2562/0233 ,  A61B2562/0247 ,  A61B2562/0271 ,  A61B2562/043 ,  A61B2562/162

摘要： A biosensor capsule having a generally cylindrical housing with a plurality of sensors including a radiation sensor including a radiation emitter and a radiation detector and at least one additional sensor. A processor uses data feeds from the radiation sensor and also from one more additional sensor of a different type. Additional sensors may be pressure or pH sensors to provide sensor signals to detect location along the GI tract in use. There may be a camera, and data derived from other sensors may be embedded in a video feed timeline. The capsule may have an asymmetric weight distribution to help keep sensing parts immersed in liquid.

公开(公告)号：US11931013B2

公开(公告)日：2024-03-19

申请号：US16307885

申请日：2017-06-07

申请人： UNIVERSITE GRENOBLE ALPES ,  CENTRE HOSPITALIER UNIVERSITAIRE GRENOBLE

发明人： Philippe Cinquin ,  Denis Favier ,  Thierry Alonso ,  Aziz Bakri ,  Nawel Khalef ,  Jacques Thelu ,  Sylvain Besson ,  Donald Martin

IPC分类号： A61B10/00

CPC分类号： A61B10/0045 ,  A61B10/0038 ,  A61B2010/0061 ,  A61B2562/162

摘要： A capsule configured for collecting samples in the intestine, comprising a body delimiting at least one compartment for receiving samples and comprising at least one opening for samples intake, and a mobile mechanism for opening and/or closing the opening controlled by the dissolution of a material which is dissolvable in the intestine.

公开(公告)号：US11896205B2

公开(公告)日：2024-02-13

申请号：US17204001

申请日：2021-03-17

申请人： Hitachi, Ltd.

发明人： Ayako Nishimura ,  Akihiko Kandori ,  Tsukasa Funane ,  Akiko Obata ,  Hirokazu Atsumori ,  Masashi Kiguchi

IPC分类号： A61B10/00 ,  A61B5/07 ,  A61B5/00 ,  A61M31/00

CPC分类号： A61B10/0045 ,  A61B5/073 ,  A61B5/6861 ,  A61B10/0038 ,  A61B5/6871 ,  A61B2010/0061 ,  A61B2560/0406 ,  A61B2562/02 ,  A61B2562/162 ,  A61M31/00

摘要： A digestive organ internal contents sampling capsule for sampling internal contents in a digestive organ includes: a cylindrical container insoluble in a digestive tract for housing the internal contents in the digestive organ; an outer lid enclosing an orifice of the cylindrical container and to dissolve at least partially in the digestive organ; an inner lid arranged in the cylindrical container, and to swell in response to contact with the internal contents in the digestive organ to enclose the orifice of the cylindrical container after the orifice is exposed by dissolving of at least a part of the outer lid; and a marker material to be discharged together with the cylindrical container housing the internal contents in the digestive organ and feces.

公开(公告)号：US20240023794A1

公开(公告)日：2024-01-25

申请号：US18043099

申请日：2021-09-15

申请人： Queen Mary University of London

发明人： Mohamed Adhnan Thaha ,  Mohammad Hasan Shaheed ,  Julius Esmann Bernth

IPC分类号： A61B1/04 ,  A61B1/045 ,  A61B5/00 ,  H02K33/18 ,  A61B1/00

CPC分类号： A61B1/041 ,  A61B1/045 ,  A61B5/6861 ,  A61B5/42 ,  H02K33/18 ,  A61B1/00156 ,  A61B2560/02 ,  A61B2560/0406 ,  A61B2562/162 ,  H02K21/14

摘要： A locomotion system for use in a medical device, including at least one magnet, a rotor including a plurality of coil windings, and a ferromagnetic member. The rotor is configured, on application of a current to the plurality of coil windings, to travel along the ferromagnetic member and to impact on a surface.

公开(公告)号：US20230380816A1

公开(公告)日：2023-11-30

申请号：US18320766

申请日：2023-05-19

申请人： Stichting IMEC Nederland

发明人： Rogier Schoeman ,  Klaus Mathwig

IPC分类号： A61B10/00

CPC分类号： A61B10/0045 ,  A61B2010/0061 ,  A61B2562/162

摘要： An ingestible device for sampling material at least one time is provided. The ingestible device includes a first chamber that is enlargeable in volume and that includes an inlet, and that can be filled with the material to be sampled, a second chamber that is diminishable in volume and that includes an outlet, and a reversible actuating mechanism. The reversible actuating mechanism is configured such that triggering the reversible actuating mechanism leads to an enlargement of the first chamber to collect the material to be sampled through the inlet and also leads to a diminishment of the second chamber.

公开(公告)号：US20230380768A1

公开(公告)日：2023-11-30

申请号：US18316954

申请日：2023-05-12

申请人： Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

发明人： Robert S. Langer ,  Carlo Giovanni Traverso ,  Yong Lin Kong

IPC分类号： A61B5/00 ,  A61B5/07 ,  A61M31/00

CPC分类号： A61B5/6885 ,  A61B5/073 ,  A61B5/6871 ,  A61B5/0031 ,  A61B5/4238 ,  A61B5/6861 ,  A61M31/002 ,  A61B2560/0443 ,  A61B2562/0285 ,  A61B2562/162 ,  A61M2205/0216 ,  A61M2205/0272 ,  A61M2205/3523 ,  A61M2210/1053

摘要： Gastric resident electronics, devices, systems, and related methods are generally provided. Some embodiments comprise administering (e.g., orally) an (electronic) resident structure to a subject (e.g., a patient) such that the (electronic) resident structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before exiting said location internal to the subject. In some embodiments, the resident structure is a gastric resident electronic. That is to say, in some embodiments, the resident structure is configured for relatively long gastric residence and comprises an electronic component. In some embodiments, the structures and components described herein may comprise one or more components configured for the delivery of an active substance(s) (e.g., a pharmaceutical agent) to the subject. In some embodiments, the device has a modular design, combining an electronic component(s) with materials configured for controlled and/or tunable degradation/dissolution to determine the time at which (gastric) residence is lost and the device exits the location internal to the subject. For example, in some embodiments, the resident structure comprises an electronic component and one or more additional components associated with the electronic component such that the resident structure is configured to be retained at a location internal to a subject for greater than or equal to 24 hours.

公开(公告)号：US11813045B2

公开(公告)日：2023-11-14

申请号：US16334665

申请日：2017-09-20

申请人： IP2IPO INNOVATIONS LIMITED

发明人： Mohammad Reza Bahmanyar ,  Christopher Neil McLeod ,  Olive H Murphy

IPC分类号： A61B5/0215 ,  A61B5/00 ,  A61B5/03 ,  G01L19/08 ,  G01L19/14

CPC分类号： A61B5/02158 ,  A61B5/0031 ,  A61B5/036 ,  A61B5/686 ,  A61B5/6861 ,  A61B5/6876 ,  G01L19/086 ,  G01L19/149 ,  A61B2560/0247 ,  A61B2560/0462 ,  A61B2562/0219 ,  A61B2562/04 ,  A61B2562/12 ,  A61B2562/162

摘要： An implantable intravascular pressure sensor comprising a first transducer arranged to provide a pressure dependent signal in response to alternating electrical signals of a first frequency band, a second transducer arranged to provide a reference signal in response to alternating electrical signals of a second frequency band different from the first frequency band and an antenna coupling for sending and receiving said signals.