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公开(公告)号：US20150174196A1
公开(公告)日：2015-06-25
申请号：US14396571
申请日：2013-04-25
Inventor： Robert G. Gourdie , Edie C. Goldsmith , L. Jane Jourdan , Joshua Matthew Rhett , Michael J. Yost
CPC classification number: A61K38/1703 , A61K9/0048 , A61K38/00 , A61K38/08 , A61K38/10 , A61K45/06 , A61K47/10 , A61L15/32 , A61L15/44 , A61L17/005 , A61L27/22 , A61L27/34 , A61L27/54 , A61L31/047 , A61L31/10 , A61L31/16 , A61L2300/25 , A61L2300/252 , A61L2300/412 , A61L2430/16 , C07K7/06 , C07K7/08 , C07K14/46 , C07K14/47 , C07K14/4703 , C07K2319/035 , C08L77/04
Abstract: Provided are peptides that can inhibit collagen synthesis, processing and/or secretion from scar forming cells or fibroblasts. Also provided are methods for using the peptides to produce an anti-fibrotic, anti-scarring, anti-inflammatory, and/or pro-regenerative effect, e.g., on an injured or diseased tissue.
Abstract translation: 提供可以抑制来自瘢痕形成细胞或成纤维细胞的胶原合成，加工和/或分泌的肽。 还提供了使用肽产生抗纤维化，抗瘢痕形成，抗炎和/或促再生作用的方法，例如在损伤或患病组织上。
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公开(公告)号：US20150105345A1
公开(公告)日：2015-04-16
申请号：US14398837
申请日：2013-03-08
Applicant: The United States of America, as represented by the Secretary, Dept. of Health and Human Services , Duke University , MUSC Foundation for Research Development , The University of North Carolina at Chapel Hill
Inventor： Stavros Garantziotis , John W. Hollingsworth , Bryan P. Toole , Jian Liu
IPC: A61K31/728 , A61K31/702 , A61K9/00 , A61K31/727
CPC classification number: A61K31/728 , A61K9/0075 , A61K9/0078 , A61K9/008 , A61K31/702 , A61K31/715 , A61K31/726 , A61K31/727
Abstract: Described herein is the finding that hyaluronan antagonists that inhibit hyaluronan signaling are capable of inhibiting airway inflammation and airway hyperresponsiveness (AHR). The present disclosure provides a method of preventing or reducing AHR in a subject suffering from or at risk for AHR by administering a hyaluronan antagonist. Also provided is a method of treating an airway disease or disorder in a subject by administering a hyaluronan antagonist. Hyaluronan antagonists include, for example, heparosan and hyaluronan oligosaccharides (oHAs). In some embodiments, the hyaluronan antagonist is administered locally to the airway, such as with an inhaler or nebulizer.
Abstract translation: 本文描述了发现抑制透明质酸信号传导的透明质酸拮抗剂能够抑制气道炎症和气道高反应性（AHR）。 本公开提供了通过施用透明质酸拮抗剂来预防或减轻患有或有风险的受试者的AHR的方法。 还提供了通过施用透明质酸拮抗剂治疗受试者的气道疾病或病症的方法。 透明质酸拮抗剂包括例如heparosan和透明质酸寡糖（oHA）。 在一些实施方案中，透明质酸拮抗剂局部施用于气道，例如用吸入器或雾化器。
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93.发明授权Methods for assessing modified LDL immune complexes in subjects having or at risk of coronary artery disease 有权用于评估冠状动脉疾病或有冠心病风险的受试者中修饰的LDL免疫复合物的方法公开(公告)号：US08911958B2
公开(公告)日：2014-12-16
申请号：US14036018
申请日：2013-09-25
Inventor： Maria F. Lopes-Virella , Gabriel T. Virella
CPC classification number: G01N33/92 , G01N33/6893 , G01N2440/38 , G01N2800/042 , G01N2800/324 , G01N2800/50 , G01N2800/52
Abstract: The present invention relates to the analysis of modified LDL in the context of immune complexes. In particular, ox-LDL and AGE-LDL are shown to predict the development of coronary artery disease and other micro- and macrovascular disorders, particularly in the context of diabetes.
Abstract translation: 本发明涉及在免疫复合物的背景下对修饰的LDL的分析。 特别地，ox-LDL和AGE-LDL显示预测冠状动脉疾病和其他微血管和大血管疾病的发展，特别是在糖尿病的背景下。
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94.发明申请METHODS FOR ASSESSING MODIFIED LDL IMMUNE COMPLEXES IN SUBJECTS HAVING OR AT RISK OF CORONARY ARTERY DISEASE 有权评估患有冠状动脉疾病风险的受试者中修饰的LDL免疫复合物的方法公开(公告)号：US20140093974A1
公开(公告)日：2014-04-03
申请号：US14036018
申请日：2013-09-25
Inventor： Maria F. LOPES-VIRELLA , Gabriel T. VIRELLA
IPC: G01N33/92
CPC classification number: G01N33/92 , G01N33/6893 , G01N2440/38 , G01N2800/042 , G01N2800/324 , G01N2800/50 , G01N2800/52
Abstract: The present invention relates to the analysis of modified LDL in the context of immune complexes. In particular, ox-LDL and AGE-LDL are shown to predict the development of coronary artery disease and other micro- and macrovascular disorders, particularly in the context of diabetes.
Abstract translation: 本发明涉及在免疫复合物的背景下对修饰的LDL的分析。 特别地，ox-LDL和AGE-LDL显示预测冠状动脉疾病和其他微血管和大血管疾病的发展，特别是在糖尿病的背景下。
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95.发明申请NOVEL BACTERIOSTATIC AND ANTI-COLLAGENOLYTIC DENTAL MATERIALS THROUGH THE INCORPORATION OF POLYACRYLIC ACID MODIFIED CuQ NANOPARTICLES 有权通过加入聚丙烯酸改性的CuQ纳米粒子制备新型的生物和抗菌胶原物质公开(公告)号：US20140037705A1
公开(公告)日：2014-02-06
申请号：US13900942
申请日：2013-05-23
Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT
Inventor： Walter George RENNE , Anthony Samuel MENNITO , Michael Gerard SCHMIDT , Jomprobe VUTHIGANON , George CHUMANOV
CPC classification number: A61K33/34 , A61C5/70 , A61K6/0017 , A61K6/0023 , A61K6/007 , A61K6/0835 , C01G3/02 , C01G3/04 , C01G3/12 , Y10S977/773
Abstract: Provided are antibacterial and antimicrobial surface coatings and dental materials by utilizing the antimicrobial properties of copper chalcogenide and/or copper halide (CuQ, where Q=chalcogens including oxygen, or halogens, or nothing). An antimicrobial barrier is created by incorporation of CuQ nanoparticles of an appropriate size and at a concentration necessary and sufficient to create a unique bioelectrical environment. The unique bioelectrical environment results in biocidal effectiveness through a multi-factorial mechanism comprising a combination of the intrinsic quantum flux of copper (Cu0, Cu1+, Cu2+) ions and the high surface-to-volume electron sink facilitated by the nanoparticle. The result is the constant quantum flux of copper which manifests and establishes the antimicrobial environment preventing or inhibiting the growth of bacteria. The presence of CuQ results in inhibiting or delaying bacterial destruction and endogenous enzymatic breakdown of the zone of resin inter-diffusion, the integrity of which is essential for dental restoration longevity.
Abstract translation: 通过利用铜硫属化物和/或铜卤化物（CuQ，其中Q =包括氧或卤素的硫属元素，或任何物质）的抗微生物性质，提供抗菌和抗微生物表面涂层和牙科材料。 通过掺入适当尺寸的CuQ纳米颗粒并以必要和足够的浓度产生独特的生物电气环境来产生抗微生物屏障。 独特的生物电气环境通过包含铜（CuO，Cu1 +，Cu2 +）的固有量子通量和由纳米颗粒促进的高表面 - 体积电子吸收的组合的多因素机制产生杀生物效果。 结果是铜的恒定量子通量显示并建立了防止或抑制细菌生长的抗微生物环境。 CuQ的存在导致抑制或延迟细菌破坏和树脂互扩散区域的内源性酶分解，其完整性对于牙齿修复寿命至关重要。
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Patent Agency Ranking
96.发明授权Cell repair and regeneration by suramin and related polysulfonated napthylureas 有权苏拉明和相关多磺化萘脲的细胞修复和再生公开(公告)号：US08633250B2
公开(公告)日：2014-01-21
申请号：US11622285
申请日：2007-01-11
Applicant: Rick G. Schnellmann , Shougang Zhuang
Inventor： Rick G. Schnellmann , Shougang Zhuang
IPC: A61K31/17 , A61K31/138
CPC classification number: A61K31/185 , A61K9/0019
Abstract: Disclosed herein are compositions and methods for promoting the repair and regeneration of injured tissues, such as injuries resulting from ischemic damage.
Abstract translation: 本文公开了用于促进损伤组织的修复和再生的组合物和方法，例如由缺血损伤引起的损伤。
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公开(公告)号：US08551489B2
公开(公告)日：2013-10-08
申请号：US12811321
申请日：2009-01-02
Applicant: Omar Moussa , Dennis K. Watson , Perry V. Halushka
Inventor： Omar Moussa , Dennis K. Watson , Perry V. Halushka
CPC classification number: A61K31/015 , A61K31/445 , A61K45/06 , A61K2300/00
Abstract: Methods for the treatment of cancers involving dysregulation of thromboxane receptor β (TP-β) are provided, including in certain aspects methods for diagnosing such cancers. Specific cancers included are genitourinary cancers, gastrointestinal cancers and leukemias.
Abstract translation: 提供了治疗涉及血栓烷受体β（TP-β）失调的癌症的方法，包括在某些方面诊断这种癌症的方法。 特定癌症包括泌尿生殖器癌，胃肠癌和白血病。
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公开(公告)号：US08489186B2
公开(公告)日：2013-07-16
申请号：US13128191
申请日：2009-11-05
Applicant: Rupak Mukherjee , Francis Spinale
Inventor： Rupak Mukherjee , Francis Spinale
IPC: A61N1/40
CPC classification number: A61N1/3627
Abstract: Provided are devices and methods for treating a subject having a myocardial condition using sub-threshold electrical stimulation.
Abstract translation: 提供了使用亚阈值电刺激来治疗具有心肌病症的受试者的装置和方法。
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99.发明授权公开(公告)号：US08357668B2
公开(公告)日：2013-01-22
申请号：US12871461
申请日：2010-08-30
Applicant: Robert Gourdie , Gautam Ghatnekar , Jane Jourdan
Inventor： Robert Gourdie , Gautam Ghatnekar , Jane Jourdan
CPC classification number: A61K38/177 , A61K38/07 , A61K38/08 , A61K38/10 , A61K38/1709 , A61K38/1767 , A61K45/06 , A61L31/08 , A61L2430/34 , C07K5/10 , C07K7/06 , C07K7/08 , C07K14/43581 , C07K14/47 , C07K14/705 , C07K2319/01 , C07K2319/10
Abstract: Provided herein are compositions and methods for use in promoting wound healing and tissue regeneration following tissue injury in a subject.
Abstract translation: 本文提供了用于促进受试者组织损伤后伤口愈合和组织再生的组合物和方法。
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100.发明申请SELF-ASSEMBLING CELL AGGREGATES AND METHODS OF MAKING ENGINEERED TISSUE USING THE SAME 有权自组装细胞聚集体及使用该方法制备工程组织的方法公开(公告)号：US20120288938A1
公开(公告)日：2012-11-15
申请号：US13529172
申请日：2012-06-21
Applicant: Gabor Forgacs , Karoly Jakab , Adrian Neagu , Vladimir Mironov
Inventor： Gabor Forgacs , Karoly Jakab , Adrian Neagu , Vladimir Mironov
IPC: C12N5/02
CPC classification number: C12N5/0062 , B29C64/112 , B29C64/209 , B29C64/386 , B29C64/393 , B29K2033/26 , B29K2105/0035 , B29K2105/0061 , B29L2031/7532 , B33Y10/00 , B33Y30/00 , B33Y50/02 , B33Y70/00 , B33Y80/00 , C12M21/08 , C12M33/12 , C12M41/48 , C12M47/00 , C12M47/02 , C12N5/0697
Abstract: A composition comprising a plurality of cell aggregates for use in producing engineered organotypic tissue by organ printing. A method of making a plurality of cell aggregates comprises centrifuging a cell suspension, extruding the resulting pellet through an orifice, and cutting the extruded pellet into pieces. Apparatus for making cell aggregates comprises an extrusion system and a cutting system. In a method of organ printing, a plurality of cell aggregates are embedded in a polymeric or gel matrix and allowed to fuse to form a desired three-dimensional tissue structure. An intermediate product comprises at least one layer of matrix and a plurality of cell aggregates embedded therein in a predetermined pattern. Modeling methods predict the structural evolution of fusing cell aggregates for combinations of cell type, matrix, and embedding patterns to enable selection of organ printing process parameters for use in producing an engineered tissue having a desired three-dimensional structure.
Abstract translation: 一种组合物，其包含用于通过器官印刷生产工程化器官组织的多个细胞聚集体。 制备多个细胞聚集体的方法包括离心细胞悬浮液，通过孔口挤出所得颗粒，并将挤出的颗粒切割成块。 用于制造细胞聚集体的装置包括挤出系统和切割系统。 在器官印刷的方法中，将多个细胞聚集体嵌入聚合物或凝胶基质中并使其融合以形成所需的三维组织结构。 中间产品包含至少一层矩阵和以预定图案嵌入其中的多个细胞聚集体。 建模方法预测用于细胞类型，基质和嵌入图案组合的融合细胞聚集体的结构演变，以便能够选择用于生产具有所需三维结构的工程组织的器官印刷工艺参数。
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