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1043 条记录 (耗时 0.058 秒)

    Method of Controlling Administration of Cancer Antigen
    91.
    发明申请
    Method of Controlling Administration of Cancer Antigen 审中-公开

    公开(公告)号：US20180280433A1

    公开(公告)日：2018-10-04

    申请号：US15923861

    申请日：2018-03-16

    申请人： City of Hope

    发明人： Laurence J.N. Cooper ,  Michael C. Jensen

    IPC分类号： A61K35/12 ,  C12N5/0783

    摘要： The present invention is directed to mammalian bi-specific T cells and methods for using these bi-specific T cells. More specifically, the invention relates to a method of controlling administration of cancer antigen to a subject by providing bi-specific T cells that express a viral antigen T cell receptor and a cancer antigen-specific chimeric receptors and triggering their activation by also administering antigen-presenting T-cells which express viral antigen. These bi-specific T cell clones are a source of effector cells that persist in vivo in response to stimulation with viral antigen, leading to long-term function after their transfer to patients with cancer and autoimmune diseases.

    Substrates for high-density cell growth and metabolite exchange
    93.
    发明授权
    Substrates for high-density cell growth and metabolite exchange 有权

    公开(公告)号：US10053660B2

    公开(公告)日：2018-08-21

    申请号：US15647156

    申请日：2017-07-11

    申请人： California Institute of Technology ,  City of Hope

    发明人： Yu-Chong Tai ,  Yang Liu ,  Colin A. Cook ,  Yuman Fong ,  Nanhai G. Chen

    IPC分类号： C12M1/04 ,  C12M1/00

    CPC分类号： C12M23/24 ,  C12M23/14 ,  C12M23/20 ,  C12M25/14 ,  C12M29/04

    摘要： A polymer or other substrate optimized for growing cells is described, which takes the form of a micro-thin bag with gas permeable sides. Sides of the bag can be held at a fixed distance from one another with a multitude of tiny micropillars or other spacers extending between them, keeping the bag at a predetermined thickness and preventing the bag from collapsing and the sides from sticking together. In other embodiments, the sides may be held apart by gas pressure alone. A 0.01 μm to 1000 μm parylene or other biocompatible coating over the bag outsides controls the permeability of the bag material and provides a bio-safe area for cell growth. An alternate configuration uses open-cell foam with skins coated with a biocompatible coating. Tubes going into multiple bags can be connected to a manifold that delivers gaseous oxygen or removes carbon dioxide and other waste gases. Multiple bags can be stacked together tightly, with o-ring spacers in between, and housed within a vessel to form a high-surface area, ultra-compact cell growing system. For cells growing on the bags, liquid nutrients can be fed by way of the tube spacers, and oxygen and waste gases permeated through the bag sides and transported within the bags.