公开(公告)号：US11851687B2

公开(公告)日：2023-12-26

申请号：US17207387

申请日：2021-03-19

Applicant: Singular Genomics Systems, Inc.

Inventor： Souad Naji ,  Eli N. Glezer ,  Youngjin Cho ,  Zachary Terranova ,  Abrehet Abdu

IPC: C12N9/12 ,  C12N15/63 ,  C12Q1/68 ,  C12Q1/6874

CPC classification number: C12N9/1252 ,  C12N15/63 ,  C12Q1/6874 ,  C12Y207/07007

Abstract: Provided herein are modified Archaeal family B polymerases derived from species of the Archaeal microorganism Pyrococcus that exhibit improved incorporation of nucleotide analogues utilized in DNA sequencing.

公开(公告)号：US20230366013A1

公开(公告)日：2023-11-16

申请号：US18356724

申请日：2023-07-21

Applicant: Singular Genomics Systems, Inc.

Inventor： Eli N. Glezer

IPC: C12Q1/6841

CPC classification number: C12Q1/6841

Abstract: Disclosed herein, inter alia, are compositions and methods of use thereof for interrogating a sample comprising a cell.

公开(公告)号：US11773439B2

公开(公告)日：2023-10-03

申请号：US18052798

申请日：2022-11-04

Applicant: Singular Genomics Systems, Inc.

Inventor： Eli N. Glezer ,  Andrew Spaventa ,  David Barker

IPC: C12Q1/6869 ,  C07H21/04 ,  C12Q1/6867

CPC classification number: C12Q1/6869 ,  C07H21/04 ,  C12Q1/6867 ,  C12Q2521/101 ,  C12Q2525/185 ,  C12Q2525/186 ,  C12Q2535/00

Abstract: The present disclosure provides improved nucleic acid sequencing-by-synthesis (SBS) methods, related kits and reagents, and systems for performing such methods using such kits and reagents.

公开(公告)号：US20230257414A1

公开(公告)日：2023-08-17

申请号：US18295770

申请日：2023-04-04

Applicant: Singular Genomics Systems, Inc

Inventor： Ronald Graham ,  Olga Adelfinskaya ,  Megha Cila ,  Rodrigo Rodriguez ,  Abrehet Abdu ,  Eli N. Glezer

IPC: C07H19/14 ,  C12Q1/6869 ,  C07H19/20 ,  C12Q1/6876 ,  C07H19/10

CPC classification number: C07H19/14 ,  C12Q1/6869 ,  C07H19/20 ,  C12Q1/6876 ,  C07H19/10

Abstract: Disclosed herein, interalia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.

公开(公告)号：US20230203579A1

公开(公告)日：2023-06-29

申请号：US18111422

申请日：2023-02-17

Applicant: Singular Genomics Systems, Inc.

Inventor： Eli N. Glezer ,  Vahid Karimkhani ,  Shahed Kay ,  Mohammad Vatankhah Varnosfaderani ,  Daan Witters

IPC: C12Q1/6874 ,  C12Q1/6876 ,  C40B40/06

CPC classification number: C12Q1/6874 ,  C12Q1/6876 ,  C40B40/06

Abstract: Disclosed herein, inter alia, are nanoarrays and methods of use thereof.

公开(公告)号：US11680288B2

公开(公告)日：2023-06-20

申请号：US17815542

申请日：2022-07-27

Applicant: Singular Genomics Systems, Inc.

Inventor： Eli N. Glezer

IPC: C12Q1/6841

CPC classification number: C12Q1/6841

Abstract: Disclosed herein, inter alia, are compositions and methods of use thereof for interrogating a sample comprising a cell.

公开(公告)号：US11649452B2

公开(公告)日：2023-05-16

申请号：US18046458

申请日：2022-10-13

Applicant: SINGULAR GENOMICS SYSTEMS, INC.

Inventor： Eli N. Glezer ,  Daan Witters ,  Niek Van Wietmarschen

IPC: C12N15/10 ,  C12Q1/6874 ,  C12Q1/6806

CPC classification number: C12N15/1068 ,  C12Q1/6874 ,  C12Q1/6806

Abstract: Disclosed herein, inter alia, are methods and compositions for sequencing a plurality of template nucleic acids.

公开(公告)号：US11643679B2

公开(公告)日：2023-05-09

申请号：US17840469

申请日：2022-06-14

Applicant: Singular Genomics Systems, Inc.

Inventor： Eli N. Glezer ,  Hu Cang ,  Zhenmin Hong

IPC: C12Q1/6841 ,  C12Q1/6804 ,  G01N33/53

CPC classification number: C12Q1/6841 ,  C12Q1/6804 ,  G01N33/5308 ,  G01N33/53

Abstract: Disclosed herein, inter alia, are compositions and methods of use thereof for interrogating a cell.

公开(公告)号：US20230095409A1

公开(公告)日：2023-03-30

申请号：US17934407

申请日：2022-09-22

Applicant: Singular Genomics Systems, Inc.

Inventor： Daan WITTERS ,  Allen Lipson ,  Eli N. Glezer

IPC: C12Q1/6874

Abstract: Disclosed herein, inter alia, are complexes, kits, and efficient methods of sequencing two strands of a double stranded polynucleotide.

公开(公告)号：US20230070067A1

公开(公告)日：2023-03-09

申请号：US17963377

申请日：2022-10-11

Applicant: Singular Genomics Systems, Inc.

Inventor： Sandor Kovacs ,  David Baranson ,  Eli N. Glezer

IPC: B01L9/00

Abstract: The present disclosure relates to a flow cell receiver. The flow cell receiver can include at least one platen, having a plurality of ports. The flow cell receiver can include magnets. The flow cell receiver can be configured to automatically align, secure, and retain a flow cell carrier containing a flow cell.