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    NUCLEOTIDE SEQUENCES WHICH CODE FOR THE ZWA1 GENE
    92.
    发明申请
    NUCLEOTIDE SEQUENCES WHICH CODE FOR THE ZWA1 GENE 失效
    编号为ZWA1基因的核苷酸序列

    公开(公告)号：US20060205046A1

    公开(公告)日：2006-09-14

    申请号：US11419529

    申请日：2006-05-22

    申请人： Bettina Mockel ,  Walter Pfefferle ,  Achim Marx ,  Jorn Kalinowski ,  Brigitte Bathe ,  Alfred Puhler

    发明人： Bettina Mockel ,  Walter Pfefferle ,  Achim Marx ,  Jorn Kalinowski ,  Brigitte Bathe ,  Alfred Puhler

    IPC分类号： C12P13/08 ,  C12N15/74 ,  C12N1/21

    CPC分类号： C07K14/34 ,  C12N9/00 ,  C12P13/08

    摘要： Disclosed herein is an isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID NO:2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID NO:2 c) polynucleotide which is complementary to the polynucleotides of a) and b) and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and processes for the fermentative preparation of L-amino acid with amplification of the zwa1 gene in the coryneform bacteria employed.

    摘要翻译： 本文公开了一种分离的多核苷酸，其包含选自以下的多核苷酸序列：a）与编码包含SEQ ID NO：2的氨基酸序列的多肽的多核苷酸的程度相同的多核苷酸 b）编码多肽的多核苷酸，其包含与SEQ ID NO：2的氨基酸序列至少70％相同程度的氨基酸序列c）与a）和 b）和d）包含a），b）或c）的多核苷酸序列的至少15个连续核苷酸的多核苷酸，以及在所用棒状细菌中扩增zwa1基因的L-氨基酸的发酵制剂的方法。

    Process for the production of L-amino acids by fermentation using coryneform bacteria with an attenuated mqo gene
    93.
    发明授权
    Process for the production of L-amino acids by fermentation using coryneform bacteria with an attenuated mqo gene 有权
    使用具有减毒mqo基因的棒状细菌通过发酵生产L-氨基酸的方法

    公开(公告)号：US07049106B2

    公开(公告)日：2006-05-23

    申请号：US10118325

    申请日：2002-04-09

    申请人： Mike Farwick ,  Brigitte Bathe ,  Thomas Hermann ,  Achim Marx ,  Walter Pfefferle

    发明人： Mike Farwick ,  Brigitte Bathe ,  Thomas Hermann ,  Achim Marx ,  Walter Pfefferle

    IPC分类号： C12P13/04

    CPC分类号： C12N9/0036 ,  C12P13/08

    摘要： A process for the production of an L-amino acid wherein coryneform bacteria (e.g. Coryneform glutamicum) in which expression of the mqo gene coding for malate quinone oxidoreductase is attenuated are fermented to produce a desired amino acid, and the amino acid is concentrated in the medium or cells and isolated. Optionally, further genes in the biosynthetic pathway of the desired amino acid are enhanced, and/or metabolic pathways that reduce formation of the amino acid are suppressed.

    摘要翻译： 其中生产L-氨基酸的方法，其中将其中编码苹果酸醌氧化还原酶的mqo基因的表达减弱的棒状细菌（例如谷氨酸棒杆菌）被发酵以产生所需的氨基酸，并且氨基酸浓缩在 培养基或细胞分离。 任选地，所需氨基酸的生物合成途径中的其它基因被增强，和/或减少氨基酸形成的代谢途径被抑制。

    Nucleotide sequences encoding the pfkA gene
    96.
    发明授权
    Nucleotide sequences encoding the pfkA gene 失效
    编码pfkA基因的核苷酸序列

    公开(公告)号：US06987015B1

    公开(公告)日：2006-01-17

    申请号：US09715035

    申请日：2000-11-20

    申请人： Bettina Möckel ,  Walter Pfefferle

    发明人： Bettina Möckel ,  Walter Pfefferle

    IPC分类号： C12N9/12

    CPC分类号： C12N9/1205 ,  C12P13/08

    摘要： An isolated polynucleotide containing a polynucleotide sequence selected from the following group: a) a polynucleotide which is at least 70% identical to a polynucleotide which codes for a polypeptide containing the amino acid sequence of SEQ ID NO:2, b) a polynucleotide which encodes a polypeptide which contains an amino acid sequence which is at least 70% identical to the amino acid sequence of SEQ ID NO:2, c) a polynucleotide which is complementary to the polynucleotides of a) or b), and d) a polynucleotide containing at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), a process for the fermentative production of L-amino acids with amplification of the pfkA gene and use as primer or hybridisation probe.

    摘要翻译： 含有选自以下组的多核苷酸序列的分离的多核苷酸：a）与编码含有SEQ ID NO：2的氨基酸序列的多肽的多核苷酸至少70％相同的多核苷酸，b）编码 含有与SEQ ID NO：2的氨基酸序列至少70％相同的氨基酸序列的多肽，c）与a）或b）的多核苷酸互补的多核苷酸，以及d）含有 a），b）或c）的多核苷酸序列的至少15个连续核苷酸，用于扩增pfkA基因并用作引物或杂交探针的L-氨基酸的发酵生产的方法。

    Nucleotide sequences coding for the glk-gene
    97.
    发明授权
    Nucleotide sequences coding for the glk-gene 有权
    编码glk基因的核苷酸序列

    公开(公告)号：US06913910B2

    公开(公告)日：2005-07-05

    申请号：US10197541

    申请日：2002-07-18

    申请人： Bettina Möckel ,  Walter Pfefferle

    发明人： Bettina Möckel ,  Walter Pfefferle

    IPC分类号： C12N15/09 ,  C12N1/21 ,  C12N9/02 ,  C12N9/04 ,  C12N9/12 ,  C12N9/14 ,  C12N9/88 ,  C12N9/90 ,  C12N15/31 ,  C12N15/52 ,  C12N15/54 ,  C12N15/63 ,  C12P13/04 ,  C12P13/08 ,  C12R1/15 ,  C12N15/00 ,  C07H21/04 ,  C12N1/20

    CPC分类号： C12N9/1205 ,  C12P13/04 ,  C12P13/08

    摘要： The invention relates to an isolated polynucleotide containing a polynucleotide sequence selected from the group comprising: a) polynucleotide that is at least 70% identical to a polynucleotide coding for a polypeptide that contains the amino acid sequence of SEQ ID No. 2, b) polynucleotide coding for a polypeptide that contains an amino acid sequence that is at least 70% identical to the amino acid sequence of SEQ ID No.2, c) polynucleotide that is complementary to the polynucleotides of a) or b), and d) polynucleotide containing at least 15 successive bases of the polynucleotide sequence of a), b) or c), and processes for the fermentative production of L-amino acids by enhancement of the glk-gene coding for the enzyme glucokinase.

    摘要翻译： 本发明涉及含有多核苷酸序列的分离多核苷酸，所述多核苷酸序列选自：a）与编码含有SEQ ID No.2的氨基酸序列的多肽的多核苷酸至少70％同一性的多核苷酸，b）多核苷酸 编码含有与SEQ ID No.2的氨基酸序列至少70％相同的氨基酸序列的多肽，c）与a）或b）的多核苷酸互补的多核苷酸，和d）含有 a），b）或c）的多核苷酸序列的至少15个连续碱基，以及通过增强编码葡萄糖激酶的glk基因来发酵生产L-氨基酸的方法。