摘要:
In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence.
摘要:
A cylinder lock with a rotating tumbler pin, a sidebar, and a slider has a keyway with a ward projection into the center of the bitting area of a key blade received by the keyway. The tip of each rotating tumbler pin seats on the bitting surfaces remaining to the sides of this center ward of the key, and the tumbler pins that are engaged by the bitting on the side of the key blade do not seat on more than half of the width of the blade. Half the pin width is removed from each tumbler pin near the tip thereof. The key has a bitted section at which one or more bittings are formed and a non-bitted section bitting that is devoid of bitting. The bittings extend at a constant depth to an edge of the key blade.
摘要:
An apparatus for processing a fluid module, including a collapsible vessel supported on a planar substrate, comprises a first actuator component configured to be movable in a first direction is generally parallel to the plane of the substrate, a second actuator component configured to be movable in a second direction having a component that is normal to the plane of the substrate, and a motion conversion mechanism coupling the first actuator component with the second actuator component and configured to convert movement of the first actuator component in the first direction into movement of the second actuator component in the second direction.
摘要:
The present invention provides pharmaceutical compositions comprising substituted 1,4 naphthoquinones that are effective in preventing oligomerization of beta amyloid and subsequent pathologies associated with amyloid fibrils. These compositions are useful for the treatment of disease involving amyloidogenesis including neurodegenerative diseases such as Alzheimer's Disease or senile dementia. Particularly effective compositions comprise 1,4 naphthoquinones substituted with an amino acid residue selected from a heterocyclic or aromatic amino acid.
摘要:
A system for separating an analyte from other components of a sample contained in a receptacle, where the system includes a receptacle holding station and a magnetic separation station. The receptacle holding station is configured to receive and hold a receptacle and includes one or more magnets positioned to apply a magnetic field to the contents of the receptacle. When present in the receptacle holding station, a receptacle remains stationary relative to the one or more magnets. The magnetic separation station includes one or more magnets and is constructed and arranged to perform a magnetic separation procedure on the contents of a receptacle transported from the receptacle holding station to the magnetic separation station by an automated receptacle transport. The magnetic separation procedure includes isolating an analyte immobilized on a magnetically-responsive solid support within the receptacle and removing other components of the sample from the receptacle. The magnetic separation station is configured to provide relative movement between the receptacle and the one or more magnets after the receptacle is transported to the magnetic separation station.
摘要:
A towable farm implement includes a plurality of wheel assemblies coupled to a frame by a plurality of suspension systems. Each suspension system includes an upper support structure and a lower support structure. Each of the upper and lower support structures have a first end configured to be pivotably coupled to the frame about a first pivot axis parallel to a longitudinal axis of the frame, and a second end pivotably coupled to a portion of the wheel assembly about a second pivot axis parallel to the first pivot axis. Each suspension system further includes a damping device having a first end configured to be pivotably coupled to the frame, and a second end pivotably coupled to the wheel assembly. The damping device is configured to move the wheel assembly generally vertically while maintaining the longitudinal position and, optionally, a steering angle of the wheel.
摘要:
A composition for use in making commercial food and skin products comprising R-equol. The composition can be used to make articles of commerce such as food supplements, pharmaceuticals, and medicaments. The compositions are useful in a method of delivering R-equol to a mammal to prevent or treat a disease or associated condition, including hormone-dependent diseases or conditions such as cardiovascular disease, lipid disorder, osteopenia, osteoporosis, liver disease, and acute ovarian estrogen deficiency. The R-equol enantiomer can be produced by chiral-phase column separation from a racemic mixture of equol.
摘要:
The invention relates to a sensor for detection of properties and structures of an organic tissue and its surface, e.g. a fingerprint sensor comprising a chosen number of sensor electrodes at chosen positions for coupling to a finger tissue and its surface having a size less or comparable to the size of the structures, characteristics or properties of the finger tissue or surface, and a processing unit including electronic circuitry connected to said electrodes for detection of the voltage at, or the current flow in the electrodes, thereby providing for detection and collection of information of related capacitance, impedance, electromagnetic field, fingerprint, tissue aliveness or other biometric, physical, physiological, thermal or optical or characteristics or properties of the tissue or its surface positioned over the electrodes, the processing unit being mounted on one side of a substrate and the electrodes being embedded in said substrate, the substrate including through going first, second and third conductive paths between said sensor electrodes and said measurement circuitry. The substrate is made from a polymer material such as Polyimide, implemented as a rigid or a flexible multi layer build-up substrate, said first, second, and third conductive paths are constituted by through going substrate sections of a chosen size and material.
摘要:
An electromechanical lock includes a spring-biased cylinder plug return mechanism for automatically rotating the rotatable plug to a home position after the plug has been rotated from the home position and thereafter released. In one embodiment, the cylinder plug return mechanism comprises a torsional spring coupled to the plug, In a second embodiment, the cylinder plug return mechanism comprises a slider that is coupled to the plug so that rotation of the plug moves the slider, thereby increasing the potential energy in a return spring, and when the plug is released, the increase potential energy is released by moving the slider, and the coupling between the slider and the plug causes the plug to rotate back to a home position.
摘要:
An novel sensor is provided having a plurality of substantially parallel drive lines configured to transmit a signal into a surface of a proximally located object, and also a plurality of substantially parallel pickup lines oriented proximate the drive lines and electrically separated from the pickup lines to form intrinsic electrode pairs that are impedance sensitive at each of the drive and pickup proximal locations.