公开(公告)号：US20240351018A1

公开(公告)日：2024-10-24

申请号：US18628195

申请日：2024-04-05

申请人： Ethan Marschall ,  Barbara Smith

发明人： Ethan Marschall ,  Barbara Smith

IPC分类号： B01L3/02 ,  G01N35/00

CPC分类号： B01L3/0237 ,  G01N35/00584 ,  B01L2300/0654

摘要： An optical system, comprises a mirror cage, a light source optically connected to a first side of the mirror cage via a first fiberoptic cable and a first collimator, an energy sensor optically connected to a second side of the mirror cage opposite the first side, a second fiber optic cable optically connected to a third side of the mirror cage via a second collimator, an avalanche photodiode (APD) optically connected to a fourth side of the mirror cage opposite the third side, and a dichroic mirror positioned within the housing at an angle relative to the first side. An automated micropipette electrode guidance system comprises the optical system as above, and a micropipette electrode connected to the optical system via the second fiber optic cable. Related methods are also disclosed.

公开(公告)号：US12030044B2

公开(公告)日：2024-07-09

申请号：US17765663

申请日：2020-10-01

申请人： HAMILTON BONADUZ AG

发明人： Jonas Hilti ,  Jürg Rast

IPC分类号： B01L3/02

CPC分类号： B01L3/0237 ,  B01L3/0227 ,  B01L2300/0663 ,  B01L2400/0478

摘要： The present application relates to a pipetting device and a pipetting method for pipetting, therefore for aspirating and/or dispensing, a metered liquid using a working gas, independently of the flow- and/or wetting characteristics of the metered liquid, wherein a pipetting channel comprises a first working region, of which the known base temperature is in a lower base temperature range, and a second working region, of which the known working temperature is in a working temperature range that is increased with respect to the base temperature range.

公开(公告)号：US20240189825A1

公开(公告)日：2024-06-13

申请号：US18584953

申请日：2024-02-22

申请人： Mettler-Toledo Rainin, LLC

发明人： Richard Hill ,  Michael McNaul ,  Bob Wells ,  Simon Shakespeare ,  Matthew Newman

IPC分类号： B01L3/00 ,  B01L3/02

CPC分类号： B01L3/54 ,  B01L3/0237 ,  B01L3/0279 ,  A61M2205/6081

摘要： Described are exemplary embodiments of a syringe identification system for use with a positive displacement pipette, such as a handheld powered positive displacement pipette. An exemplary syringe identification system may include a sensor, such as a color sensor, that is located at or near a distal end of the pipette and arranged such that the sensor is operative to read an identifying marking(s) on a syringe that has been installed to the pipette. The sensor may be a color sensor having an illumination source and configured to read a color code on the syringe. The color code may be usable to identify the syringe to the pipette.

公开(公告)号：US11911757B2

公开(公告)日：2024-02-27

申请号：US17258488

申请日：2019-07-09

申请人： Hamilton Bonaduz AG

发明人： Hanspeter Romer ,  Reto Ettinger ,  Fridolin Gysel ,  Jürg Rast ,  Jonas Hilti

IPC分类号： B01L3/02

CPC分类号： B01L3/0227 ,  B01L3/0237 ,  B01L3/0268 ,  B01L2200/14 ,  B01L2300/0663 ,  B01L2400/043 ,  B01L2400/0478

摘要： A pipetting device includes a pipetting channel at least partially filled with working gas, a pipetting tip accessible through a pipetting opening such that the volume of dosing liquid drawn into the receiving chamber can be varied by changing the pressure of the working gas in the receiving chamber, a pipetting piston for changing the pressure of the working gas and accommodated in the pipetting channel to be movable along the pipetting channel, a drive driving the pipetting piston to perform a movement along the pipetting channel, a control device controlling the drive, and a pressure sensor sensing the pressure of the working gas. The control device controls the drive to generate a pressure pulse in the pipetting channel based on the pressure signal output by the pressure sensor whereby the pressure of the working gas during the pulse follows a predefined working gas target pressure pulse curve.

公开(公告)号：US11850582B2

公开(公告)日：2023-12-26

申请号：US17080788

申请日：2020-10-26

申请人： Mettler-Toledo Rainin, LLC

发明人： Michael McNaul ,  Hans Bergmann ,  Richard Hill

IPC分类号： B01L3/02

CPC分类号： B01L3/0227 ,  B01L3/0237 ,  B01L3/0279 ,  B01L2300/027

摘要： Described are exemplary methods for dispensing liquid from a handheld, powered positive displacement pipette.

公开(公告)号：US20230408540A1

公开(公告)日：2023-12-21

申请号：US18207424

申请日：2023-06-08

申请人： TECAN TRADING AG

发明人： Francois UEBELHART ,  Marianne ANGST-HELBLING ,  Werner HÄLG

IPC分类号： G01N35/10 ,  B01L3/02

CPC分类号： G01N35/1011 ,  G01N35/1016 ,  B01L3/0237 ,  G01N35/1079 ,  G01N2035/102 ,  G01N2035/103

摘要： A method is described of operating a pipetting system (10) that has a worktable (12), at least one manipulator arm (18), and first and second Z-rods (20′,20″) arranged on the at least one manipulator arm (18). The method involves receiving by the second Z-rod (20″) a tool (24) via an adapter attached to the second Z-rod (20″), wherein the tool (24) has a central axis and a working area, the working area being defined by a circle which center is located on the central axis of the tool (24) and which radius being a distance between the central axis and a largest extension of an outline of the tool (24) in a projection.

公开(公告)号：US11781959B2

公开(公告)日：2023-10-10

申请号：US16827439

申请日：2020-03-23

申请人： Freenome Holdings, Inc.

发明人： Daniel Delubac

IPC分类号： G01N11/08 ,  G01N35/10 ,  B01L3/02 ,  G01F1/36

CPC分类号： G01N11/08 ,  B01L3/0237 ,  B01L3/0293 ,  G01F1/363 ,  G01N35/1016 ,  B01L3/0279 ,  B01L2200/143 ,  B01L2300/0663 ,  B01L2400/0478 ,  B01L2400/0487 ,  G01N2035/1062

摘要： The present disclosure provides methods and devices for sample extraction.

公开(公告)号：US11697113B2

公开(公告)日：2023-07-11

申请号：US16934243

申请日：2020-07-21

申请人： Eppendorf AG

发明人： Burkhardt Reichmuth

IPC分类号： B01L3/02

CPC分类号： B01L3/0224 ,  B01L3/0234 ,  B01L3/0279 ,  B01L3/0237 ,  B01L2200/0605 ,  B01L2300/025 ,  B01L2300/027 ,  B01L2300/0627 ,  B01L2400/0478

摘要： A pipette with an adjustable dosing increment, wherein a control apparatus determines a dosing volume by a set dosing increment when a syringe is inserted in the pipette, and determines a maximum possible number of dosing steps following an execution of a reverse stroke without refilling the syringe given the set dosing increment and completely or partially filled syringe by the position of a displacement means on the path, and displays the maximum number of dosing steps on a display apparatus until the reverse stroke is executed. The control apparatus also determines the number of executed dosing steps and displays the number of executed dosing steps and/or the number of dosing steps still possible without refilling the syringe on the display apparatus.

公开(公告)号：US11660592B2

公开(公告)日：2023-05-30

申请号：US17175287

申请日：2021-02-12

申请人： DENOVIX, INC.

发明人： Daniel A. Schieffer ,  David L. Ash ,  David B. Ward

IPC分类号： B01L3/02

CPC分类号： B01L3/0224 ,  B01L3/0227 ,  B01L3/0237 ,  B01L3/0279 ,  B01L2400/049 ,  B01L2400/0478

摘要： Multivolume liquid pipettes with nested plunger and vacuum chamber configurations and methods of using such pipettes are disclosed herein. These pipettes typically include a body and a fluid displacement assembly with a small plunger element slideably received within a larger plunger element, each movable within a vacuum chamber for the precise and accurate control of the displacement of fluid, such as air. In turn, this allows for a single device to aspirate and dispense a broad range of liquids in a dynamic, accurate, and precise manner. In addition, the devices disclosed herein may also include a multi-tiered spring-loaded ejection mechanism to allow the user to use and eject pipette tips of different sizes.

公开(公告)号：US20190247846A1

公开(公告)日：2019-08-15

申请号：US15892477

申请日：2018-02-09

申请人： Chris Suh ,  Douglas T. Gjerde ,  Lee Hoang ,  Mark Abel

发明人： Chris Suh ,  Douglas T. Gjerde ,  Lee Hoang ,  Mark Abel

IPC分类号： B01L3/02 ,  C12Q1/6806 ,  B01L3/00 ,  B01L9/06 ,  B01D15/38

CPC分类号： B01L3/0282 ,  B01D15/3804 ,  B01L3/0237 ,  B01L3/5082 ,  B01L9/06 ,  B01L2200/02 ,  B01L2200/0631 ,  B01L2200/0652 ,  B01L2300/0832 ,  C12Q1/6806

摘要： An apparatus and method of using a pipette with pipette tip columns were developed in which a pipette is operated with the pipette tip columns inserted into the wells of a microplate. In this configuration the pipette is free standing and is essentially perpendicular to the microplate. The pipette is hand-held when transferring between positions, e.g., between operation steps that take place in different rows of wells. The open lower ends of the pipette tip column are approximately centered within the plate well. The columns and plate are designed in such a way that the open lower ends of the pipette tip columns are in contact with liquid in the plate well however, the columns do not seal on the well bottom, preventing flow in and out of the column. The pipette contains the appropriate firmware and software to control flow for all steps of pipette tip column operation. In some embodiments, cells are purified from biological samples.