公开(公告)号：US20240351018A1

公开(公告)日：2024-10-24

申请号：US18628195

申请日：2024-04-05

申请人： Ethan Marschall ,  Barbara Smith

发明人： Ethan Marschall ,  Barbara Smith

IPC分类号： B01L3/02 ,  G01N35/00

CPC分类号： B01L3/0237 ,  G01N35/00584 ,  B01L2300/0654

摘要： An optical system, comprises a mirror cage, a light source optically connected to a first side of the mirror cage via a first fiberoptic cable and a first collimator, an energy sensor optically connected to a second side of the mirror cage opposite the first side, a second fiber optic cable optically connected to a third side of the mirror cage via a second collimator, an avalanche photodiode (APD) optically connected to a fourth side of the mirror cage opposite the third side, and a dichroic mirror positioned within the housing at an angle relative to the first side. An automated micropipette electrode guidance system comprises the optical system as above, and a micropipette electrode connected to the optical system via the second fiber optic cable. Related methods are also disclosed.

公开(公告)号：US20240337585A1

公开(公告)日：2024-10-10

申请号：US18626733

申请日：2024-04-04

申请人： Barbara Smith ,  Ethan Marschall ,  Christopher Miranda

发明人： Barbara Smith ,  Ethan Marschall ,  Christopher Miranda

IPC分类号： G01N21/03 ,  G01N21/17

CPC分类号： G01N21/03 ,  G01N21/1702 ,  G01N2201/021

摘要： Aspects of the present invention relate to a cuvette platform including a body having a base and at least one cuvette mounting surface positioned above and parallel to the base and comprising at least one of side retainers and corner retainers configured to retain a cuvette, at least one peripheral mounting surface extending upward from a first edge of the base forming a right angle with the base and configured to receive at least one peripheral, at least one flange extending outward from a second edge of the base forming a right angle with the base and comprising at least one mounting feature.

公开(公告)号：US08706862B2

公开(公告)日：2014-04-22

申请号：US11962425

申请日：2007-12-21

申请人： Jonathan Roll ,  Barbara Smith ,  Joel Freeman

发明人： Jonathan Roll ,  Barbara Smith ,  Joel Freeman

IPC分类号： G06F15/173 ,  G06F15/177

CPC分类号： H04L43/50 ,  H04L41/5003 ,  H04L41/5009 ,  H04L41/5032 ,  H04L43/0811 ,  H04L43/0852

摘要： Methods and apparatus for performing non-intrusive data link layer performance measurement in communication networks are disclosed. An example method to measure data link layer performance between existing network nodes disclosed herein comprises coupling a first intelligent network interface (INI) to an available access port of a first existing network node providing access to a network, wherein the first INI obtains power and input information only from the access port after being coupled thereto, and exchanging test messages between the first INI and a second INI coupled to a second existing network node during normal operation of the first and second existing network nodes to measure data link layer performance, wherein the test messages originate in the first INI and are routed through the first and second existing network nodes using a first data link layer address associated with the first INI and a second data link layer address associated with the second INI.

摘要翻译： 公开了在通信网络中执行非侵入式数据链路层性能测量的方法和装置。 测量本文公开的现有网络节点之间的数据链路层性能的示例性方法包括将第一智能网络接口（INI）耦合到提供对网络的接入的第一现有网络节点的可用接入端口，其中所述第一INI获得电力和输入 在第一和第二现有网络节点的正常操作期间，仅在来自所述接入端口的信息被耦合之后，在所述第一INI和耦合到第二现有网络节点的第二INI之间交换测试消息以测量数据链路层性能，其中， 测试消息始发于第一INI，并且使用与第一INI相关联的第一数据链路层地址和与第二INI相关联的第二数据链路层地址通过第一和第二现有网络节点路由。

公开(公告)号：US20090164626A1

公开(公告)日：2009-06-25

申请号：US11962425

申请日：2007-12-21

申请人： Jonathan Roll ,  Barbara Smith ,  Joel Freeman

发明人： Jonathan Roll ,  Barbara Smith ,  Joel Freeman

IPC分类号： G06F15/173

CPC分类号： H04L43/50 ,  H04L41/5003 ,  H04L41/5009 ,  H04L41/5032 ,  H04L43/0811 ,  H04L43/0852

摘要： Methods and apparatus for performing non-intrusive network layer performance measurement in communication networks are disclosed. An example method to measure network layer performance between existing network nodes disclosed herein comprises coupling a first intelligent network interface (INI) to an available access port of a first existing network node providing access to a network, wherein the first INI obtains power and input information only from the access port after being coupled thereto, and exchanging test messages between the first INI and a second INI coupled to a second existing network node during normal operation of the first and second existing network nodes to measure network layer performance, wherein the test messages originate in the first INI and are routed through the first and second existing network nodes using a first network layer address associated with the first INI and a second network layer address associated with the second INI.

公开(公告)号：US20230400412A1

公开(公告)日：2023-12-14

申请号：US18455470

申请日：2023-08-24

申请人： Barbara Smith ,  Joel Lusk

发明人： Barbara Smith ,  Joel Lusk

IPC分类号： G01N21/64 ,  G01N15/14

CPC分类号： G01N21/6458 ,  G01N15/14 ,  G01N21/6402 ,  G02B21/0076

摘要： The disclosure provides a system, compositions, and methods for detecting ovarian cancer cells by photoacoustic flow cytometry.

公开(公告)号：US20050040109A1

公开(公告)日：2005-02-24

申请号：US10646393

申请日：2003-08-22

申请人： Barbara Smith ,  Thomas Robison

发明人： Barbara Smith ,  Thomas Robison

IPC分类号： B01D61/00 ,  B01D61/14 ,  B01D61/16

CPC分类号： B01D61/145 ,  B01D61/16 ,  B01D2311/04 ,  B01D2311/12 ,  B01D2311/2603

摘要： A method separating for small molecules from an aqueous solution is presented. The method can be used selectively separate small molecules from a solution while leaving untargeted molecules dissolved in the solution. The method uses polymer filtration to selectively remove the small molecules from the aqueous solution. An aqueous solution containing the dissolved small molecule is contacted with a polymer which is capable of forming a complex with the small molecule. The aqueous solution is then subjected to ultrafiltration which creates a concentrated solution of the polymer-small molecule complex. The small molecule may be released from the polymer and the polymer recycled for another round of removal.

摘要翻译： 提出了从水溶液中分离小分子的方法。 该方法可以选择性地从溶液中分离出小分子，同时留下溶解在溶液中的非靶向分子。 该方法使用聚合物过滤从水溶液中选择性地除去小分子。 含有溶解的小分子的水溶液与能够与小分子形成络合物的聚合物接触。 然后对水溶液进行超滤，产生聚合物 - 小分子复合物的浓缩溶液。 小分子可以从聚合物中释放出来，聚合物再循环再循环一次。

公开(公告)号：US12082938B2

公开(公告)日：2024-09-10

申请号：US17533278

申请日：2021-11-23

申请人： Barbara Smith ,  Christopher Miranda

发明人： Barbara Smith ,  Christopher Miranda

IPC分类号： A61B5/00 ,  G01N15/10 ,  G01N15/01

CPC分类号： A61B5/4064 ,  A61B5/0095 ,  G01N15/1023 ,  G01N15/01 ,  G01N2015/1006

摘要： A system for measuring a membrane potential is disclosed. The system comprises a photoacoustic probe including a laser and an ultrasound transducer. The laser is configured to emit a light signal at one or more wavelengths to a neuronal cell. The neuronal cell may comprise a voltage-sensitive protein configured to absorb the light signal in a voltage-dependent manner. The ultrasound transducer is configured to receive a photoacoustic signal from the voltage-sensitive protein in response to absorbing the light signal. The system further comprises a processor configured to receive the photoacoustic signal from the ultrasound transducer and calculate a membrane potential of the neuron based on the photoacoustic signal. Methods of measuring a membrane potential and biomaterials related to the voltage-sensitive protein are also disclosed herein.

公开(公告)号：US20220331803A1

公开(公告)日：2022-10-20

申请号：US17715352

申请日：2022-04-07

申请人： Barbara Smith ,  Jarrett Eshima ,  Joel Lusk ,  Benjamin Ambrose

发明人： Barbara Smith ,  Jarrett Eshima ,  Joel Lusk ,  Benjamin Ambrose

IPC分类号： B01L3/00

摘要： A collection device for collecting volatile organic compounds (VOCs) from a living biological sample is disclosed. The collection device comprises a housing defining an interior chamber and an inlet and outlet each fluidly communicating with the interior chamber. The housing is formed by an upper surface, a lower surface, and a substantially circular sidewall extending between the upper and lower surfaces. The interior chamber comprises a substantially cylindrical volume enclosed by the housing and configured to receive the living biological sample. The inlet and the outlet may extend through the upper surface and may be substantially diametrically opposed with respect to the circular sidewall. The collection device may be configured to pass fluid in a substantially laminar flow path through the inlet, across the interior chamber, and out of the outlet. At least a portion of the housing may comprise a substantially transparent material configured to transmit light therethrough.

公开(公告)号：US20190110691A1

公开(公告)日：2019-04-18

申请号：US16159167

申请日：2018-10-12

申请人： Barbara Smith ,  Christopher Miranda

发明人： Barbara Smith ,  Christopher Miranda

IPC分类号： A61B5/00 ,  G01N21/17 ,  G01N29/24

摘要： Photoacoustic targeting systems for intracellular recording. In one embodiment, the photoacoustic targeting system includes a light source, a micropipette electrode, an acoustic transducer, and a controller. The light source is configured to emit pulsed light. The micropipette electrode is configured to deliver the pulsed light to a target cell. The acoustic transducer is configured to receive photoacoustic signals generated due to optical absorption of light energy by the target cell. The controller is configured to determine a position of the micropipette electrode relative to the target cell based on the photoacoustic signals.

公开(公告)号：US20150052773A1

公开(公告)日：2015-02-26

申请号：US13970662

申请日：2013-08-20

申请人： Amelia Thomas ,  Barbara Smith

发明人： Amelia Thomas ,  Barbara Smith

IPC分类号： A45D20/18

CPC分类号： A45D20/18

摘要： A portable hands free hair dryer that gently dries the hair of a user The hair dyer comprises a flexible bonnet having heating coils disposed within, a fan blowing unit, and an air hose connecting the two. When the device is powered on, the heating coils warm the area around the user's hair and scalp, and the fan blows air up through the air hose into the bonnet. Warm air in the bonnet is blown around, drying the user's hair. The fan unit is a small portable unit that can be clipped to a user's clothing, and may be used while cordless or plugged into a wall socket. In either manner of use, the device dries the user's hair without the need for user participation.

摘要翻译： 便携式免提吹风机，其轻轻地干燥使用者的头发。染发机包括具有设置在其内的加热线圈的柔性发动机罩，风扇吹风单元和连接两者的空气软管。 当设备通电时，加热线圈会加热用户头发和头皮周围的区域，风扇将空气吹过空气软管进入发动机罩。 发动机罩中的暖风吹过，干燥使用者的头发。 风扇单元是一个小型便携式单元，可以被夹到用户的衣服上，可以在无绳或插入墙上插座时使用。 以任何一种使用方式，该装置干燥使用者的头发而不需要用户参与。