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公开(公告)号：US12013069B2
公开(公告)日：2024-06-18
申请号：US17010331
申请日：2020-09-02
Inventor： Clemens E. Zoellner , Jason Osentoski
CPC classification number: F16L47/32 , B29C33/0033 , B29C45/2624 , B29C45/2626 , B29C45/2628 , F16L41/021 , F16L41/03
Abstract: A fluid manifold may include a body that may include a proximal end, a distal end, and a primary manifold component extending from the proximal end of the body to the distal end of the body and enclosing a primary channel. The fluid manifold may further include at least one auxiliary manifold component diverging from the primary manifold component and enclosing an auxiliary channel connected to the primary channel at a primary channel exit port. The fluid manifold may further include at least one compression valve region disposed along the body of the manifold where the compression valve region may be operable between an open position and a closed position.
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公开(公告)号：US11884468B2
公开(公告)日：2024-01-30
申请号：US17646246
申请日：2021-12-28
Inventor： Thomas R. Nixon , Clemens E. Zoellner , Jason Osentoski , Joshua Martell
CPC classification number: B65D71/50 , A61B50/3001 , B65D81/18 , B65D85/24
Abstract: The present application is directed to a packaging container including a body including; a first portion including a coupling feature; a second portion including a coupling feature and complementary to the first portion; and a hinge portion coupling the first portion to the second portion adapted to move the packaging container from an open position to a closed position around a product, where the first portion and the second portion combine to form a void port in the closed position.
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公开(公告)号：US12226846B2
公开(公告)日：2025-02-18
申请号：US17182669
申请日：2021-02-23
Inventor： Jianfeng Zhang , Rachel Z. Pytel , Jian L. Ding , Anthony P. Pagliaro , Clemens E. Zoellner
IPC: B23K10/02 , B29C65/20 , H05H1/26 , B23K103/00
Abstract: Systems and methods are disclosed that include an operation chamber, a plasma generator having at least one plasma head disposed within the operation chamber and in proximity to a profile formed by cutting a piece of tubing, and a mechanical motion module. The plasma generator generates a plasma treatment and applies the plasma treatment via the at least one plasma head to the profile to activate material on an end surface of the profile, within a lumen of the profile, or a combination thereof. Once the material of the profile is activated by the plasma treatment, the mechanical motion module manipulates the profile to close the lumen of the profile to aseptically seal the profile.
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公开(公告)号：US11666743B2
公开(公告)日：2023-06-06
申请号：US16682066
申请日：2019-11-13
Inventor： Albert A. Werth , Clemens E. Zoellner
CPC classification number: A61M39/22 , A61M39/16 , F16K5/0414 , F16K5/0442 , A61M2039/2486 , A61M2205/33
Abstract: A valve comprising: a valve body; and a valve stem disposed at least partially within the valve body, the valve stem comprising a sidewall defining a central lumen and at least one opening in the sidewall, wherein the valve is adapted to prevent fluid flow through the lumen when the at least one opening is disposed within the valve body and permit fluid flow through the lumen when the at least one opening is exposed from the valve body, and wherein the valve is essentially free of a spring.
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公开(公告)号：US11987784B2
公开(公告)日：2024-05-21
申请号：US17348961
申请日：2021-06-16
Inventor： Clemens E. Zoellner , Thomas R. Nixon , Jonathon Wheatley
CPC classification number: C12M33/04 , B01L3/0293 , B01L3/502 , B01L13/00 , C12M23/22 , C12M23/28 , C12M23/38 , C12M37/00 , G01N1/14 , B01L2300/042 , B01L2300/168 , B01L2400/0406 , B01L2400/06 , G01N2001/1427
Abstract: The present application is directed to a sampling system for sampling a fluid from a vessel, where the sampling system includes a sterile dispenser assembly operatively connected to the vessel, the sterile dispenser assembly including a valve operatively connected to the vessel, a membrane, and a needle, and a detachable sterile sampling container assembly operatively connected to the sterile dispenser assembly, the detachable sterile sampling container assembly including a sampling container, a membrane attached to the sampling container, and a sampling container housing enclosing the sampling container, where the sampling container housing includes a compressible portion having a deflated configuration and an expanded configuration.
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Patent Agency Ranking
公开(公告)号：US20210291291A1
公开(公告)日：2021-09-23
申请号：US17182669
申请日：2021-02-23
Inventor： Jianfeng Zhang , Rachel Z. Pytel , Jian L. Ding , Anthony P. Pagliaro , Clemens E. Zoellner
Abstract: Systems and methods are disclosed that include an operation chamber, a plasma generator having at least one plasma head disposed within the operation chamber and in proximity to a profile formed by cutting a piece of tubing, and a mechanical motion module. The plasma generator generates a plasma treatment and applies the plasma treatment via the at least one plasma head to the profile to activate material on an end surface of the profile, within a lumen of the profile, or a combination thereof. Once the material of the profile is activated by the plasma treatment, the mechanical motion module manipulates the profile to close the lumen of the profile to aseptically seal the profile.
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公开(公告)号：US20210178506A1
公开(公告)日：2021-06-17
申请号：US16952414
申请日：2020-11-19
Inventor： Jianfeng ZHANG , Rachel Z. Pytel , Anthony P. Pagliaro , Clemens E. Zoellner , Jian L. Ding , Thomas R. Nixon
Abstract: Systems and methods are disclosed that include generating a plasma treatment and applying the plasma treatment to end contact surfaces of a first profile and a second profile in a sterile environment, manipulating at least one of the first profile and the second profile to force contact between the end contact surface of the first profile and the end contact surface of the second profile to permanently connect, join, or weld the end contact surfaces of the first profile and the second profile together, thereby forming a sterile connection between the first profile and a second profile.
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公开(公告)号：US10794525B2
公开(公告)日：2020-10-06
申请号：US14948020
申请日：2015-11-20
Inventor： Brandon J. Pennock , Clemens E. Zoellner , Gerald M. Pennington
Abstract: A leak-proof fluid transfer assembly including a thermoplastic tube, a thermoset tube, and connector coupling the thermoplastic tube and the thermoset tube, where the fluid transfer assembly is adapted to maintain a substantially leak-proof fluid connection between the thermoplastic tube and the thermoset tube after autoclave sterilization.
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公开(公告)号：US09663750B2
公开(公告)日：2017-05-30
申请号：US14713592
申请日：2015-05-15
Inventor： Mitchell L. Snyder , Clemens E. Zoellner , Thomas R. Nixon
CPC classification number: C12M23/04 , B01L3/0289 , B01L3/527 , B01L3/563 , B01L9/00 , B01L9/06 , C12M23/40 , C12M23/54 , C12M29/00
Abstract: A manufacturing article adapted for use in the production of pharmaceuticals comprising a tray comprising a base having a top surface; and a manifold extending from the top surface of the base, the manifold comprising a sidewall and an upper surface, the upper surface further comprising a channel, wherein, when viewed from the top surface, the base has an area, AB, the upper surface of the manifold has an area AM, and AB>AM, and wherein the base is adapted to support a plurality of vessels each adapted to contain a fluid.
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公开(公告)号：US20150329812A1
公开(公告)日：2015-11-19
申请号：US14713592
申请日：2015-05-15
Inventor： Mitchell L. Snyder , Clemens E. Zoellner , Thomas R. Nixon
CPC classification number: C12M23/04 , B01L3/0289 , B01L3/527 , B01L3/563 , B01L9/00 , B01L9/06 , C12M23/40 , C12M23/54 , C12M29/00
Abstract: A manufacturing article adapted for use in the production of pharmaceuticals comprising a tray comprising a base having a top surface; and a manifold extending from the top surface of the base, the manifold comprising a sidewall and an upper surface, the upper surface further comprising a channel, wherein, when viewed from the top surface, the base has an area, AB, the upper surface of the manifold has an area AM, and AB>AM, and wherein the base is adapted to support a plurality of vessels each adapted to contain a fluid.
Abstract translation: 适用于制造药物的制造制品，其包含托盘，所述托盘包括具有顶表面的基底; 以及从所述基座的顶表面延伸的歧管，所述歧管包括侧壁和上表面，所述上表面还包括通道，其中，当从所述顶表面观察时，所述基部具有面积AB，所述上表面 所述歧管具有面积AM和AB> AM，并且其中所述底座适于支撑各自容纳流体的多个容器。
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