公开(公告)号：US10793518B2

公开(公告)日：2020-10-06

申请号：US15894057

申请日：2018-02-12

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Wenjun Zhou ,  Kyle Gee ,  Yolanda Tennico ,  Peter Slade ,  Hee Chol Kang ,  Shaheer Khan ,  Brian Evans ,  James Stray

IPC: C07C309/47 ,  C07D311/84 ,  C07C309/51 ,  G01N33/58

Abstract: The present disclosure is directed dye compounds containing a hydrazinyl substituent and optionally, one or more negatively charged groups, such as sulfonate, phosphate, phosphonate, and/or carboxylate groups and dye compounds containing an aminooxy substitutent. The compounds are useful in the detection of analytes containing aldehyde and ketone groups, including, for example, glycans.

公开(公告)号：US10246410B2

公开(公告)日：2019-04-02

申请号：US15529437

申请日：2015-12-03

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Wenjun Zhou ,  Kyle Gee ,  Yolanda Tennico ,  Peter Slade ,  Hee Chol Kang ,  Shaheer Khan ,  Brian Evans ,  James Stray

IPC: C07C309/47 ,  G01N33/58 ,  C07D311/84 ,  C07C309/51

Abstract: The present disclosure is directed dye compounds containing a hydrazinyl substituent and optionally, one or more negatively charged groups, such as sulfonate, phosphate, phosphonate, and/or carboxylate groups and dye compounds containing an aminooxy substitutent. The compounds are useful in the detection of analytes containing aldehyde and ketone groups, including, for example, glycans.

公开(公告)号：US11820978B2

公开(公告)日：2023-11-21

申请号：US17146163

申请日：2021-01-11

Applicant: Life Technologies Corporation

Inventor： James Stray ,  Jason Yingjie Liu ,  Maxim Brevnov ,  Jaiprakash Shewale ,  Allison Holt

IPC: C12Q1/6806 ,  C12N15/10 ,  C12N1/06

CPC classification number: C12N15/1003 ,  C12N1/06 ,  C12N15/1006 ,  C12N15/1013 ,  C12Q1/6806

Abstract: The present teachings relate to the extraction of nucleic acid from solid materials. Provided are useful compositions, methods, and kits for obtaining nucleic acids from a solid biological sample or an adhesive material having a biological material adherent or embedded within the adhesive substrate. The extracted nucleic acid can be used in downstream applications such as genotyping, detection, quantification, and identification of the source of the biological material.

公开(公告)号：US10894957B2

公开(公告)日：2021-01-19

申请号：US16013938

申请日：2018-06-21

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： James Stray ,  Jason Yingjie Liu ,  Maxim Brevnov ,  Jaiprakash Shewale ,  Allison Holt

IPC: C12N15/10 ,  C12N1/06 ,  C12Q1/6806

Abstract: The present teachings relate to the extraction of nucleic acid from solid materials. Provided are useful compositions, methods and kits for obtaining nucleic acids from a solid biological sample or an adhesive material having a biological material adherent or embedded within the adhesive substrate. The extracted nucleic acid can be used in downstream applications such as genotyping, detection, quantification, and identification of the source of the biological material.

公开(公告)号：US10309959B2

公开(公告)日：2019-06-04

申请号：US15532271

申请日：2015-12-03

Applicant: Life Technologies Corporation

Inventor： James Stray ,  Shaheer H. Khan

IPC: G01N33/53 ,  G01N33/533 ,  C12Q1/6876 ,  C12Q1/40 ,  G01N33/58 ,  G01N27/447 ,  G16C20/90 ,  G01N30/00 ,  G01N33/66 ,  G16C99/00 ,  G01N30/34 ,  G01N30/88

Abstract: Methods, systems, compositions and kits are described for detecting cleaved glycans from a glycoconjugate. After labeling the glycan with a nucleic acid charged oligomer described herein, the labeled glycans can be separated under the influence of an electric field or based on their detectable tag and identified.