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77 条记录 (耗时 0.047 秒)

    Condomless External Catheter
    1.
    发明公开
    Condomless External Catheter 审中-公开

    公开(公告)号：US20240350297A1

    公开(公告)日：2024-10-24

    申请号：US18640918

    申请日：2024-04-19

    申请人： Zachary Walter Newman ,  Abbie Riva Harooni

    发明人： Zachary Walter Newman ,  Abbie Riva Harooni

    IPC分类号： A61F5/453 ,  A61F5/44 ,  A61F5/441

    CPC分类号： A61F5/453 ,  A61F5/4401 ,  A61F5/4407 ,  A61F5/441

    摘要： A urine collection system for a male person generally includes a portable collection pouch having a chamber configured to receiving an absorbent pad. A penis receptable having an elastomeric band securely positions the penis of the person so that urine enters the chamber. Pull tabs can be used to expand an opening defined by the band. The absorbent pad has a hole or is otherwise configured such that the penis shaft can extend through the pad. An opposite side of the pouch from the penis receptable can have an opening through which a Foley catheter can be inserted. The pouch can have another opening for insertion and removal of pads.

    ANTIBODIES WHICH BIND HUMAN CXCR3
    3.
    发明申请
    ANTIBODIES WHICH BIND HUMAN CXCR3 审中-公开
    抗体人类CXCR3

    公开(公告)号：US20110280875A1

    公开(公告)日：2011-11-17

    申请号：US13170233

    申请日：2011-06-28

    申请人： Shixin Qin ,  Nasim Kassam ,  Walter Newman

    发明人： Shixin Qin ,  Nasim Kassam ,  Walter Newman

    IPC分类号： A61K39/395 ,  G01N33/566 ,  A61P37/06 ,  A61P35/00 ,  A61P29/00 ,  A61P37/00

    CPC分类号： C07K16/2866 ,  A61K47/6849 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/76

    摘要： Antibodies and antigen-binding fragments of antibodies that bind human CXCR3 are disclosed. In preferred embodiments, the antibodies are human. Nucleic acids and vectors encoding the antibodies or portions thereof, recombinant cells that contain the nucleic acids, and compositions comprising the antibodies or antigen-binding fragments are also disclosed. The invention also provides therapeutic and diagnostic methods which employ the antibodies and antigen-binding fragments.

    摘要翻译： 公开了结合人CXCR3的抗体的抗体和抗原结合片段。 在优选的实施方案中，抗体是人。 还公开了编码抗体或其部分的核酸和载体，含有核酸的重组细胞，以及包含抗体或抗原结合片段的组合物。 本发明还提供了使用抗体和抗原结合片段的治疗和诊断方法。

    Method of diagnosis of inflammatory disease using eotaxin antibodies
    4.
    发明授权
    Method of diagnosis of inflammatory disease using eotaxin antibodies 失效
    使用嗜酸细胞活化趋化因子抗体诊断炎性疾病的方法

    公开(公告)号：US07858326B2

    公开(公告)日：2010-12-28

    申请号：US12221458

    申请日：2008-08-01

    申请人： Paul D. Ponath ,  Shixin Qin ,  Douglas J. Ringler ,  Walter Newman ,  Charles Mackay

    发明人： Paul D. Ponath ,  Shixin Qin ,  Douglas J. Ringler ,  Walter Newman ,  Charles Mackay

    IPC分类号： G01N33/53 ,  G01N33/567

    CPC分类号： C07K16/24 ,  A61K38/00 ,  A61K47/642 ,  C07K14/523 ,  C07K14/7158 ,  C07K2317/76 ,  C07K2319/00

    摘要： The invention relates to isolated and/or recombinant nucleic acids which encode a human chemotactic cytokine designated human eotaxin, and to isolated and/or recombinant human eotaxin proteins or polypeptides, including synthetic polypeptides. The invention further relates to recombinant nucleic acid constructs, comprising a nucleic acid which encodes a human eotaxin, a portion thereof, or a variant; to host cells comprising such constructs, useful for the production of recombinant human eotaxin; and to antibodies reactive with human eotaxin, useful in in vitro methods, diagnosis and/or therapy. Also provided are methods of use of the eotaxin proteins, e.g., in the recruitment of eosinophils to a particular site or in the treatment of allergic conditions. Human eotaxins can be used to identify inhibitors (e.g., antagonists) or promoters (agonists) of human eotaxin, which can be used to selectively modulate leukocyte function, in inflammatory and autoimmune diseases, or in infections.

    摘要翻译： 本发明涉及编码人类趋化性细胞因子（命名为人类嗜酸细胞活化趋化因子）的分离和/或重组核酸，以及包含合成多肽的分离和/或重组人类嗜酸细胞活化趋化因子蛋白或多肽。 本发明还涉及重组核酸构建体，其包含编码人类嗜酸细胞活化趋化因子，其部分或变体的核酸; 包含可用于生产重组人类嗜酸性粒细胞趋化因子的这种构建体的宿主细胞; 以及可用于体外方法，诊断和/或治疗的与人嗜酸细胞活化趋化因子反应的抗体。 还提供了使用嗜酸细胞活化趋化因子蛋白质的方法，例如将嗜酸性粒细胞募集到特定部位或用于治疗过敏性病症。 人类嗜酸性粒细胞趋化因子可用于鉴定可用于选择性调节白细胞功能，炎性和自身免疫疾病或感染的人类嗜酸细胞活化趋化因子的抑制剂（例如拮抗剂）或启动子（激动剂）。

    Humanized immunoglobulin reactive with α4β7 integrin
    9.
    发明授权
    Humanized immunoglobulin reactive with α4β7 integrin 有权
    人源化免疫球蛋白与α4β7整合素反应

    公开(公告)号：US07402410B2

    公开(公告)日：2008-07-22

    申请号：US11511164

    申请日：2006-08-28

    申请人： Paul D. Ponath ,  Douglas J. Ringler ,  S. Tarran Jones ,  Walter Newman ,  José Saldanha ,  Mary M. Bendig

    发明人： Paul D. Ponath ,  Douglas J. Ringler ,  S. Tarran Jones ,  Walter Newman ,  José Saldanha ,  Mary M. Bendig

    IPC分类号： C12N15/13 ,  C12N15/63 ,  C12N5/10 ,  C12P21/04

    CPC分类号： C07K16/2839 ,  A61K38/00 ,  C07K14/70503 ,  C07K2317/24 ,  C07K2319/00

    摘要： The present invention relates to isolated nucleic acids encoding humanized immunoglobulins having binding specificity for α4β7 integrin, isolated nucleic acids encoding a humanized immunoglobulin heavy chain and isolated nucleic acids encoding a humanized light chain having binding specificity for α4β7 integrin. The invention also relates to expression vectors and host cells comprising a nucleotide sequence which encodes a humanized immunoglobulin or antigen-binding fragment thereof having binding specificity for α4β7. The invention further relates to methods of preparing a humanized immunoglobulin, humanized immunoglobulin heavy chain and humanized immunoglobulin light chain that has binding specificity for α4β7 integrin.

    摘要翻译： 本发明涉及编码对α4β7整联蛋白具有结合特异性，编码人源化免疫球蛋白重链的分离的核酸和编码具有α4β7整联蛋白的结合特异性的人源化轻链的分离的核酸的分离的核酸。 本发明还涉及包含编码具有对α4β7具有结合特异性的人源化免疫球蛋白或其抗原结合片段的核苷酸序列的表达载体和宿主细胞。 本发明还涉及制备对α4β7整联蛋白具有结合特异性的人源化免疫球蛋白，人源化免疫球蛋白重链和人源化免疫球蛋白轻链的方法。

    Human chemotactic cytokine
    10.
    发明申请
    Human chemotactic cytokine 失效

    公开(公告)号：US20060141567A1

    公开(公告)日：2006-06-29

    申请号：US11133140

    申请日：2005-05-19

    申请人： Paul Ponath ,  Shixin Qin ,  Douglas Ringler ,  Walter Newman ,  Charles Mackay

    发明人： Paul Ponath ,  Shixin Qin ,  Douglas Ringler ,  Walter Newman ,  Charles Mackay

    IPC分类号： C12P21/06 ,  C07H21/04 ,  C07K14/74

    CPC分类号： C07K16/24 ,  A61K38/00 ,  A61K47/642 ,  C07K14/523 ,  C07K14/7158 ,  C07K2317/76 ,  C07K2319/00

    摘要： The invention relates to isolated and/or recombinant nucleic acids which encode a human chemotactic cytokine designated human eotaxin, and to isolated and/or recombinant human eotaxin proteins or polypeptides, including synthetic polypeptides. The invention further relates to recombinant nucleic acid constructs, comprising a nucleic acid which encodes a human eotaxin, a portion thereof, or a variant; to host cells comprising such constructs, useful for the production of recombinant human eotaxin; and to antibodies reactive with human eotaxin, useful in in vitro methods, diagnosis and/or therapy. Also provided are methods of use of the eotaxin proteins, e.g., in the recruitment of eosinophils to a particular site or in the treatment of allergic conditions. Human eotaxins can be used to identify inhibitors (e.g., antagonists) or promoters (agonists) of human eotaxin, which can be used to selectively modulate leukocyte function, in inflammatory and autoimmune diseases, or in infections.