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公开(公告)号：US09163084B2
公开(公告)日：2015-10-20
申请号：US13170233
申请日：2011-06-28
申请人： Shixin Qin , Nasim Kassam , Walter Newman
发明人： Shixin Qin , Nasim Kassam , Walter Newman
CPC分类号： C07K16/2866 , A61K47/6849 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/76
摘要： Antibodies and antigen-binding fragments of antibodies that bind human CXCR3 are disclosed. In preferred embodiments, the antibodies are human. Nucleic acids and vectors encoding the antibodies or portions thereof, recombinant cells that contain the nucleic acids, and compositions comprising the antibodies or antigen-binding fragments are also disclosed. The invention also provides therapeutic and diagnostic methods which employ the antibodies and antigen-binding fragments.
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公开(公告)号：US07994287B2
公开(公告)日：2011-08-09
申请号：US12214891
申请日：2008-06-23
申请人： Shixin Qin , Nasim Kassam , Walter Newman
发明人： Shixin Qin , Nasim Kassam , Walter Newman
CPC分类号： C07K16/2866 , A61K47/6849 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/76
摘要： Antibodies and antigen-binding fragments of antibodies that bind human CXCR3 are disclosed. In preferred embodiments, the antibodies are human. Nucleic acids and vectors encoding the antibodies or portions thereof, recombinant cells that contain the nucleic acids, and compositions comprising the antibodies or antigen-binding fragments are also disclosed. The invention also provides therapeutic and diagnostic methods which employ the antibodies and antigen-binding fragments.
摘要翻译： 公开了结合人CXCR3的抗体的抗体和抗原结合片段。 在优选的实施方案中，抗体是人。 还公开了编码抗体或其部分的核酸和载体，含有核酸的重组细胞，以及包含抗体或抗原结合片段的组合物。 本发明还提供了使用抗体和抗原结合片段的治疗和诊断方法。
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公开(公告)号：US20050112119A1
公开(公告)日：2005-05-26
申请号：US10949135
申请日：2004-09-24
申请人： Shixin Qin , Nasim Kassam , Walter Newman
发明人： Shixin Qin , Nasim Kassam , Walter Newman
IPC分类号： A61K39/395 , C07H21/04 , C07K20060101 , C07K16/28 , C12N5/06
CPC分类号： C07K16/2866 , A61K47/6849 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/76
摘要： Antibodies and antigen-binding fragments of antibodies that bind human CXCR3 are disclosed. In preferred embodiments, the antibodies are human. Nucleic acids and vectors encoding the antibodies or portions thereof, recombinant cells that contain the nucleic acids, and compositions comprising the antibodies or antigen-binding fragments are also disclosed. The invention also provides therapeutic and diagnostic methods which employ the antibodies and antigen-binding fragments.
摘要翻译： 公开了结合人CXCR3的抗体的抗体和抗原结合片段。 在优选的实施方案中，抗体是人。 还公开了编码抗体或其部分的核酸和载体，含有核酸的重组细胞，以及包含抗体或抗原结合片段的组合物。 本发明还提供了使用抗体和抗原结合片段的治疗和诊断方法。
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公开(公告)号：US06723570B2
公开(公告)日：2004-04-20
申请号：US09961068
申请日：2001-09-21
申请人： Shixin Qin , Walter Newman , Nasim Kassam
发明人： Shixin Qin , Walter Newman , Nasim Kassam
IPC分类号： G01N33566
CPC分类号： C07K16/2866 , A61K2039/505
摘要： The present invention relates to an antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 1 (CCR1) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR1 with a ligand thereof, and to use of the antibodies and fragments in research, therapeutic, prophylactic and diagnostic methods.
摘要翻译： 本发明涉及与哺乳动物（例如人）CC趋化因子受体1（CCR1）或受体的一部分结合并阻断配体与受体的结合的抗体或其功能片段。 本发明还涉及抑制携带哺乳动物CCR1的细胞与其配体的相互作用的方法，以及在研究，治疗，预防和诊断方法中使用抗体和片段。
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公开(公告)号：US20110280875A1
公开(公告)日：2011-11-17
申请号：US13170233
申请日：2011-06-28
申请人： Shixin Qin , Nasim Kassam , Walter Newman
发明人： Shixin Qin , Nasim Kassam , Walter Newman
IPC分类号： A61K39/395 , G01N33/566 , A61P37/06 , A61P35/00 , A61P29/00 , A61P37/00
CPC分类号： C07K16/2866 , A61K47/6849 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/76
摘要： Antibodies and antigen-binding fragments of antibodies that bind human CXCR3 are disclosed. In preferred embodiments, the antibodies are human. Nucleic acids and vectors encoding the antibodies or portions thereof, recombinant cells that contain the nucleic acids, and compositions comprising the antibodies or antigen-binding fragments are also disclosed. The invention also provides therapeutic and diagnostic methods which employ the antibodies and antigen-binding fragments.
摘要翻译： 公开了结合人CXCR3的抗体的抗体和抗原结合片段。 在优选的实施方案中，抗体是人。 还公开了编码抗体或其部分的核酸和载体，含有核酸的重组细胞，以及包含抗体或抗原结合片段的组合物。 本发明还提供了使用抗体和抗原结合片段的治疗和诊断方法。
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公开(公告)号：US06329510B1
公开(公告)日：2001-12-11
申请号：US09239938
申请日：1999-01-29
申请人： Shixin Qin , Walter Newman , Nasim Kassam
发明人： Shixin Qin , Walter Newman , Nasim Kassam
IPC分类号： C07K1628
CPC分类号： C07K16/2866 , A61K2039/505
摘要： The present invention relates to an antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 1 (CCR1) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR1 with a ligand thereof, and to use of the antibodies and fragments in research, therapeutic, prophylactic and diagnostic methods.
摘要翻译： 本发明涉及与哺乳动物（例如人）CC趋化因子受体1（CCR1）或受体的一部分结合并阻断配体与受体的结合的抗体或其功能片段。 本发明还涉及抑制携带哺乳动物CCR1的细胞与其配体的相互作用的方法，以及在研究，治疗，预防和诊断方法中使用抗体和片段。
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公开(公告)号：US20090285835A1
公开(公告)日：2009-11-19
申请号：US12214891
申请日：2008-06-23
申请人： Shixin Qin , Nasim Kassam , Walter Newman
发明人： Shixin Qin , Nasim Kassam , Walter Newman
IPC分类号： A61K39/395 , C07K16/28 , C12N5/06 , C07H21/00
CPC分类号： C07K16/2866 , A61K47/6849 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/76
摘要： Antibodies and antigen-binding fragments of antibodies that bind human CXCR3 are disclosed. In preferred embodiments, the antibodies are human. Nucleic acids and vectors encoding the antibodies or portions thereof, recombinant cells that contain the nucleic acids, and compositions comprising the antibodies or antigen-binding fragments are also disclosed. The invention also provides therapeutic and diagnostic methods which employ the antibodies and antigen-binding fragments.
摘要翻译： 公开了结合人CXCR3的抗体的抗体和抗原结合片段。 在优选的实施方案中，抗体是人。 还公开了编码抗体或其部分的核酸和载体，含有核酸的重组细胞，以及包含抗体或抗原结合片段的组合物。 本发明还提供了使用抗体和抗原结合片段的治疗和诊断方法。
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公开(公告)号：US07405275B2
公开(公告)日：2008-07-29
申请号：US10949135
申请日：2004-09-24
申请人： Shixin Qin , Nasim Kassam , Walter Newman
发明人： Shixin Qin , Nasim Kassam , Walter Newman
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , C12N5/06
CPC分类号： C07K16/2866 , A61K47/6849 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/76
摘要： Antibodies and antigen-binding fragments of antibodies that bind human CXCR3 are disclosed. In preferred embodiments, the antibodies are human. Nucleic acids and vectors encoding the antibodies or portions thereof, recombinant cells that contain the nucleic acids, and compositions comprising the antibodies or antigen-binding fragments are also disclosed. The invention also provides therapeutic and diagnostic methods which employ the antibodies and antigen-binding fragments.
摘要翻译： 公开了结合人CXCR3的抗体的抗体和抗原结合片段。 在优选的实施方案中，抗体是人。 还公开了编码抗体或其部分的核酸和载体，含有核酸的重组细胞，以及包含抗体或抗原结合片段的组合物。 本发明还提供了使用抗体和抗原结合片段的治疗和诊断方法。
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公开(公告)号：US07232567B2
公开(公告)日：2007-06-19
申请号：US10832985
申请日：2004-04-26
申请人： Shixin Qin , Walter Newman , Nasim Kassam
发明人： Shixin Qin , Walter Newman , Nasim Kassam
CPC分类号： C07K16/2866 , A61K2039/505
摘要： The present invention relates to an antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 1 (CCR1) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR1 with a ligand thereof, and to use of the antibodies and fragments in research, therapeutic, prophylactic and diagnostic methods.
摘要翻译： 本发明涉及与哺乳动物（例如人）CC趋化因子受体1（CCR1）或受体的一部分结合并阻断配体与受体的结合的抗体或其功能片段。 本发明还涉及抑制携带哺乳动物CCR1的细胞与其配体的相互作用的方法，以及在研究，治疗，预防和诊断方法中使用抗体和片段。
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公开(公告)号：US06756035B2
公开(公告)日：2004-06-29
申请号：US09960547
申请日：2001-09-21
申请人： Shixin Qin , Walter Newman , Nasim Kassam
发明人： Shixin Qin , Walter Newman , Nasim Kassam
IPC分类号： A61K39395
CPC分类号： C07K16/2866 , A61K2039/505
摘要： The present invention relates to an antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 1 (CCR1) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR1 with a ligand thereof, and to use of the antibodies and fragments in research, therapeutic, prophylactic and diagnostic methods.
摘要翻译： 本发明涉及与哺乳动物（例如人）CC趋化因子受体1（CCR1）或受体的一部分结合并阻断配体与受体的结合的抗体或其功能片段。 本发明还涉及抑制携带哺乳动物CCR1的细胞与其配体的相互作用的方法，以及在研究，治疗，预防和诊断方法中使用抗体和片段。
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