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    Method of inhibiting stenosis and restenosis
    7.
    发明授权
    Method of inhibiting stenosis and restenosis 有权
    抑制狭窄和再狭窄的方法

    公开(公告)号：US06663863B2

    公开(公告)日：2003-12-16

    申请号：US09809739

    申请日：2001-03-15

    申请人： Christopher J. Horvath ,  Patricia E. Rao

    发明人： Christopher J. Horvath ,  Patricia E. Rao

    IPC分类号： A61K39395

    CPC分类号： C07K16/2866 ,  A61K2039/505 ,  A61M25/104 ,  C07K16/2845 ,  C07K2317/24 ,  C07K2317/76 ,  C07K2319/00

    摘要： The invention relates to a method of inhibiting stenosis or restenosis in a subject. In one embodiment, an agent which inhibits recruitment and/or adhesion of neutrophils and mononuclear cells to a site of vascular injury is administered to a subject in need thereof. In another embodiment, a first agent which inhibits recruitment and/or adhesion of neutrophils to a site of vascular injury, and a second agent which inhibits recruitment and/or adhesion of mononuclear cells to a site of vascular injury are administered to a subject in need thereof. In particular embodiments, the agents are antibodies or antigen-binding fragments thereof which bind to CD18 or CCR2.

    摘要翻译： 本发明涉及一种抑制受试者狭窄或再狭窄的方法。 在一个实施方案中，向有需要的受试者施用抑制嗜中性粒细胞和单核细胞向血管损伤部位的募集和/或粘附的药剂。 在另一个实施方案中，将抑制嗜中性粒细胞募集和/或粘附到血管损伤部位的第一药剂和抑制单核细胞募集和/或粘附到血管损伤部位的第二药剂施用于需要的受试者 其中。 在具体实施方案中，所述试剂是结合CD18或CCR2的抗体或其抗原结合片段。