公开(公告)号：US12227748B1

公开(公告)日：2025-02-18

申请号：US18646631

申请日：2024-04-25

Applicant: KING SAUD UNIVERSITY

Inventor： Md. Ashrafuzzaman

IPC: C12N15/115 ,  A61K31/7088 ,  C12Q1/02 ,  C12Q1/70

Abstract: A lipid-binding drug for binding to a membrane-based or membrane lipid comprises at least one aptamer having a sequence selected from the group consisting of GGCGGCAAAAAAAAAA (SEQ ID NO: 1), GGCGGCAAAAAAAAAAA (SEQ ID NO: 2), GGCGGCAAAAAAAAAAAA (SEQ ID NO: 3), GGCGGCAAAAAAAAAAAAA (SEQ ID NO: 4), GGCGGCGGGGGGGGGG (SEQ ID NO: 5), GGCGGCGGGGGGGGGGG (SEQ ID NO: 6), GGCGGCGGGGGGGGGGG (SEQ ID NO: 7), GGCGGCGGGGGGGGGGG (SEQ ID NO: 8), CAAAAGGAGCAAAAAAAAAAAAAAAAAAAAAAA (SEQ ID NO: 9) CAAAAGGAGCAAAAAAAAAAAAAAAAAAAAAAAA (SEQ ID NO: 10), CAAAAGGAGCAAAAAAAAAAAAAAAAAAAAAAAAA (SEQ ID NO: 11), CAAAAGGAGCAAAAAAAAAAAAAAAAAAAAAAAAAA (SEQ ID NO: 12), CAAAAGGAGCGGGGGGGGGGGGGGGGGGGGGGG (SEQ ID NO: 13), CAAAAGGAGCGGGGGGGGGGGGGGGGGGGGGGGG (SEQ ID NO: 14), CAAAAGGAGCGGGGGGGGGGGGGGGGGGGGGGGGG (SEQ ID NO: 15), and CAAAAGGAGCGGGGGGGGGGGGGGGGGGGGGGGGGG (SEQ ID NO: 16).

公开(公告)号：US20250027168A1

公开(公告)日：2025-01-23

申请号：US18778195

申请日：2024-07-19

Applicant: The Regents of the University of California ,  South Australian Health & Medical Research Institute

Inventor： Robert Cooper ,  Jeff Hasty ,  Daniel Lindsay Worthley ,  Susan Lesley Woods ,  Josephine Wright

IPC: C12Q1/6886 ,  C12N9/22 ,  C12N15/11 ,  C12N15/90 ,  C12Q1/02 ,  C12Q1/44 ,  C12Q1/6888

Abstract: Disclosed herein are methods of detecting a target nucleic acid in a sample (e.g., biological sample or environmental sample). The method includes administering to the sample an effective amount of a composition comprising an engineered bacterium (e.g., A. baylyi) and detecting an output signal. In some cases, the mammal has a cancer or an infectious disease.

公开(公告)号：US20250020667A1

公开(公告)日：2025-01-16

申请号：US18808814

申请日：2024-08-19

Applicant: Baylor College of Medicine

Inventor： Robert Allen Britton ,  Jeffrey David Galley

IPC: G01N33/68 ,  C12Q1/02 ,  C12Q1/6897

Abstract: Embodiments of the disclosure include systems, methods, and compositions for detection of imminent onset of a symptom of a gut inflammation medical condition. The disclosure also concerns microbial biosensors that detect a marker in the gut that is predictive of onset of at least one symptom of inflammatory bowel disease (IBD), for example, and such a sensor may include a promoter sensitive to the marker that is linked to expression of a detectable readout, such as in the feces of the individual with IBD.

公开(公告)号：US20240401065A1

公开(公告)日：2024-12-05

申请号：US18806599

申请日：2024-08-15

Applicant: Universitaet Basel

Inventor： Cécile Arrieumerlou ,  Simon Ittig

IPC: C12N15/74 ,  A61K48/00 ,  C07K14/195 ,  C07K14/24 ,  C12N15/70 ,  C12Q1/02

Abstract: The present invention relates to recombinant Gram-negative bacterial strains and the use thereof for delivery of heterologous proteins into eukaryotic cells.

公开(公告)号：US20240385336A1

公开(公告)日：2024-11-21

申请号：US18689863

申请日：2023-05-06

Applicant: Zhejiang Cancer Hospital

Inventor： Wenjie WU ,  Guoping SHAN ,  Jinhui CHANG ,  Jiping LIU ,  Binbing WANG ,  Feng LU ,  Yixuan JIN ,  Xue BAI ,  Xiaolong CHENG ,  Xiaotong WANG

IPC: G01T1/20 ,  C12Q1/02 ,  G01T7/00

Abstract: The present disclosure discloses a method for measuring two-dimensional distribution of an industrial irradiation dose based on sprouting lag time of spores, and provides a film for measuring distribution of an industrial irradiation dose. The method includes the following steps: (1) manufacturing the film: spreading a layer of spore suspension flat on a plane of a carrier, and evaporating a suspension solvent to fix a layer of spore pixel surface on the plane of the carrier; covering the carrier with a glass lid to form a sprouting cavity to cover the spore pixel surface within the sprouting cavity; and providing the glass lid with a filling hole configured to add a sprouting agent; (2) obtaining a calibration curve; and (3) measuring the irradiation dose.

公开(公告)号：US20240376516A1

公开(公告)日：2024-11-14

申请号：US18665203

申请日：2024-05-15

Applicant: TRAC Research, LLC

Inventor： Rella P. Christensen ,  Brad J. Ploeger

IPC: C12Q1/04 ,  A61L2/00 ,  C12Q1/02 ,  G16B35/10 ,  G16B35/20 ,  G16H50/20

Abstract: A system and method for novel processes of isolation, aseptic collection, genus-specie identification and quantification, and mapping of a restricted mixed microbe infection in living tissues in situ showing spatial distribution of the microbes within a sample of the living tissue. A tooth lesion or extraction socket and an endodontic entry excavation adjacent to an implant are examples of lesions resulting from such mixed microbe infections. The process may be incorporated into treatment procedures in a restricted area within hard or soft tissue, diagnostic techniques, minimizing failure of treatment processes, and validation of methods and products claiming antimicrobial or other properties in a treatment or preventive technique.

公开(公告)号：US20240319174A1

公开(公告)日：2024-09-26

申请号：US18732216

申请日：2024-06-03

Applicant: MEMORIAL SLOAN-KETTERING CANCER CENTER ,  SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH ,  MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES

Inventor： Karuna Ganesh

IPC: G01N33/50 ,  C12N1/20 ,  C12N5/0783 ,  C12N5/09 ,  C12Q1/02

CPC classification number: G01N33/5088 ,  C12N1/20 ,  C12N5/0636 ,  C12N5/0693 ,  C12Q1/025 ,  C12N2501/11 ,  C12N2501/415 ,  C12N2501/998 ,  C12N2503/02

Abstract: The present disclosure provides organoid co-cultures and methods of using such co-cultures. In particular, the present disclosure provides organoid-immune cell and organoid-bacterial cell co-cultures. The present disclosure further provides methods for testing therapeutic agents using the disclosed organoid co-cultures.

公开(公告)号：US12098414B2

公开(公告)日：2024-09-24

申请号：US17217041

申请日：2021-03-30

Applicant: Nankai University

Inventor： Tian Li ,  Qixing Zhou

IPC: C12Q1/02 ,  B09C1/10 ,  G01N27/327 ,  G01N33/24

CPC classification number: C12Q1/02 ,  B09C1/10 ,  G01N27/327 ,  G01N33/24

Abstract: It is provided a monitoring reactor and a method for using the same, belonging to microbiologic electrochemical early-warning technology. The monitoring reactor enriches microorganisms therein before use, and consumes the organic matter. When the organic matter in the monitoring reactor is consumed completely, i.e. the microorganisms are in a starved state, the monitoring reactor is placed in a system to be monitored for monitoring, thereby avoiding the interference of the organic matter in the soil in the monitoring reactor to the electrical signal and improving the monitoring accuracy. Furthermore, since the electrical signal in the monitoring reactor is conducted through the electricigens, the process of generating electricity of the electricigens is a process of growth and propagation of microorganism. This process is less affected by the monitored environment. Therefore, the signal output process is stable, without swell and sag of the electrical signal.

公开(公告)号：US12091652B2

公开(公告)日：2024-09-17

申请号：US17101871

申请日：2020-11-23

Applicant: AOBIOME LLC

Inventor： David R. Whitlock ,  Spiros Jamas ,  Larry Weiss ,  Ioannis Gryllos

IPC: C12N1/20 ,  A61K8/99 ,  A61K9/00 ,  A61K35/74 ,  A61K35/744 ,  A61K35/745 ,  A61K35/747 ,  A61K48/00 ,  A61L15/36 ,  A61Q15/00 ,  A61Q17/04 ,  A61Q19/00 ,  C07K14/195 ,  C12N1/00 ,  C12Q1/02 ,  C12Q1/689 ,  A61Q19/02 ,  A61Q19/04 ,  C12R1/01

CPC classification number: C12N1/20 ,  A61K8/99 ,  A61K9/0014 ,  A61K35/74 ,  A61K35/744 ,  A61K35/745 ,  A61K35/747 ,  A61K48/00 ,  A61L15/36 ,  A61Q15/00 ,  A61Q17/04 ,  A61Q19/00 ,  C07K14/195 ,  C12N1/00 ,  C12N1/205 ,  C12Q1/02 ,  C12Q1/689 ,  A61Q19/02 ,  A61Q19/04 ,  C12R2001/01

Abstract: This disclosure provides, inter alia, an optimized strain of Nitrosomonas eutropha (N. eutropha) designated D23, D23-100, or AOB D23-100. N. eutropha bacteria disclosed in this application have desirable properties, e.g., optimized properties, such as the ability to suppress growth of pathogenic bacteria, and an enhanced ability to produce nitric oxide and nitric oxide precursors. The N. eutropha herein may be used, for instance, to treat diseases associated with low nitrite levels, skin diseases, and diseases caused by pathogenic bacteria.

公开(公告)号：US12071648B2

公开(公告)日：2024-08-27

申请号：US16650492

申请日：2018-09-25

Applicant: GENOSKIN

Inventor： Claire Jardet ,  Pascal Descargues ,  Hanne Norsgaard ,  Paola Lovato

IPC: C12Q1/02 ,  C12N5/071

CPC classification number: C12Q1/025 ,  C12N5/0629 ,  C12N2501/15 ,  C12N2501/2301 ,  C12N2501/2302 ,  C12N2501/2323 ,  C12N2501/51 ,  C12N2501/515

Abstract: Disclosed is an ex-vivo model of inflamed skin, an in-vitro method for obtaining the same and uses thereof for screening anti-inflammatory compounds. The method includes injecting, into the dermis of a healthy skin biopsy previously taken from a mammal, a composition including an effective amount for activating dermal resident T cells of an anti-CD3 antibody and an anti-CD28 antibody; and b) incubating the injected skin biopsy obtained in step a) in the presence of a composition including an effective amount, for obtaining the polarization of the T cells activated in step a) into LTh1 and/or LTh17 and the synthesis of inflammation markers, of at least one mixture of IL-1β, IL-23, and TGF-β.