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公开(公告)号：US20170189454A1
公开(公告)日：2017-07-06
申请号：US15313178
申请日：2015-05-21
Applicant: AOBIOME LLC
Inventor： James Heywood , Spiros Jamas , David R. Whitlock , Larry Weiss
CPC classification number: A61K35/74 , A61J1/20 , A61J1/2003 , A61J1/202 , A61J1/2089 , A61K8/645 , A61K8/99 , A61K35/741 , B65D81/32 , C12M41/00 , C12Q1/12
Abstract: This disclosure provides, inter alia, systems and methods for storage and delivery of ammonia oxidizing bacteria, and preparations comprising ammonia oxidizing bacteria. The ammonia oxidizing bacteria may be provided in a container or a kit, with one or more other components that may enhance delivery. The systems and methods herein may be used, for instance, to treat diseases associated with low nitrite levels, skin diseases, and diseases caused by pathogenic bacteria.
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公开(公告)号：US11225640B2
公开(公告)日：2022-01-18
申请号：US16137291
申请日：2018-09-20
Applicant: AOBIOME LLC
Inventor： David R. Whitlock , Spiros Jamas , Larry Weiss
IPC: A61K9/00 , A61K48/00 , A61K35/74 , A61K8/99 , A61K35/744 , A61K35/745 , A61K35/747 , C12R1/01 , C12N1/20 , C12N1/00 , C07K14/195 , A61L15/36 , A61Q15/00 , A61Q19/00 , C12Q1/689 , A61Q17/04 , C12Q1/02 , A61Q19/02 , A61Q19/04
Abstract: A method for treating a skin disorder, e.g., acne, e.g. acne vulgaris, in a subject is provided. The method comprises administering, e.g., applying, e.g., topically administering, ammonia oxidizing bacteria, e.g., a preparation comprising ammonia oxidizing bacteria, to a surface of the subject. Preparations comprising ammonia oxidizing bacteria for treating such skin disorder, e.g., acne, e.g. acne vulgaris in a subject are also provided.
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公开(公告)号：US10131871B2
公开(公告)日：2018-11-20
申请号：US15958803
申请日：2018-04-20
Applicant: AOBIOME LLC
Inventor： David R. Whitlock , Spiros Jamas , Larry Weiss
IPC: A61K35/66 , C12R1/01 , C12N1/20 , A61K8/99 , A61Q15/00 , A61Q17/04 , A61Q19/00 , A61K35/74 , A61K48/00 , C12Q1/689 , A61K35/744 , A01N63/00 , A61K35/747 , A61K9/00 , C07K14/195 , A61K35/745 , C12N1/00 , C12Q1/02 , A61L15/36 , A61Q19/02 , A61Q19/04
Abstract: A method for treating a skin disorder, e.g., acne, e.g. acne vulgaris, in a subject is provided. The method comprises administering, e.g., applying, e.g., topically administering, ammonia oxidizing bacteria, e.g., a preparation comprising ammonia oxidizing bacteria, to a surface of the subject. Preparations comprising ammonia oxidizing bacteria for treating such skin disorder, e.g., acne, e.g. acne vulgaris in a subject are also provided.
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公开(公告)号：US20180237738A1
公开(公告)日：2018-08-23
申请号：US15958803
申请日：2018-04-20
Applicant: AOBIOME LLC
Inventor： David R. Whitlock , Spiros Jamas , Larry Weiss
IPC: C12N1/20 , A61Q15/00 , A61K8/99 , A61K35/74 , A61Q17/04 , A01N63/00 , C07K14/195 , A61Q19/00 , A61K35/745 , A61K48/00 , A61K9/00 , A61K35/744 , C12Q1/689 , A61L15/36 , A61K35/747 , C12R1/01 , C12N1/00 , C12Q1/02 , A61Q19/02 , A61Q19/04
CPC classification number: C12N1/20 , A01N63/00 , A61K8/99 , A61K9/0014 , A61K35/74 , A61K35/744 , A61K35/745 , A61K35/747 , A61K48/00 , A61L15/36 , A61Q15/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , A61Q19/04 , C07K14/195 , C12N1/00 , C12Q1/02 , C12Q1/689 , C12R1/01
Abstract: A method for treating a skin disorder, e.g., acne, e.g. acne vulgaris, in a subject is provided. The method comprises administering, e.g., applying, e.g., topically administering, ammonia oxidizing bacteria, e.g., a preparation comprising ammonia oxidizing bacteria, to a surface of the subject. Preparations comprising ammonia oxidizing bacteria for treating such skin disorder, e.g., acne, e.g. acne vulgaris in a subject are also provided.
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公开(公告)号：US20160151427A1
公开(公告)日：2016-06-02
申请号：US14882284
申请日：2015-10-13
Applicant: AOBIOME LLC
Inventor： David R. Whitlock , Spiros Jamas , Larry Weiss
CPC classification number: C12N1/20 , A01N63/00 , A61K8/99 , A61K9/0014 , A61K35/74 , A61K35/744 , A61K35/745 , A61K35/747 , A61K48/00 , A61L15/36 , A61Q15/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , A61Q19/04 , C07K14/195 , C12N1/00 , C12Q1/02 , C12Q1/689 , C12R1/01
Abstract: A method for treating a skin disorder, e.g., acne, e.g. acne vulgaris, in a subject is provided. The method comprises administering, e.g., applying, e.g., topically administering, ammonia oxidizing bacteria, e.g., a preparation comprising ammonia oxidizing bacteria, to a surface of the subject. Preparations comprising ammonia oxidizing bacteria for treating such skin disorder, e.g., acne, e.g. acne vulgaris in a subject are also provided.
Abstract translation: 一种治疗皮肤病症的方法，例如痤疮，例如痤疮。 提供了寻常痤疮，在一个主题。 该方法包括例如施用，例如将氨氧化细菌例如包含氨氧化细菌的制剂局部施用于受试者的表面。 包含用于治疗这种皮肤病症的氨氧化细菌的制剂，例如痤疮，例如痤疮。 还提供了受试者的寻常痤疮。
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Patent Agency Ranking
公开(公告)号：US20250066834A1
公开(公告)日：2025-02-27
申请号：US18939049
申请日：2024-11-06
Applicant: AOBIOME LLC
Inventor： David R. Whitlock , James Heywood , Spiros Jamas , Larry Weiss
Abstract: This disclosure provides, inter alia, systems and methods for testing products for ammonia oxidizing bacteria, quality control, and providing products with ammonia oxidizing bacteria. The systems and methods herein may be used, inter alia, to treat diseases associated with low nitrite levels, skin diseases, and diseases caused by pathogenic bacteria.
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公开(公告)号：US12091652B2
公开(公告)日：2024-09-17
申请号：US17101871
申请日：2020-11-23
Applicant: AOBIOME LLC
Inventor： David R. Whitlock , Spiros Jamas , Larry Weiss , Ioannis Gryllos
IPC: C12N1/20 , A61K8/99 , A61K9/00 , A61K35/74 , A61K35/744 , A61K35/745 , A61K35/747 , A61K48/00 , A61L15/36 , A61Q15/00 , A61Q17/04 , A61Q19/00 , C07K14/195 , C12N1/00 , C12Q1/02 , C12Q1/689 , A61Q19/02 , A61Q19/04 , C12R1/01
CPC classification number: C12N1/20 , A61K8/99 , A61K9/0014 , A61K35/74 , A61K35/744 , A61K35/745 , A61K35/747 , A61K48/00 , A61L15/36 , A61Q15/00 , A61Q17/04 , A61Q19/00 , C07K14/195 , C12N1/00 , C12N1/205 , C12Q1/02 , C12Q1/689 , A61Q19/02 , A61Q19/04 , C12R2001/01
Abstract: This disclosure provides, inter alia, an optimized strain of Nitrosomonas eutropha (N. eutropha) designated D23, D23-100, or AOB D23-100. N. eutropha bacteria disclosed in this application have desirable properties, e.g., optimized properties, such as the ability to suppress growth of pathogenic bacteria, and an enhanced ability to produce nitric oxide and nitric oxide precursors. The N. eutropha herein may be used, for instance, to treat diseases associated with low nitrite levels, skin diseases, and diseases caused by pathogenic bacteria.
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公开(公告)号：US20230190828A1
公开(公告)日：2023-06-22
申请号：US18168911
申请日：2023-02-14
Applicant: AOBIOME LLC
Inventor： David R. Whitlock , Spiros Jamas
CPC classification number: A61K35/74 , A61P9/12 , A61K9/0014 , A61K45/06
Abstract: A method of regulating blood pressure in a subject is provided. The method comprises administering a preparation comprising ammonia oxidizing microorganisms to the subject, thereby regulating blood pressure in the subject. Related preparations, kits, and devices are also provided.
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公开(公告)号：US10383900B2
公开(公告)日：2019-08-20
申请号：US15313178
申请日：2015-05-21
Applicant: AOBIOME LLC
Inventor： James Heywood , Spiros Jamas , David R. Whitlock , Larry Weiss
Abstract: This disclosure provides, inter alia, systems and methods for storage and delivery of ammonia oxidizing bacteria, and preparations comprising ammonia oxidizing bacteria. The ammonia oxidizing bacteria may be provided in a container or a kit, with one or more other components that may enhance delivery. The systems and methods herein may be used, for instance, to treat diseases associated with low nitrite levels, skin diseases, and diseases caused by pathogenic bacteria.
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公开(公告)号：US20180016544A1
公开(公告)日：2018-01-18
申请号：US15649323
申请日：2017-07-13
Applicant: AOBIOME LLC
Inventor： David R. Whitlock , Spiros Jamas , Larry Weiss
IPC: C12N1/20 , A01N63/00 , C12Q1/02 , C12N1/00 , C07K14/195 , C12Q1/68 , A61Q17/04 , A61L15/36 , A61K48/00 , A61K35/74 , A61K9/00 , A61K8/99 , C12R1/01 , A61Q19/00
CPC classification number: C12N1/20 , A01N63/00 , A61K8/99 , A61K9/0014 , A61K35/74 , A61K35/744 , A61K35/745 , A61K35/747 , A61K48/00 , A61L15/36 , A61Q15/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , A61Q19/04 , C07K14/195 , C12N1/00 , C12Q1/02 , C12Q1/689 , C12R1/01
Abstract: A method for treating a skin disorder, e.g., acne, e.g. acne vulgaris, in a subject is provided. The method comprises administering, e.g., applying, e.g., topically administering, ammonia oxidizing bacteria, e.g., a preparation comprising ammonia oxidizing bacteria, to a surface of the subject. Preparations comprising ammonia oxidizing bacteria for treating such skin disorder, e.g., acne, e.g. acne vulgaris in a subject are also provided.
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