公开(公告)号：US20240360397A1

公开(公告)日：2024-10-31

申请号：US18647679

申请日：2024-04-26

申请人： CORNING INCORPORATED

发明人： Ye Fang ,  Anthony Glenn Frutos ,  Vasiliy Nikolaevich Goral ,  Joel Andrew Schultes ,  Elena Ravilievna Streltsova ,  Todd Michael Upton ,  Jennifer Lynn Weber

IPC分类号： C12M1/12 ,  C12M1/00 ,  C12M1/34

CPC分类号： C12M25/18 ,  C12M29/04 ,  C12M41/36

摘要： A cell culture bioreactor is disclosed that has a cell culture vessel with an interior reservoir to contain a cell substrate, an inlet fluidly connected to the reservoir, and an outlet fluidly connect to the reservoir. The bioreactor also has a sensor system for measuring impedance within the reservoir. The sensor system includes a pair of electrodes that are spaced apart from each other with at least a portion of the cell substrate disposed between the pair of electrodes. Each electrode of the pair of electrodes includes a plurality of pores to allow at least one of cells and culture media to flow through the electrode.

公开(公告)号：US20240360394A1

公开(公告)日：2024-10-31

申请号：US18646757

申请日：2024-04-26

申请人： City University of Hong Kong ,  Huazhong University of Science and Technology

发明人： Xianjin XIAO ,  Mengsu YANG ,  Xiaoyu ZHOU ,  Yaoqin MU ,  Yuan WANG

IPC分类号： C12M3/06 ,  C12M1/12 ,  C12M1/26 ,  C12M1/36 ,  C12M3/00 ,  C12N5/076

CPC分类号： C12M23/16 ,  C12M21/06 ,  C12M25/16 ,  C12M33/04 ,  C12M41/48 ,  C12N5/061 ,  C12N2533/74

摘要： The present invention relates to a Biochemical-Level Automatic-screening Smart droplet-TO-micro-hydrogels chip (BLASTO-chip) system for sperm selection. The BLASTO-chip technology advances sperm selection from the primitive morphology level to a more sophisticated biochemical level, and it will not only provide a powerful tool to patients who have fertility problems but also work as a platform for further development of more advanced sperm selection technologies. The present invention also provides a method for improving the success rate of in vitro fertilization in a patient with asthenospermia.

公开(公告)号：US20240352408A1

公开(公告)日：2024-10-24

申请号：US18654976

申请日：2024-05-03

申请人： WILLIAM MARSH RICE UNIVERSITY

发明人： Jordan Miller ,  Anderson Ta ,  Bagrat Grigoryan

IPC分类号： C12N5/00 ,  B29C64/129 ,  B29C64/393 ,  B29K71/00 ,  B33Y10/00 ,  B33Y50/02 ,  B33Y70/00 ,  C12M1/12 ,  C12M3/00 ,  C12N5/078

CPC分类号： C12N5/0062 ,  B29C64/129 ,  B29C64/393 ,  B33Y10/00 ,  B33Y50/02 ,  B33Y70/00 ,  C12M3/00 ,  C12M21/08 ,  C12M25/14 ,  C12N5/0068 ,  C12N5/0641 ,  B29K2071/02 ,  C12N2513/00 ,  C12N2533/30 ,  C12N2537/00

摘要： The present disclosure provides compositions and methods for producing hydrogel matrix constructs. Methods of using hydrogel matrix constructs for tissue repair and regeneration and for the oxygenation of red blood cells are also disclosed.

公开(公告)号：US20240352392A1

公开(公告)日：2024-10-24

申请号：US18682738

申请日：2022-08-16

申请人： Vertex Pharmaceuticals Incorporated

发明人： Christopher Thanos ,  John Mills ,  Matthew Watson ,  Rahul R. Rajendran ,  Noah Nguyen

IPC分类号： C12M1/12

CPC分类号： C12M25/16 ,  C12M25/02

摘要： Macroencapsulation devices and related methods of manufacture are described where bonded membranes of a device may be mounted to an associated frame in an arrangement to provide stress relief between the frame and a seal perimeter of the bonded membranes. The seal perimeter may be arranged radially inward from an outer perimeter of the membranes such that when the membranes are mounted to a corresponding perimeter frame, the seal perimeter is spaced radially inwards from the frame with a unbonded portion of the one or more membranes disposed between the frame and seal perimeter.

公开(公告)号：US20240352390A1

公开(公告)日：2024-10-24

申请号：US18685764

申请日：2021-08-23

申请人： CORESTEMCHEMON INC.

发明人： Kyung Suk KIM ,  Seok Kee HONG ,  Tae Yong LEE ,  Si Eun YANG ,  Min Sung KIM ,  Chang Jae SHIM

IPC分类号： C12M1/12 ,  C12M1/00 ,  C12M3/00

CPC分类号： C12M25/00 ,  C12M23/38 ,  C12M23/46

摘要： Provided are a spiral type cell culture vessel and a cell culture system using same. The present invention comprises: a housing having a certain length and having respective ends which are open; first and second caps respectively assembled to one end and the other end of the housing; and at least one spiral type culture support which is disposed in an internal space of the housing and in which a cell culture is performed. The spiral type culture support comprises at least one culture sheet of which one edge is in contact with and is fixed to a support shaft having a certain length, the culture sheet is spirally wound around the support shaft, and a culture medium passes in one direction due to a gap formed between the spirally wound culture sheet and the inner side thereof, and thus, a cell culture space is formed in which the cell culture is performed.

公开(公告)号：US20240344006A1

公开(公告)日：2024-10-17

申请号：US18291524

申请日：2022-08-19

申请人： MERCK PATENT GMBH

发明人： Kevin T. Dicker ,  Ryan Sylvia ,  Aletta Schnitzler ,  Jaivin Patel ,  Luca Cera

IPC分类号： C12M1/12 ,  B01D67/00 ,  B01D69/02 ,  B01D69/06 ,  B01D69/08 ,  B01D71/08 ,  B01D71/74

CPC分类号： C12M25/02 ,  B01D67/0011 ,  B01D67/00165 ,  B01D67/0083 ,  B01D67/0086 ,  B01D67/0088 ,  B01D67/009 ,  B01D67/0093 ,  B01D69/02 ,  B01D69/06 ,  B01D69/08 ,  B01D71/08 ,  B01D71/74 ,  C12M25/10 ,  B01D2323/081 ,  B01D2323/10 ,  B01D2323/12 ,  B01D2323/20 ,  B01D2323/21811 ,  B01D2323/21826 ,  B01D2323/219 ,  B01D2323/30 ,  B01D2323/34 ,  B01D2325/56 ,  B01D2325/58

摘要： A method of manufacture of crosslinked, edible, porous hollow fibers and sheet membranes suitable for the manufacture of clean meat products, the hollow fibers and sheet membranes made therefrom and methods of use thereof.

公开(公告)号：US12116557B2

公开(公告)日：2024-10-15

申请号：US16958182

申请日：2018-12-27

申请人： SEKISUI CHEMICAL CO., LTD.

发明人： Satoshi Haneda ,  Yuriko Manabe ,  Ryoma Ishii ,  Hiroki Iguchi ,  Hiroshi Yamauchi ,  Takahiro Omura

IPC分类号： C12N5/074 ,  C08F124/00 ,  C08L79/02 ,  C12M1/12 ,  C12M3/00 ,  C12N5/00 ,  C12N5/0735

CPC分类号： C12M25/14 ,  C08F124/00 ,  C08L79/02 ,  C12M21/06 ,  C12N5/0068 ,  C12N5/0606 ,  C12N5/0607 ,  C12N5/0696 ,  C08L2666/36 ,  C12N2533/30 ,  C12N2533/70

摘要： A scaffolding material for culturing a stem cell, which contains a synthetic resin, and has a nitrogen content of the synthetic resin of 0.1% by mass or more and 10% by mass or less. According to the scaffolding material for stem cell culture, the scaffolding material can have suitable hydrophilicity and strength, high fixation of stem cells after seeding, and highly efficient cell proliferation.

公开(公告)号：US20240336882A1

公开(公告)日：2024-10-10

申请号：US18681554

申请日：2022-08-25

申请人： TOKYO OHKA KOGYO CO., LTD.

发明人： Takashi KAMIZONO ,  Takashi FUJIMOTO ,  Takafumi AKABANE ,  Taku SATOH ,  Hiroyuki MORIGUCHI

IPC分类号： C12M3/06 ,  C12M1/00 ,  C12M1/12

CPC分类号： C12M23/16 ,  C12M25/06 ,  C12M29/04

摘要： A chip for cell culture, including a laminate having a flow path structure inside, in which respective members constituting respective layers of the laminate are adhered by adhesive layers, and the adhesive layer includes a first adhesive layer formed of an adhesive that contains a polyester-based resin having a glass transition temperature of 37° C. or higher and 120° C. or lower.

公开(公告)号：US20240327795A1

公开(公告)日：2024-10-03

申请号：US18576102

申请日：2022-07-05

申请人： BRAINSTORM CELL THERAPEUTICS LTD.

发明人： Yossef LEVY ,  Jonathan SEMO ,  Lena ELSTER KHOMSKY ,  Keren MIZRAHI

IPC分类号： C12N5/0775 ,  C12M1/12

CPC分类号： C12N5/0663 ,  C12M25/10 ,  C12N2500/32 ,  C12N2500/38

摘要： The disclosure relates to a method for generating cells which secrete neurotrophic factors (NTFs) in a functionally closed and automated hollow-fiber bioreactor system comprising inducing differentiation of a population of undifferentiated mesenchymal stem cells (MSCs) in a differentiating medium supplemented with ascorbic acid. The disclosure further relates to a method of treating a disease for which administration of neurotrophic factor is beneficial and to a pharmaceutical composition including the described cells.

公开(公告)号：US20240309304A1

公开(公告)日：2024-09-19

申请号：US18598039

申请日：2024-03-07

申请人： University of North Texas

发明人： Yong Yang ,  Jiafeng Liu ,  Kun Man

IPC分类号： C12M3/06 ,  C12M1/00 ,  C12M1/12 ,  C12M1/34 ,  C12M1/42 ,  C12N5/071 ,  C12N5/077

CPC分类号： C12M23/16 ,  C12M23/26 ,  C12M23/58 ,  C12M25/02 ,  C12M35/04 ,  C12M41/46 ,  C12N5/0656 ,  C12N5/0688 ,  C12N2533/90 ,  C12N2539/00

摘要： Provided herein is a 3D microfluidic device mimicking an anatomy and physiology of a human lung alveolar interstitium comprising: at least one inlet and one outlet in fluid communication with an inlet chamber and an outlet chamber; an interstitium chamber that comprises an electrospun nanofibrous membrane to support the growth of lung epithelial cells and fibroblasts, at least one inlet chamber and an outlet chamber to provide a growth media to the lung epithelial cells and fibroblasts; a pneumatic chamber separated from the interstitium chamber by a water-impermeable membrane and a source of air in fluid communication with the pneumatic chamber; and an air chamber in fluid communication a second side of the with electrospun nanofibrous membrane of the interstitium chamber, wherein the air chamber is opposite the pneumatic chamber; wherein the integration of inputs and outputs mimics the anatomy and physiology of the human lung alveolar interstitium.