公开(公告)号：US20240352392A1

公开(公告)日：2024-10-24

申请号：US18682738

申请日：2022-08-16

申请人： Vertex Pharmaceuticals Incorporated

发明人： Christopher Thanos ,  John Mills ,  Matthew Watson ,  Rahul R. Rajendran ,  Noah Nguyen

IPC分类号： C12M1/12

CPC分类号： C12M25/16 ,  C12M25/02

摘要： Macroencapsulation devices and related methods of manufacture are described where bonded membranes of a device may be mounted to an associated frame in an arrangement to provide stress relief between the frame and a seal perimeter of the bonded membranes. The seal perimeter may be arranged radially inward from an outer perimeter of the membranes such that when the membranes are mounted to a corresponding perimeter frame, the seal perimeter is spaced radially inwards from the frame with a unbonded portion of the one or more membranes disposed between the frame and seal perimeter.