公开(公告)号：US20240287015A1

公开(公告)日：2024-08-29

申请号：US18564780

申请日：2022-05-26

申请人： NanoVation Therapeutics Inc.

发明人： Marco A. Ciufolini ,  Fariba Saadati ,  Anthony C. Y. Tam ,  Daniel Kurek ,  Dominik Witzigmann ,  Jayesh Kulkarni

IPC分类号： C07D317/28 ,  A61K9/51 ,  C07C29/143 ,  C07C45/65 ,  C07C227/18 ,  C07C319/20

CPC分类号： C07D317/28 ,  A61K9/5123 ,  A61K9/5192 ,  C07C29/143 ,  C07C45/65 ,  C07C227/18 ,  C07C319/20

摘要： Provided herein is a method for producing an ionizable lipid that comprises: (i) reacting fatty esters in a Claisen condensation reaction in the presence of a catalyst, the Claisen condensation employing a weak base and carried out at a temperature of between −10 and 60 degrees Celsius to produce a ketoester; (ii) reacting the ketoester produced in step (i) under conditions to produce a ketone from the ketoester in one or more steps via a hydrolysis and decarboxylation of the ketoester; and (iii) preparing the ionizable lipid from the ketone thereof using one or more synthesis steps resulting in an addition of an ionizable head group moiety to (a) the ketone; or (b) an alcohol produced from an optional reduction of the ketone to produce the alcohol, thereby producing the ionizable lipid. The ionizable lipid produced in step (iii) may be formulated in a drug delivery vehicle.

公开(公告)号：US20240254066A1

公开(公告)日：2024-08-01

申请号：US18560341

申请日：2022-05-12

申请人： GW Research Limited

发明人： Alan James SILCOCK ,  Karen Ka-Yen TSE ,  Paul Stuart HINCHLIFFE ,  Andrew SHARPE ,  Iain David SIMPSON ,  Joanne PEACH ,  Stefano LEVANTO ,  Antoine MILLET ,  Inderjit Singh MANN

IPC分类号： C07C43/295 ,  A61K31/05 ,  A61K31/055 ,  A61K31/075 ,  A61K31/085 ,  A61K31/137 ,  A61K31/277 ,  A61K31/351 ,  A61K31/36 ,  A61K31/415 ,  A61K31/42 ,  A61K31/426 ,  A61K31/4418 ,  A61K31/505 ,  A61P25/08 ,  C07C29/143 ,  C07C35/18 ,  C07C37/48 ,  C07C37/56 ,  C07C39/23 ,  C07C39/42 ,  C07C41/03 ,  C07C41/26 ,  C07C41/30 ,  C07C43/23 ,  C07C67/08 ,  C07C67/287 ,  C07C69/94 ,  C07C213/08 ,  C07C215/50 ,  C07C253/30 ,  C07C255/36 ,  C07C303/30 ,  C07C309/87 ,  C07D211/70 ,  C07D213/30 ,  C07D213/61 ,  C07D213/64 ,  C07D213/65 ,  C07D231/12 ,  C07D239/34 ,  C07D261/08 ,  C07D277/24 ,  C07D309/22 ,  C07D317/54

CPC分类号： C07C43/295 ,  A61K31/05 ,  A61K31/055 ,  A61K31/075 ,  A61K31/085 ,  A61K31/137 ,  A61K31/277 ,  A61K31/351 ,  A61K31/36 ,  A61K31/415 ,  A61K31/42 ,  A61K31/426 ,  A61K31/4418 ,  A61K31/505 ,  A61P25/08 ,  C07C29/143 ,  C07C35/18 ,  C07C37/48 ,  C07C37/56 ,  C07C39/23 ,  C07C39/42 ,  C07C41/03 ,  C07C41/26 ,  C07C41/30 ,  C07C43/23 ,  C07C67/08 ,  C07C67/287 ,  C07C69/94 ,  C07C213/08 ,  C07C215/50 ,  C07C253/30 ,  C07C255/36 ,  C07C303/30 ,  C07C309/87 ,  C07D211/70 ,  C07D213/30 ,  C07D213/61 ,  C07D213/64 ,  C07D213/65 ,  C07D231/12 ,  C07D239/34 ,  C07D261/08 ,  C07D277/24 ,  C07D309/22 ,  C07D317/54 ,  C07C2601/02 ,  C07C2601/10 ,  C07C2601/16

摘要： The present invention relates to a group of resorcinol derivatives as a pharmaceutically active compounds and methods of preparation thereof. Resorcinol derivatives have been used to treat various diseases and disorders. While such treatments hold promise, there remains a need in the art for more effective treatments and this has been brought about by way of the resorcinol derivative of the invention.

公开(公告)号：US20220168720A1

公开(公告)日：2022-06-02

申请号：US17673220

申请日：2022-02-16

申请人： UNIVERSITA DEGLI STUDI DI UDINE ,  INNOVATION FACTORY S.R.L.

发明人： Walter BARATTA ,  Salvatore BALDINO ,  Steven GIBOULOT

IPC分类号： B01J31/24 ,  C07B41/02 ,  C07F15/00 ,  C07C29/143 ,  C07C29/145 ,  C07C41/26 ,  C07C201/12 ,  C07C29/14 ,  B01J31/18

摘要： The invention relates to monocarbonyl complexes of ruthenium and osmium with bi- and tridentate nitrogen and phosphine ligands. The invention relates to methods for preparing these complexes and the use of these complexes, isolated or prepared in situ, as catalysts for reduction reactions of ketones and aldehydes both via transfer hydrogenation or hydrogenation with hydrogen.

公开(公告)号：US20220119345A1

公开(公告)日：2022-04-21

申请号：US17503176

申请日：2021-10-15

申请人： Nikang Therapeutics, Inc.

发明人： Jiping FU ,  Yan LOU ,  Yigang HE ,  Yuetao SHI ,  Peng ZHOU ,  Xingxing LI

IPC分类号： C07C253/30 ,  C07C45/27 ,  C07C29/00 ,  C07C29/143 ,  C07C45/66 ,  C07C67/307 ,  C07C45/00 ,  C07C67/343

摘要： Disclosed herein are processes for preparing certain intermediates useful in the synthesis of 3-fluoro-5-(((1S,2aR)-1,3,3,4,4-pentafluoro-2a-hydroxy-2,2a,3,4-tetrahydro-1H-cyclopenta[cd]inden-7-yl)oxy)benzonitrile or a pharmaceutically acceptable salt thereof.

公开(公告)号：US11278876B2

公开(公告)日：2022-03-22

申请号：US16075315

申请日：2017-02-03

申请人： UNIVERSITA DEGLI STUDI DI UDINE ,  INNOVATION FACTORY S.R.L.

发明人： Walter Baratta ,  Salvatore Baldino ,  Steven Giboulot

IPC分类号： B01J31/24 ,  C07B41/02 ,  C07F15/00 ,  C07C29/143 ,  C07C29/145 ,  C07C41/26 ,  C07C201/12 ,  C07C29/14 ,  B01J31/18

摘要： The invention relates to monocarbonyl complexes of ruthenium and osmium with bi- and tridentate nitrogen and phosphine ligands. The invention relates to methods for preparing these complexes and the use of these complexes, isolated or prepared in situ, as catalysts for reduction reactions of ketones and aldehydes both via transfer hydrogenation or hydrogenation with hydrogen.

公开(公告)号：US20210284929A1

公开(公告)日：2021-09-16

申请号：US17250115

申请日：2019-05-23

申请人： S H KELKAR & COMPANY LIMITED

发明人： Freddy POST ,  Leszek DOSZCZAK ,  Nitesh CHAUDHARI ,  Raju KAPSE

IPC分类号： C11B9/00 ,  C07C33/025 ,  C07C29/143 ,  A61Q5/02 ,  A61K8/34 ,  C07C31/125 ,  A23L27/20

摘要： The present invention relates to new classes of odorous alcohols (odorants) derived from 2,3-dimethylbutene which are useful as fragrance or flavor materials in particular in providing natural piney olfactory notes with a complex profile to perfume, aroma or deodorizing/masking compositions.

公开(公告)号：US10710948B2

公开(公告)日：2020-07-14

申请号：US16546906

申请日：2019-08-21

申请人： Roivant Sciences GmbH

发明人： Stéphane De Lombaert ,  Daniel R. Goldberg

IPC分类号： C07C29/32 ,  C07C29/143 ,  C07C259/10 ,  C07C45/45 ,  C07C49/80

摘要： The present invention relates to processes for the preparation of (R)-1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanol, 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone, and intermediates thereof, which are useful in the preparation of inhibitors of TPH1 for the treatment of, for example, gastrointestinal, cardiovascular, pulmonary, inflammatory, metabolic, low bone mass diseases, serotonin syndrome, and cancer.

公开(公告)号：US20190023680A1

公开(公告)日：2019-01-24

申请号：US16024368

申请日：2018-06-29

申请人： James William Leahy ,  Zachary Paul Shultz ,  Grant Alexander Lawrence

发明人： James William Leahy ,  Zachary Paul Shultz ,  Grant Alexander Lawrence

IPC分类号： C07D311/80 ,  C07C45/67 ,  C07C45/41 ,  C07C67/08 ,  C07C45/68 ,  C07C29/143 ,  C07C29/132 ,  C07C69/533 ,  C07C49/248

摘要： Provided are synthesis processes and intermediates for preparing cannabinoids and analogs.

公开(公告)号：US20180009730A1

公开(公告)日：2018-01-11

申请号：US15547425

申请日：2016-01-29

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE DE MONTPELLIER

发明人： Claude GRISON ,  Vincent ESCANDE

IPC分类号： C07C45/65 ,  C07C45/62 ,  C01G9/04 ,  C07C29/143 ,  C01G49/10 ,  C01F7/56 ,  C07F7/08 ,  C07C29/17

CPC分类号： C07C45/65 ,  C01F7/56 ,  C01G9/04 ,  C01G49/10 ,  C07C29/143 ,  C07C29/175 ,  C07C45/62 ,  C07C67/31 ,  C07C2601/08 ,  C07C2601/14 ,  C07F7/0896 ,  C07C69/732 ,  C07C35/12 ,  C07C35/08 ,  C07C31/125 ,  C07C49/297 ,  C07C49/303 ,  C07C49/245

摘要： Disclosed is an adduct between a Lewis acid, preferably aluminum trichloride, iron trichloride, or zinc dichloride, and a hydrosilane;—a method for preparing same; and a method for for reducing, particularly, an aldehyde, a ketone, an α,β-unsaturated ketone, an imine, or an α,β-unsaturated imine.

公开(公告)号：US20160251287A1

公开(公告)日：2016-09-01

申请号：US15033847

申请日：2014-11-03

申请人： COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH

发明人： Anil Kisan KINAGE ,  Balasaheb Rajendra JAVALE ,  Pralhad Arjun BURATE

IPC分类号： C07C29/143 ,  B01J29/50 ,  B01J29/85 ,  B01J29/40 ,  C01B39/48 ,  B01J37/10 ,  B01J37/08 ,  C01B39/54 ,  C01B39/40 ,  B01J29/70 ,  B01J37/00

CPC分类号： C07C29/143 ,  B01J29/40 ,  B01J29/50 ,  B01J29/7007 ,  B01J29/7038 ,  B01J29/85 ,  B01J31/0274 ,  B01J31/0275 ,  B01J37/0018 ,  B01J37/082 ,  B01J37/10 ,  B01J2231/643 ,  C01B39/40 ,  C01B39/48 ,  C01B39/54

摘要： The present invention discloses chiral siliceous composition comprising chiral or achiral silane moiety ‘A’, substituted in another moiety ‘B’ with tetrahedral metallo-silica or silica framework with mesoporous and microporous structure, useful as chiral heterogeneous catalyst and in enantioselective separations. The invention further discloses a method for introducing molecular level chirality in crystalline framework of silicate and metallosilicate with mesoporous or microporous structure thereof.

摘要翻译： 本发明公开了包含手性或非手性硅烷部分“A”的手性硅质组合物，其在另一部分“B”中被四面体金属二氧化硅或具有介孔和微孔结构的二氧化硅骨架取代，可用作手性非均相催化剂和对映选择性分离。 本发明还公开了一种在具有介孔或微孔结构的硅酸盐和金属硅酸盐的结晶骨架中引入分子级手性的方法。