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    Sertraline hydrochloride polymorphs
    3.
    发明申请
    Sertraline hydrochloride polymorphs 审中-公开
    舍曲林盐酸多晶型物

    公开(公告)号：US20080176949A1

    公开(公告)日：2008-07-24

    申请号：US12077993

    申请日：2008-03-21

    Applicant: Eduard Schwartz ,  Tamar Nidam ,  Anita Liberman ,  Marioara Mendelovici ,  Judith Aronhime ,  Claude Singer ,  Evgeni Valdman

    Inventor： Eduard Schwartz ,  Tamar Nidam ,  Anita Liberman ,  Marioara Mendelovici ,  Judith Aronhime ,  Claude Singer ,  Evgeni Valdman

    IPC: A61K31/135 ,  A61P43/00 ,  C07C211/33

    CPC classification number: C07C209/84 ,  A61K31/135 ,  C07C211/42 ,  C07C2602/10

    Abstract: The present invention is directed to forms II, III, V, VI, VII, VIII, IX and X of sertraline hydrochloride and novel methods for their preparation. According to the present invention, sertraline hydrochloride polymorph II may be produced by slurrying sertraline hydrochloride polymorph VI in aprotic organic solvent. Sertraline hydrochloride polymorphic form III may be produced by heating sertraline hydrochloride polymorphs V and VI. Sertraline hydrochloride forms V and VI may be produced from either sertraline hydrochloride or sertraline base by crystallization. Sertraline hydrochloride Form VII may be produced by suspending sertraline chloride polymorph V in water, followed by filtration. Sertraline hydrochloride Forms VIII and IX may be produced by suspending sertraline base in water followed by acidification and filtration. Sertraline hydrochloride Form X may be produced by suspending sertraline hydrochloride in benzyl alcohol with heating, followed by filtration.

    Abstract translation: 本发明涉及舍曲林盐酸盐的形式II，III，V，VI，VII，VIII，IX和X及其制备方法。 根据本发明，盐酸舍曲林多晶型II可以通过将盐酸舍曲林多晶型VI制成非质子有机溶剂来制备。 舍曲林盐酸盐多晶型III可以通过加热舍曲林盐酸盐多晶型物V和VI来制备。 舍曲林盐酸盐形成V和VI可以通过结晶从舍曲林盐酸盐或舍曲林碱产生。 盐酸舍曲林形式VII可以通过将舍曲林氯化物多晶型V悬浮在水中，然后过滤来制备。 盐酸舍曲林形式VIII和IX可以通过将舍曲林碱悬浮在水中然后酸化和过滤来制备。 舍曲林盐酸盐形式X可以通过在加热下将舍曲林盐酸舍曲林悬浮在苄醇中，然后过滤来制备。

    METHOD FOR PRODUCING AROMATIC AMINO COMPOUND
    4.
    发明申请
    METHOD FOR PRODUCING AROMATIC AMINO COMPOUND 审中-公开
    生产芳族氨基化合物的方法

    公开(公告)号：US20070249866A1

    公开(公告)日：2007-10-25

    申请号：US11764912

    申请日：2007-06-19

    Applicant: Toshihiro IWAKUMA ,  Fumio Moriwaki

    Inventor： Toshihiro IWAKUMA ,  Fumio Moriwaki

    IPC: C07C211/33

    CPC classification number: C07C211/54 ,  C07C209/10 ,  C07C209/62 ,  C07C211/55

    Abstract: A method for producing aromatic amino compound (V): by synthesizing intermediate compound (IV): by the reaction of compound (I): H2N—R1 with a mixture of halogenated aryl compounds (II): Ar1-X and (III): Ar2-X in the presence of a noble metal catalyst, followed by eliminating the substituent R1 from the nitrogen atom in compound (IV) under an acidic condition or an alkaline condition or by addition of a reducing agent or an oxidizing agent. (R1: a substituent having 2 to 50 carbon atoms; Ar1 and Ar2: a substituted or unsubstituted hydrocarbon group or heterocyclic group having 6 to 50 carbon atoms and the same with or different from each other; and X: a halogen group). The aromatic amino compound useful as the charge transporting material can be produced efficiently at a great yield without using highly toxic raw materials.

    Abstract translation: 制备芳香族氨基化合物（V）的方法：通过合成中间体化合物（IV）：通过化合物（I）：H 2 NR 1 R 1与 卤化芳基化合物（II）：Ar 1 -X和（III）：Ar 2 -X在贵金属催化剂存在下，然后除去取代基R' 在酸性条件或碱性条件下，通过添加还原剂或氧化剂，在化合物（IV）中的氮原子上加成物质。 （R 1）：具有2至50个碳原子的取代基; Ar 1和Ar 2：取代或未取代的烃基或杂环基，其具有 6〜50个碳原子，并且彼此相同或不同; X为卤素基团）。 用作电荷输送材料的芳族氨基化合物可以在不使用剧毒原料的情况下以高产率有效地制备。

    Process for aminating a mixture obtained in cracking a mineral oil fraction with ammonia or a primary or secondary amine over specific heterogeneous catalysts
    5.
    发明授权
    Process for aminating a mixture obtained in cracking a mineral oil fraction with ammonia or a primary or secondary amine over specific heterogeneous catalysts 失效
    在特定的非均相催化剂上胺化与氨或伯或仲胺裂解矿物油馏分获得的混合物的方法

    公开(公告)号：US5763668A

    公开(公告)日：1998-06-09

    申请号：US675731

    申请日：1996-07-03

    Applicant: Uwe Dingerdissen ,  Jurgen Herrmann ,  Karsten Eller

    Inventor： Uwe Dingerdissen ,  Jurgen Herrmann ,  Karsten Eller

    IPC: B01J29/04 ,  B01J29/08 ,  B01J29/40 ,  C07B61/00 ,  C07C209/00 ,  C07C209/02 ,  C07C209/60 ,  C07C211/01 ,  C07C211/33

    CPC classification number: C07C209/02 ,  Y02P20/582

    Abstract: Amines are prepared by reacting a mixture obtained in the cracking of mineral oil fractions with ammonia or a primary or secondary amine of the general formula I ##STR1## where R.sup.1 and R.sup.2 are each hydrogen, C.sub.1 -C.sub.20 -alkyl, C.sub.2 -C.sub.20 -alkenyl, C.sub.2 -C.sub.20 -alkynyl, C.sub.3 -C.sub.20 -cycloalkyl, C.sub.4 -C.sub.20 -alkylcycloalkyl, C.sub.4 -C.sub.20 -cycloalkylalkyl, aryl, C.sub.7 --C.sub.20 -alkylaryl or C.sub.7 --C.sub.20 -aralkyl or together are a saturated or unsaturated C.sub.2 -C.sub.12 -alkylene ene chain, at from 200.degree. to 350.degree. C. and from 100 to 300 bar in the presence of a heterogeneous catalyst, by a process which comprises using one or more members of the following classes as the heterogeneous catalyst: a) zeolites b) aluminosilicates c) hydrothermally prepared phosphates d) mesoporous oxides having a large surface area e) pillared interlayered clays (PILCs) f) amorphous oxides which are prepared by the sol-gel process g) acid-treated sheet silicates

    Abstract translation: 通过使在矿物油馏分裂解中获得的混合物与氨或通式I的伯胺或仲胺反应制备胺，其中R1和R2各自为氢，C1-C20烷基，C2- C20-烯基，C2-C20-炔基，C3-C20-环烷基，C4-C20-烷基环烷基，C4-C20-环烷基烷基，芳基，C7-C20-烷基芳基或C7-C20-芳烷基或一起是饱和或不饱和的C2- 在多相催化剂存在下，在200-350℃和100-300巴条件下，通过包括使用一种或多种以下类别的成员作为多相催化剂的方法：a） 沸石b）铝硅酸盐c）水热制备的磷酸盐d）具有大表面积的介孔氧化物e）柱状层间粘土（PILC）f）通过溶胶 - 凝胶法制备的无定形氧化物g）酸处理的片状硅酸盐

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